Advertisement

Giant-Cell Tumor (Osteoclastoma)

Chapter

Abstract

Definition, WHO: “An aggressive tumor, characterized by richly vascularized tissue consisting of rather plump spindle-shaped or ovoid cells and by the presence of numerous giant cells of osteoclast type, which are uniformly distributed throughout the tumor tissue. Relatively little collagen is present. Areas of hemorrhage and regressive changes, such as necrosis, fibrosis, and fibrohistiocytic reaction, are frequently present, especially in larger or longstanding tumors.”

Keywords

Giant Cell Multinucleated Giant Cell Giant Cell Tumour Aneurysmal Bone Cyst Myeloid Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abelanet R, Daudet-Monsac M, Laoussadi S et al. (1986) Frequency and diagnostic value of the virus-like filamentous intranuclear inclusions in giant cell tumor of bone, not associated with Paget’s disease: a study of 43 cases. Virchows Arch [A] 410:65–68Google Scholar
  2. Ackerman LV, Spjut HJ (1962) Tumors of bone and cartilage. Atlas of tumor pathology, Fasc 4. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  3. Aegerter EE (1947) Giant cell tumors of bone: a critical survey. Am J Pathol 23:283–297PubMedGoogle Scholar
  4. Aegerter EE, Kirkpatrick JA Jr (1975) Orthopedic diseases: physiology, pathology, radiology, 4th edn. W.B. Saunders, PhiladelphiaGoogle Scholar
  5. Aoki J, Moser RP, Vinh TN (1989) Giant-cell tumor of the scapula: a review of 13 cases. Skeletal Radiol 18:427–434PubMedGoogle Scholar
  6. Aparisi T, Arborgh B, Ericsson JLE (1977) Giant cell tumor of bone: detailed fine structural analysis of different cell components. Virchows Arch [A] 376:273–298Google Scholar
  7. Aparisi T, Arborgh B, Ericsson JLE (1978) Giant cell tumor of bone: fine structural localization of alkaline phosphatase. Virchows Arch [A] 378:287–295Google Scholar
  8. Athanasou NA, Bliss E, Gatter KC et al. (1985) An immunohistological study of giant-cell tumor of bone: evidence for an osteoclast origin of the giant cells. J Pathol 147:153–158PubMedGoogle Scholar
  9. Bernstrom P, Stark HH (1971) Giant cell reaction of a metacarpal. Am J Clin Pathol 55:77–81Google Scholar
  10. Bertheussen KJ, Hoick S, Schiodt T (1983) Giant cell lesion of bone of the hand with particular emphasis on giant cell reparative granuloma. J Hand Surg [Am] 8:46–49Google Scholar
  11. Bertoni F, Present D, Enneking WF (1985) Giant-cell tumor of bone with pulmonary metastases. J Bone Joint Surg [Am] 8:890–900Google Scholar
  12. Bertoni F, Calderoni P, Bacchini P et al. (1986) Benign fibrous histiocytoma of bone. J Bone Joint Surg [Am] 68:1225–1230Google Scholar
  13. Bertoni F, Present D, Sudanese A et al. (1988) Giant-cell tumor of bone with pulmonary metastases. Six case reports and a review of the literature. Clin Orthop 237:275–285PubMedGoogle Scholar
  14. Bhaskar SN, Bernier JL, Godby F (1959) Aneurysmal bone cyst and other giant cell lesions of the jaws; report of 104 cases. J Oral Surg 17:30–41PubMedGoogle Scholar
  15. Bloodgood JC (1923) Benign giant-cell tumor of bone: its diagnosis and conservative treatment. Am J Surg 37:105–116Google Scholar
  16. Boquist L, Larsson SE, Lorentzon R (1976) Genuine giant-cell tumour of bone: a combined cytological, histopathological and ultrastructural study. Pathol Eur 11:117–127PubMedGoogle Scholar
  17. Brecher ME, Franklin WA, Simon MA (1986) Immunohistochemical study of mononuclear phagocyte antigens in giant cell tumor of bone. Am J Pathol 125:252–257PubMedGoogle Scholar
