Among the wide variety of human tumors, primary bone tumors are comparatively rare, which explains why only a few centers have been able to collect an appreciable number of cases. A major factor in the progress in the study of bone tumors was the establishment in many countries (Holland, Sweden, England, Japan, Latin America, and others) of regional tumor centers or registries, following the American example. Having centralized data collection centers makes it possible to assemble in a relatively short time abundant material that can be used in standardizing terminology and diagnosis, in carrying out research and epidemiologic studies, and above all in teaching and training medical specialists.


Bone Tumor Aspiration Biopsy Malignant Fibrous Histiocytoma Ewing Sarcoma Osteoid Osteoma 
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  1. Adler CP (1983) Knochenkrankheiten. Thieme, StuttgartGoogle Scholar
  2. Aegerter E, Kirkpatrick JAJ (1975) Orthopedic diseases: physiology, pathology, radiology, 4th edn. W.B. Saunders, PhiladelphiaGoogle Scholar
  3. Bougmill GP, Schwamsu HA (1984) Orthopaedic pathology: a synopsis with clinical and radiographic correlations. W.B. Saunders, PhiladelphiaGoogle Scholar
  4. Bullogh P, Vigorita VJ (1984) Atlas of orthopaedic pathology with clinical and radiologic correlations. University Park Press, Gower Medical Publishing, New York, LondonGoogle Scholar
  5. Campanacci M (1981) Tumori delle Ossa e delle Parti Molli. 2 volumes. Aulo Gaggi Editore, Bologna, ItalyGoogle Scholar
  6. Campanacci M (1990) Bone and soft tissue tumors. Springer, Vienna New YorkGoogle Scholar
  7. Cohen J, Bonfiglio M, Campbell CJ (1990) Orthopedic pathophysiology in diagnosis and treatment. Churchill Livingstone, New YorkGoogle Scholar
  8. Dahlin DC (1978) Bone tumors, 3rd edn. Charles C. Thomas, Springfield, ILGoogle Scholar
  9. Dahlin DC, Unni KK (1986) Bone tumors: general aspects and data on 8542 cases. Charles C. Thomas, Springfield, ILGoogle Scholar
  10. Dominok GW, Knoch G (1982) Knochengeschwülste und geschwulstähnliche Knochenerkrankungen. Fischer, JenaGoogle Scholar
  11. Edeiken J, Hodes P (1973) Roentgen diagnosis of bone, 2nd edn, vols I and II. Williams and Wilkins, BaltimoreGoogle Scholar
  12. Edeiken J, Dalinka M, Karasick D (1990) Edeiken’s roentgendiagnosis of diseases of bone, 4th edn. Williams and Wilkins, BaltimoreGoogle Scholar
  13. Enneking WF (1983) Musculoskeletal tumor surgery. Churchill Livingtone, New YorkGoogle Scholar
  14. Ewing J (1939) A review of the classification of bone tumors. Bull Am Coll Surg 24:290Google Scholar
  15. Ewing J (1940) Neoplastic diseases: a treatise on tumors (3rd edn 1928), 4th edn. W.B. Saunders, PhiladelphiaGoogle Scholar
  16. Freyschmidt J, Ostertag H (1988) Knochentumoren: Klinik, Radiologie, Pathologie. Springer, Berlin Heidelberg New YorkGoogle Scholar
  17. Greenfield GB (1980) Radiology of bone disease, 3rd edn. J.B. Lippincott, PhiladelphiaGoogle Scholar
  18. Hajdu SL (1985) Differential diagnosis of soft tissue and bone tumors. Lea & Febiger, PhiladelphiaGoogle Scholar
  19. Hudson TM (1987) Radiologic-pathologic correlation of musculoskeletal lesion. Williams and Wilkins, BaltimoreGoogle Scholar
