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MRI of experimental cerebral ischemia: response to NMDA antagonist therapy

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Book cover Proceedings of the XIV Symposium Neuroradiologicum

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Summary

MRI was used to assess the efficacy of the N-methyl-D-aspartate (NMDA) antagonists dextromethorphan and dextrorphan, for the treatment of cerebral ischemia in an animal model. Marked protective effects of treatment were seen by MRI and histologic measures (67% to 83% reduction in the lesion size, compared to controls). Relaxation time measurements showed that treatment reduced the prolongation of T1 and T2 in lesions. A close correlation was seen between high signal on T2-weighted images, histologic measures of ischemic neuronal damage, and reduced lesion blood flow. Meg-netic susceptibility effects of intravascular dysprosium-DTPA-BMA were seen on dynamic gradient recalled acquisition in the steady state (GRASS) images and T2-weighted spin-echo images. This contrast agent enhanced the early detection of ischemia on T2-weighted spin-echo images.

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References

  1. Buchan A (1990) Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cerebrovasc Brain Metab Rev 2:1–26

    PubMed  CAS  Google Scholar 

  2. Choi D (1990) Methods for antagonizing glutamate neurotoxicity. Cerebrovasc Brain Metab Rev 2:105–147

    PubMed  CAS  Google Scholar 

  3. Steinberg GK, Saleh J, Kunis D, DeLaPaz RL, Zarnegar SR (1988) Protective effect of post-ischemic treatment with the NMDA antagonists, dextromethorphan and dextrorphan after focal cerebral ischemia in rabbits. Stroke 19:1112–1118

    Article  PubMed  CAS  Google Scholar 

  4. Villringer A, Rosen BR, Belliveau JW (1988) Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic suceptibility effects. Magn Reson Med 6:164–174

    Article  PubMed  CAS  Google Scholar 

  5. Brown FF (1983) The effect of compartmental location on the proton T2* of small molecules in cell suspension: a cellular field gradient model. J Magn Reson 54:385–399

    Article  CAS  Google Scholar 

  6. Belliveau JW, Rosen BR, Kantor HL (1990) Functional cerebral imaging by susceptibility-contrast NMR. Magn Reson Med 14: 538–546

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, Stanford University Medical Center, Stanford, California, USA

    Dr. Robert DeLaPaz & A. Poljack

  2. Division of Neurosurgery, Stanford University Medical Center, Stanford, California, USA

    G. K. Steinberg & D. Kunis

  3. Salutar Corporation, Sunnyvale, California, USA

    S. M. Rocklage

  4. Department of Radiology, Rm. S072, Stanford University Medical Center, Stanford, CA, 94305, USA

    Dr. Robert DeLaPaz

Authors
  1. Dr. Robert DeLaPaz
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  2. G. K. Steinberg
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  3. A. Poljack
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  4. D. Kunis
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  5. S. M. Rocklage
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Editor information

Editors and Affiliations

  1. Old Manor House, Brington, Huntington, Cambridgeshire, PEI8 0PX, UK

    George du Boulay CBE

  2. Neuroradiology Department, Radcliffe Infirmary, Oxford, OX2 6HE, UK

    Andrew Molyneux

  3. Lysholm Department of Radiology, The National Hospital, Queen Square, London, WC1N 3BG, UK

    Ivan Moseley

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© 1991 Springer-Verlag

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DeLaPaz, R., Steinberg, G.K., Poljack, A., Kunis, D., Rocklage, S.M. (1991). MRI of experimental cerebral ischemia: response to NMDA antagonist therapy. In: du Boulay, G., Molyneux, A., Moseley, I. (eds) Proceedings of the XIV Symposium Neuroradiologicum. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49329-4_20

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  • DOI: https://doi.org/10.1007/978-3-642-49329-4_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49331-7

  • Online ISBN: 978-3-642-49329-4

  • eBook Packages: Springer Book Archive

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