  18. Bridge JA, Neff JR, Bhatja PS, Singer WG, Murphy MD (1990) Cytogenetic findings and biologic behaviour of giant cell tumors of bone. Cancer 65:2697–2703PubMedGoogle Scholar
  19. Burmester GR, Winchester RJ, Dimitriu-Bona A et al. (1983) Delineation of four cell types comprising the giant cell tumor of bone. Expression of IA and monocyte-macrophage lineage antigens. J Clin Invest 71:1633–1648PubMedGoogle Scholar
  20. Caballes RL (1981) The mechanism of metastasis in the so-called benign giant cell tumor of bone. Hum Pathol 12:762–767PubMedGoogle Scholar
  21. Cade S (1949) Giant-cell tumour of bone (editorial). J Bone Joint Surg [Br] 31:158–160Google Scholar
  22. Cahan GW, Woodard HQ, Higinbotham NL, Stewart JW, Coley BL (1948) Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1:3–29PubMedGoogle Scholar
  23. Campanacci M (1981) Tumori delle ossa e delle parti molli. 2 volumes. Aulo Gaggi Editore, Bologna, ItalyGoogle Scholar
  24. Campanacci M (1990) Bone and soft tissue tumors. Springer, Vienna New YorkGoogle Scholar
  25. Campanacci M, Giunti A, Olmi R (1973) La localizazzione meta-diafisiaria del tumore a cellula giganti. Chir Organi Mov 62:29–38Google Scholar
  26. Campanacci M, Giunti A, Olmi R (1975) Giant-cell tumors of bone: a study of 209 cases with long-term follow-up in 130. Ital J Orthop Traumatol 1:249–277Google Scholar
  27. Campanacci M, Baldini N, Boriani S et al. (1987) Giant-cell tumor of bone. J Bone Joint Surg [Am] 69:106–114Google Scholar
  28. Campbell CJ, Akbarnia BA (1975) Giant-cell tumor of the radius treated by massive resection and tibial bone graft. J Bone Joint Surg [Am] 57:982–986Google Scholar
  29. Caskey PM, Wolf MD, Fechner RE (1985) Multicentric giant cell reparative granuloma of the small bones of the hand: a case report and review of the literature. Clin Orthop 193:199–205PubMedGoogle Scholar
  30. Coley BL, Higinbotham NL, Kogure T (1958) Giant cell tumor of bone. Am J Surg 96:479–491PubMedGoogle Scholar
  31. Cooper KL, Beabout JW, Dahlin DC (1984) Giant cell tumor: ossification in soft-tissue implants. Radiology 15:597–602Google Scholar
  32. Cruz M, Coley BL, Stewart FW (1957) Post irradiation bone sarcoma: report of 11 cases. Cancer 10:72–88PubMedGoogle Scholar
  33. Dahlin DC (1978) Bone tumors, 3rd edn. Charles C. Thomas, Springfield, ILGoogle Scholar
  34. Dahlin DC (1977) Giant cell tumor of vertebrae above the sacrum: a review of 31 cases. Cancer 39:1350–1356PubMedGoogle Scholar
  35. Dahlin DC, Unni KK (1986) Bone tumors: general aspects and data on 8542 cases. Charles C. Thomas, Springfield, ILGoogle Scholar
  36. Dahlin DC, Cupps RE, Johnson EW Jr (1970) Giant-cell tumor: a study of 195 cases. Cancer 25:1061–1070PubMedGoogle Scholar
  37. D’Alonzo RT, Pitcock JA, Milford LW (1972) Giant-cell reaction of bone: report of two cases. J Bone Joint Surg [Am] 54:1267–1271Google Scholar
  38. De Santis E, Porfiri B, Simoni C et al. (1982) L’ultrastruttural del tumore a cellule giganti dell’osso. Arch Putti Chir Organi Mov 32:333–344PubMedGoogle Scholar
  39. Duncan CP, Morton KS, Arthur JF (1983) Giant cell tumour of bone: its aggressiveness and potential for malignant changes. Can J Surg 26:475–477PubMedGoogle Scholar
  40. Dyke SC (1931) Metastases of the “benign” giant cell tumor of bone (osteoclastoma). J Pathol Bacteriol 34:259–263Google Scholar
  41. Eckhardt JJ, Grogan TJ (1986) Giant cell tumor of bone. Clin Orthop 204:45–58Google Scholar
  42. Ewing J (1922) A review and classification of bone sarcomas. Arch Surg 4:485–533Google Scholar
  43. Ewing J (1928) The classification and treatment of bone sarcomas. Cancer. Wood, New York, p 365Google Scholar
  44. Finch GF, Gleave HH (1926) A case of osteoclastoma (myeloid sarcoma, benign giant tumor) with pulmonary metastases. J Pathol Bacteriol 29:339Google Scholar
  45. Fitzpatrick DJ, Bullough PG (1977) Giant cell tumor of the lunate bone: a case report. J Hand Surg 2:269–270Google Scholar
  46. Fornasier VL, Flores L, Hastings D et al. (1985) Virus-like filamentous intranuclear inclusions in a giant-cell tumor, not associated with Paget’s disease of bone. J Bone Joint Surg [Am] 67:333–336Google Scholar
  47. Gallardo H, Lustig ES, Schajowicz F (1970) Growth and maintenance of human giant cell bone tumors (osteoclastomas) in continuous culture. Oncology 24:146–159PubMedGoogle Scholar
  48. Gilmer WS (1954) Histochemical studies in bone disease. I. Distribution of acid and alkaline phosphatase in bone tumors as a diagnostic acid. J Bone Joint Surg [Am] 36:182–183Google Scholar
  49. Gitelis S, Wang J, Quast M, Schajowicz F, Templeton A (1990) Recurrence of a giant-cell tumor with malignant transformation to a fibrosarcoma 25 years after primary treatment. J Bone Joint Surg [Am] 71:757–761Google Scholar
  50. Glass TA, Mills SE, Fechner RE et al. (1983) Giant-cell reparative granuloma of the hands and feet. Radiology 149:65–68PubMedGoogle Scholar
  51. Goidanich IF (1956) I tumori primitivi dell’osso. Atti 41st Congr Soc Ital Ortop TraumatolGoogle Scholar
  52. Goldenberg RR, Campbell CJ, Bonfiglio M (1970) Giant-cell tumor of bone: an analysis of 218 cases. J Bone Joint Surg [Am] 52:619–663Google Scholar
  53. Goldring SR, Schiller AL, Mankin HJ et al. (1986) Characterization of cells from human giant cell tumors of bone. Clin Orthop 204:59–74PubMedGoogle Scholar
  54. Goldring SR, Roelke MS, Petrison KK et al. (1987) Human giant cell tumors of bone: identification and characterization of cell types. J Clin Invest 79:483–491PubMedGoogle Scholar
  55. Gomori G (1941) Distribution of acid phosphatase in tissues under normal and pathologic conditions. Arch Pathol 32:189–199Google Scholar
  56. Gomori G (1956) Histochemical methods for acid phosphatase. Stain Technol 4:425–461Google Scholar
  57. Gresen AA, Dahlin DC, Peterson LFA, Payne WS (1973) “Benign” giant cell tumor of bone metastasizing to lung: report of a case. Ann Thorac Surg 16:531–535PubMedGoogle Scholar
  58. Gross SA (1879) Sarcoma of the long bone: based upon a study of 175 cases. Am J Med Sci 155:2–57Google Scholar
  59. Hanaoka H, Friedman B, Mack RP (1970) Ultrastructure and histogenesis of giant cell tumors of bone. Cancer 25:1408PubMedGoogle Scholar
  60. Hancox N (1956) The osteoclast. In: Bourne GH (ed) The biochemistry and physiology of bone. Academic, New YorkGoogle Scholar
  61. Hatcher CH (1945) The pathogenesis of localized fibrous lesion in the metaphyses of long bones. Ann Surg 122:1016–1030Google Scholar
  62. Hermann SD, Mesgarzadeh M, Bonakdarpour A et al. (1987) The role of magnetic resonance imaging in giant cell tumor of bone. Skeletal Radiol 16:635–643Google Scholar
  63. Horton MA, Lewis D, McNulty K et al. (1985) Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res 45:5663–5669PubMedGoogle Scholar
