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Interleukin-1

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

It is now known that there are two classes of IL-1 molecules known as IL-1α and IL-1β, each encoded by a single gene. The IL-1 literature prior to 1984, when the first IL-1 cDNAs were cloned (Lomedico et al. 1984; Auron et al. 1984), has been comprehensively reviewed (Dinarello 1984). This review will therefore largely focus on the literature from 1984 onward.

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References

  • Abraham RT, Ho SN, Barna TJ, McKean DJ (1987) Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanisms. J Biol Chem 262: 2719–2728

    PubMed  CAS  Google Scholar 

  • Acres RB, Larsen A, Gillis S, Conlon PJ (1987a) Production of IL-1a and IL-1ß by clones of EBV transformed, human B cells. Mol Immunol 24: 479–485

    Article  PubMed  CAS  Google Scholar 

  • Acres RB, Larsen A, Conlon PJ (1987b) IL 1 expression in a clone of human T cells. J Immunol 138: 2132–2136

    Google Scholar 

  • Akahoshi T, Oppenheim JJ, Matsushima K (1988) Induction of high-affinity interleukin 1 receptor on human peripheral blood lymphocytes by glucocorticoid hormones. J Exp Med 167: 924–936

    Article  PubMed  CAS  Google Scholar 

  • Albrightson CR, Baenziger NL, Needleman P (1985) Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1. J Immunol 135: 1872–1877

    PubMed  CAS  Google Scholar 

  • Ansel JC, Luger TA, Kock A, Hochstein D, Green I (1984) The effect of in vitro UV irradiation on the production of IL 1 by murine macrophages and P388D1 cells. J Immunol 133: 1350–1355

    PubMed  CAS  Google Scholar 

  • Ansel JC, Luger TA, Lowry D, Perry P, Roop DR, Mountz JD (1988) The expression and modulation of IL-1a in murine keratinocytes. J Immunol 140: 2274–2278

    PubMed  CAS  Google Scholar 

  • Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarrello CA (1984) Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci 81: 7907–7911

    Article  PubMed  CAS  Google Scholar 

  • Auron PE, Rosenwasser LJ, Matsushima K, Copeland T, Dinarello CA, Oppenheim JJ, Webb AC (1985) Human and murine interleukin-1 possess sequence and structural similarities. J Mol Cell Immunol 2: 169–177

    PubMed  CAS  Google Scholar 

  • Auron PE, Warner SJ, Webb AC, Cannon JG, Bernheim HA, McAdam KJ, Rosenwasser LJ, LoPreste G, Mucci SF, Dinarello CA (1987) Studies on the molecular nature of human interleukin 1. J Immunol 138: 1447–1456

    PubMed  CAS  Google Scholar 

  • Avissar S, Stenzel KH, Novogrodsky A (1985) Selective effects of TPA and IL-1 on protein phosphorylation in murine thymocytes. Cell Immunol 96: 462–471

    Article  PubMed  CAS  Google Scholar 

  • Bagby GC, Dinarello CA, Wallace P, Wagner C, Hefeneider S, McCall E (1986) Interleukin-1 stimulates granulocyte macrophage colony stimulating activity release by vascular endothelial cells. J Clin Invest 78: 1316–1323

    Article  PubMed  CAS  Google Scholar 

  • Bagby GC, Dinarello CA, Neerhout RC, Ridgway D, McCall E (1988) Interleukin 1-dependent paracrine granulopoiesis in chronic granulocytic leukemia of the juvenile type. J Clin Invest 82: 1430–1436

    Article  PubMed  Google Scholar 

  • Bakouche O, Brown DC, Lachman LB (1987) Subcellular localization of human monocyte interleukin 1: evidence for an inactive precursor molecule and a possible mechanism for IL 1 release. J Immunol 138: 4249–4255

    PubMed  CAS  Google Scholar 

  • Baldari C, Massone A, Macchia G, Telford JL (1987) Differential stability of human interleukin 1 beta fragments expressed in yeast. Protein Eng 1: 433–437

    Article  PubMed  CAS  Google Scholar 

  • Balavoine JF, de Rochemonteix B, Williamson K, Seckinger P, Cruchaud A, Dayer JM (1986) Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s). J Clin Invest 78: 1120–1124

    Article  PubMed  CAS  Google Scholar 

  • Bauman H, Richards C, Gauldie J (1987) Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J Immunol 139: 4122–4128

    Google Scholar 

  • Bayne EK, Rupp EA, Limjuco G, Chin J, Schmidt JA (1986) Immunocytochemical detection of interleukin 1 within stimulated human monocytes. J Exp Med 163: 1267–1280

    Article  PubMed  CAS  Google Scholar 

  • Beck G, Habicht GS, Benach JL, Miller F (1986) Interleukin 1: a common endogenous mediator of inflammation and the local Shwartzman reaction. J Immunol 136: 3025–3031

    PubMed  CAS  Google Scholar 

  • Bendtzen K, Mandrup-Poulsen T, Nerup J, Nielsen JH, Dinarello CA, Svenson M (1986) Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science 232: 1545–1547

    Article  PubMed  CAS  Google Scholar 

  • Bensi G, Raugei G, Palla E, Carinci V, Tornese-Buonamassa D, Melli M (1987) Human interleukin-1 beta gene. Gene 52: 95–101

    Article  PubMed  CAS  Google Scholar 

  • Beresini MH, Lempert MJ, Epstein LB (1988) Overlapping polypeptide induction in human fibroblasts in response to treatment with interferon-a, interferon-y, interleukin 1a, interleukin lß, and tumor necrosis factor. J Immunol 140: 485–493

    PubMed  CAS  Google Scholar 

  • Berkenbosch F, Van Oers J, Del Ray A, Tilders F, Besedovsky H (1987) Corticotropinreleasing factor-producing neurons in the rat activated by interleukin 1 Science 238: 524–526

    CAS  Google Scholar 

  • Bernaudin JF, Yamauchi K, Wewers MD, Tocci MJ, Ferrans VJ, Crystal RG (1988) Demonstration by in situ hybridization of dissimilar IL-1ß gene expression in human alveolar macrophages and blood monocytes in response to lipopolysaccharide. J Immunol 140: 3822–3829

    PubMed  CAS  Google Scholar 

  • Bernton EW, Beach JE, Holaday JW, Smallridge RC, Fein HG (1987) Release of multiple hormones by a direct action of interleukin-1 on pituitary cells. Science 238: 519–521

    Article  PubMed  CAS  Google Scholar 

  • Besedovsky H, Del Rey A, Sorkin E, Dinarello CA (1986) Immunoregulatory feed- back between interleukin-1 and glucocorticoid hormones. Science 233: 652–654

    Article  PubMed  CAS  Google Scholar 

  • Beuscher HU, Fallon RJ, Colten HR (1987) Macrophage membrane interleukin 1 regulates the expression of acute phase proteins in human hepatoma hep 3B cells. J Immuno1139: 1896–1901

    Google Scholar 

  • Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone MA (1984) Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 160: 618–623

    Article  PubMed  CAS  Google Scholar 

  • Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA (1985) Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest 76: 2003–2011

    Article  PubMed  CAS  Google Scholar 

  • Bhardwaj N, Lau L, Rivelis M, Steinman RM (1988) Interleukin-1 production by monoclear cells from rheumatoid synovial effusions. J Cell Immunol 114: 405–423

    Article  CAS  Google Scholar 

  • Bird TA, Saklatvala J (1986) Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells. Nature 324: 263–266

    Article  PubMed  CAS  Google Scholar 

  • Bird TA, Saklatvala J (1987) Studies on the fate of receptor-bound ‘25I-Interleukin 1ß in porcine synovial fibroblasts. J Immunol 139: 92–97

    PubMed  CAS  Google Scholar 

  • Bird TA, Gearing AJH, Saklatvala J (1987) Murine interleukin-1 receptor: differences in binding properties between fibroblastic and thymoma cells and evidence for a two-chain receptor model. FEBS Lett 225: 21–26

    Article  PubMed  CAS  Google Scholar 

  • Bitterman PB, Wewers MD, Rennard SI, Adelberg S, Crystal RG (1985) Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J Clin Invest 77: 700–708

    Article  Google Scholar 

  • Black RA, Kronheim SR, Cantrell M, Deeley MC, March CJ, Prickett KS, Wignall J, Conlon PJ, Cosman D, Hopp TP, Mochizuki DY (1988) Generation of biologically active interleukin-1ß by proteolytic cleavage of the inactive precursor. J Biol Chem 263: 9437–9442

