Abstract
Giant-cell tumor of bone is a locally aggressive neoplasm that presents a management dilemma. This tumor frequently occurs in proximity to major weight-bearing joints (see Chap. III). In most reported series of giant-cell tumor, almost half of the neoplasms involve the distal femur or proximal tibia. They frequently cause significant bone destruction, placing the joint at great risk for pathologic fracture. Because of the propensity of giant-cell tumors to involve subchondral bone, care must be taken to try to preserve the articular surface during surgical management (Fig. X.1).
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References
Giant-Cell Tumor
Bell RS, Harwood AR, Goodman SB et al. (1983) Supervoltage radiotherapy in the treatment of difficult giant cell tumors of bone. Clin Orthop Rel Res 174:208
Bertoni F, Present D, Enneking WF (1985) Giant cell tumor of bone with pulmonary metastases. J Bone Joint Surg [Am] 67:890
Campanacci M, Costa P (1979) Total resection of the distal femur or proximal tibia for bone tumors. J Bone Joint Surg [Br] 61:445
Campanacci M, Baldini N, Boriani S, Sudanese A (1987) Giant-cell tumor of bone. J Bone Joint Surg [Am] 69:106–114
Capanna R, Fabbri N, Bertelli G (1989) Curettage of giant cell tumor of bone: the effect of surgical technique and adjuvants on local recurrence rate. Chir Organi Movi 75:206–207
Carrasco CH, Murray JA (1989) Giant cell tumors. Orthop Clin North Am 20:395–405
Chen ZX, Gu DZ, Yu ZH et al. (1986) Radiation therapy of giant-cell tumor of bone: analysis of 35 patients. Int J Radiat Oncol Biol Phys 12:329
Dahlin DC, Cupps RE, Johnson EW Jr (1970) Giant cell tumor. A study of 195 cases. Cancer 25:1061–1070
Enneking WF (1983a) Staging musculoskeletal tumors. In: Enneking WF (ed) Musculoskeletal tumor surgery, vol 1. Churchill Livingstone, New York, pp 69–88
Enneking WF (1983b) Surgical margins. In: Enneking WF (ed) Musculoskeletal tumor surgery, vol 1. Churchill Livingstone, New York, pp 89–122
Frassica FJ, Sim FH, Pritchard DJ, Chao EYS (1989) Subchondral replacement: a comparative analysis of reconstruction with methylmethacrylate or autogenous bone graft. Chir Organi Movi 75:189–191
Goldenberg RR, Campbell CJ, Bonfiglio M (1970) Giant-cell tumor of bone. An analysis of two hundred and eighteen cases. J Bone Joint Surg [Am] 52:619–663
Hackbarth DA (1991) Resections and reconstructions for tumors of the distal radius. Orthop Clin North Am 22:49
Jacobs PA, Clemency RE (1985) The closed cryosurgical treatment of giant cell tumor. Clin Orthop Rel Res 192:149–158
Kreicbergs A, Lonnguist PA, Nilsson B (1985) Curettage of benign lesions of bone: factors related to recurrence. Int Orthop 8:287
Lackman RD, McDonald DJ, Beckenbaugh R, Sim FH (1987) Fibular reconstruction for giant cell tumor of the distal radius. Clin Orthop 218:232
Lane JM (1989) Liquid nitogren as an adjunct. Chir Organi Movi 75:198–203
Larsson SE, Lorentzon R, Boquist L (1975) Giant cell tumor of bone. J Bone Joint Surg [Am] 57:167–173
Mankin HJ, Gebhardt MC, Tomford WW (1987) The use of frozen cadaveric allografts in the management of patients with bone tumors of the extremities. Orthop Clin North Am 18:275
Marcove RC, Weis LD, Vaghaiwalla MR et al. (1978) Cryosurgery in the treatment of giant cell tumors of bone: a report of 52 consecutive cases. Cancer 41:957–969
McDonald DJ, Sim FH, McLeod RA, Dahlin DC (1986) Giant cell tumor of bone. J Bone Joint Surg [Am] 68:235–242
Mjöberg B, Petersson H, Rosenquist R, Rydholm A (1984) Bone cement, thermal injury and the radio-lucent zone. Acta Orthop Scand 55:597–600
Ottolenghi CE (1972) Massive osteo and osteoarticular bone grafts. Clin Orthop Rel Res 87:156–164