  64. Hutter RVP, Worcester JN Jr, Francis KC, Foote FW Jr, Stewart FW (1962) Benign and malignant giant cell tumors of bone: a clinicopathological analysis of the natural history of the disease. Cancer 15:653–690PubMedGoogle Scholar
  65. Huvos AG (1979) Bone tumors: diagnosis, treatment and prognosis. W.B. Saunders, PhiladelphiaGoogle Scholar
  66. Huvos AG (1991) Bone tumors: diagnosis, treatment, prognosis. W.B. Saunders, PhiladelphiaGoogle Scholar
  67. Imura S, Takeda M (1968) Histochemical and electron microscopic studies on the giant cell tumors of bone (especially cultured cells). Springer, New York Berlin HeidelbergGoogle Scholar
  68. Jacobs P (1972) The diagnosis of osteoclastoma (giant cell tumors): a radiological and pathological correlation. Br J Radiol 45:121–136PubMedGoogle Scholar
  69. Jaffe HL (1953a) Giant cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jaw bones. J Oral Surg 67:159–175Google Scholar
  70. Jaffe HL (1953b) Giant cell tumour (osteoclastoma) of bones: its pathologic delimitation and the inherent clinical implications. Ann R Coll Surg Engl 13:343–355PubMedGoogle Scholar
  71. Jaffe HL (1958) Tumors and tumorous conditions of the bones and joints. Lea & Febiger, PhiladelphiaGoogle Scholar
  72. Jaffe JL, Lichtenstein L, Portis RB (1940) Giant cell tumor of bone: its pathologic appearance, grading, supposed variants and treatment. Arch Pathol 30:993–1031Google Scholar
  73. Jeffree GM, Price CHG (1965) Bone tumors and their enzymes: a study of the phosphatases, non-specific esterases and betaglucuronidase of osteogenic and cartilaginous tumors, fibroblastic and giant cell lesions. J Bone Joint Surg [Br] 47:120Google Scholar
  74. Jernstrom P, Stark HH (1971) Giant cell reaction of a metacarpal. Am J Clin Pathol 55:77–81PubMedGoogle Scholar
  75. Jewell JH, Bush LF (1964) “Benign” giant cell tumor of bone with a solitary pulmonary metastasis: a case report. J Bone Joint Surg [Am] 56:848–852Google Scholar
  76. Johnston J (1977) Giant cell tumor of bone: the role of the giant cell in orthopedic pathology. Orthop Clin North Am 8:751–770PubMedGoogle Scholar
  77. Kraievski NA, Raikhlin NT, Soloviov JN (1970) Histochemical characteristics of giant cell bone tumors. Folia Histochem Cytochem (Krakow) 8:3–10Google Scholar
  78. Kuwana K (1967) Electron microscopic study on giant cell tumor of bone. Nippon Geka Hokan 36:819PubMedGoogle Scholar
  79. Ladanyi M, Traganos F, Huvos AG (1989) Benign metastasizing giant-cell tumors of bone: a DNA flow cytometric study. Cancer 64:1521–1526PubMedGoogle Scholar
  80. Larsson SE, Lorentzon R, Boquist L (1975) Giant cell tumor of bone: a demographic, clinical and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968. J Bone Joint Surg [Am] 57:167–173Google Scholar
  81. Lasser EC, Tetewsky H (1957) Metastasizing giant cell tumors: report of an unusual case with indolent bone and pulmonary metastases. Am J Roentgenol Radium Ther Nucl Med 78:804–811PubMedGoogle Scholar
  82. Le Charpentier Y, Forest M, Daudet-Monsac M et al. (1975) Ultrastructure of giant cell tumors of bone. Rev Chir Orthop 61:387–390PubMedGoogle Scholar
  83. Le Charpentier Y, Le Charpentier M, Forest M et al. (1977) Intranuclear inclusions in giant cell bone tumor. Demonstration by electron microscopy. Nouv Presse Med 6:259–262PubMedGoogle Scholar
  84. Lichtenstein L (1977) Bone tumors, 5th edn. C.V. Mosby, St. LouisGoogle Scholar
  85. Louis DS, Hankin FM, Braunstein EM (1986) Giant cell tumour of the triquetrum. J Hand Surg [Br] 11:279–280Google Scholar