    PubMed  CAS  Google Scholar 

  • Blanton RA, Kupper TS, McDougall JK, Dower S (1989) Regulation of interleukin 1 and its receptor in human keratinocytes. Proc Natl Acad Sci USA 86: 1273–1277

    Article  PubMed  CAS  Google Scholar 

  • Bochner BS, Rudledge BK, Schleimer RP (1987) Interleukin 1 production by human lung tissue. Inhibition by anti-inflammatory steroids. J Immunol 139: 2303–2307

    Google Scholar 

  • Booth RJ, Watson JD (1984) Interleukin 1 induces proliferation in two distinct B cell subpopulations responsive to two different murne B cell growth factors. J Immunol 133: 1346–1349

    PubMed  CAS  Google Scholar 

  • Boraschi D, Nencioni L, Villa L, Censini S, Bossu P, Ghiara P, Presentini R, Perin F, Frasca D, Doria G, Forni G, Musso T, Giovarelli M, Ghezzi P, Bertini R, Besedovsky H, Del Rey A, Sipe J, Antoni G, Silvestri S, Tagliabue A (1988) In vivo stimulation and restoration of the immune response by the non inflammatory fragment 163–171 of human interleukin 1ß. J Exp Med 168: 675686

    Google Scholar 

  • Boswell JM, Yui MA, Endres S, Burt DW, Kelley VE (1988 a) Novel and enhanced IL-1 gene expression in autoimmune mice with lupus. J Immunol 141: 118–124

    Google Scholar 

  • Boswell JM, Yui MA, Burt DW, Kelley VE (1988 b) Increased tumor necrosis factor and IL-1ß gene expression in the kidneys of mice with lupus nephritis. J Immunol 141: 3050–3054

    Google Scholar 

  • Boyle M, Yamamoto G, Chen M, Rivier J, Vale W (1988) Interleukin 1 prevents loss of corticotropic responsiveness to ß-adrenergic stimulation in vitro. Proc Natl Acad Sci USA 85: 5556–5560

    Article  PubMed  CAS  Google Scholar 

  • Breder CD, Dinarello CA, Saper CB (1988) Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240: 321–324

    Article  PubMed  CAS  Google Scholar 

  • Breviario F, Bertocchi F, Dejana E, Bussolino F (1988) IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. J Immunol 141: 3391–3397

    PubMed  CAS  Google Scholar 

  • Brody TB, Durum SK (1988) A plasma membrane anchoring mechanism for IL-1. In: Powanda MC, Oppenheim JJ, Kluger MJ, Dinarello CA (eds) Monokines and other non-lymphocytic cytokines. Liss, New York, pp 101–107 (Progress in leukocyte biology, vol 8 )

    Google Scholar 

  • Bron C, MacDonald HR (1987) Identification of the plasma membrane receptor for interleukin-1 on mouse thymoma cells. FEBS Lett 219: 365–368

    Article  PubMed  CAS  Google Scholar 

  • Brown KM, Rosenstreich DL (1987) Mechanism of action of a human interleukin 1 inhibitor. Cell Immun. 1105: 45

    Article  Google Scholar 

  • Burch RM, Connor JR, Axelrod J (1988) Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts. Proc Natl Acad Sci USA 85: 6306–6309

    Article  PubMed  CAS  Google Scholar 

  • Burchett SK, Weaver WM, Westall JA, Larsen A, Kronheim S, Wilson CB (1988) Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human monoculear phagocytes. J Immunol 140: 3473–3481

    PubMed  CAS  Google Scholar 

  • Bursten SL, Locksley RM, Ryan JL, Lovett DH (1988) Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors. J Clin Invest 82: 1479–1488

    Article  PubMed  CAS  Google Scholar 

  • Cameron P, Limjuco G, Rodkey J, Bennett C, Schmidt JA (1985) Amino acid sequence analysis of human interleukin 1 (IL-1) Evidence for biochemically distinct forms of IL-1. J Exp Med 162: 790–801

    Article  PubMed  CAS  Google Scholar 

  • Cameron PM, Limjuco GA, Chin J, Silberstein L, Schmidt JA (1986) Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1. J Exp Med 164: 237–250

    Article  PubMed  CAS  Google Scholar 

  • Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A (1986) Identification of a common nucleotide sequence in the 3’-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci USA 83: 1670–1674

    Article  PubMed  CAS  Google Scholar 

  • Carter DB, Curry KA, Tomich CSC, Yem AW, Deibel MR, Tracey DE, Paslay JW, Carter JB, Theriault NY, Harris PKW, Reardon IM, Jurcher-Neely HA, Heinrikson RL, Clancy LL, Muchmore SW, Watenpaugh KD, Einspahr HM (1988) Crystallization of purified recombinant human interleukin-1 ß. Proteins 3: 121–129

    Article  PubMed  CAS  Google Scholar 

  • Castelli MP, Black PL, Schneider M, Pennington R, Abe F, Talmadge JE (1988) Protective, restorative, and therapeutic properties of recombinant human IL-1 in rodent models. J Immunol 140: 3830–3837

    PubMed  CAS  Google Scholar 

  • Cavender DE, Haskard DO, Joseph B, Ziff M (1986) Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers. J Immunol 136: 203–207

    PubMed  CAS  Google Scholar 

  • Chang J, Gilman SC, Lewis AJ (1986) Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action. J Immunol 136: 12831287

    Google Scholar 

  • Chin J, Cameron PM, Rupp E, Schmidt JA (1987) Identification of a high-affinity receptor for native human interleukin 1ß and interleukin 1a on normal human lung fibroblasts. J Exp Med 165: 70–86

    Article  PubMed  CAS  Google Scholar 

  • Chin J, Rupp E, Cameron PM, MacNaul KL, Lotke PA, Tocci MJ, Schmidt JA, Bayne EK (1988) Identification of a high-affinity receptor for interleukin 1a and interleukin 1ß on cultured human rheumatoid synovial cells. J Clin Invest 82: 420–426

    Article  PubMed  CAS  Google Scholar 

  • Chiplunkar S, Langhorne J, Kaufmann SHE (1986) Stimulation of B cell growth and differentiation by murine recombinant interleukin 1 J Immunol 137: 3748–3752

    CAS  Google Scholar 

  • Clark BD, Collins KL, Gandy MS, Webb AC, Auron PE (1986) Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. Nucleic Acids Res 14: 7897–7914

    Article  PubMed  CAS  Google Scholar 

  • Clark BD, Fenton MJ, Rey HL, Webb AC, Auron PE (1988) Characterization of cis and transacting elements involved in human prolL-1 beta gene expression. In: Powanda MC, Oppenheim JJ, Kluger MJ, Dinarello CA (eds) Monokines and other non-lymphocytic cytokines. Liss, New York, pp 47–53 (Progress in leukocyte biology, vol 8 )

    Google Scholar 

  • Conlon PJ, Grabstein KH, Alpert A, Prickett KS, Hopp TP, Gillis S (1987) Localization of human mononuclear cell interleukin 1. J Immunol 139: 98–102

    PubMed  CAS  Google Scholar 

  • Content J, De Wit L, Poupart P, Opdenakker G, Van Damme J, Billiau A (1985) Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1related, leukocyte-derived factor. Eur J Biochem 152: 253–257

    Article  PubMed  CAS  Google Scholar 

  • Corbo L, Pizzano R, Scala G, Venuta S (1987) Expression of interleukins in L cells transfected with human DNA. Eur J Biochem 669: 674

    Google Scholar 

  • Cosman D (1987) Control of messenger RNA stability. Immunol Today 8: 16–17

    Article  CAS  Google Scholar 

  • Cousins RJ, Leinart AS (1988) Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin 1. FASEB J 2: 2884–2890

    PubMed  CAS  Google Scholar 

  • Craig S, Schmeissner U, Wingfield P, Pain RH (1987) Conformation, stability, and folding of interleukin 1ß. Biochemistry 26: 3570–3576

    Article  PubMed  CAS  Google Scholar 

  • Cybulsky MI, McComb DJ, Movat HZ (1988) Neutrophil leukocyte emigration induced by endotoxin. Mediator roles of interleukin 1 and tumor necrosis factor alpha 1. J Immunol 140: 3144–3149