  20. Huvos AG (1991) Bone tumors: diagnosis, treatment, prognosis. W.B. Saunders, PhiladelphiaGoogle Scholar
  21. Jaffe HL (1958) Tumors and tumorous conditions of the bones and joints. Lea & Febiger, PhiladelphiaGoogle Scholar
  22. Johnson LC (1953) A general theory of bone tumors. Bull NY Acad Med 29:164Google Scholar
  23. Lichtenstein L (1977) Bone tumors, 5th edn. C.V. Mosby, St. LouisGoogle Scholar
  24. Mirra JM, Picci P, Gold RH (1989) Bone tumors: clinical, radiologic and pathologic correlations. Lea & Febiger, PhiladelphiaGoogle Scholar
  25. Moser RP (1990) Cartilaginous tumors of the skeleton. AFIP atlas of radiologie-pathologie correlations. Fasc IL Hanley & Belfus, PhiladelphiaGoogle Scholar
  26. Murray RO, Jacobson HG (1977) The radiology of skeletal disorders, 2nd edn. Churchill Livingstone, EdinburghGoogle Scholar
  27. Netherlands Committee on Bone Tumors (1973) Radiological atlas on bone tumors, vols I and II. Williams and Wilkins, BaltimoreGoogle Scholar
  28. Povysil C (1986) Histopathology and ultrastructure of tumours and tumor-like lesions of bones. Acta Univ Carol [Med] (Praha) vol 116Google Scholar
  29. Ranniger K (1977) Bone tumours. In: Diethelm L (ed) Handbuch der medizinischen. Radiologie vol V/6. Springer, Berlin Heidelberg New YorkGoogle Scholar
  30. Resnick D, Niwayama G (1988) Diagnosis of bone and joint disorders, 2nd edn, vol 6. W.B. Saunders, PhiladelphiaGoogle Scholar
  31. Roessner A (1984) Zur Zyto-und Histogenese der malignen und semimalignen Knochentumoren. Gustav Fischer, StuttgartGoogle Scholar
  32. Schajowicz F (1981) Tumors and tumorlike lesions of bone and joints. Springer, New York Berlin HeidelbergGoogle Scholar
  33. Schajowicz F (1983) Current trends in the diagnosis and treatment of malignant bone tumors. Clin Orthop 180:22Google Scholar
  34. Schajowicz F, Ackerman LV, Sissons HA (1972) Histological typing of bone tumours. World Health Organization, GenevaGoogle Scholar
  35. Schajowicz F, McGuire MH (1989) Diagnostic difficulties in bone pathology. Clin Orthop 240:281PubMedGoogle Scholar
  36. Sissons HA, Murray RO, Kemp HBS (1984) Orthopaedic diagnosis: clinical, radiological, and pathological coordinates. Springer, Berlin Heidelberg New YorkGoogle Scholar
  37. Spjut HJ, Dorfman HD, Fechner RE, Ackerman LV (1971) Tumors of bone and cartilage. Atlas of tumor pathology, 2nd series, Fasc 5. Armed Forces Institute of Pathology, Washington DCGoogle Scholar
  38. Spjut HJ, Fechner RE, Ackerman LV (1981) Tumors of bone and cartilage. Atlas of tumor pathology. Fascicle 5, Supplement. Armed Forces Institute of Pathology, Washington DCGoogle Scholar
  39. Uhthoff K (ed) (1984) Current concepts of diagnosis and treatment of bone and soft tissue tumors. Springer, Heidelberg New York BerlinGoogle Scholar
  40. Unni KK (ed) (1988) Bone tumors. In: Contemporary issues in surgical pathology. Churchill Livingstone, New YorkGoogle Scholar
  41. Wilner D (1982) Radiology of bone tumors and allied disorders. W.B. Saunders, PhiladelphiaGoogle Scholar
  42. Wold LE, McLeod RA, Sim FH, Unni KK (1990) Atlas of orthopedic pathology. W.B. Saunders, PhiladelphiaGoogle Scholar

Diagnosis and Classification of Bone Tumors

  1. Ackermann W (1956) Vertebral trephine biopsy. Ann Surg 143:373–385PubMedGoogle Scholar