  86. Lustig ES, Schajowicz F (1944) Cultivo de tejido de tumor gigantocelular de los huesos. Contribución a la histogénesis de la célula gigante. Rev Ortop Traumatol 14:134–151Google Scholar
  87. Maloney WG, Vaughan LM, Jones MH, Ross J (1983) Benign metastasizing giant-cell tumor of bone. Report of three cases and review of the literature. Clin Orthop 243:208–215Google Scholar
  88. Mankin HJ, Fogelson FS, Trasher AZ, Jaffer F (1976) Massive resection and autograft transplantation in the treatment of malignant bone tumors. N Engl J Med 294:1247PubMedGoogle Scholar
  89. Marcove RC, Weis LD, Vaghaiwalla MR, Pearson NR, Huvos AG (1978) Cryosurgey in the treatment of giant cell tumors of bone: a report of 52 consecutive cases. Cancer 41:957–969PubMedGoogle Scholar
  90. Matsuno T (1990) Benign fibrous histiocytoma involving the ends of long bone. Skeletal Radiol 19:561–566PubMedGoogle Scholar
  91. McCarthy EF (1980) Giant-cell tumor of bone: an historical perspective. Clin Orthop 153:14–25PubMedGoogle Scholar
  92. McCarthy EF, Serrano JA, Wasserkrug HL et al. (1979) The ultrastructural localization of secretory acid phosphatase in giant cell tumor of bone. Clin Orthop 141:295–302PubMedGoogle Scholar
  93. McGrath PM (1972) Giant cell tumours of bone: an analysis of 52 cases. J Bone Joint Surg [Br] 52:216–219Google Scholar
  94. Mclnerney DP, Middlemis JH (1978) Giant cell tumors of bone. Skeletal Radiol 2:195–204Google Scholar
  95. McKenna RJ, Schwinn CP, Soong KY, Higinbotham NL (1964) Osteogenic sarcoma arising in Paget’s disease. Cancer 17:42–66PubMedGoogle Scholar
  96. Merle d’Aubigné R, Tomeno B (1977) The treatment of giant cell tumors: an analysis of 85 consecutive cases. Int Orthop 1:159–164Google Scholar
  97. Meyerding HW (1941) Benign and malignant giant cell tumor of bone: diagnosis and results of treatment. JAMA 117:1849–1855Google Scholar
  98. Mills BG, Singer FR (1976) Nuclear inclusions in Paget’s disease of bone. Science 194:201–202PubMedGoogle Scholar
  99. Mirra JM (1980) Bone tumors: diagnosis and treatment. J.B. Lippincott, PhiladelphiaGoogle Scholar
  100. Mirra JM, Gold RH (1982) Giant cell tumor containing viral-like intranuclear inclusions, in association with Paget disease. Skeletal Radiol 8:67–70PubMedGoogle Scholar
  101. Mirra JM, Ulich T, Magidson J et al. (1982) A case of probable benign pulmonary “metastases” or implants arising from a giant cell tumor of bone. Clin Orthop 162:245–254PubMedGoogle Scholar
  102. Mnaymneh WA, Dudley HR, Mnaymneh LG (1964) Giant cell tumor of bone. J Bone Joint Surg [Am] 46:63–75Google Scholar
  103. Murphy WR, Ackerman LV (1956) Benign and malignant giant cell tumors of bone. Cancer 9:317–339PubMedGoogle Scholar
  104. Nascimento AG, Huvos AG, Marcove RC (1979) Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. Cancer 44:1393–1402PubMedGoogle Scholar
  105. Nelaton E (1860) D’une nouvelle espèce de tumeurs benignes des os, ou tumeurs a myeloplaxes. Delahaye, ParisGoogle Scholar
  106. Ottolenghi CE (1972) Massive osteo- and osteoarticular bone grafts. Technic and results of 62 cases. Clin Orthop 87:156–164PubMedGoogle Scholar
  107. Pais C, Barrufaldi O (1958) Richerche istochimiche sui tumori a mieloplassi (contributo allo studio istogenetico del tumore delle cellule giganti; significato dei reperti nella valutazione della malignita). Arch Putti Chir Organi Mov 9:12–46Google Scholar
