Abstract
Since the work of B.G. Goodwin (1965) who pointed out the biological relevance of negative feedback loops, the dynamics of the corresponding differential equations has been extensively analysed (2). Most of these studies deal with regulatory chains in which the last element, Ym, exerts a negative control on the production of the first one, Y1 (Figure 1).
“Ce qui nous rend ces solutions périodiques si précieuses, c’est qu’elles sont, pour ainsi dire, la seule brèche par où nous puissions pénétrer dans une place jusqu’ici réputée inabordable”.
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Richelle, J. (1979). Comparative analysis of negative loops by continuous, boolean and stochastic approaches. In: Thomas, R. (eds) Kinetic Logic A Boolean Approach to the Analysis of Complex Regulatory Systems. Lecture Notes in Biomathematics, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49321-8_14
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DOI: https://doi.org/10.1007/978-3-642-49321-8_14
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