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Clinical Experience with cis-Platinum (II) Diamminedichloride

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 48))

Abstract

From the experimental data of Rosenberg et al. [3, 4] and others [1, 2] it is clear that various platinum complexes have good antitumour properties. Their primary action probably involves inhibition of DNA synthesis. At the National Ontological Institute in Budapest preclinical investigations of cis-platinum(II) diamminedichloride (PDD) have been carried out by Kellner, Nemeth and Somfai.

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References

  1. Gale, G. R., Howle, J., Walker, E. M.: Anti-tumour and anti-mitogen properties of cisdichloro(dipyridine)platinum(II). Cancer Res. 31, 950 (1971).

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  2. Leonard, B. J., Eccleston, E., Jones, D., Todd, P., Walpole, A.: Anti-leukaemic and nephrotoxic properties of platinum compounds. Nature (Lond.) 234, 43 (1971).

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  3. Rosenberg, B., Van Camp, L.: The successful regression of large solid sarcoma 180 tumors by platinum compounds. Cancer Res. 30, 1799 (1970).

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  4. Rosenberg, B., Van Camp, L., Trosko, J. E., Mansour, V. H.: Platinum compounds: a new class of potent antitumour agent. Nature (Lond.) 222, 385 (1969).

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© 1974 Springer-Verlag Berlin · Heidelberg

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Hindy, I., Sellei, C., Varsanyi, R., Eckhardt, S. (1974). Clinical Experience with cis-Platinum (II) Diamminedichloride. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_17

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  • DOI: https://doi.org/10.1007/978-3-642-49306-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49308-9

  • Online ISBN: 978-3-642-49306-5

  • eBook Packages: Springer Book Archive

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