    PubMed  CAS  Google Scholar 

  • Czuprynski CJ, Brown JF, Yong KM, Cooley AJ, Kurtz RS (1988) Effects of murine recombinant interleukin 1a on the host response to bacterial infection. J Immunol 140: 962–968

    PubMed  CAS  Google Scholar 

  • Dayer JM, Stephenson ML, Schmidt E, Karge W, Krane SM (1981) Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues. FEBS Lett 124: 253–256

    Article  PubMed  CAS  Google Scholar 

  • Daynes RA, Robertson BA, Cho BH, Burnham DK, Newton R (1987) a-Melanocytestimulating hormone exhibits target cell selectivity in its capacity to affect interleukin 1-inducible responses in vivo and in vitro. J Immunol 139: 103–109

    Google Scholar 

  • DeChiara TM, Yong D, Semionow R, Stern AS, Batula-Bernardo C, Fiedler-Nagy C, Kaffka KL, Kilian PL, Yamazaki S, Mizel SB, Lomedico PT (1986) Structure-function analysis of murine interleukin 1: biologically active polypeptides are at least 127 amino acids long and are derived from the carboxyl terminus of a 270-amino acid precursor. Proc Natl Acad Sci USA 83: 8303–8307

    Article  PubMed  CAS  Google Scholar 

  • Dejana E, Breviario F, Erroi A, Bussolino F, Mussoni L, Gramse M, Pintucci G, Casali B, Dinarello CA, Van Damme J, Mantovani A (1987) Modulation of endothelial cell functions by different molecular species of interleukin 1. Blood 69: 695–699

    PubMed  CAS  Google Scholar 

  • Dejana E, Bertocchi F, Bortolami MC, Regonesi A, Tonta A, Breviario F, Giavazzi R (1988) Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells. J Clin Invest 82: 1466–1470

    Article  PubMed  CAS  Google Scholar 

  • Demczuk S (1988) IL1/etaf activity and undetectable IL1ß mRNA and minimal IL1 a mRNA levels in normal adult heat-separated epidermis. Biochem Biophys Res Commun 156: 463–469

    Article  PubMed  CAS  Google Scholar 

  • D’Eustachio P, Jadidi S, Fuhlbrigge RC, Gray PW, Chaplin DD (1987) Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse. Immunogenetics 26: 339–343

    Article  PubMed  Google Scholar 

  • Dewhirst FE, Stashenko PP, Mole JE, Tsurumachi T (1985) Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1ß. J Immuno1135: 2562–2568

    Google Scholar 

  • De Wit L, Poupart P, Opdenakker G, Van Damme J, Billiau A (1985) Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor. Eur J Biochem 152: 253–257

    Article  PubMed  Google Scholar 

  • Didier M, Aussel C, Pellassy C, Fehlmann M (1988) IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis. J Immunol 141: 3078–3080

    PubMed  CAS  Google Scholar 

  • Di Giovine FS, Malawista SE, Nuki G, Duff GW (1987) Interleukin 1 (IL1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J Immunol 138: 3213–3218

    PubMed  Google Scholar 

  • Dinarello CA (1984) Interleukin-1. Rev Infect Dis 6: 51–95

    Article  CAS  Google Scholar 

  • Dinarello CA, Clowes GHA, Gordon AH, Saravis CA, Wolff SM (1984a) Cleavage of human interleukin 1: isolation of a peptide fragment from plasma of febrile humans and activated monocytes. J Immunol 133: 1332–1338

    PubMed  CAS  Google Scholar 

  • Dinarello CA, Bishai I, Rosenwasser U, Coceani F (1984b) The influence of lipoxygenase inhibitors on the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (IL-1). Int J Immunopharmacol 6: 43–50

    Article  PubMed  CAS  Google Scholar 

  • Dinarello CA, Cannon JG, Mier JW, Bernheim HA, LoPreste G, Lynn DL, Love RN, Webb AC, Auron PE, Reuben RC, Rich A, Wolff S, Putney SD (1986 a) Multiple biological activities of human recombinant interleukin 1. J Clin Invest 77: 1734–1739

    Google Scholar 

  • Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, Figari IS, Palladino MA, O’Connor JV (1986b) Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med 163: 1433–1450

    Article  PubMed  CAS  Google Scholar 

  • Dinarello CA, Ikejima T, Warner SJC, Orencole SF, Lonnemann G, Cannon JG, Libby P (1987) Interleukin 1 induces interleukin 1. I Induction of circulating interleukin 1 in rabbits in vivo and in human monoclear cells in vitro. J Immunol 139: 1902–1910

    PubMed  CAS  Google Scholar 

  • Dower SK, Urdal DL (1987) The interleukin-1 receptor. Immunol Today 8: 46–51

    Article  CAS  Google Scholar 

  • Dower SK, Call SM, Gillis S, Urdal DL (1985a) Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line. Proc Natl Acad Sci USA 83: 1060–1064

    Article  Google Scholar 

  • Dower SK, Kronheim SR, March CJ, Conlon PJ, Hopp TP, Gillis S, Urdal DL (1985b) Detection and characterization of high affinity plasma membrane receptors for human interleukin 1. J Exp Med 162: 501–515

    Article  PubMed  CAS  Google Scholar 

  • Dower SK, Kronheim SR, Hopp TP, Cantrell M, Deeley M, Gillis S, Henney CS, Ur-dal DL (1986) The cell surface receptors for interleukin 1a and interleukin-1ß are identical. Nature 324: 266–268

    Article  PubMed  CAS  Google Scholar 

  • Duff GW, Dickens E, Wood N, Manson J, Symons J, Poole S, Di Giovine F (1988) Immunoassay, bioassay and in situ hybridization of monokines in human arthritis. In: Powanda MC, Oppenheim JJ, Kluger MJ, Dinarella CA (eds) Monokines and other non-lymphocytic cytokines. Liss, New York, pp 387–392 (Progress in leukocyte biology, vol 8 )

    Google Scholar 

  • Durum SK, Schmidt JA, Oppenheim JJ (1985) Interleukin-1: an immunological perspective. Annu Rev Immunol 3: 263–287

    Article  PubMed  CAS  Google Scholar 

  • Elias JA, Schreiber AD, Gustilo K, Chien P, Rossmann MD, Lammie PJ, Daniel RP (1985) Differential interleukin 1 elaboration by unfractionated and density fractionated human alveolar macrophages and blood monocytes: relationship to cell maturity. J Immunol 135: 3198–3204

    PubMed  CAS  Google Scholar 

  • Ernst JF (1988) Efficient secretion and processing of heterologous proteins in Saccharomyces cervisiae is mediated solety by the pre-segment of OE-factor precursor. DNA 7: 355–360

    Article  PubMed  CAS  Google Scholar 

  • Estes JE, Pledger WJ, Gillespie GY (1984) Macrophage-derived growth factor for fibroblasts and interleukin-1 are distinct entities. J Leukocyte Biol 35: 115–129

    PubMed  CAS  Google Scholar 

  • Falkoff RJM, Muraguchi A, Hong JX, Butler JL, Dinarello CA, Fauci AS (1983) The effects of interleukin 1 on human B cell activation and proliferation J Immunol 131: 801–805

    CAS  Google Scholar 

  • Farrar WL, Kilian P, Hill JM, Ruff MR, Pert CB (1987 a) Visualization of cytokine and virus receptors common to the immune and central nervous system. Lymphokine Res 6: 29–34

    Google Scholar 

  • Farrar WL, Kilian PL, Ruff MR, Hill JM, Pert CB (1987 b) Visulization and characterization of interleukin 1 receptors in brain. J Immunol 139: 459–463

    Google Scholar 

  • Fenton MJ, Clark BD, Collins KL, Webb AC, Rich A, Auron PE (1987) Transcrip- tional regulation of the human prointerleukin 1# gene. J Immunol 138: 3972–3979

    PubMed  CAS  Google Scholar 

  • Fenton MJ, Vermeulen MW, Clark BD, Webb AC, Auron PE (1988) Human pro-IL1ß gene expression in monocytic cells is regulated by two distinct pathways. J Immunol 140: 2267–2273

    PubMed  CAS  Google Scholar 

  • Ferreira SH, Lorenzetti BB, Bristow AF, Poole S (1988) Interleukin-1ß as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature 334: 698–700

    Article  PubMed  CAS  Google Scholar 

  • Fibbe WE, VanDamme J, Billiau A, Voogt PJ, Duinkerken N (1987) Purified human interleukin-1 induces GM-CSF release by mononuclear phagocytes. Blood 68: 1316–1321