  108. Pan P, Dahlin DC, Lipscomb PR, Bernatz PE (1964) “Benign” giant cell tumor of the radius with pulmonary metastasis. Proc Staff Meet Mayo Clin 39:344–349Google Scholar
  109. Parish FF (1973) Allograft replacement of all or part of a long bone following excision of a tumor: report of 21 cases. J Bone Joint Surg [Am] 55:1–22Google Scholar
  110. Peimer CA, Schiller AL, Mankin HJ et al. (1980) Multicentric giant cell tumor. J Bone Joint Surg [Am] 62:652–656Google Scholar
  111. Peison B, Feigenbaum J (1976) Metaphysial giant-cell tumor in a girl of 14. Radiology 118:145–146PubMedGoogle Scholar
  112. Pepler WD (1958) The histochemistry of a giant cell tumour (osteoclastoma and giant cell epulis). J Pathol Bacteriol 76:505–510PubMedGoogle Scholar
  113. Persson B, Wouters HW (1976) Curettage and acrylic cementation in surgery of giant cell tumors of bone. Clin Orthop 120:125–133PubMedGoogle Scholar
  114. Picci P, Manfrini M, Zucchi V et al. (1983) Giant-cell tumor bone in skeletally immature patients. J Bone Joint Surg [Am] 65:486–490Google Scholar
  115. Pindborg JJ, Kramer IR (1971) Histological typing of odontogenic tumors, jaw cysts and allied lesions, vol 5. World Health Organization, GenevaGoogle Scholar
  116. Rebel A, Malkani K, Basle M (1974) Anomalies nucleaires des ostéoclastes de la maladie osseuse de Paget. Nouv Presse Med 3:1299–1301PubMedGoogle Scholar
  117. Reddy CRRM, Rao PS, Rajakumari K (1974) Giant cell tumors of bone in South India. J Bone Joint Surg [Am] 56:617–619Google Scholar
  118. Rock MG, Pritchard DJ, Unni KK (1984) Metastases from histologically benign giant-cell tumor of bone. J Bone Joint Surg [Am] 66:269–274Google Scholar
  119. Rock MG, Sim FH, Unni KK et al. (1986) Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of 19 patients. J Bone Joint Surg [Am] 68:1073–1079Google Scholar
  120. Roessner A, von-Bassewitz DB, Schlake W et al. (1984) Biologic characterization of human bone tumors. III. Giant cell tumor of bone: a combined electron microscopical, histochemical, and autoradiographical study. Pathol Res Pract 178:431–440PubMedGoogle Scholar
  121. Russell DS (1949) Malignant osteoclastoma and the association of malignant osteoclastoma with Paget’s osteitis deformans. J Bone Joint Surg [Br] 31:281–290Google Scholar
  122. Sabanas AO, Dahlin DC, Childs DS Jr et al. (1956) Postradiation sarcoma of bone. Cancer 9:528–542PubMedGoogle Scholar
  123. Savini R, Gherlinzoni F, Morandi M et al. (1983) Surgical treatment of giant-cell tumor of the spine. The experience at the Istituto Ortopedico Rizzoli. J Bone Joint Surg [Am] 65:1283–1289Google Scholar
  124. Scaglietti O, Mondolfo S (1938) Sulla varieta xantomatosa die tumori gigantocellulari. Chir Organi Mov 23:435–459Google Scholar
  125. Schajowicz F (1961) Giant cell tumors of bone (osteoclastoma): a pathological and histochemical study. J Bone Joint Surg [Am] 43:1–29Google Scholar
  126. Schajowicz F (1981) Tumors and tumorlike lesions of bone and joints. Springer, New York Berlin HeidelbergGoogle Scholar
  127. Schajowicz F, Cabrini RL (1954) Histochemical studies of bone in normal and pathological conditions. With special reference to alkaline phosphatase, glycogen and mucopolysaccharides. J Bone Joint Surg [Br] 36:474–489Google Scholar
  128. Schajowicz F, Cabrini RL (1958) Histochemical localization of acid phosphatase in bone tissue. Science 127:1447–1448PubMedGoogle Scholar
  129. Schajowicz F, Oleaga Alarcon F (1945) La transformación sarcomatosa de la osteitis deformante de Paget. Bol Trab Soc Argent Cirug Ortop 10:116–130Google Scholar
