Abstract
The t complex of the mouse is located on the proximal half of chromosome 17 and spans approximately 1% of the genome (for Review see Frischauf 1985; Silver 1985). Wild mouse populations of the species Mus.m.musculus and M.m.domesticus carry two variant forms of this chromosomal region, designated wild type (+) and t haplotype (t). The t haplotype form has several very unusual properties. If a mouse is heterozygous for a t haplotype (+/t), meiotic recombination is strongly suppressed between the markers T and H-2 that are separated by 12cM. Therefore a t haplotype behaves as a genetic unit. In heterozygous (+/t) males the t chromosome has a selective advantage. Up to 99% of the offspring of such a male will inherit the t chromosome. Several factors have been shown to be responsible for this property of t haplotypes (Lyon 1984), but no biochemical explanation has been found so far.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Herrmann, B.G., Lehrach, H. (1988). From Phenotype to Gene: Molecular Cloning in the Brachyury (T) Locus Region. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_12
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DOI: https://doi.org/10.1007/978-3-642-50059-6_12
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