Persson BM, Wouters HW (1976) Curettage and acrylic cementation in surgery of giant cell tumors of bone. Clin Orthop Rel Res 120:125–133
Persson BM, Ekelund L, Lövdahl R, Gunterberg B (1984) Favourable results of acrylic cementation for giant cell tumors. Acta Orthop Scand 55:209–214
Rock M (1989) Adjuvant management of benign tumors: basic concepts of phenol and cement use. Chir Organi Movi 75:195–198
Rock MG, Pritchard DJ, Unni KK (1984) Metastases from histologically benign giant cell tumor of bone. J Bone Joint Surg [Am] 66:269
Sanerkin NG (1980) Malignancy, aggressiveness and recurrence in giant cell tumor of bone. Cancer 46:1641–1649
Sim FH, Beauchamp CP, Chao EYS (1987) Reconstructions of musculoskeletal defects about the knee for tumor. Clin Orthop Rel Res 221:188
Sung HW, Kuo DP, Shu WP et al. (1982) Giant-cell tumor of bone: analysis of 208 cases in Chinese patients. J Bone Joint Surg [Am] 64:755–761
Turcotte RE, Biagini R, Sim FH, Unni KK (1989) Giant cell tumor of the spine and sacrum. Chir Organi Movi 75:104–108
Wray CC, MacDonald AW, Richardson RA (1990) Benign giant cell tumor with metastases to bone and lung. J Bone Joint Surg [Br] 72:486
Chondrosarcoma
Bertoni F, Picci P, Bacchini P et al. (1983) Mesenchymal chondrosarcoma of bone and soft tissue. Cancer 53:533
Campanacci M, Capanna R (1991) Pelvic resections: the Rizzoli Institute experience. In: Springfield DS (ed) The orthopedic clinics of North America, vol 1. W.B. Saunders, Philadelphia, pp 65–86
Capanna R, Bertoni F, Betelli G et al. (1988) Dedifferentiated chondrosarcoma. J Bone Joint Surg [Am] 70:60
Cohen L, Hendrickson F, Mansell J et al. (1984) Response of sarcomas of bone and of soft tissue to neutron beam therapy. Int J Radiat Oncol Biol Phys 10:821
Enneking WF (1983) Staging musculoskeletal tumors. In: Enneking WF (ed) Musculoskeletal tumor surgery, vol 1. Churchill Livingstone, New York, pp 69–88
Eriksson AI, Schiller A, Mankin HJ (1980) The management of chondrosarcoma of bone. Clin Orthop Rel Res 153:44
Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 40:818
Frassica FJ, Unni KK, Beabout JW et al. (1986) Dedifferentiated chondrosarcoma: a report of the clinicopathological features and treatment of 78 cases. J Bone Joint Surg [Am] 68:1197
Gitelis S, Bertoni F, Picci P, Campanacci M (1981) Chondrosarcoma of bone: the experience at the Istituto Ortopedico Rizzoli. J Bone Joint Surg [Am] 63:1249
Guerra A, Briccoli A, Capanna R et al. (1985) Resection with preservation of the lower limb in chondrosarcoma of the pelvis. Rev Chir Orthop 71:493
Harwood AR, Krajbich JI, Fornasier VL (1980a) Mesenchymal chondrosarcoma: a report of 17 cases. Clin Orthop 158:144
Harwood AR, Krajbich JI, Fornasier VL (1980b) Radiotherapy of chondrosarcoma of bone. Cancer 45:2769
Healy JH, Lane JM (1986) Chondrosarcoma. Clin Orthop Rel Res 204:119
Hudson TM, Springfield DS, Spanier SS et al. (1984) Benign exostoses and exostotic chondrosarcomas: evaluation of cartilage thickness by CT. Radiology 152:595
Huvos AG, Rosen G, Dabska M et al. (1983) Mesenchymal chondrosarcoma: a clinicopathologic analysis of 35 patients with emphasis on treatment. Cancer 51:1230
Kaufman JH, Douglass HO Jr, Blake W et al. (1977) The importance of initial presentation and treatment upon the survival of patients with chondrosarcoma. Surg Gynecol Obstet 145:357
Kim RY, Salter MM, Brascho DJ (1983) High-energy irradiation in the management of chondrosarcoma. South Med J 76:739
Krochak R, Harwood AR, Cummings BJ et al. (1983) Results of radical radiation for chondrosarcoma of bone. Radiother Oncol 1:109