  2. Adapon BD, Legada BD, Lim EVA, Silao JV, Dalmacio-Cruz A (1981) CT guided closed biopsy of the spine. J Comput Assist Tomogr 5:73PubMedGoogle Scholar
  3. Awtar K (1975) Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol 66:188Google Scholar
  4. Ayala AG, Zornosa J (1983) Primary bone tumors: percutaneous needle biopsy. Radiology 149:675–679PubMedGoogle Scholar
  5. Baldwin RW, Pimm MV (1983) Antitumor monoclonal antibodies for radioimmunodetection of tumors and drug targeting. Cancer Metastasis Rev 2:89–106PubMedGoogle Scholar
  6. Battifora H (1984) Recent progress in the immuno-histochemistry of solid tumors. Semin Diagn Pathol 1:251–272PubMedGoogle Scholar
  7. Bender CE, Berquist TH, Wold LE (1986) Imaging assisted percutaneous biopsy of the thoracic spine. Mayo Clin Proc 61:942PubMedGoogle Scholar
  8. Berenstein M (1984) Punción biopsia de las lesiones óseas con aguja de Jamshidi. Rev Asoc Arg Ortop y Traumatol 50:393–402Google Scholar
  9. Bilbao JL, Algawa SM, de Negri M et al. (1990) Osteosarcoma: correlation between radiological and histological changes after intra-arterial chemotherapy. Eur J Radiol 11:98PubMedGoogle Scholar
  10. Birge EA, Imhoff CD (1952) Versenate as a decalcifying agent for bone. Am J Clin Pathol 22:192–193PubMedGoogle Scholar
  11. Bloem JL, Taminian AH, Eulderink F et al. (1988) Radiologic staging of primary bone sarcoma: MR imaging, scintigraphy, angiography and CT correlated with pathologic examination. Radiology 169: 805PubMedGoogle Scholar
  12. Bohndorf K, Reiser M, Lochner B et al. (1986) Magnetic resonance imaging of primary tumours and tumourlike lesions of bone. Skeletal Radiol 15:511PubMedGoogle Scholar
  13. Chuang VP, Benjamin R, Jaffe M et al. (1982) Radiographic and angiographic changes in osteosarcoma after intra-arterial chemotherapy. AJR 139:1065PubMedGoogle Scholar
  14. Codman EA (1922) The registry of cases of bone sarcoma. Surg Gynecol Obstet 34:335Google Scholar
  15. Coley BL, Higinbotham NL (1938) Giant cell tumor of bone. J Bone Joint Surg 20:870Google Scholar
  16. Coley BL, Sharp GS, Ellis EB (1931) Diagnosis of bone tumors by aspiration. Am J Surg 13:215–224Google Scholar
  17. Dahlin DC (1978) Bone tumors, 3rd edn. Charles C. Thomas, Springfield, ILGoogle Scholar
  18. DeSantos LA, Murray JA, Ayala AG (1979) The value of percutaneous needle biopsy in the management of primary bone tumors. Cancer 43:735–744PubMedGoogle Scholar
  19. Dollahite HA, Tatum L, Moinuddin SM, Carnesale PG (1989) Aspiration biopsy of primary neoplasms of bone. J Bone Joint Surg [Am] 71:1166–1169Google Scholar
  20. Eilber FR, Eckhardt J, Morton DL (1984) Advances in the treatment of sarcomas of the extremity: current status of limb salvage. Cancer 54:2695–2701PubMedGoogle Scholar
  21. Ellis F (1947) Needle biopsy in the clinical diagnosis of tumors. Br J Surg 34:240–261PubMedGoogle Scholar
  22. Embleton MJ, Glenn B, Byers VS, Baldwin RW (1981) Antitumour reactions of monoclonal antibody against a human osteogenic sarcoma cell line. Br J Cancer 43:582–587PubMedGoogle Scholar
  23. Embleton MJ, Rowland GF, Simmonds RG et al. (1983) Selective cytotoxicity against human tumour cells by a vindesine-monoclonal antibody conjugate. Br J Cancer 47:43–49PubMedGoogle Scholar
