Abstract
The discovery of new types of anti-cancer agent is not always the result of large scale screening or of working hypotheses which suggest that a particular chemical may have anti-tumour properties. Quite frequently new agents are found because of unexpected observations which may be made in fields completely unrelated to cancer chemotherapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Clarke, D. A.: Mouse Sarcoma 180. Cancer Res. Suppl. 3, 15 (1955).
Cleare, M. J., Hoeschele, J. D.: Anti-tumour platinum compounds. Relationship between structure and activity. Platinum Metals Review 17, 2 (1973).
Cleare, M. J., Hoeschele, J. D.: Studies on the anti-tumour activity of Group VIII transition metal complexes. Part I. Platinum(II)complexes. Bio inorganic Chemistry 2, 187 (1973).
Cobb, L. M., Mitchley, B. C. V.: Personal communication.
Connors, T. A.: Chemotherapy of animal tumours with platinum compounds. In: Advances in anti-microbial and anti-neoplastic chemotherapy, Vol. 2, p. 237. München, Berlin, Wien: Urban Schwarzenberg 1972.
Connors, T. A., Jones, M., Ross, W. C. J., Braddock, P. D., Khokhar, A. R., Tobe, M. L.: New platinum complexes with anti-tumour activity. Chem.-Biol. Interactions 5, 415 (1972).
Goldin, A.: Rationale of combination chemotherapy based on preclinical experiments. Cancer Chemother. Rep. (part 3 ) 4, 189 (1973).
Goldin, A., Mantel, N.: Cancer Chemother. Rep. (in press).
Goldin, A., Sandberg, J. S., Henderson, E. S., Newman, J. W.: The chemotherapy of human and animal acute leukaemia. Cancer Chemother. Rep. 55, 309 (1971).
Goldin, A., Serpick, A. A., Mantel, N.: Experimental screening procedures and clinical predictability value. Cancer Chemother. Rep. 50, 173 (1966).
Harder, H. C., Rosenberg, B.: Inhibitory effects of anti-tumour platinum compounds on DNA, RNA and protein synthesis in mammalian cells in vitro. Int. J. Cancer 6, 207 (1970).
Howle, J. A., Gale, G. R.: Cis-dichlorodiammine platinum(II) persistent and selective inhibition of DNA synthesis in vivo. Biochem. Pharmacol. 19, 2757 (1970).
Kociba, R. J., Sleight, S. D.: Acute toxicologic and pathologic effects of cis-diammine dichloroplatinum (NSC-119 875) in the male rat. Cancer Chemother. Rep. (part 1 ) 55, 1 (1971).
Kociba, R. J., Sleight, S. D., Rosenberg, B.: Inhibition of dunning ascitic leukaemia and Walker 256 carcinoma with cis-diammine-dichloroplatinum (NSC-119 875). Cancer Chemother. Rep. 54, 325 (1970).
Leonard, B. J., Eccleston, E., Jones, D., Todd, P., Walpole, A.: Anti-leukaemic and nephrotoxic properties of platinum compounds. Nature (Lond.) 234, 43 (1971).
Roberts, J. J., Pascoe, J. M.: Cross-linking of complementary strands of DNA in mammalian cells by anti-tumour platinum compounds. Nature (Lond.) 235, 282 (1972).
Rosenberg, B., Van Camp, L., Trosko, J. E., Mansour, V. H.: Platinum compounds: a new class of potent anti-tumour agent. Nature (Lond.) 222, 385 (1969).
Schmidt, L. H., Fradkin, R., Sullivan, R., Flowers, A.: Comparative pharmacology of alkylating agents. Cancer Chemother. Rep. Suppl. 2, pt. I-III (1965).
Speer, R. J., Lapis, S., Ridgway, H., Meyers, T. D., Hill, J. M.: Cis platinous diammino dichloride (PDD) in combination therapy of leukaemia L 1210. Advances in anti-microbial and anti-neoplastic chemotherapy. Vol. 2, p. 253. München, Berlin, Wien: Urban Schwarzenberg 1972.
Talley, R. W.: Chemotherapy of a mouse reticulum cell sarcoma. Proc. Amer. Ass. Cancer Res. 11, 78 (1970).
Van Camp, L., Rosenberg, B.: Combination therapy of cis-dichloro-diammineplatinum(II) with cytoxan against the sarcoma 180 tumor in Swiss white mice. In: Advances in antimicrobial and anti-neoplastic chemotherapy. Vol. 2, p. 239. München, Berlin, Wien: Urban Schwarzenberg 1972.
Venditti, J. M., Goldin, A.: Drug synergism in anti-neoplastic chemotherapy. In: Ed. GOLDIN and HAWKING. Advances in Chemotherapy. Vol. 1, p. 397. New York: Academic Press 1964.
Welsch, C. W.: Growth inhibition of rat mammary carcinoma induced by cis platinum diamminodichloride(II). J. nat. Cancer. Inst. 47, 1071 (1971).
Woodman, R. J., Strica, A. E., Gang, M., Kline, I., Venditti, J. M.: The enhanced therapeutic effect of cis-platinum(II) diamminodichloride against L 1210 leukaemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxo-piperazine-1-yl) propane or several other anti-tumour agents. Chemotherapy 18, 169 (1973).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Connors, T.A. (1974). Anti-Tumour Effects of Platinum Complexes in Experimental Animals. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-49306-5_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-49308-9
Online ISBN: 978-3-642-49306-5
eBook Packages: Springer Book Archive