Malawer MM, Sugerbaker PH, Lampert M et al. (1985) The Tikhoff-Linberg procedure: report of ten patients and presentation of a modified technique for tumors of the proximal humerus. Surgery 97:518
Marcove RC (1977) Chondrosarcoma: diagnosis and treatment. Orthop Clin North Am 8:811
Marcove RC, Miké V, Hutter RVP et al. (1972) Chondrosarcoma of the pelvis and upper end of the femur: an analysis of factors influencing survival time in 113 cases. J Bone Joint Surg [Am] 54:561
Marcove RC, Lewis MM, Huvos AG (1977a) En bloc upper humeral interscapulothoracic resection. The Tikhoff-Linberg procedure. Clin Orthop 124:219
Marcove RC, Stovell PB, Huvos AG et al. (1977b) The use of cryosurgery in the treatment of low and medium grade chondrosarcoma: a preliminary report. Clin Orthop 122:147
Nielsen HKL, Veth RPH, Oldhoff J et al. (1985) Resection of a peri-acetabular chondrosarcoma and reconstruction of the pelvis: a case report. J Bone Joint Surg [Br] 67:413
Sannerkin NG, Gallagher P (1979) A review of the behaviour of chondrosarcoma of bone. J Bone Joint Surg [Br] 61:395
Smith WS, Simon MA (1975) Segmental resection for chondrosarcoma. J Bone Joint Surg [Am] 57:1097
Osteosarcoma
Avella M, Bacci G, McDonald DJ et al. (1988) Adjuvant chemotherapy with six drugs (adriamycin, methotrexate, cisplatinum, bleomycin, cyclophosphamide and dactinomycin) for non-metastatic high-grade osteosarcoma of the extremities. Results of 32 patients and comparison to 127 patients concomitantly treated with the same drugs in a neoadjuvant form. Chemioterapia 9:133–137
Bacci G, Ghlerinzoni F, Picci P et al. (1986) Adriamycin-methotrexate high dose versus adriamycin-metho-trexate moderate dose as adjuvant chemotherapy for osteosarcoma of the extremities: a randomized study. Eur J Cancer Clin Oncol 22:1337–1345
Bacci G, Picci P, Ruggieri P et al. (1990) Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities: the Istituto Rizzoli experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin. Cancer 65:2539–2553
Blasier D, Mayba T, Ferguson C et al. (1986) Metastatic osteosarcoma and multiple lung resection. J Bone Joint Surg [Br] 68:748
Bonnadonna G, Monfardi S, De Lena M et al. (1970) Phase I and preliminary phase II evaluation of adriamycin (NSC/123127). Cancer Res 30:2572–2582
Bos G, Sim FH, Pritchard DJ et al. (1987) Prosthetic proximal humerus replacement: the Mayo Clinic experience. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Burk CD, Belasco JB, O’Neill JA Jr, Lange B (1991) Pulmonary metastasis and bone sarcomas. Clin Orthop 262:88–92
Cammisa FP, Glasser DB, Phil M et al. (1990) The Ven Nes tibial rotationplasty. J Bone Joint Surg [Am] 72:1541–1547
Campanacci M, Capanna R (1991) Pelvic resections: the Rizzoli Institute experience. Orthop Clin North Am 22:65–86
Campanacci M, Costa P (1979) Total resection of distal femur or proximal tibia for bone tumors. Autogenous bone grafts and arthrodesis in 26 cases. J Bone Joint Surg [Br] 61:455
Campanacci M, Bacci G, Bertoni F et al. (1981) The treatment of osteosarcoma of the extremities: twenty years’ experience at the Istituto Ortopedico Rizzoli. Cancer 48:1569–1581
Campanacci M, Cervellati L, Guerra A et al. (1987) Knee resection-arthrodesis. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Capanna R, Giunti A, Biagini R et al. (1989a) Modular endoprosthesis for humerus and Tikhoff-Linberg resection. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Capanna R, Leonessa C, Bettelli G et al. (1989b) Modular Kotz prosthesis: the Rizzoli experience. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Capanna R, Ruggieri P, Biagini R et al. (1991) The effect of quadriceps excision on functional results after distal femoral resection and prosthetic replacement for bone tumors. Clin Orthop 267:186–196