  24. Enneking WF (1985) Staging of musculoskeletal neoplasms. Skeletal Radiol 13:183Google Scholar
  25. Enneking WF, Jewett EL (1982) The issue of biopsy. J Bone Joint Surg [Am] 64:1119–1120Google Scholar
  26. Erlemann R, Sciuk J, Bosse A et al. (1990) Response of osteosarcoma and Ewing’s sarcoma to pre-operative chemotherapy: assessment with dynamic and static MR imaging and skeletal scintigraphy. Radiology 175:791PubMedGoogle Scholar
  27. Evarts CMcC (1975) Diagnostic techniques: Closed biopsy of bone. Clin Orthop 107:100–111PubMedGoogle Scholar
  28. Ewing J (1939) A review of the classification of bone tumors. Bull Am Coll Surg 24:290–295Google Scholar
  29. Farrands PA, Perkins A, Sully L, Hopkins JS, Pimm MV, Baldwin RW, Hardcastle JD (1983) Localisation of human osteosarcoma by antitumour monoclonal antibody. J Bone Joint Surg [Br] 65:638–640Google Scholar
  30. Fordham EW, Ramachandran PC (1977) Study of bone tumors with radionuclides. Encyclopedia of medical radiology, vol V, part 6. Springer Berlin Heidelberg New York, pp 603–633Google Scholar
  31. Frager DH, Goldman MJ, Seimon LP et al. (1987) Computed tomography guidance for skeletal biopsy. Skeletal Radiol 16:644–646PubMedGoogle Scholar
  32. Frankel CJ (1954) Aspiration biopsy of the spine. J Bone Joint Surg [Am] 36:69–74Google Scholar
  33. Galasko CSB (1969) The detection of skeletal metastasis from mammary cancer by gamma camera scintigraphy. Br J Surg 56:575Google Scholar
  34. Galasko CSB (1975) The pathological basis for skeletal scintigraphy. J Bone Joint Surg [Br] 57:353–359Google Scholar
  35. Gatenby RA, Mulhern CB, Modofsky PJ (1984) Computed tomography guided thin needle biopsy of small lytic bone lesions. Skeletal Radiol 11:289PubMedGoogle Scholar
  36. Gay S, Miller EJ (1978) Collagen in the physiology and pathology of connective tissue. Fischer, StuttgartGoogle Scholar
  37. Geschickter CF, Copeland MM (1949) Tumors of bone, 3rd edn. J.B. Lippincott, PhiladelphiaGoogle Scholar
  38. Glass AG, Fraumeni JF (1970) Epidemiology of bone cancer in children. JNCI 44:187–199PubMedGoogle Scholar
  39. Goidanich IF (1956) I tumori primitivi dell’osso. Atti 41st Congr Soc Ital Ortop Traumatol, BolognaGoogle Scholar
  40. Goldstein H, McNeil BJ, Zufall E et al. (1989) Is there still a place for bone scanning in Ewing’s sarcoma? J Nucl Med 21:10Google Scholar
  41. Greep RO, Fischer CJ, Morse A (1948) Alkaline phosphatase in odontogenesis and osteogenesis and its histochemical demonstration after demineralization. J Am Dent Assoc 36:427PubMedGoogle Scholar
  42. Haaga JR, Alfidi RJ (1976) Precise biopsy localization by computed tomography. Radiology 118:603PubMedGoogle Scholar
  43. Hardy DC, Murphy WA, Gilula LA (1980) Computed tomography in planning percutaneous bone biopsy. Radiology 134:447–450PubMedGoogle Scholar
  44. Hudson TM, Enneking WF, Hawkins IF Jr (1981) The value of angiography in planning surgical treatment of bone tumors. Radiology 138:283–289PubMedGoogle Scholar
  45. Hudson TM, Schiebler M, Springfield DS et al. (1983) Radiologic imaging of osteosarcoma: role in planning surgical treatment. Skeletal Radiol 10:137PubMedGoogle Scholar
