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Mechanisms of Schistosome Immunity

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Bilharziasis

Abstract

In 1953, Vogel and Minning [50] published their well-documented study of acquired resistance to S. japonicum in Macaca mulatta, following long-term infection. Since then, immunity has been produced in macaques with the cattle adapted Taiwan strain of S. japonicum [7, 34], and with gamma-radiated cercariae of the human-pathogenic strains of S. japonicum and S. mansoni [6, 33]. Recent results indicate that a high degree of resistance can be attained by repeated infection of macaques with “attenuated” schistosomes, but the applicability of these findings to human vaccination is not clear. The present status of this research has been ably summarized by Sadun [30]. Both practical and biological considerations demand that research be directed toward the underlying mechanisms of schistosome immunity. Progress in this field, however, has been slow.

This work was supported by a grant from the Institute of Allergy and Infectious Diseases, National Institutes of Health (No. AI-2631) and by a contract with the U.S. Army Medical Research and Development Command (No. DA-49-193-MD-2253).

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Authors and Affiliations

  1. Department of Pathology, Peter Bent Brigham Hospital, Harvard Medical School, Boston, Massachusetts, USA

    F. v. Lichtenberg

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  1. F. v. Lichtenberg
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Editors and Affiliations

  1. Division of Special and General Pathology, Armed Forces Institute of Pathology and Veterans Administration Central Laboratory for Anatomic Pathology and Research, Washington, D. C., USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

  2. Georgetown Medical School, Washington, D. C., USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

  3. Johns Hopkins University, Baltimore, Maryland, USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

  4. International Academy of Pathology, Washington, D. C., USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

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© 1967 Springer-Verlag GmbH Berlin Heidelberg

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v. Lichtenberg, F. (1967). Mechanisms of Schistosome Immunity. In: Mostofi, F.K. (eds) Bilharziasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49777-3_28

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  • DOI: https://doi.org/10.1007/978-3-642-49777-3_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49492-5

  • Online ISBN: 978-3-642-49777-3

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