Cortes EP, Holland JF, Wang JJ, Sinks LF (1972) Chemotherapy of advanced osteosarcoma. In: Price CHG, Ross FGM (eds) Bone — certain aspects of neoplasia. Butterworths, London
Cortes EP, Holland JF, Wang JJ et al. (1974) Amputation and adriamycin in primary osteosarcoma. N Engl J Med 291:998–1000
Dahlin DC, Coventry MB (1967) Osteogenic sarcoma: a study of six hundred cases. J Bone Joint Surg [Am] 49:101–110
Delepine G, Delepine N (1989) Titanium long-stem prosthesis combined with bone allografts in reconstructive surgery of high-grade bone sarcomas. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Eckardt JJ, Eilber FR, Grant TT et al. (1987a) The UCLA experience in the management of stage IIB osteogenic sarcoma. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Eckardt JJ, Eilber FR, Kabo JM, Mirra JM (1987b) Kinematic rotating hinge knee-distal femoral replacement. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Eckardt JJ, Matthews JB, Eilber RF (1991a) Endo-prosthetic reconstruction after bone tumor resection of the proximal tibia. Orthop Clin North Am 22:149–160
Eckardt JJ, Eilber FR, Rosen G et al. (1991b) Endo-prosthetic replacement for stage IIB osteosarcoma. Clin Orthop 270:202–213
Edmonson JH, Green SJ, Ivins JC et al. (1984) A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2:152–156
Enneking WF, Dunham WK (1978) Resection and reconstruction for primary neoplasms involving the innominate bone. J Bone Joint Surg [Am] 60:731–746
Enneking WF, Shirley PD (1977) Resection-arthrodesis for malignant and potentially malignant lesions about the knee using an intramedullary rod and local bone grafts. J Bone Joint Surg [Am] 59:223
Frassica FJ, Chao EY, Shives TC, Sim FH (1991) Resection of malignant bone tumors about the shoulder. Clin Orthop 267:57–64
Friedman MA, Carter SK (1972) The therapy of osteogenic sarcoma: current status and thoughts for the future. J Surg Oncol 45:482–510
Gebhardt MC, McGuire MH, Mankin HJ (1987) Resection and allograft arthrodesis for malignant bone tumors of the extremity. In: Enneking WF (ed) Lung salvage in musculoskeletal oncology. Churchill Livingstone, New York
Gebhardt MC, Goorin AM, Traina J et al. (1989) Long-term results of limb salvage and amputation in extremity osteosarcoma: DFCI/TCH results in patients receiving postoperative weekly high-dose methotrexate and doxorubicin. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Gebhardt MC, Roth YF, Mankin HJ (1990) Osteo-articular allografts for reconstruction in the proximal part of the humerus after excision of a musculoskeletal tumor. J Bone Joint Surg [Am] 72:334–345
Gehan EA, Sutow WW, Uribe-Botero G et al. (1978) Osteosarcoma: the MD Anderson experience, 1950–1974. Prog Cancer Res Ther 6:271–282
Gitelis S, Piasecki P (1991) Allograft prosthetic composite arthroplasty for osteosarcoma and other aggressive bone tumors. Clin Orthop 270:197–201
Goorin AM, Deloney M, Gelber R et al. (1985) Dana Farber Cancer Institute/The Children’s Hospital adjuvant chemotherapy trials for osteosarcoma. Three sequential studies. Cancer Treat Symp 3:155–159
Gottlieb JA, Baker LH, O’Bryan RM et al. (1975) Adriamycin (NSC-123127) used alone and in combination with soft tissue and bone sarcoma. Cancer Chemother Rep 3:271–282
Han M, Telander R, Pairolero PC et al. (1981) Aggressive thoracotomy for pulmonary metastatic osteogenic sarcoma in children and young adolescents. J Pediatr Surg 16:928
Head WC, Berklacich FM, Malinin T, Emerson RH (1987) Proximal femoral allografts in revision total hip arthroplasty. Clin Orthop 225:22–36
