Skip to main content
  • 89 Accesses

Abstract

The field of radiobiological investigation is now so vast that it is quite impracticable in a short review to attempt to cover the whole of the subject. Also there are a number of excellent comprehensive reviews available, such as that edited by Hollaender (1954). A selection of topics has to be made and in the present review the main topics discussed, apart from general considerations of the physical interaction of radiation and matter which are essential to any understanding of the subject, will be the mechanism of cytological effects of radiation, some problems of tissue response, in particular with regard to fractionation and protraction of radiation, and the problem of radiation-induced malignancy. Each of these topics is of significance in the clinical use of radiation and they are also subjects which are being very actively investigated at the present time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albert, M. D.: X-irradiation-induced mitotic abnormalities in mouse liver regenerating after carbon tetrachloride injury. I. Total-body irradiation, II. Partial-body irradiation. J. nat. Cancer Inst. 20, 309, 321 (1958).

    Google Scholar 

  • Bacq, Z. M., and P. Alexander: Fundamentals of radiobiology. London: Butterworth 1955.

    Google Scholar 

  • Blau, M., u. K. Altenburger: Über einige Wirkungen von Strahlen. Z. Physik 12, 315 (1923).

    Article  CAS  Google Scholar 

  • Bloom, M. A.: Acquired radioresistance of the crypt epithelium of the duodenum. Radiology 55, 104 (1950).

    PubMed  CAS  Google Scholar 

  • Bloom, W.: Histopathology of irradiation. New York: McGraw Hill 1948.

    Google Scholar 

  • Bonet-Maury, P.: Chemical phenomena in irriadiated pure water. Disc. Faraday Soc. 12, 72 (1952).

    Article  Google Scholar 

  • Burton, M., J. L. Magee, and A. H. Samuel: Excited molecule theory of radiation chemistry in liquids. J. chem. Physics 20, 760 (1952).

    Article  CAS  Google Scholar 

  • Cormack, D. V., and H. E. Johns: Electron energies and ion densities in water irradiated with 200 keV, 1 MeV and 25 MeV radiation. Brit. J. Radiol. 25, 369 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Court Brown, W. M., and R. Doll: Leukaemia and aplastic anaemia in patients irradiated for ankylosing spondylitis. M. R. C. Report. London: H. M. Stationery Office 1957.

    Google Scholar 

  • Court Brown, W. M., and R. Doll: Radiation and leukaemia. Lancet 1958 I, 162.

    Article  Google Scholar 

  • Crowther, J. A.: Some considerations relative to the actions of X-rays on tissue cells. Proc. roy. Soc. B 96, 207 (1924).

    Article  Google Scholar 

  • Duryee, W. R.: The nature of radiation injury to amphibian cell nuclei. J. nat. Cancer Inst.: 10, 735 (1949).

    PubMed  CAS  Google Scholar 

  • Elson, L. A., D. A. G. Galton, L. F. Lamerton, and M. Till: Comparison of the physiological response to radiation and to radiomimetic chemicals — bone marrow effects. Progress in Radiobiology p. 285. Edinburgh: Oliver and Boyd 1956.

    Google Scholar 

  • Elson, L. A., D. A. G. Galton, and M. Till: Action of chlorambucil (CB 1348) and busulphan (myleran) on haemopoietic organs of the rat. Brit. J. Haematol. 4, 355 (1958).

    Article  CAS  Google Scholar 

  • Finkel, M. P.: Mice, men, and fallout. Science 128, 637 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Ford, C. E., and R. H. Mole: Chromosomes and carcinogenesis: observations on radiationinduced leukaemias. Second United Nations International Conference on the Peaceful Uses of Atomic Energy, P/98, United Nations, New York 1958. (In the Press.)

    Google Scholar 

  • Glucksmann, A., L. F. Lamerton, and W. V. Mayneord: Carcinogenic effects of radiation. Cancer, Vol. 1, Ed. R. W. Raven, p. 497. London: Butterworth 1957.

    Google Scholar 

  • Goolden, A. W. G.: Radiation cancer. A review with special reference to radiation tumours in the pharynx, larynx and thyroid. Brit. J. Radiol. 30, 626 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Gray, L. H.: The distribution of the ions resulting from the irradiation of living cells. Brit. J. Radiol. Suppl. No. 1, 7 (1947).

    Google Scholar 

  • Gray, L. H.: Biological actions of ionizing radiations. Progr. Biophysics Biophys. Chem. 2, Chap. 8 (1951).

    Google Scholar 

  • Gray, L. H.: Some characteristics of biological damage induced by ionizing radiations. Rad. Res. 1, 189 (1954).