    Google Scholar 

  • Fontana A, Kristensen F, Dubs R, Gemsa D, Weber E (1982) Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells. J Immunol 129: 2413–2419

    PubMed  CAS  Google Scholar 

  • Frasca D, Boraschi D, Baschieri S, Bossu P, Tagliabue A, Adorini L, Doria G (1988) In vivo restoration of T cell functions by human IL-1ß or its 163–171 nonapeptide in immunodepressed mice. J Immunol 141: 2651–2655

    PubMed  CAS  Google Scholar 

  • Freedman AS, Freeman G, Whitman J, Segil J, Daley J, Nadler LM (1988) Pre-exposure of human B cells to recombinant IL-1 enhances subsequent proliferation. J Immunol 141: 3398–3404

    PubMed  CAS  Google Scholar 

  • Frisch SM, Ruley HE (1987) Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone. J Biol Chem 262: 16300–16304

    PubMed  CAS  Google Scholar 

  • Fuhlbrigge RC, Sheehan KCF, Schreiber RD, Chaplin DD, Unanue ER (1988) Monoclonal antibodies to murine IL-1 a. Production, characterization, and inhibition of membrane-associated IL-1 activity. J Immunol 141: 2643–2650

    PubMed  CAS  Google Scholar 

  • Furutani Y, Notake M, Yamayoshi M, Yamagishi J, Nomura H, Ohue M, Furuta R, Fukui T, Yamada M, Nakamura S (1985) Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor. Nucleic Acids Res 13: 5869–5882

    Article  PubMed  CAS  Google Scholar 

  • Furutani Y, Notake M, Fukui T, Ohue M, Normura H, Yamada M, Nakamura S (1986) Complete nucleotide sequence of the gene for human interleukin 1 alpha. Nucleic Acids Res 14: 3167–3179

    Article  PubMed  CAS  Google Scholar 

  • Garman RD, Raulet DH (1987 a) Characterization of a novel murine T cell-activating factor. J Immunol 138: 1121–1129

    Google Scholar 

  • Garman RD, Jacobs KA, Clark SC, Raulet HD (1987 b) B-cell-stimulatory factor 2 (ß2infereron) functions as a second signal for interleukin 2 production by mature murine T cells. Proc Natl Acad Sci USA 84: 7629–7633

    Google Scholar 

  • Georgilis K, Schaefer C, Dinarello CA, Klempner MS (1987) Human recombinant interleukin 1ß has no effect on intracellular calcium or on functional responses of human neutrophils. J Immunol 138: 3403–3407

    PubMed  CAS  Google Scholar 

  • Gerrard TL, Siegel JP, Dyer DR, Zoon KC (1987) Differential effects of interferon-a and interferon-y on interleukin 1 secretion by monocytes. J Immunol 138: 2535–2540

    PubMed  CAS  Google Scholar 

  • Gery I, Gershon RK, Waksman B (1972) Potentiation of the T lymphocyte response to mitogens. I. The responding cell. J Exp Med 136: 128–142

    Google Scholar 

  • Gery I, Davis P, Derr J, Krett N, Barranger JA (1981) Relationship between production and release of lymphocyte-activating factor (interleukin 1) by murine macrophages. Effects of various agents. Cell Immunol 64: 293–303

    Google Scholar 

  • Ghezzi P, Dinarello CA (1988) IL-1 induces IL-1. III. Specific inhibition of IL-1 production by IFN-gamma. J Immunol 140: 4238–4244

    PubMed  CAS  Google Scholar 

  • Gilliland GL, Winborne EL, Masui Y, Hirai Y (1987) A preliminary crystallographic study of recombinant human interleukin 113. J Biol Chem 262:12 323–12 324

    Google Scholar 

  • Giulian D, Baker TJ, Shih LCN, Lachman LB (1986) Interleukin 1 of the central nervous system is produced by ameboid microglia. J Exp Med 164: 594–604

    Article  PubMed  CAS  Google Scholar 

  • Gimenez-Gallego G, Rodkey J, Bennett C, Rios-Candelore M, DiSalvo J, Thomas K (1985) Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies. Science 230: 1385–1388

    Article  PubMed  CAS  Google Scholar 

  • Giri JG, Lomedico PT, Mizel SB (1985) Studies on the synthesis and secretion of interleukin 1. I. A 33,000 molecular weight precursor for interleukin 1. J Immunol 134: 343–349

    PubMed  CAS  Google Scholar 

  • Goldring MB, Birkhead J, Sandell U, Kimura T, Krane SM (1988) Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in chondrocytes. J Clin Invest 82: 2026–2031

    Article  PubMed  CAS  Google Scholar 

  • Goto F, Goto K, Ohkawara S, Kitamura M, Mori S, Takahashi H, Sengoku Y, Yoshinaga M (1988) Purification and partial sequence of rabbit polymorphonuclear leukocyte-derived lymphocyte proliferation potentiating factor resembling IL-1ß. J Immunol 140: 1153–1158

    PubMed  CAS  Google Scholar 

  • Goud SN, Muthusamy N, Subbarao B (1988) Differential responses of B cells from the spleen and lymph node to TNP-Ficoll. J Immunol 140: 2925–2930

    PubMed  CAS  Google Scholar 

  • Gowen M, Mundy GR (1986) Actions of recombinant interleukin 1, interleukin 2, and interferon-y on bone resorption in vitro J Immunol 136: 2478–2482

    CAS  Google Scholar 

  • Gowen M, Wood DD, Ihrie EJ, McGuire MKB, Russell RGG (1983) An interleukin 1-like factor stimulates bone resorption in vitro. Nature 306: 378–380

    Article  PubMed  CAS  Google Scholar 

  • Gowen M, Wood DD, Ihrie EJ, Meats JE, Russell RG (1984) Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro. Biochim Biophys Acta 797: 186–193

    Article  PubMed  CAS  Google Scholar 

  • Granstein RD, Margolis R, Mizel SB, Sauder DN (1985) In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse. J Clin Invest 44: 1020

    Google Scholar 

  • Gray PW, Glaister D, Chen E, Goeddel DV, Pennica D (1986) Two interleukin 1 genes in the mouse: cloning and expression of the eDNA for murine interleukin 1ß. J Immunol 137: 3644–3648

    PubMed  CAS  Google Scholar 

  • Greenbaum LA, Horowitz JB, Woods A, Pasqualini, Reich EP, Bottomly K (1988) Autocrine growth of CD4 T cells. Differential effects of IL-1 on helper and inflammatory T cells. J Immunol 140: 1555–1560

    PubMed  CAS  Google Scholar 

  • Gubler U, Chua AO, Stern AS, Hellmann CP, Vitek MP, Dechiara TM, Benjamin WR, Collier KJ, Dukovich M, Familletti PC, Fiedler-Nagy C, Jenson J, Kaffk K, Kilian PL, Stremlo D, Wittreich BH, Woehle D, Mizel SB, Lomedico PT (1986) Recombinant human interleukin la: purification and biological characterization. J Immunol 136: 2492–2497

    PubMed  CAS  Google Scholar 

  • Hackett RJ, Davis LS, Lipsky PE (1988) Comparative effects of tumor necrosis factor-a and IL-1ß on mitogen-induced T cell activation. J Immunol 140: 2639–2644

    PubMed  CAS  Google Scholar 

  • Hagiwara H, Huang HJ, Arai N, Herzenberg LA, Arai K, Zlotnik A (1987) Interleukin 1 modulates messenger RNA levels of lymphokines and of other molecules associated with T cell activation in the T cell lymphoma LBRM33–1A5. J Immunol 138: 2514–2519

    PubMed  CAS  Google Scholar 

  • Hazuda DJ, Lee JC, Young PR (1988) The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta. J Biol Chem 263: 8473–8479

    PubMed  CAS  Google Scholar 

  • Hazuda D, Webb RL, Simon P, Young P (1989) Purification and characterization of human recombinant precursor interleukin 1ß. J Biol Chem 264: 1689–1693

    PubMed  CAS  Google Scholar 

  • Hession C, Decker JM, Sherblom AP, Kumar S, Yue CC, Mattalliano RJ, Tizard R, Kawashima E, Schmeissner U, Heletky S, Chow EP, Burne CA, Shaw A, Muchmore AV (1987) Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines. Science 237: 1479–1484

