Abstract
The higher organisms are equipped with two different systems for immunological defence. One system is characterized by the production of humoral antibodies, the other by the appearence of specifically sensitized lymphocytes, which are capable of direct interaction with the antigen. If the antigen happens to be attached to a cell, this interaction may lead to the destruction of the antigen carrying cell.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ax, W., H. Malchow, I. Zeiss, and H. Fischer: The behaviour of lymphocytes in the process of target cell destruction in vitro. Exp. Cell Res. 53, 108 (1968).
Brunner, K. T.: Personal communication. Swiss Institute for Experimental Cancer Research, Lausanne, Schweiz, Bugnon 21.
Brunner, K. T.: Personal communication.
Fisher, D. B., and G. C. Mueller: An early alteration in the phospholipid metabolism of lymphocytes by phytohaemagglutinin. Proc. nat. Acad. Sci. (Wash.) 60, 1396 (1968).
Ginsburg, H., and L. Sachs: Destruction of mouse and rat embryo cells in tissue culture by lymph node cells from unsensitized rats. J. cell. comp. Physiol. 66, 199 (1965).
Hirschhorn, K., R. R. Schreibman, S. Verbo, and R. H. Gruskin: The action of streptolysin S on peripheral lymphocytes of normal subjects and patients with acute rheumatic fever. Proc. nat. Acad. Sci. (Wash.) 52, 1151 (1964).
Holm, G.: The in vitro cytotoxicity of human lymphocytes; comparison with other cells. Exp. Cell Res. 48, 327 (1967a).
Holm, G., The in vitro cytotoxicity of human lymphocytes: the effect of metabolic inhibitors. Exp. Cell Res. 48, 334 (1967b).
Holm, G., P. Perlmann, and B. Johansson: Impaired phytohaemagglutinin-induced cytotoxicity in vitro of lymphocytes from patients with Hodgkin’s disease or chronic leukemia. Clin. exp. Immunol. 2, 351 (1967c).
KAY, J. E.: Phytohaemagglutinin: An early effect on lymphocyte lipid metabolism. Nature (Lond.) 219, 172 (1968).
Ling, N. R.: In: Lymphocyte stimulation, p. 152. Amsterdam: North-Holland Publ. Co. 1968.
Möller, E.: Contact-induced cytotoxicity by lymphoid cells containing foreign isoantigens. Science 147, 873 (1965).
Munder, P. G., M. Modolell, E. Ferber u. H. Fischer: Phospholipide in quarzgeschädigten Makrophagen. Biochem. Z. 344, 310 (1966).
Perlmann, P., H. Perlmann, and G. Holm: Cytotoxic action of stimulated lymphocytes on allogenic and autologous erythrocytes. Science 160, 306 (1968).
Rosenau, W.: In: Interaction of lymphoid cells with target cells in tissue culture. Cell bound antibodies, p. 75–80. ( Amos, B., H. Koprowski, Eds.). Philadelphia: Wistar Institute Press 1963.
Wilson, D. B.: Quantitative studies on the behaviour of sensitized lymphocytes in vitro. J. exp. Med. 122, 143 (1965).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1969 Springer-Veralg Berlin · Heidelberg
About this chapter
Cite this chapter
Fischer, H., Ax, W., Malchow, H., Zeiss, I. (1969). Studies on the Cytotoxicity of Lymphocytes. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-49733-9_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-49454-3
Online ISBN: 978-3-642-49733-9
eBook Packages: Springer Book Archive