    Article  CAS  Google Scholar 

  • Harriss, E. B.: The effect of whole body irradiation on bone marrow as studied by radioactive iron incorporation. Radioactive Isotope in Klinik und Forschung 3, p. 6. Berlin: Urban and Schwarzenberg 1958.

    Google Scholar 

  • Hollaender, A. (Editor): Radiation biology. Vol. 1, New York: McGraw Hill 1954.

    Google Scholar 

  • Jacobson, L. O.: The hematologic effects of ionizing radiation. Radiation biology, Vol. (2), Chap. 16. New York: McGraw Hill 1954.

    Google Scholar 

  • Jaffé, G.: Zur Theorie der Ionisation in Kolonnen. Ann. Physik. (Lpz.) 42, 303 (1913).

    Article  Google Scholar 

  • Jones, A.: Irradiation sarcoma. Brit. J. Radiol. 26, 273 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, H. S., and M. B. Brown: A quantitative dose-response study of lymphoid-tumor development in irradiated C 57 black mice. J. nat. Cancer Inst. 13, 185 (1952).

    PubMed  CAS  Google Scholar 

  • Kaplan, H. S., W. H. Carnes, M. B. Brown and B. B. Hirsch: Indirect induction of lymphomas in irradiated mice. I. Tumor incidence and morphology in mice bearing non-irradiated thymic grafts. II. Factors of irradiation of the host. III. Rôle of the thymic graft. IV. Genetic evidence of the origin of the tumor cells from the thymic grafts. Cancer Res. 16, 422, 426, 429, 434 (1956).

    PubMed  CAS  Google Scholar 

  • Kaufmann, B. T.: Chromosome aberrations induced in animal cells by ionizing radiations. Radiation biology, 1 Vol. (2). Chap. 9. New York: McGraw Hill 1954.

    Google Scholar 

  • Kelly, L. S.: Effect of radiation on DNA synthesis in mammalian cells. Progr. Biophys. Biophys. Chem. 8, 143 (1957).

    CAS  Google Scholar 

  • Koller, P. C.: Comparative effects of alkylating agents on cellular morphology. Ann. N. Y. Acad. Sci. 68, 783 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Koller, P. C., and D. W. Smithers: Cytological analysis of the response of malignant tumours to irradiation as an approach to a biological basis for dosage in radiotherapy. Brit. J. Radiol. 19, 89 (1946).

    Article  PubMed  CAS  Google Scholar 

  • Lajtha, L. G., R. Oliver, T. Kumatori and F. Ellis: On the mechanism of radiation effect on DNA synthesis. Rad. Res. 8, 1 (1958).

    Article  CAS  Google Scholar 

  • Lamerton, L. F., and C. F. Baxter: An experimental study of radiation-induced anaemia with reference to shielding procedures and platelet changes. Brit. J. Radiol. 28, 87 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Latarjet, R.: Some factors influencing cell radiosensitivity by acting at the level of the primary biochemical action. Symposium on radiobiology, Chap. 13. New York: Wiley 1952.

    Google Scholar 

  • Lea, D. E.: Actions of radiations on living cells. Cambridge: Cambridge University Press 1946. Also 2nd Edition, 1955.

    Google Scholar 

  • Lea, D. E.: The actions of radiations on dilute aqueous solutions: the spatial distribution of H and OH. Brit. J. Radiol. Suppl. 1, 59 (1947).

    Google Scholar 

  • Lebedinsky, A. V., Y. G. Grigoryev, and G. C. Demirchoglyan: The biological effect of small doses of ionizing radiation. Second United Nations International Conference on the Peaceful Uses of Atomic Energy, P/2068, United Nations, New York 1958. (In the Press.)

    Google Scholar 

  • Lewis, E. B.: Leukaemia and ionizing radiation. Science 125, 965 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Lorenz, T., L. O. Jacobson, W. E. Heston, M. Shimkin, A. B. Eschenbrenner, M. K. Deringer, J. Donigar, and R. Schweisthal: Effects of long-continued total-body gamma irradiation on mice, guinea pigs and rabbits. III. Effects on life span, weight, blood picture, and carcinogenesis and the role of the intensity of radiation. Biological effects of external X and gamma radiation, Chap. 3. New York: McGraw Hill 1954.

    Google Scholar 

  • Mole, R. H.: The development of leukaemia in irradiated animals. Brit. med. Bull. 14, 174 (1958).

    PubMed  CAS  Google Scholar 

  • Patt, H. M., and A. M. Brues: The pathological physiology of radiation injury in the mammal. I. Physical and biological factors in radiation action. II. Specific aspects of the physiology of radiation injury. Radiation biology, Vol. 1 (2), Chaps. 14 and 15. New York: McGraw Hill 1954.