    Article  PubMed  CAS  Google Scholar 

  • Ho SN, Abraham RT, Nilson A, Handwerger BS, McKean DJ (1987) Interleukin 1-mediated activation of interleukin 4 (IL 4)-producing T lymphocytes. Proliferation by IL 4-dependent and IL 4-independent mechanisms. J Immunol 139: 1532–1540

    PubMed  CAS  Google Scholar 

  • Holtmann H, Wallach D (1987) Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4ß-phorbol-12 myristate-13-acetate. J Immunol 139: 1161–1167

    PubMed  CAS  Google Scholar 

  • Hom JT, Bendele AM, Carlson DG (1988) In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice. J Immunol 141: 834–841

    PubMed  CAS  Google Scholar 

  • Horuk R, Huang JJ, Covington M, Newton RC (1987) A biochemical and kinetic analysis of the interleukin-1 receptor. Evidence for differences in molecular properties of IL-1 receptors. J Biol Chem 262: 16275–16278

    PubMed  CAS  Google Scholar 

  • Howard M, Mizel SB, Lachman L, Ansel J, Johnson B, Paul WE (1983) Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation. J Exp Med 157: 1529–1543

    Article  PubMed  CAS  Google Scholar 

  • Huang JJ, Newton RC, Horuk R, Matthew JB, Covington M, Pezzella K, Lin YA (1987) Muteins of human interleukin-1 that show enhanced bioactivities. FEBS Lett 223: 294–298

    Article  PubMed  CAS  Google Scholar 

  • Huang JJ, Newton RC, Rutledge SJ, Horuk R, Matthew JB, Covington M, Lin Y (1988) Characterization of Murine IL-1ß isolation, expression, and purification. J Immunol 140: 3838–3843

    PubMed  CAS  Google Scholar 

  • Hurme M (1987) Membrane-associated interleukin 1 is required for the activation of T cells in the anti-CD3 antibody-induced T cell response. J Immunol 139: 1168–1172

    PubMed  CAS  Google Scholar 

  • Jacobs C, Young D, Tyler S, Callis G, Gillis S, Conlon PJ (1988) In vivo treatment with IL-1 reduces the severity and duration of antigen-induced arthritis in rats. J Immunol 141: 2967–2974

    PubMed  CAS  Google Scholar 

  • Jelinek DF, Lipsky PE (1987) Enhancement of human B cell proliferation and differentiation by tumor necrosis factor-a and interleukin 1. J Immunol 139: 2970–2976

    PubMed  CAS  Google Scholar 

  • Jobling SA, Auron PE, Gurka G, Webb AC, McDonald B, Rosenwasser U, Gehrke L (1988) Biological activity and receptor binding of human prointerleukin-1ß and subpeptides. J Biol Chem 31:16 372–16 378

    Google Scholar 

  • Karin M, Imbra RJ, Heguy A, Wong G (1985) Interleukin 1 regulates human metallothionein gene expression. Mol Cell Biol 5: 2866–2869

    PubMed  CAS  Google Scholar 

  • Kasahara T, Mukaida N, Shinomiya H, Imai M, Matsushima K, Wakasugi H, Nakano K (1987) Preparation and characterization of polyclonal and monoclonal antibodies against human interleukin la ( IL la ). J Immunol 138: 1804–1812

    Google Scholar 

  • Kaye J, Gillis S, Mizel SB, Shevach EM, Malek TR, Dinarello CA, Lachman LB, Janeway CA (1984) Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol 133: 1339–1345

    PubMed  CAS  Google Scholar 

  • Kenney JS, Masada MP, Eugui EM, Delustro BM, Mulkins MA, Allison AC (1987) Monoclonal antibodies to human recombinant interleukin 1 (IL 1)ß: quantitation of IL 1ß and inhibition of biological activity. J Immunol 138: 4236–4242

    PubMed  CAS  Google Scholar 

  • Kern JA, Lamb RJ, Reed JC, Daniele RP, Nowell PC (1987) Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms. J Clin Invest 81: 237–244

    Google Scholar 

  • Kilian PL, Kaffka KL, Stern AS, Woehle D, Benjamin WR, Dechiara TM, Gubler U, Farrar JJ, Mizel SB, Lomedico PT (1986) Interleukin 1a and interleukin 1ß bind to the same receptor on T cells. J Immunol 136: 4509–4514

    PubMed  CAS  Google Scholar 

  • Kimball ES, Fisher MC (1988) Potentiation of IL-1-induced Balb/3T3 fibroblast proliferation by neuropeptides. J Immunol 141: 4203–4208

    PubMed  CAS  Google Scholar 

  • Kimball ES, Persico FJ, Vaught JL (1988) Substance P, neurokinin A and neurokinin B induce generation of IL-1-like activity in P388D1 cells. J Immunol 141: 3564–3569

    PubMed  CAS  Google Scholar 

  • Klempner MS, Dinarello CA, Gallin JI (1978) Human leukocytic pyrogen induces release of specific granule contents from human neutrophils. J Clin Invest 61: 1330–1336

    Article  PubMed  CAS  Google Scholar 

  • Knudsen PJ, Dinarello CA, Strom TB (1986) Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol 137: 3189–3194

    PubMed  CAS  Google Scholar 

  • Knudsen PJ, Dinarello CA, Strom TB (1987) Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol 139: 4129–4134

    PubMed  CAS  Google Scholar 

  • Kobayashi Y, Appella E, Yamada M, Copeland TD, Oppenheim JJ, Matsushima K (1988) Phosphorylation of intracellular precursors of human IL-1. J Immunol 140: 2279–2287

    PubMed  CAS  Google Scholar 

  • Kock A, Danner M, Stadler BM, Luger TA (1986) Characterization of a monoclonal antibody directed against the biologically active site of human interleukin 1. J Exp Med 163: 463–468

    Article  PubMed  CAS  Google Scholar 

  • Koide S, Steinman RM (1987) Induction of murine interleukin 1: stimuli and responsive primary cells. Proc Natl Acad Sci USA 84: 3802–3806

    Article  PubMed  CAS  Google Scholar 

  • Koide SL, Inaba K, Steinman RM (1987) Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells. J Exp Med 165: 515–530

    Article  PubMed  CAS  Google Scholar 

  • Korn JH, Brown KM, Downie E, Liao ZH, Rosenstreich DL (1987) Augmentation of IL 1-induced fibroblast PGE2 production by a urine-derived IL 1 inhibitor. J Immunol 138: 3290–3294

    PubMed  CAS  Google Scholar 

  • Kovacs EJ, Oppenheim JJ, Young HA (1986) Induction of c-fos and c-myc expression in T lymphocytes after treatment with recombinant interleukin 1-a. J Immunol 137: 3649–3651

    PubMed  CAS  Google Scholar 

  • Kovacs EJ, Radzioch D, Young HA, Varesio L (1988) Differential inhibition of IL-1 and TNF-a mRNA expression by agents which block second messenger pathways in murine macrophages. J Immunol 141: 3101–3105

    PubMed  CAS  Google Scholar 

  • Krakauer T, Oppenheim JJ (1983) Interleukin 1 production by a human acute monocytic leukemia cell line. Cell Immunol 80: 223–229

    Article  PubMed  CAS  Google Scholar 

  • Krakauer T, Oppenheim JJ, Jasin HE (1985) Human interleukin 1 mediates cartilage matrix degradation. Cell Immunol 91: 92–95

    Article  PubMed  CAS  Google Scholar 

  • Krane SM, Dayer JM, Simon LS, Byrne MS (1985) Mononuclear cell-conditioned medium containing mononuclear cell factor (MCF) homologous with interleukin 1, stimulates collagen and fibronectin synthesis by adherent rheumatoid synovial cells: effects of prostaglandin El and indomethacin. Coll Relat Res 5: 99–117

    PubMed  CAS  Google Scholar 

  • Kriegler M, Perez C, DeFay Albert I, Lu SD (1988) A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 53: 45–53

    Article  PubMed  CAS  Google Scholar 

  • Kronheim SR, Cantrell MA, Deeley MC, March CJ, Glackin PJ, Anderson DM, Hemenway T, Merriam JE, Cosman D, Hopp TP (1986) Purfication and characterization of human interleukin-1 expressed in Escherichia coli. Biotechnology 4: 1079–1082

