Abstract
Most drugs being low molecular weight chemicals eventually functioning as haptens, sensitization and allergic reactions to drugs should (according to the Landsteiner’s theory) only occur if the drug or one of its reactive metabolites is able to form suitable conjugates with autologous proteins in vivo. Accordingly, research on the immunochemical mechanisms of drug allergy has been mostly oriented towards study of the reactivity of the drug itself and towards a search for reactive derivatives, eventually able to form immunogenic conjugates.
This work has been supported in part by the Swiss National Foundation for Scientific Research (Grant No. 4182) and by the Emil Barell Foundation of F. Hoffmann-La Roche, Inc., Basle.
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References
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De Weck, A.L. (1969). Research in Drug Allergy: A Search for Impurities?. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_33
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DOI: https://doi.org/10.1007/978-3-642-49733-9_33
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