    Google Scholar 

  • Pochin, E. E.: Radiation and leukaemia. Lancet 1958,I, 51.

    Article  Google Scholar 

  • Pollard, E. C.: Primary ionization as a test of molecular organization. Advanc. Biol. Med. Phys. 3, 153 (1953).

    CAS  Google Scholar 

  • Tuch, T. T.: The genetics of somatic mammalian cells. Advanc. Biol. Med. Phys. 5, 75 (1957).

    Google Scholar 

  • Tuch, T. T., and P. I. Marcus: Action of X-rays on mammalian cells. J. exp. Med. 103, 653 (1956).

    Article  Google Scholar 

  • Quastler, H.: The nature of intestinal radiation death. Rad. Res. 4, 303 (1956).

    Article  CAS  Google Scholar 

  • Quastler, H., J. P. M. Bensted, L. F. Lamerton, and S. M. Simpson: Brit. J. Radiol. 32, 501 (1959).

    Article  Google Scholar 

  • Quastler, H., and M. Zucker: Rad. Res. (1959) (In course of publication.)

    Google Scholar 

  • Report of the United Nations Scientific Committee on the Effects of Atomic Radiation. United Nations, New York 1958.

    Google Scholar 

  • Revell, S. H.: Chromosome breakage by X-rays and radiomimetic substances in vicia. Heredity, Suppl. 6, 107 (1953).

    Google Scholar 

  • Samuel, A. H., and J. L. Magee: Theory of radiation chemistry. II. Track effects in radiolysis of water. J. chem. Physics 21, 1080 (1953).

    Article  CAS  Google Scholar 

  • Sault, L. du: Time-dose relationships. Amer. J. Roentgenol. 75, 597 (1956).

    Google Scholar 

  • Schrek, R.: Radiosensitivity of lymphocytes and granulocytes in vitro according to the method of unstained cell counts. Proc. Soc. exp. Biol. (N. Y.) 58, 285 (1945).

    Article  Google Scholar 

  • Schrödinger, E.: What is life ? Cambridge 1948.

    Google Scholar 

  • Shellabarger, C J., E. P. Cronkite, V. P. Bond, and S. W. Lippincott: The occurrence of mammary tumors in the rat after sublethal whole-body irradiation. Rad. Res. 6, 501 (1957).

    Article  CAS  Google Scholar 

  • Simpson, C. L., and L. H. Hempelmann: The association of tumors and roentgen ray treatment of the thorax in infancy. Cancer 10, 42 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Sjöstrand, F. S., and V. Hanzon: Membrane structures of cytoplasm and mitochondria in exocrine cells of mouse pancreas as revealed by high resolution electron microscopy. Exp. Cell Res. 7, 393 (1954).

    Article  PubMed  Google Scholar 

  • Spear, F. G.: Radiations and living cells. Chap. 6. London: Chapman and Hall 1953.

    Google Scholar 

  • Stearner, S. P., and S. A. Tyler: An analysis of the role of dose and dosage rate in the early radiation mortality of the chick. Rad. Res. 7, 253 (1957).

    Article  CAS  Google Scholar 

  • Stewart, A., J. Webb, and D. Hewitt: A survey of childhood malignancies. Brit. med. J. 1958, 1495.

    Google Scholar 

  • Timoféeff-Ressovsky, N. W., u. K. G. Zimmer: Das Trefferprinzip in der Biologic Leipzig 1947.

    Google Scholar 

  • Trowell, O. A.: The sensitivity of lymphocytes to ionizing radiation. J. Path. Bact. 64, 687 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Trowell, O. A.: The effect of environmental factors on the radiosensitivity of lymph nodes cultured in vitro. Brit. J. Radiol. 26, 302 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Vogel, Н. H., Jr., J. W. Clark, D. L. Jordan, H. Alt, J. Cooper, and W. Rambach: The effect of single and spaced multiple doses of C 60 у and fission neutron radiation on the incorporation of Fe 59 into the rat erythropoietic system. Argonne National Semi-Annual, Report, ANL-5732, 113 (1957).

    Google Scholar 

  • Zirkle, R. E.: The radiobiological importance of linear energy transfer. Radiation biology, Vol. 1(1) Chap. 6. New York: McGraw Hill 1954.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1961 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Lamerton, L.F. (1961). Aspects of the biological Effects of Radiation. In: Aisenberg, A.C., et al. Radioactive Isotopes in Physiology Diagnostics and Therapy / Künstliche Radioaktive Isotope in Physiologie Diagnostik und Therapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49761-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49761-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49477-2

  • Online ISBN: 978-3-642-49761-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics