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Geographic Pathology of Schistosomiasis Mansoni

Studies on Liver Injury

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Bilharziasis

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Abstract

The interpretation of the structural damage to the liver in schistosomiasis and the relationship of this damage to pathogenesis are still subject to considerable disagreement [1, 5, 10, 12, 22, 24, 31]. Although a relatively large amount of research, especially in the fields of immunology and immuno-pathology has been carried out [2, 11, 27, 28, 29, 30, 32, 40], the results, unfortunately, are not entirely comparable with human pathology. Man is a more complex host and subject to many factors, some of which have not yet been completely evaluated. There can be no question, however, that in the pathogenesis of the fibrotic schistosomal liver, the basic lesion consists of confluent granulomas surrounding the ova [5, 13]. Their peculiar intraluminal position causes venous obstruction. The experimental evidence for these facts is irrefutable [11, 15, 27, 28, 40].

This paper was partially supported by the U.S. Public Health Service Research grant AI 00518801. National Institutes of Health, Bethesda, Md. U.S.A.

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Authors and Affiliations

  1. Department of Tropical Diseases, National Faculty of Medicine, University of Brazil, Rio de Janeiro, Brazil

    Domingos De Paola

  2. Armed Forces Institute of Pathology, Washington, D.C., 20305, USA

    Donald J. Winslow

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  1. Domingos De Paola
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Editors and Affiliations

  1. Division of Special and General Pathology, Armed Forces Institute of Pathology and Veterans Administration Central Laboratory for Anatomic Pathology and Research, Washington, D. C., USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

  2. Georgetown Medical School, Washington, D. C., USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

  3. Johns Hopkins University, Baltimore, Maryland, USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

  4. International Academy of Pathology, Washington, D. C., USA

    F. K. Mostofi M.D. (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer) (Chief, Clinical Professor of Pathology, Assistant Professor of Pathology, Secretary- Treasurer)

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© 1967 Springer-Verlag GmbH Berlin Heidelberg

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De Paola, D., Winslow, D.J. (1967). Geographic Pathology of Schistosomiasis Mansoni. In: Mostofi, F.K. (eds) Bilharziasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49777-3_22

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  • DOI: https://doi.org/10.1007/978-3-642-49777-3_22

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  • Print ISBN: 978-3-642-49492-5

  • Online ISBN: 978-3-642-49777-3

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