    Google Scholar 

  • Kupper TS, Ballard DW, Chua AO, McGuire JS, Flood PM, Horowitz MC, Langdon R, Lightfoot L, Gubler U (1986) Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1a and ß mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1. J Exp Med 164: 2095–2100

    Article  PubMed  CAS  Google Scholar 

  • Kupper TS, Chua AO, Flood P, McGuire J, Gubler U (1987) Interleukin gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation. J Clin Invest 80: 430–436

    Article  PubMed  CAS  Google Scholar 

  • Kupper TS, Lee F, Birchall N, Clark S, Dower S (1988) Interleukin 1 binds to specific receptors on human keratinocytes and induces granulocyte macrophage colony-stimulating factor mRNA and protein. A potential autocrine role for interleukin 1 in epidermis. J Clin Invest 82: 1787–1792

    Article  PubMed  CAS  Google Scholar 

  • Kurt-Jones EA, Beller DI, Mizel SB, Unanue ER (1985 a) Identification of a membrane-associated interleukin 1 in macrophages. Proc Natl Acad Sci USA 82: 1204–1208

    Google Scholar 

  • Kurt-Jones EA, Kiely JM, Unanue ER (1985 b) Conditions required for expression of membrane IL 1 on B cells. J Immunol 135: 1548–1550

    Google Scholar 

  • Kurt-Jones EA, Virgin HW IV, Unanue ER (1986) In vivo and in vitro expression of macrophage membrane interleukin 1 in response to soluble and particulate stimuli. J Immuno1137: 10–14

    Google Scholar 

  • Kurt-Jones EA, Fiers W, Pober JS (1987 a) Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts. J Immunol 139: 2317–2324

    Google Scholar 

  • Kurt-Jones EA, Hamberg S, Ohara J, Paul WE, Abbas AK ( 1987 b) Heterogeneity of helper inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med 166: 1774–1787

    Google Scholar 

  • Last-Barney K, Homon CA, Faanes RB, Merluzzi VJ (1988) Synergistic and overlap-ping activities of tumor necrosis factor-a and IL-1. J Immunol 141: 527–530

    PubMed  CAS  Google Scholar 

  • Le JM, Weinstein D, Gubler U, Vilcek J (1987) Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts. J Immuno1138: 2137–2142

    Google Scholar 

  • Le PT, Tuck DT, Dinarello CA, Haynes BF, Singer KH (1987) Human thymic epithelial cells produce interleukin 1. J Immunol 138: 2520–2526

    PubMed  CAS  Google Scholar 

  • Lee JC, Griswold DE, Votta B, Hanna N (1988) Inhibition of monocyte IL-1 production by the anti-inflammatory compound. SK and F 86002. Int J Immunopharmacol 10: 835–843

    Article  PubMed  CAS  Google Scholar 

  • Lee SW, Tsou AP, Chan H, Thomas J, Petrie K, Eugui EM, Allison AC (1988) Glucocorticoids selectively inhibit the transcription of the interleukin 1ß gene and decrease the stability of interleukin 1# mRNA. Proc Natl Acad Sci USA 85: 1204–1208

    Article  PubMed  CAS  Google Scholar 

  • Lemaire I (1988) Neurotensin enhances IL-1 production by activated alveolar macrophages. J Immunol 140: 2983–2988

    PubMed  CAS  Google Scholar 

  • Lew W, Oppenheim J, Matsushima K (1988) Analysis of the suppression of IL-1a and IL-1ß production in human peripheral blood mononuclear adherent cells by a glucocorticoid hormone. J Immunol 140: 1895–1902

    PubMed  CAS  Google Scholar 

  • Liao Z, Haimovitz A, Chen Y, Chan J, Rosenstreich DL (1985) Characterization of a human interleukin 1 inhibitor. J Immunol 134: 3882–3886

    PubMed  CAS  Google Scholar 

  • Libby P, Warner SJC, Friedman GB (1988) Interleukin 1a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest 81: 487–498

    Article  PubMed  CAS  Google Scholar 

  • Lichtman AH, Kurt-Jones EA, Abbas AK (1987) B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymhocytes. Proc Natl Acad Sci 84: 824–827

    Article  PubMed  CAS  Google Scholar 

  • Lichtman AH, Chin J, Schmidt JA, Abbas AK (1988) Role of interleukin 1 in the activation of T lymphocytes. Proc Natl Acad Sci USA 85: 9699–9703

    Article  PubMed  CAS  Google Scholar 

  • Lillquist JS, Simon PL, Summers MA, Jonak Z, Young PR (1988) Structure-activity studies of human IL-1ß with mature and truncated proteins expressed in Escherichia coli. J Immunol 141: 1975–1981

    PubMed  CAS  Google Scholar 

  • Limjuco G, Galuska S, Chin J, Cameron P, Boger J, Schmidt JA (1986) Antibodies of predetermined specificity to the major charged species of human interleukin 1. Proc Natl Acad Sci USA 83: 3972–3976

    Article  PubMed  CAS  Google Scholar 

  • Lin JX, Vilcek J (1987) Tumor necrosis factor and interleukin-1 cause a rapid and transient stimulation of c-fos and c-myc mRNA levels in human fibroblasts. J Biol Chem 262:11 908–11 911

    Google Scholar 

  • Lindemann A, Riedel D, Oster W, Meuer SC, Blohm D, Mertelsmann RH, Herrmann F (1988) Granulocyte/macrophage colony-stimulating factor induces interleukin 1 production by human polymorphonuclear neutrophils. J Immunol 140: 837–839

    PubMed  CAS  Google Scholar 

  • Lipsky PE, Thompson PA, Rosenwasser U, Dinarello CA (1983) The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocyte pyrogen. J Immunol 130: 2708–2714

    PubMed  CAS  Google Scholar 

  • Lomedico PT, Gubler U, Hellmann CP, Dukovich M, Giri JG, Pan YE, Collier K, Semionow R, Chua AO, Mizel SB (1984) Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312: 458–461

    Article  PubMed  CAS  Google Scholar 

  • Loppnow H, Brade L, Brade H, Rietschel ET, Kusumoto S, Shiba T, Flad HD (1986) Induction of human interleukin 1 by bacterial and synthetic lipid A. Eur J Immunol 16: 1263–1267

    Article  PubMed  CAS  Google Scholar 

  • Lovett DH, Larsen A (1988) Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells. J Clin Invest 82: 115–122

    Article  PubMed  CAS  Google Scholar 

  • Lovett DH, Ryan JL, Sterzel RB (1983) Stimulation of rat mesangial cell proliferation by macrophage interleukin 1. J Immunol 131: 2830–2836

    PubMed  CAS  Google Scholar 

  • Lovett DH, Szamel M, Ryan JL, Sterzel RB, Gemsa D, Resch K (1986) Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor. J Immunol 136: 3700–3705

    Google Scholar 

  • Low MG, Ferguson MAJ, Futerman AH, Silman I (1986) Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins. Trends Biochem Sei 11: 212–215

    Article  CAS  Google Scholar 

  • Lowenthal JW, MacDonald HR (1986) Binding and internalization of interleukin 1 by T cells: direct evidence for high-and low-affinity classes of interleukin 1 receptor. J Exp Med 164: 1060–1074

    Article  PubMed  CAS  Google Scholar 

  • Lowenthal JW, MacDonald HR (1987) Expression of interleukin 1 receptors is restricted to the L3T4+ subset of mature T lymphocytes. J Immunol 138: 1–3

    PubMed  CAS  Google Scholar 

  • Lubinski J, Fong TC, Babbitt JT, Ranson L, Yodoi JJ, Bloom ET (1988) Increased binding of IL-2 and increased IL-2 receptor mRNA synthesis are expressed by an NK-like cell line in response to IL-1. J Immunol 140: 1903–1909

    PubMed  CAS  Google Scholar 

  • Luger TA, Stadler BM, Katz SI, Oppenheim JJ (1981) Epidermal cell (keratinocyte) derived thymocyte activating factor ( ETAF ). J Immunol 127: 1493–1498

    Google Scholar 

  • Luger TA, Stadler BM, Luger BM, Mathieson BJ, Mage M, Schmidt JA, Oppenheim JJ (1982) Murine epidermal cell-derived thymocyte activating factor resembles murine interleukin 1. J Immunol 125: 2147–2152

    Google Scholar 

  • Lumpkin MD (1987) The regulation of ACTH secretion by IL-1. Science 238: 452–454

    Article  PubMed  CAS  Google Scholar 

  • MacDonald HR, Wingfield P, Schmeissner U, Shaw A, Clore GM, Gronenborn AM (1986) Point mutations of human interleukin-1 with decreased receptor binding affinity. FEBS Lett 209: 295–298

    Article  PubMed  CAS  Google Scholar 

  • Malek TR, Schmidt JA, Shevach EM (1985) The murine IL 2 receptor. III. Cellular requirements for the induction of IL2 receptor expression on T cell subpopulations. J Immunol 134: 2405–2413

    PubMed  CAS  Google Scholar 

  • Maliszewski CR, Baker PE, Schoenborn MA, Davis BS, Cosman D, Gillis S, Cerretti DP (1988) Cloning, sequence and expression of bovine interleukin 1a and interleukin 1ß complementary DNAs. Mol Immunol 25: 429–437

    Article  PubMed  CAS  Google Scholar 

  • Mandrup-Poulsen T, Bendtzen K, Dinarello CA, Nerup J (1987) Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic ß-cell cytotoxicity. J Immunol 139: 4077–4082

    PubMed  CAS  Google Scholar 

  • Manger B, Weiss A, Weyand C, Goronzy J, Stobo JD (1985) T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells. J Immunol 135: 3669–3673

    PubMed  CAS  Google Scholar 

  • March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, Conlon PJ, Hopp TP, Cosman D (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNA’s. Nature 315: 641–647

    Article  PubMed  CAS  Google Scholar 

  • Massone A, Baldari C, Censini S, Bartalini M, Nucci D, Broaschi D, Telford JL (1988) Mapping of biologically relevant sites on human IL-ß using monoclonal antibodies. J Immuno1140: 3812–3816

    Google Scholar 

  • Masuda A, Longo DL, Kobayashi Y, Appella E, Oppenheim JJ, Matsushima K (1988) Induction of mitochondrial manganese superoxide dismutase by interleukin 1. FASEB J 2: 3087–3091

    PubMed  CAS  Google Scholar 

  • Masui Y, Kamogashira T, Hong Y-M, Kikumoto Y, Nakai S, Hirai Y (1988) The role of cysteine residues in human interleukin-1ß. In: Marshall GR (ed) Peptides: chemistry and biology. Escom, Leiden, pp 396–398

    Google Scholar 

  • Matsushima K, Copeland TD, Onozaki K, Oppenheim JJ (1986a) Purifcation and biochemical characteristics of two distinct human interleukins 1 from the myelomonocytic THP-1 cell line. Biochemistry 25: 3424–3429

    Article  PubMed  CAS  Google Scholar 

  • Matsushima K, Yodoi J, Tagaya Y, Oppenheim JJ (1986b) Down-regulation of interleukin 1 (IL 1) receptor expression by IL 1 and fate of internalized l25I-labeled IL 1ß in a human large granular lymphocyte cell line. J Immunol 137: 3183–3188

    PubMed  CAS  Google Scholar 

  • Matsushima K, Akahoshi T, Yamada M, Furutani Y, Oppenheim JJ (1986c) Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1 a and IL lß J Immunol 136: 4496–4502

    CAS  Google Scholar 

  • Matsushima K, Taguchi M, Kovacs EJ, Young HA, and Oppenheim JJ (1986d) Intracellular localization of human monocyte associated interleukin 1 (IL 1) activity and release of biologically active IL 1 from monocytes by trypsin and plasmin. J Immunol 136: 2883–2891

    PubMed  CAS  Google Scholar 

  • Matsushima K, Kobayashi Y, Copeland TD, Akahoshi T, Oppenheim JJ (1987) Phosphorylation of a cytosolic 65-kDa protein induced by interleukin 1 in glucocorticoid pretreated normal human peripheral blood mononuclear leukocytes. J Immuno1139: 3367–3374

    Google Scholar 

  • Matsushima K, Morishita K, Yoshimura T, Lavu S, Kobayashi Y, Lew W, Appella E, Kung HF, Leonard EJ, Oppenheim JJ (1988) Molecular cloning of a human monocyte-derived neutrophil chemotatic factor (MDNCF) and the induction ofMDNCF mRNA by interleukin 1 and tumor necrosis factor. J Exp Med 167: 1883–1893

    Article  PubMed  CAS  Google Scholar 

  • McCroskery PA, Arai S, Amento EP, Krane SM (1985) Stimulation of procollagenase synthesis in human rheumatoid synovial fibroblasts by mononuclear cell factor/interleukin-1. FEBS Lett 191: 7–12

    Article  PubMed  CAS  Google Scholar 

  • McGuire-Goldring MB, Meats JE, Wood DD, Ihrie EJ, Ebsworth NM, Russell RGG (1984) In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor. Arthritis Rheum 27: 654–662

    Article  PubMed  CAS  Google Scholar 

  • Meyers CA, Johanson KO, Miles LM, McDevitt PJ, Simon PL, Webb RL, Chen MJ, Holskin BP, Lillquist JS, Young PR (1987) Purification and characterization of human recombinant interleukin lß. J Biol Chem 262: 11176–11181

    PubMed  CAS  Google Scholar 

  • Michie HR, Manogue KR, Spriggs DR, Revhaug A, O’Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW (1988) Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318: 1481–1486

    Article  PubMed  CAS  Google Scholar 

  • Minnich-Carruth LL, Suttles J, Mizel SB (1989) Evidence against the existence of a membrane form of murine IL-1a. J Immunol 142: 526–530

    PubMed  CAS  Google Scholar 

  • Mizel SB, Dayer JM, Krane SM, Mergenhagen SE (1981) Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1). Proc Natl Acad Sci USA 78: 2474–2477

    Article  PubMed  CAS  Google Scholar 

  • Mizel SB, Kilian PL, Lewis JC, Paganelli KA, Chizzonite RA (1987) The interleukin 1 receptor. Dynamics of interleukin 1 binding and internalization in T cells and fibroblasts. J Immunol 138: 2906–2912

    PubMed  CAS  Google Scholar 

  • Mochizuki DY, Eisenman JR, Conlon PJ, Larsen AD, Tushinski RJ (1987) Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Cell Biol 84: 5267–5271

    CAS  Google Scholar 

  • Moore MAS, Warren DJ (1987) Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA 84: 7134–7138

    Article  PubMed  CAS  Google Scholar 

  • Morgan EL, Hobbs MV, Noonan DJ, Weigly WO (1988) Induction of IL-1 secretion from human monocytes by Fc region subfragments of human IgG1. J Immunol 140: 3014–3020

    PubMed  CAS  Google Scholar 

  • Mori S, Goto F, Goto K, Ohkawara S, Maeda S, Shimada K, Yoshinaga M (1988) Cloning and sequence analysis of a CDNA for lymphocyte proliferation potentiating factor of rabbit polymorphonuclear leukocytes: identification as rabbit interleukin 1 ß. Biochem Biophys Res Commun 150: 1237–1243

    Article  PubMed  CAS  Google Scholar 

  • Morrissey PJ, Charrier K, Alpert A, Bressler L (1988a) In vivo administration of IL-1 induces thymic hypoplasia and increased levels of serum corticosterone. J Immunol 141:1456–1463

    PubMed  CAS  Google Scholar 

  • Morrissey P, Charrier K, Bressler L, Alpert A (1988b) The influence of IL-1 treatment on the reconstitution of the hemopoietic and immune systems after sublethal radiation. J Immunol 140: 4204–4210

    PubMed  CAS  Google Scholar 

  • Mortensen RF, Shapiro J, Lin BF, Douches S, Neta R (1988) Interaction of recombinant IL-1 and recombinant tumor necrosis factor in the induction of mouse acute phase proteins. J Immunol 140: 2260–2266

    PubMed  CAS  Google Scholar 

  • Moser R, Schleiffenbaum B, Groscurth P, Fehr J (1989) Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage. J Clin Invest 83: 444–455

    Article  PubMed  CAS  Google Scholar 

  • Mosley B, Dower SK, Gillis S, Cosman D (1987a) Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1a and 1ß. Proc Natl Acad Sci USA 84: 4572–4576

    Article  PubMed  CAS  Google Scholar 

  • Mosley B, Urdal DL, Prickett KS, Larsen A, Cosman D, Conlon PJ, Gillis S, Dower SK (1987b) The interleukin-1 receptor binds the human interleukin-1a precursor but not the interleukin-1 ß precursor. J Biol Chem 262: 2941–2944

