Abstract
A reviewer of a subject tends to be convinced that everyone is familiar with the interesting and relevant aspects of his topic. The attitude I have taken is that any really good story can withstand any amount of retelling. The discovery of the antitumour platinum compounds is just such a story and remains many years after it was first announced as one of the classical examples of serendipity operating in science. Who could have foretold that the modest opening sentence of the first paper which related to these compounds ([14]) and reads: “In an investigation of the possible effects of an electric field on growth processes we have discovered a new and interesting effect” would have been followed by so many other valuable discoveries and result in the innovation into cancer chemotherapy of an entirely new class of chemical agent. In this survey of the bacterial, viral and tissue culture effects of platinum compounds I will begin by briefly describing some of the elegant series of experiments by Rosenberg et al. [14], then mention other relevant studies in the bacterial field, before proceeding to discuss more recent viral and tissue culture studies.
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References
Drobnik, J., Urbánková, M., Krbkulova, A.: The effect of cis-dichlorodiammine platinum(II) on Escherichia coli B: the role of fil, exr and her markers. Mutation Res. 17, 13 (1973).
Harder, H. C., Rosenberg, B.: Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein synthesis in mammalian cells in vitro. Int. J. Cancer 6, 207 (1970).
Heinemann, B., Howard, A. J.: Induction of lambda bacteriophage in Escherichia coli as a screening test for potential anti-tumour agents. Appl. Microbiol. 12, 234 (1964).
Howle, J. A., Gale, G. R.: Cis-dichlorodiammine platinum(II) persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo. Biochem. Pharmacol. 19, 2757 (1970).
Howle, J. A., Gale, G. R.: Cis-dichlorodiammine platinum(II): cytological changes induced in Escherichia coli. J. Bact. 103, 259 (1970).
Kara, J., Svoboda, J., Drobnik, J.: Cis-dichlorodiammine platinum(II): irreversible inhibition of DNA synthsesis and cell growth in tissue culture and inhibition of chick embryo cell transformation by Rous sarcoma virus. Abstracts of VIIth Int. Chemotherapy Congress. Prague 1971.
Kutinova, L., Vonda, V., Drobnik, J.: Inactivation of papovavirus SV40 by cisdichlorodiammine platinum(II). Neoplasma (Bratisl.) 19, 453 (1972).
Renshaw, E., Thomson, A. J.: Tracer studies to locate the site of platinum ions within filamentous and inhibited cells of Escherichia coli. J. Bact. 94, 1915 (1967).
Reslova, S., Srogl, M., Drobnik, J.: The transforming activity of ß-subtilis DNA treated with cis-Pt(II) complexes. Abstracts of VIIth Int. Congress of Chemotherapy. Prague 1971.
Reslova, S.: Induction of lysogenic strains of Escherichia coli by cis-dichlorodiammine platinum(II). Chem.-Biol. Interactions 4, 66 (1971/72).
Roberts, J. J., Brent, T. P., Crathorn, A. R.: Evidence for the inactivation and repair of the mammalian DNA template after alkylation by mustard gas and half mustard gas. Europ. J. Cancer 7, 515 (1971).
Roberts, J. J., Pascoe, J. M.: Evidence for cross-linking of complementary strands of DNA in cultured mammalian cells by platinum compounds and mustard gas. Abstracts of VIIth Int. Congress of Chemotherapy. Prague 1971.
Roberts, J. J., Pascoe, J. M.: Cross-linking of complementary strands of DNA in mammalian cells by anti-tumour platinum compounds. Nature (Lond.) 235, 282 (1972).
Rosenberg, B., Van Camp, L., Krigas, T.: Inhibition of cell division in Escherichia cols by electrolysis products from a platinum electrode. Nature (Lond.) 203, 698 (1965).
Rosenberg, B., Renshaw, E., Van Camp, L., Hartwick, J., Drobnik, J.: Platinum-induced filamentous growth in Escherichia coll. J. Bact. 93, 716 (1967).
Rosenberg, B., Van Camp, L., Grimley, E. B., Thomson, A. J.: The inhibition of growth or cell division in Escherichia coli by different ionic species of platinum(IV) complexes. J. biol. Chem. 242, 1347 (1967).
Shooter, K. V., Howse, R., Merrifield, R. K., Robins, A. B.: The interaction of platinum(II) compounds with bacteriophages T7 and R17. Chem.-Biol. Interactions 5, 289 (1972).
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© 1974 Springer-Verlag Berlin · Heidelberg
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Roberts, J.J. (1974). Bacterial, Viral and Tissue Culture Studies on Neutral Platinum Complexes. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_5
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DOI: https://doi.org/10.1007/978-3-642-49306-5_5
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