Jaffe N (1972) Recent advances in the chemotherapy of metastatic osteogenic sarcoma. Cancer 30:1627–1631
Jaffe N, Farber S, Traggis D et al. (1973) Favorable response of metastatic osteogenic sarcoma to pulse high dose methotrexate with citrovorum rescue and radiation therapy. Cancer 31:1367–1373
Jaffe N, Frei E III, Traggis D et al. (1974) Adjuvant methotrexate and citrovorum factor treatment of osteogenic sarcoma. N Engl J Med 291:994–997
Jaffe N, Frei E III, Watts H, Traggis D (1978a) High-dose methotrexate in osteogenic sarcoma: a 5-year experience. Cancer Treat Rep 62:259–264
Jaffe N, Watts H, Fellows KE et al. (1978b) Local en bloc resection for limb preservation. Cancer Treat Rep 62:217–273
Jaffe N, Link M, Cohen D et al. (1981) High dose methotrexate in osteogenic sarcoma. In: Sarcomas of soft tissue and bone in childhood. NCI Monogr 56:201–206
Jofe MH, Gebhardt MC, Tomford WW, Mankin HJ (1988) Reconstruction for defects of the proximal part of the femur using allograft arthroplasty. J Bone Joint Surg [Am] 70:507–516
Juvara E (1921) Procédé de résection de la partie supérieure du tibia avec substitution, a la partie enlevée d’une grèffe prélevée sur le fémur. Presse Med 29:241
Katzner M, Schwingt E (1982) Etude de 100 arthroplasties totales de hanche avec mégaprothèse fémorale réalisées après reséction étendues de l’extrémité supérieure du fémur. Int Orthop 6:233–241
Khong KS, Chao EYS, Sim FH (1989) Long-term performance of custom prosthetic replacement for neoplastic disease of the proximal femur. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal oncology. Springer, Tokyo
Kotz R, Salzer M (1982) Rotation-plasty for childhood osteosarcoma of the distal part of the femur. J Bone Joint Surg [Am] 64:959–969
Kotz R, Winkler K, Salzer-Kuntschik M et al. (1989) Surgical margins influencing oncological results in osteosarcoma. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Lewis MM (1986) The use of an expandable and adjustable prosthesis in the treatment of childhood malignant bone tumors of the extremity. Cancer 57:499–502
Lewis MM, Chekofsky KM (1982) Proximal femur replacement for neoplastic disease. Clin Orthop 171:72–79
Linberg BE (1928) Interscapulo-thoracic resection for malignant tumors of the shoulder region. J Bone Joint Surg 10:344
Link MP, Goorin AM, Miser AW et al. (1986) The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 314:1600–1616
Makley JT (1985) The use of allograft to reconstruct intercalary defects of long bones. Clin Orthop 197:58–75
Malawar MM (1991) Tumors of the shoulder girdle: technique of resection and description of a surgical classification. In: Limb salvage in the treatment of musculoskeletal tumors. Orthop Clin North Am 22:7–35
Malawar MM, McHale KA (1989) Limb sparing surgery for high grade malignant tumors of the proximal tibia. Clin Orthop 239:231–248
Mankin HJ, Doppelt SH, Sullivan TR, Tomford WW (1982) Osteoarticular and intercalary allograft transplantation in the management of malignant tumors of bone. Cancer 50:613–630
Mankin HJ, Gebhardt MC, Tomford WW (1987) Use of frozen cadaveric osteoarticular allografts in the treatment of benign and malignant tumors about the knee. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Marcove RC, Lewis MM, Huvos AG (1977) En bloc upper humeral interscapulo-thoracic resection: the Tikhoff-Linberg Procedure. Clin Orthop 124:219–228
McDonald DJ, Capanna R, Gherlinzoni F, Campanacci M (1990) Complications of limb salvage surgery of the extremities. Cancer 65:1509–1516
Merle D’Aubigné R, Dejouany JP (1958) Diaphysoepiphysial resection for bone tumor at the knee. J Bone Joint Surg [Br] 40:385
Meyer WH, Schell MJ, Kumar APM et al. (1987) Thoracotomy for pulmonary metastatic osteosarcoma. Cancer 59:374
Mike V, Marcove RC (1978) Osteogenic sarcoma under the age of 21: experience at Memorial Sloan-Kettering Cancer Center. Prog Cancer Res Ther 6:283–292
Murray MP, Jacobs PA, Gore DR (1985) Functional performance after tibial rotationplasty. J Bone Joint Surg [Am] 67:392
Nieder E, Keller A (1989) The saddle prosthesis Mark II, Endo-Modell. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Nieder E, Elson RA, Engelbrecht E et al. (1990) The saddle prosthesis for salvage of the destroyed acetabulum. J Bone Joint Surg [Br] 72:1014–1022
O’Connor MI, Sim FH (1989) Salvage of the limb in the treatment of malignant pelvic tumors. J Bone Joint Surg [Am] 71:481–494
Ochs JJ, Freeman AI, Douglass HO Jr et al. (1978) Cisdiammine-dichloroplatinum (II) in advanced osteogenic sarcoma. Cancer Treat Rep 62:239–245
Picci P, Bacci G, Campanacci M et al. (1985) Histologic evaluation of necrosis in osteosarcoma induced by chemotherapy. Cancer 56:1515–1521
Pratt CB, Champion JE, Senzer N et al. (1985) Treatment of unresectable or metastatic osteosarcoma with cisplatin or cisplatin doxorubicin. Cancer 56:1930–1933
Putnam JB Jr, Roth JA, Wesley NM et al. (1983) Survival following aggressive resection of pulmonary metastases from osteogenic sarcoma: analysis of prognostic factors. Ann Thorac Surg 36:516
Rock M (1987) Intercalary allograft and custom Neer prosthesis after en bloc resection of the proximal humerus. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Rosen G (1985) Preoperative (neoadjuvant) chemotherapy for osteogenic sarcoma: a ten year experience. Orthopedics 8:659–664
Rosen G, Tefft M, Martinez A et al. (1975) Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma. Cancer 35:622–630
Rosen G, Murphy ML, Huvos A et al. (1976) Chemotherapy, en bloc resection and prosthesis bone replacement in the treatment of osteogenic sarcoma. Cancer 37:1–11
Rosen G, Caparros B, Huvos AG et al. (1982) Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49:1221–1230
Rosenberg SA, Chabner BA, Young RC et al. (1979) Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation. Cancer Treat Rep 63:739–751
Sim FH, Chao EYS (1987) Segmental prosthetic replacement of the knee after tumor resection. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, New York
Sim FH, Chao EYS, Pritchard DJ, Salzer M (1980) Replacement of the proximal humerus with a ceramic prosthesis: a preliminary report. Clin Orthop 146:161–174
Sim FH, Wins JC, Taylor WF, Chao EYS (1985) Limb-sparing surgery for osteosarcoma: Mayo Clinic experience. Cancer Treat Symp 3:139–154
Simon MA, Aschliman MA, Thomas N, Mankin HJ (1986) Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg [Am] 68:1331–1337
Taylor WF, Wins JC, Dahlin DC et al. (1978) Trends and variability in survival from osteosarcoma. Mayo Clin Proc 53:695–700
Telander RL, Pairolero PC, Pritchard DJ et al. (1978) Resection of pulmonary metastatic osteogenic sarcoma in children. Surgery 84:335
Tornita K, Tsuchiya H (1989) Intermediate results and functional evaluation of limb-salvage surgery for osteosarcoma: an intergroup study in Japan. J Surg Oncol 42:71–76
Ueda T, Uchida A, Yoshikawa H et al. (1989) Surgical management of osteosarcoma in extremities: survival between limb salvage and amputation. In: Yamamuro T (ed) New developments for limb salvage in musculoskeletal tumors. Springer, Tokyo
Van Nes CP (1950) Rotation-plasty for congenital defects of the femur. Making use of the ankle of the shortened limb to control the knee joint of a prosthesis. J Bone Joint Surg [Br] 32:1–16