  46. Jamshidi K, Swaim WR (1971) Bone marrow biopsy with unaltered architecture: a new biopsy device. J Lab Clin Med 77:335–342PubMedGoogle Scholar
  47. Jeffree GM, Price CHG (1965) Bone tumors and their enzymes: a study of the phosphatases, non-specific esterases and betaglucuronidase of osteogenic and cartilaginous tumors, and fibroblastic and giant cell lesions. J Bone Joint Surg [Br] 47:120–136Google Scholar
  48. Jensen RD, Drake RM (1970) Rarity of Ewing’s tumors in Negroes. Lancet I:777Google Scholar
  49. Johnson LC (1953) A general theory of bone tumors. Bull NY Acad Med 29:164–171Google Scholar
  50. Katz RL, Silva EG, DeSantos LA, Lukeman JM (1980) Diagnosis of eosinophilic granuloma of bone by cytology, histology, and electron microscopy of transcutaneous bone-aspiration biopsy. J Bone Joint Surg [Am] 62:1284–1290Google Scholar
  51. Kreicbergs A, Boquist L, Borssen B, Larsson SE (1982a) Prognostic factors in chondrosarcoma: a comparative study of cellular DNA content and clinicopathologic features. Cancer 50:577PubMedGoogle Scholar
  52. Kreicbergs A, Brostrom LA, Cewrien G, Einhorn S (1982b) Cellular DNA content in human osteosarcoma: aspects of diagnosis and prognosis. Cancer 50:2476PubMedGoogle Scholar
  53. Kreicbergs A, Silversward C, Tribukait B (1984) Flow DNA analysis of primary bone tumors: relationship between cellular DNA content and histopathologic classification. Cancer 53:129PubMedGoogle Scholar
  54. Kumpan W, Lechner G, Wittich GR et al. (1986) The angiographic response following pre-operative chemotherapy. Skeletal Radiol 15:96PubMedGoogle Scholar
  55. Layfield LJ, Glasgow BJ, Anders KH, Mirra JM (1987) Fine needle aspiration cytology of primary bone lesions. Acta Cytol 31:177–184PubMedGoogle Scholar
  56. Lichtenstein L (1952) Bone tumors. C.V. Mosby, St. LouisGoogle Scholar
  57. Linden G, Dunn JE (1970) Ewing’s sarcoma in Negroes. Lancet 1:1171PubMedGoogle Scholar
  58. MacKenzie A, Court Brown W, Doll R, Sissons HA (1961) Mortality from primary tumors of bone in England and Wales. Br Med J I:1782–1790Google Scholar
  59. Mankin HJ, Connor JF, Schiller AL et al. (1985) Grading of bone tumors by analysis of nuclear DNA content using flow cytometry. J Bone Joint Surg [Am] 67:404Google Scholar
  60. Mankin HJ, Lange TA, Spanier SS (1982) The hazards of biopsy in patients with malignant primary bone and soft tissue tumors. J Bone Joint Surg [Am] 64: 1121–1127Google Scholar
  61. Mankin HJ, Matsuno T, Gebhardt MC, Schiller AL, Rosenberg A (1988) Flow cytometry in the management of bone tumors. In: Unni KK (ed) Bone tumors. Churchill Livingstone, New York, pp 85–106Google Scholar
  62. Martin HE, Ellis EB (1934) Aspiration biopsy. Surg Gynecol Obstet 59:578–589Google Scholar
  63. Martin HE, Steward RW (1936) The advantages and limitations of aspiration biopsy. Am J Roentgenol Radium Ther 35:345–347Google Scholar
  64. McDonald DJ, Sim FH, McLeod RA et al. (1986) Giant-cell tumor of bone. J Bone Joint Surg [Am] 68:235Google Scholar
  65. Meyerding HW (1941) Benign and malignant cell tumors of bone. Diagnosis and treatment. J Am Med Assoc 117:1849–1855Google Scholar
  66. Mick CA, Zinrecih J (1985) Percutaneous trephine biopsy of the thoracic spine. Spine 10:737PubMedGoogle Scholar
