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Quantal Aspects of the Secretion of Catecholaminess and Dopamine-ß-hydroxylase from the Adrenal Medulla

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New Aspects of Storage and Release Mechanisms of Catecholamines

Part of the book series: Bayer Symposium ((BAYER-SYMP,volume 2))

Abstract

During the past several years a number of laboratories have provided evidence which has established that secretion of Catecholaminess from the adrenal medulla occurs by a process in which the soluble contents of the Catecholamines storage vesicles are secreted directly to the exterior of the cell leaving the vesicle membranes within. In the first studies, the materials which appeared in perfusates of isolated glands following chemical stimulation were determined and compared to the amounts which were present in the Catecholamines storage vesicles. More recently the composition and properties of the storage vesicles which remain in the gland after stimulation have been examined and provide additional information on the mechanism of the secretory process.

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Authors and Affiliations

  1. Department of Biochemistry and Pathology, Duke University, Medical Center, Durham, North Carolina, 27706, USA

    Dr. N. Kirshner

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  1. Dr. N. Kirshner
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  2. O. H. Viveros
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Editors and Affiliations

  1. Klinikum Essen, Ruhruniversität Bochum, 4300, Essen-Holsterhausen, Deutschland

    Hans-Joachim Schümann (Direktor des Pharmakologischen Institutes) (Direktor des Pharmakologischen Institutes)

  2. Farbenfabriken Bayer AG., 5600, Wuppertal-Elberfeld, Deutschland

    Günter Kroneberg (Vorstand des Institutes für Pharmakologie) (Vorstand des Institutes für Pharmakologie)

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Kirshner, N., Viveros, O.H. (1970). Quantal Aspects of the Secretion of Catecholaminess and Dopamine-ß-hydroxylase from the Adrenal Medulla. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49747-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-49747-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49465-9

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