Watts HG (1980) Introduction to resection of musculoskeletal sarcomas. Clin Orthop 153:31–38
Winkler K, Beron G, Kotz R et al. (1984) Neoadjuvant chemotherapy for osteogenic sarcoma: results of cooperative German-Austrian study. J Clin Oncol 2:318–325
Winkler K, Beron G, Dellinger G et al. (1988) Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 6:329–337
Yasko AW, Lane JM (1991) Chemotherapy for bone and soft-tissue sarcomas of the extremities. Current concepts review. J Bone Joint Surg [Am] 73:1263–1271
Ewing Sarcoma
Bacci G, Picci P, Gitelis S et al. (1982) The treatment of localized Ewing’s sarcoma: the experience at the Istituto Ortopedico Rizzoli in 163 cases treated with and without adjuvant chemotherapy. Cancer 49:1561–1570
Bacci G, Picci P, Gherlinzoni F et al. (1985) Localized Ewing’s sarcoma of bone: ten years’ experience at the Istituto Ortopedico Rizzoli in 124 cases treated with multimodal therapy. Eur J Cancer Clin Oncol 24:163–173
Bacci G, Toni A, Avella M et al. (1989) Long-term results in 144 localized Ewing’s sarcoma patients treated with combined therapy. Cancer 63:1477–1486
Capanna R, Toni A, Sudanese A et al. (1990) Ewing’s sarcoma of the pelvis. Int Orthop 14:57–61
Evans R, Nesbit M, Askin F et al. (1985) Local recurrence, rate and sites of metastases, and time to relapse as a function of treatment regimen, size of primary and surgical history in 62 patients presenting with non-metastatic Ewing’s sarcoma of the pelvic bones. Int J Radiat Oncol Biol Phys 11:129–136
Falk S, Alpert M (1967) Five-year survival of patients with Ewing’s sarcoma. Surg Gynecol Obstet 23:319–324
Jurgens H, Exner U, Gadner H et al. (1988) Multidis-ciplinary treatment of primary Ewing’s sarcoma of bone: a 6-year experience of a European cooperative trial. Cancer 61:23–32
Li WK, Lane JM, Rosen G et al. (1983) Pelvic Ewing’s sarcoma: advances in treatment. J Bone Joint Surg [Am] 65:738–747
Nesbit ME Jr, Perez CA, Tefft M et al. (1981) Multimodal therapy for the management of primary, nonmetastatic Ewing’s sarcoma of bone: an intergroup study. NCI Monogr 56:255
Phillips RF, Higinbotham NL (1967) The curability of Ewing’s endothelioma of bone in children. J Pediatr 70:391–397
Pritchard DJ, Dahlin DC, Dauphine RT et al. (1975) Ewing’s sarcoma: a clinicopathological and statistical analysis of patients surviving five years or longer. J Bone Joint Surg [Am] 57:10–16
Rosen G, Caparros B, Nirenberg A et al. (1981) Ewing’s sarcoma: ten-year experience with adjuvant chemotherapy. Cancer 47:2204–2213
Sailer SL, Harmon DC, Mankin HJ et al. (1988) Ewing’s sarcoma: surgical resection as a prognostic factor. Int J Radiat Oncol Biol Phys 15:43–52
Sauer R, Jurgens J, Burgers JM et al. (1987) Prognostic factors in the treatment of Ewing’s sarcoma. The Ewing’s Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81. Radiother Oncol 10:101–110
Telles NC, Rabson AS, Pomeroy TC (1978) Ewing’s sarcoma: an autopsy study. Cancer 41:2321–2329
Tepper J, Glanbiger D, Lichter A et al. (1980) Local control of Ewing’s sarcoma of bone with radiotherapy and combination chemotherapy. Cancer 46:1669–1673
Thomas PRM, Perez CA, Neff JR et al. (1984) The management of Ewing’s sarcoma: role of radiotherapy in local tumor control. Cancer Treat Rep 68:703
Wilkins RM, Pritchard DJ, Burgert EO, Unni KK (1986) Ewing’s sarcoma of bone: experience with 140 patients. Cancer 58:2551–2555
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Gitelis, S., McDonald, D.J. (1994). Current Concepts of Treatment of Bone Tumors. In: Tumors and Tumorlike Lesions of Bone. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49954-8_11
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