  67. Miller RW (1976) Etiology of childhood bone cancer: epidemiologic observations. Recent Results Cancer Res 54:50–62PubMedGoogle Scholar
  68. Miller RW, Dalager NA (1974) U.S. childhood cancer deaths by cell types, 1960–68. J Pediatr 85:664–668PubMedGoogle Scholar
  69. Mink J (1986) Percutaneous bone biopsy in the patient with known or suspected osseous metastases. Radiology 161:191PubMedGoogle Scholar
  70. Misdorp W, Hart G, Delemarre JFM et al. (1988) An analysis of spontaneous and chemotherapy-associated changes in osteosarcoma. J Pathol 156:119PubMedGoogle Scholar
  71. Morris RE Jr, Benton RS (1956) Studies on demineralization of bone. Am J Clin Pathol 26:579–595, 596–603, 771–777PubMedGoogle Scholar
  72. Murphy WA (1983) Radiologically guided percutaneous musculoskeletal biopsy. Orthop Clin North Am 14: 233–241PubMedGoogle Scholar
  73. Murphy WA, Destouet JM, Gilula LA (1981) Percutaneous skeletal biopsy 1981: a procedure for radiologists — results, review, and recommendations. Radiology 139:545–549PubMedGoogle Scholar
  74. Nakamura Y, Becker LE, Marks A (1983) S-100 protein in tumors of cartilage and bone: an immuno-histochemical study. Cancer 52:1820PubMedGoogle Scholar
  75. Neville AM, Foster CSF, Moshakis V et al. (1982) Monoclonal antibodies in human tumor pathology. Hum Pathol 13:1067–1081PubMedGoogle Scholar
  76. Ottolenghi CE (1955) Diagnosis of orthopaedic lesions by aspiration biopsy. Results of 1061 punctures. J Bone Joint Surg [Am] 37:443–464Google Scholar
  77. Ottolenghi CE (1969) Aspiration biopsy of the spine. Technique for the thoracic spine and results of twenty-eight biopsies of this region. J Bone Joint Surg [Am] 51:1531–1544Google Scholar
  78. Ottolenghi CE, Schajowicz F, DeSchant FA (1964) Aspiration biopsy of the cervical spine. J Bone Joint Surg [Am] 46:715–733Google Scholar
  79. Parker F, Jackson H (1939) Primary reticulum cell sarcoma of bone. Surg Gynecol Obstet 68:45Google Scholar
  80. Pettersson H, Gillespy T III, Hamlin DJ et al. (1987) Primary musculoskeletal tumors: examinations with MR imaging compared with conventional modalities. Radiology 164:237PubMedGoogle Scholar
  81. Phemister DB (1930) Chondrosarcoma of bone. Surg Gynecol Obstet 50:216Google Scholar
  82. Phemister DB (1949) Panel on bone tumors. Proc 1st Natl Cancer Conf, p 217Google Scholar
  83. Picci P, Bacci G, Campanacci M et al. (1985) Histologic evaluation of necrosis in osteosarcoma induced by chemotherapy. Regional mapping of viable and nonviable tumor. Cancer 56:1515PubMedGoogle Scholar
  84. Picci P, Bacci G, Ricci M et al. (1988) Histological evaluation and prognostic correlation in Ewing’s sarcoma. In: Kotz R (ed) Proceedings of First Meeting of the European Musculoskeletal Oncology Society (EMSOS). Howmedica International, Vienna, pp 69–70Google Scholar
  85. Ray RD (1953) Needle biopsy of the lumbar vertebral bodies. A modification of the Valls technique. J Bone Joint Surg [Am] 35:760–762Google Scholar
  86. Raymond AK, Ayala AG (1988) Specimen management after osteosarcoma chemotherapy. In: Unni KK (ed) Bone tumors. Churchill Livingstone, New York, pp 157–181Google Scholar
  87. Remberger K, Gay S (1977) Immunohistochemical demonstration of different collagen types in the normal epiphyseal plate and in benign and malignant tumors of bone and cartilage. Z Krebsforschung 90: 95–106Google Scholar
  88. Richman IM, Gelfand M, Hill JM (1947) A method of decalcifying bone for histologic section. Arch Pathol 44:92–95Google Scholar
  89. Robertson WW, Janssen HF, Pugh JL (1984) The spread of tumor-cell sized particles after bone biopsy. J Bone Joint Surg [Br] 66:1243–1247Google Scholar
  90. Roessner A, Mellin W, Hiddemann B, Voss B, Vollmer L, Grundmann E (1984) New cytomorphologic methods in the diagnosis of bone tumors: possibilities and limitations. Semin Diagn Pathol 1:199–214PubMedGoogle Scholar
  91. Rosen G, Caparros B, Huvos AG et al. (1982) Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49:1221–1230PubMedGoogle Scholar
  92. Salzer-Kuntschik M, Delling G, Beron G et al. (1983) Morphological grades of regression in osteosarcoma after polychemotherapy — study COSS 80. J Cancer Res Clin Oncol 106:21–24PubMedGoogle Scholar
  93. Schajowicz F (1955) Aspiration biopsy in bone lesions — cytological and histological techniques. J Bone Joint Surg [Am] 37:465–471Google Scholar
  94. Schajowicz F (1959) Ewing’s sarcoma and reticulum cell sarcoma of bone. With special reference to the histo-chemical demonstration of glycogen as an aid to differential diagnosis. J Bone Joint Surg [Am] 41: 185–192Google Scholar
  95. Schajowicz F, Cabrini RL (1954) Histochemical studies of bone in normal and pathological conditions. J Bone Joint Surg [Br] 36:474–489Google Scholar
  96. Schajowicz F, Cabrini RL (1958a) Histochemical studies on glycogen in normal ossification and calcification. J Bone Joint Surg [Am] 40:1081Google Scholar
  97. Schajowicz F, Cabrini RL (1958b) Histochemical localization of acid phosphatase in bone tissue. Science 127:1447–1448PubMedGoogle Scholar
  98. Schajowicz F, Derqui JC (1968) Puncture biopsy in lesions of the locomotor system. Review of results in 4050 cases, including 941 vertebral punctures. Cancer 21:531–548PubMedGoogle Scholar
  99. Schajowicz F, Gimenez IB, Conti CJ, Cabrini RL (1976) Estudio microespectrofotométrico del ADN en condromas y condrosarcomas. Boletín de la Sociedad Argentina de Ortopedia Y Traumatologia 24:147Google Scholar
  100. Schajowicz F, Hokama J (1976) Aspiration (puncture or needle) biopsy in bone lesions. Recent Results Cancer Res 54:139–144PubMedGoogle Scholar
  101. Schajowicz F, Mondolfo S (1955) Clasificación de los tumores óseos. Rev Ortop Traumatol Lat-Am 37:266Google Scholar
  102. Shaltot A, Micheli PA, Betts JA, Darby AJ, Gishen P (1982) Jamshidi needle biopsy of bone lesions. Clin Radiol 33:193–196PubMedGoogle Scholar
  103. Sicard A, Boureau M, Marsan C (1958) La biopsie transcutanée des corps vertebraux. J Chir (Paris) 76:57–75Google Scholar
  104. Siffert RS, Arkin AM (1949) Trephine biopsy of bone with special reference to the lumbar vertebral bodies. J Bone Joint Surg [Am] 31:146–149Google Scholar
  105. Simon MA (1982) Current concepts review: biopsy of musculoskeletal tumors. J Bone Joint Surg [Am] 64: 1253–1257Google Scholar
  106. Sreebny LM, Nikiforuk G (1951) Demineralization of hard tissues by organic chelating agents. Science 113:560PubMedGoogle Scholar
  107. Stewart FW (1933) The diagnosis of tumors by aspiration. Am J Pathol 9:801–811PubMedGoogle Scholar
  108. Stoker DJ, Kissin CM (1985) Percutaneous vertebral biopsy: a review of 135 cases. Clin Radiol 36:569–577PubMedGoogle Scholar
  109. Subramanian G, McAfee JG (1977) A new complex of 99mTC for skeletal imaging. Radiology 99:192Google Scholar
  110. Subramanian G, McAfee JG, Bell EG et al. (1972) 99mTC labeled polyphosphate as a skeletal agent. Radiology 102:701PubMedGoogle Scholar
  111. Sundaram M, McDonald DJ (1989) The solitary tumor or tumorlike lesion. Top Magn Reson Imag 1(4): 17Google Scholar
  112. Sundaram M, McGuire MH (1988) Computed tomography or magnetic resonance for evaluating the solitary tumor or tumor-like lesion of bone? Skeletal Radiol 17:393PubMedGoogle Scholar
  113. Sundaram M, McGuire MH, Herbold DR et al (1986) Magnetic resonance imaging in planning limb-salvage surgery for primary malignant tumors of bone. J Bone Joint Surg [Am] 68:809Google Scholar
  114. Sundaram M, McLeod RA (1990) MR imaging of tumor and tumorlike lesions of bone and soft tissue. AJR 155:817PubMedGoogle Scholar
  115. Taylor SR, Nunez C (1984) Fine-needle aspiration biopsy in a pediatric population. Report of 64 consecutive cases. Cancer 54:1449–1453PubMedGoogle Scholar
  116. Thomas P, Battifora H, Maderino GL, Patrick J (1987) A monoclonal antibody against neuron-specific enolase: immunohistochemical comparison with a polyclonal antiserum. Am J Clin Pathol 88:146PubMedGoogle Scholar
  117. Tsai CC, McGuire MH, Mellitt RJ, Ritter RA III, Xu J, Litwicki DJ, Roodman ST (1990) Monoclonal antibody to human osteosarcoma: a novel M r 26000 protein recognized by murine hybridoma TMMR-21. Cancer Res 50:152–158PubMedGoogle Scholar
  118. Tsang KY, Warren RQ, Bishop L, Pathak S, Koger B, Lavia MF (1986) Monoclonal antibodies to human osteosarcoma-associated antigen(s). JNCI 77: 1175–1180PubMedGoogle Scholar
  119. Tsokos M, Linnoil RI, Chandra RS, Triche TJ (1984) Neuron-specific enolase in the diagnosis of neuroblastoma and other small round-cell tumors in children. Hum Pathol 15:575PubMedGoogle Scholar
  120. Urban C, Rosen G, Huvos AG et al. (1983) Chemotherapy of malignant fibrous histiocytoma of bone: a report of five cases. Cancer 51:795–802PubMedGoogle Scholar
  121. Valls J, Ottolenghi CE, Schajowicz F (1948) Aspiration biopsy in diagnosis of lesions of vertebral bodies. JAMA 136:376–382Google Scholar
  122. Valls J, Ottolenghi CE, Schajowicz F (1954) La biopsia per aspirazione nella diagnosi delle lesioni dei corpi vertebrali. Chir Organi Mov 4:49–68Google Scholar
  123. Virchow R (1864–1865) Die krankhaften Geschwülste, 2nd vol. Hirschwald, BerlinGoogle Scholar
  124. Wada T, Uede T, Ishii S, Matsuyama K, Yamawaki S, Kikuchi K (1988) Monoclonal antibodies that detect different antigenic determinants of the same human osteosarcoma-associated antigen. Cancer Res 48: 2273–2279PubMedGoogle Scholar
  125. Weiss AP, Dorfman HD (1986) S-100 protein in human cartilage lesions. J Bone Joint Surg [Am] 68:521Google Scholar
  126. Williams AD (1975) Tumors in childhood in Ibadan, Nigeria. Cancer 36:370–378PubMedGoogle Scholar
  127. Young JL, Miller RW (1975) Incidence of malignant tumors in United States children. J Pediatr 86: 254–258PubMedGoogle Scholar

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