Abstract
Previous results (Thornton and Brownrigg, 1961) have indicated that ascorbic acid influenced the skeletal response of chicks to vitamin D3 deficiency. Turnover of skeletal 45Ca was enhanced in vitamin D3 deficient individuals in the presence of ascorbic acid, suggesting a change in the bone metabolic rate. No specific role for vitamin D in bone cells has been evolved; however, investigations with cartilage have suggested a metabolic function in that tissue. It appears to be needed for normal formation and metabolism of citric acid (Neuman and Neuman, 1958).
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References
Barker, S. B., and W. H. Summerson. The colorimetric determination of lactic acid in biological material. J. biol. Chem. 138, 535 (1941).
Borle, A. B., N. Nichols, and G. Nichols, Jr.. Metabolic studies of bone in vitro. I. Normal bone. J. biol. Chem. 235, 1206 (1960).
Cohn, D. V., and B. K. Forscher. Aerobic metabolism of glucose by bone. J. biol. Chem. 237, 615 (1962).
Fiske, C. H., and Y. Subbarow. The colorimetric determination of phosphorus. J. biol. Chem. 66, 375 (1925).
Goldhaber, P.: Some factors affecting bone resorption in tissue culture. J. Bone Jt Surg. 43 B, 180 (1961).
Gould, B. S., and H. Schwachman. Bone and tissue phosphatase in experimental scurvy and studies on the source of serum phosphatase. Amer. J. Physiol. 135, 485 (1941).
Huggett, A. S. C., and D. A. Nixon. Use of glucose oxidase, peroxidase and O-dianisdine in determination of blood and urinary glucose. Lancet, 273, 368 (1957).
Levy, B. M., and R. V. GorlinThe temporomandibular joint in vitamin C deficiency. J. dent. Res. 32, 622 (1953).
Lilienthal, J. L., Jr.K. L. Zierler, B. P. Folk, R. Buka, and M. J. RileyA reference base and system for analysis of muscle constituents. J. biol. Chem. 182, 501 (1950).
Neuman, W. F., and M. W. Neuman. The Chemical Dynamics of Bone. Chicago: The Uni versity of Chicago Press 1958.
Thornton, P. A.: Unpublished.
Thornton, P. A., and D. Brownrigg. Calcium utilization and skeletal development in chicks as influenced by parental dietary ascorbic acid. J. Nutr. 75, 354 (1961).
Thornton, P. A., C. W. Weber, and R. E. Moreng. The effect of ascorbic acid in the diet of adult chickens on calcium utilization by the progeny. J. Nutr. 69, 33 (1959).
Walker, D. G.: Citric acid cycle in osteoblasts and osteoclasts. Bull. Johns Hopk. Hosp. 106, 80 (1961).
Willis, J. B.: Determinations of calcium and magnesium in urine by atomic absorption spectroscopy. Analyt. Chem. 33, 556 (1961).
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© 1966 Springer-Verlag Berlin Heidelberg
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Thornton, P.A. (1966). Vitamin D-ascorbic Acid Association in Bone Metabolism. In: Fleisch, H., Blackwood, H.J.J., Owen, M. (eds) Calcified Tissues 1965. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49802-2_8
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DOI: https://doi.org/10.1007/978-3-642-49802-2_8
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