  130. Schajowicz F, Slullitel J (1966) Giant cell tumor associated with Paget’s disease of bone. J Bone Joint Surg [Am] 48:1340–1349Google Scholar
  131. Schajowicz F, Ackerman LV, Sissons HA (1972) Histological typing of bone tumors. International histological classification of tumors, No. 6. World Health Organization, GenevaGoogle Scholar
  132. Schajowicz F, Giménez IB, Cabrini RL (1977) Estudio microespectrofotométrico del ADN de las células gigantes multinucleadas en el osteoclastoma y osteosarcoma. Bol Trab Soc Argent Ortop Traumatol 42:323–330Google Scholar
  133. Schajowicz F, Cabrini RL, Gimenez I (1981) Micro-spectrophotometric quantitation of DNA in bone tumors with giant cells (osteoclastoma, osteosarcoma and chondroblastoma). Clin Orthop 156:91–97PubMedGoogle Scholar
  134. Schajowicz F, Santini Araujo E, Berenstein M (1983) Sarcoma complicating Paget’s disease of bone. A clinicopathological study of 62 cases. J Bone Joint Surg [Br] 65:299–307Google Scholar
  135. Schajowicz F, Ubios AM, Santini Araujo E et al. (1985) Virus-like intranuclear inclusions in giant cell tumor of bone. Clin Orthop 201:247–250PubMedGoogle Scholar
  136. Schatzki SC, Dudley HR (1961) Bone sarcoma complicating Paget’s disease. A report of 3 cases with long survival. Cancer 14:517–523PubMedGoogle Scholar
  137. Schwinn P (1976) Giant cell lesions of bone. In: Bones and joints, I.A.P. Monogr No. 17. Williams & Wilkins, Baltimore, pp 236–299Google Scholar
  138. Sherman M, Fabricius R (1961) Giant cell tumor in metaphysis in a child. Report of an unusual case. J Bone Joint Surg [Am] 43:1225–1229Google Scholar
  139. Shuffstall RM, Gregory JE (1953) Osteoid formation in giant cell tumors of bone. Am J Pathol 29:1123–1127PubMedGoogle Scholar
  140. Sim FH, Dahlin DC, Beabout JW (1977) Multicentric giant cell tumors of bone. J Bone Joint Surg [Am] 59:1052–1060Google Scholar
  141. Singson R, Feldman F (1983) Case report 229. Diagnosis: multiple (multicentric) giant cell tumors of bone. Skeletal Radiol 9:276–281PubMedGoogle Scholar
  142. Slullitel I, Slullitel J, Schajowicz F (1959) Tumor de células gigantes con transformación sarcomatosa a los 18 anos. Bol Trab Soc Argent Ortop Traumatol 24:85–93Google Scholar
  143. Small S, Rowe NH (1975) A “true giant cell tumor” in the mandible? J Oral Surg 33:296–301PubMedGoogle Scholar
  144. Spjut HJ, Dorfman HD, Fechner RE, Ackerman LV (1971) Tumors of bone and cartilage. Atlas of tumor pathology, 2nd series, Fasc 5. Armed Forces Institute of Pathology, Washington, DCGoogle Scholar
  145. Steiner GC, Ghosh L, Dorfman HD (1972) Ultrastructure of giant cell tumors of bone. Hum Pathol 3:569–586PubMedGoogle Scholar
  146. Stewart MJ (1914) Observations on myeloid sarcoma with an analysis of 50 cases. Lancet 11:1236–1242Google Scholar
  147. Sung HW, Kuo DP, Shu WP et al. (1981) Giant-cell tumor of bone: analysis of 280 cases in Chinese patients. J Bone Joint Surg [Am] 64:755–761Google Scholar
  148. Sybrandy S, De la Fuente AA (1973) Multiple giant-cell tumor of bone: report of a case. J Bone Joint Surg [Br] 55:350–356Google Scholar
  149. Thiery JP, Mazabraud A, Veisin MC, Lacroix G (1974) L’étude cytologique de la tumeur à cellules géantes. Rev Chir Orthop 61:337–386Google Scholar
  150. Thomson AD, Turner-Warwick RT (1955) Skeletal sarcomata and giant cell tumours. J Bone Joint Surg [Br] 37:266–303Google Scholar
