Tumors Arising at Site of Preexisting Bone Lesions



The development of sarcoma is the most serious complication of Paget disease. In fact, Paget’s original case (1877) developed a fibrosarcoma in the radius after 22 years, and five of his 23 patients died of sarcoma. Although well recognized as a possible complication of Paget disease, the exact incidence of malignancy is difficult to establish because there is no reliable statistical information on the frequency of uncomplicated disease; in the world literature the reported incidence of malignancy ranges from 0.15% to 20%.


Bone Sarcoma Paget Disease Pagetic Bone Malignant Fibrous Histiocytomas Postradiation Sarcoma 
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Sarcoma Developing in Paget Disease of Bone

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Postradiation Sarcoma of Bone

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  1. 1.W.H.O. Collaborating Center for the Histological Definition and Classification of Bone TumorsSweden
  2. 2.National University of Buenos AiresBuenos AiresArgentina
  3. 3.Department of Orthopedic SurgerySt. Louis University Medical CenterSt. LouisUSA
  4. 4.Rush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

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