Abstract
Very little is known of the long-range sequence organisation of mammalian chromosomes; or of the relationship of long-range sequence organisation to the physical and genetic properites of. mammalian chromosomes. While the organisation of sequences of varying repetition in individual DNA clones of limited size (< 50 kb) is well documented, the detailed physical and genetic relationships of unique and repeat sequences over long distances on the mammalian chromosome is poorly characterised. In order to allow us to determine the physical and genetic relationships of individual DNA sequences over long distances it has been necessary to construct long-range genetic and physical maps that encompass chromosome regions much greater in size than the average DNA clone. At the same time such long-range genetic and physical maps can determine the genetic and physical limits on the chromosome of a number of genetic loci of known phenotype and unknown gene product and provide a number of molecular start-points for the isolation of such genes, which are not approachable by classical genetic engineering techniques.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Brown, S.D.M. et al. (1988). The Long-Range Mapping of Mammalian Chromosomes. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_1
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DOI: https://doi.org/10.1007/978-3-642-50059-6_1
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