  151. Tornberg DN, Dick HM, Johnston AD (1975) Multicentric giant-cell tumors in the long bones: a case report. J Bone Joint Surg [Am] 57:420–422Google Scholar
  152. Trifaud A, Faysse R, Papillon J (1956) Les tumeurs à myéloplaxes des os ou tumeurs à cellules géantes. Rev Chir Orthop 43:413–513Google Scholar
  153. Troup JB, Dahlin DC, Coventry MB (1960) The significance of giant cells in osteogenic sarcoma. Do they indicate a relationship between osteogenic sarcoma and giant cell tumors of bone? Proc Staff Meet Mayo Clin 35:170–186Google Scholar
  154. Uehlinger E (1976) Primary malignancy, secondary malignancy and semimalignancy of bone tumors. In: Grundmann E (ed) Malignant bone tumors. Springer, New York Berlin Heidelberg, pp 109–119Google Scholar
  155. Ueno K (1964) Electron microscopic observations of giant cell tumors of bone. J Jpn Orthop Assoc 38:724Google Scholar
  156. Vacher-Lavenu MC, Louvel A, Daudet-Monsac M et al. (1981) Inclusions tubulofilamenteuses intranucleaired dans les cellules multinuclées des tumeurs à cellules géantes des os. Etude ultrastructurale d’une series de 31 tumeurs. CR Acad Sci Paris 293:639–644Google Scholar
  157. Vanel D, Contesso G, Rebibo G et al. (1983) Benign giant-cell tumours of bone with pulmonary metastases and favourable prognosis. Report on two cases and review of the literature. Skeletal Radiol 10:221–226PubMedGoogle Scholar
  158. Volkov M (1970) Allotransplantation of joints. J Bone Joint Surg [Am] 52:49Google Scholar
  159. von Albertini A (1928) Gutartige Riesenzellengeschwülste. Thieme, LeipzigGoogle Scholar
  160. Weinmann JP, Sicher H (1947) Bone and bones. Fundamentals of bone biology. C.V. Mosby, St. LouisGoogle Scholar
  161. Welsh RA, Meyer AT (1970) Nuclear fragmentations and associated fibrils in giant cell tumor of bone. Lab Invest 22:63–72PubMedGoogle Scholar
  162. Willis RA (1949) Pathology of osteoclastoma or giant cell tumour of bone. J Bone Joint Surg [Br] 31:236–240Google Scholar
  163. Wilson PD, Lance EM (1965) Surgical reconstruction of the skeleton following segmental resection for bone tumors. J Bone Joint Surg [Am] 47:1629–1656Google Scholar
  164. Windeyer BW, Woodyatt PB (1949) Osteoclastoma: a study of 38 cases. J Bone Joint Surg [Br] 31:252–267Google Scholar
  165. Wold LE, Swee RG (1984) Giant cell tumor of the small bones of the hands and feet. Semin Diagn Pathol 1:173–184PubMedGoogle Scholar
  166. Wold LE, Dobyns JH, Swee RG et al. (1986) Giant cell reaction (giant cell reparative granuloma) of small bones of the hands and feet. Am J Surg Pathol 10:491–496PubMedGoogle Scholar
  167. Wray CC, MacDonald AW, Richardson RA (1990) Benign giant-cell tumor with metastases to bone and lung. J Bone Joint Surg [Br] 72:486–489Google Scholar
  168. Xiang J, Spanier SS, Benson NA, Braylan RC (1987) Flow cytometric analysis of DNA in bone and soft tissue tumors using nuclear suspensions. Cancer 59:1951–1958PubMedGoogle Scholar
  169. Yoshida H, Akeho M, Yumoto T (1982) Giant cell tumor of bone. Enzyme histochemical, biochemical and tissue culture studies. Virchows Arch [A] 395:319–330Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  1. 1.W.H.O. Collaborating Center for the Histological Definition and Classification of Bone TumorsSweden
  2. 2.National University of Buenos AiresBuenos AiresArgentina
  3. 3.Department of Orthopedic SurgerySt. Louis University Medical CenterSt. LouisUSA
  4. 4.Rush-Presbyterian-St. Luke’s Medical CenterChicagoUSA

Personalised recommendations