    PubMed  CAS  Google Scholar 

  • Mosmann TR, Cherwinski H, Bond MW, Geidlin MA, Coffman RL (1986) Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348

    Google Scholar 

  • Muchmore AV, Decker JM (1986) Uromodulin, an immunosuppressive 85 kD glycoprotein isolated from human pregnancy urine, is a high affinity ligand for recombinant IL 1. J Biol Chem 261: 13404

    PubMed  CAS  Google Scholar 

  • Muchmore AV, Decker JM (1987) Evidence that recombinant IL1 a exhibits lectin-like specificity and binds to homogeneous uromodulin via N-linked oligosaccharides. J Immunol 138: 2541–2546

    PubMed  CAS  Google Scholar 

  • Mukaida N, Kasahara T, Yagisawa H, Shioiri-Nakano K, Kawai T (1987) Signal requirement for interleukin 1-dependent interleukin 2 production by a human leukemia-derived HSB.2 subclone. J Immunol 139: 3321–3329

    PubMed  CAS  Google Scholar 

  • Murphy G, Reynolds JJ, Werb Z (1985) Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture: stimulation by 12–0-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase. J Biol Chem 260: 3079–3083

    PubMed  CAS  Google Scholar 

  • Nagelkerken LM, van Breda Vriesman PJC (1986) Membrane-associated IL 1-like activity on rat dendritic cells. J Immunol 136: 2164–2170

    PubMed  CAS  Google Scholar 

  • Neta R, Douches SD, Oppenheim JJ (1986) Interleukin 1 is a radioprotector. J Immunol 136: 2483–2485

    PubMed  CAS  Google Scholar 

  • Neta R, Sztein MB, Oppenheim JJ, Gillis S, Douches SD (1987) The in vivo effects of interleukin 1. I. Bone marrow cells are induced to cycle after administration of interleukin 1. J Immunol 139: 1861–1986

    PubMed  CAS  Google Scholar 

  • Neta R, Oppenheim JJ, Douches SD (1988) Interdependence of the radioprotective effects of human recombinant interleukin 1a, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. J Immunol 140: 208–211

    Google Scholar 

  • Numerof RP, Aronson FR, Mier JW (1988) IL-2 stimulates the production of IL-1a and IL-1 ß by human peripheral blood mononuclear cells. J Immunol 141: 4250–4257

    PubMed  CAS  Google Scholar 

  • Okusawa S, Dinarello CA, Yancey KB, Endres S, Lawley TJ, Frank MM, Burke JF, Gelfand JA (1987) C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-y. J Immunol 139: 2635–2640

    Google Scholar 

  • Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA (1988) Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest 81: 1162–1172

    Google Scholar 

  • Ollivierre F, Gubler U, Towle CA, Laurencin C, Treadwell BV (1986) Expression of IL-1 genes in human and bovine chondrocytes: a mechanism for autocrine control of cartilage matrix degradation. Biochem Biophys Commun 141: 904–911

    Article  CAS  Google Scholar 

  • Onozaki K, Urawa H, Tamatani T, Iwamura Y, Hashimoto T, Baba T, Suzuki H, Yamada M, Yamamoto S, Oppenheim JJ, Matsushima K (1988) Synergistic interactions of interleukin 1, interferon-ß, and tumor necrosis factor in terminally differentiating a mouse myeloid leukemic cell line (ml). Evidence that interferon-beta is an autocrine differentiating factor. J Immunol 140: 112–119

    Google Scholar 

  • Oppenheim JJ, Gery I (1982) Interleukin 1 is more than an interleukin. Immunol Today 3: 113–119

    Article  CAS  Google Scholar 

  • Ozaki Y, Ohashi T, Minami A, Nakamura S (1987) Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin-1a. Infect Immun 55: 1436–1440

    PubMed  CAS  Google Scholar 

  • Paganelli KA, Stern AS, Kilian PL (1987) Detergent solubilization of the interleukin 1 receptor. J Immunol 138: 2249–2253

    PubMed  CAS  Google Scholar 

  • Paganelli-Parker K, Kilian PL (1988) Evidence for an essential disulfide bond required for binding activity of the interleukin-1 receptor. In: Powanda MC, Oppenheim JJ, Kluger J, Dinarello CA (eds) Monokines and other non-lymphocytic cytokines. Liss, New York, pp 185–190 (Progress in leukocyte biology, vol 8 )

    Google Scholar 

  • Palade G (1975) Intracellular aspects of the process of protein synthesis. Science 189: 347–358

    Article  PubMed  CAS  Google Scholar 

  • Palaszynski EW (1987) Synthetic C-terminal of IL-1 functions as a binding domain as well as an antagonist for the IL-1 receptor. Biochem Biophys Res Commun 147: 204–211

    Article  PubMed  CAS  Google Scholar 

  • Palmiter RD, Gagnon J, Walsh KA (1978) Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci USA 75: 94–98

    Article  PubMed  CAS  Google Scholar 

  • Pennica D, Kohr WJ, Kuang WJ, Glaister D, Aggarwal BB, Chen EY, Goeddel DV (1987) Identification of human uromodulin as ’ the Tamm-Horsfall urinary glycoprotein. Science 236: 83–88

    Article  PubMed  CAS  Google Scholar 

  • Perlmutter DH, Goldberger G, Dinarello CA, Mizel SB, Colten HR (1986) Regulation of class III major histocompatibility complex gene products by interleukin 1 Science 232: 850–852

    CAS  Google Scholar 

  • Pettipher ER, Higgs GA, Henderson B (1986) Interleukin 1 induces leukocytic infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sci USA 83: 8749–8753

    Article  PubMed  CAS  Google Scholar 

  • Pierart ME, Najdovski T, Appelboom TE, Deschodt-Lanckman MM (1988) Effect of human endopeptidase 24.11 (“enkephalinase”) on IL-1-induced thymocyte proliferation activity. J Immunol 140: 3808–3811

    PubMed  CAS  Google Scholar 

  • Pike BL, Nossal GJV (1985) Interleukin 1 can act as a B-cell growth and differentiation factor. Immunology 82: 8153–8157

    CAS  Google Scholar 

  • Pistoia V, Cozzolino F, Rubartelli A, Torcia M, Roncella S, Ferrarini M (1986) In vitro production of interleukin 1 by normal and malignant human B lymphocytes. J Immunol 136: 1688–1692

    PubMed  CAS  Google Scholar 

  • Pledger WJ, Stiles CD, Antoniades HN, Scher CD (1978) An ordered sequence of events is required before BALB/C-3T3 cells become committed to DNA synthesis. Proc Natl Acad Sci 75: 2839–2843

    Article  PubMed  CAS  Google Scholar 

  • Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, Gimbrone MA (1986) Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 136: 1680–1687

    PubMed  CAS  Google Scholar 

  • Postlethwaite AE, Lachman LB, Mainardi CL, Kang AH (1983) Interleukin 1 stimula- tion of collagenase production by cultured fibroblasts. J Exp Med 157: 801–806

    Article  PubMed  CAS  Google Scholar 

  • Postlethwaite AE, Lachman LB, Kang AH (1984) Induction of fibroblast proliferation by interleukin-1 derived from human monocytic leukemia cells. Arthritis Rheum 27: 995–1001

    Article  PubMed  CAS  Google Scholar 

  • Powers GD, Abbas AK, Miller RA (1988) Frequencies of IL-2 and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations. J Immunol 140: 3352–3357

    PubMed  CAS  Google Scholar 

  • Priestle JP, Schar HP, Grutter MG (1988) Crystal structure of the cytokine interleukin1ß. EMBO J 7: 339–343

    PubMed  CAS  Google Scholar 

  • Prieur AM, Griscelli C, Kaufmann MT, Dayer JM (1987) Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis. Lancet II: 1240–1242

    Google Scholar 

  • Qwarnstrom EE, Page RC, Gillis S, Dower SK (1988) Binding, internalization, and intracellular localization of interleukin-1ß in human diploid fibroblasts. J Biol Chem 263: 8261–8269

    PubMed  CAS  Google Scholar 

  • Ramadori G, Sipe JD, Dinarello CA, Mizel SB, Colten HR (1985) Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J Exp Med 162: 930–942

    Article  PubMed  CAS  Google Scholar 

  • Rappolee DA, Mark D, Banda MJ, Werb Z (1988) Wound macrophages express TGFa and other growth factors in vivo: analysis by mRNA phenotyping. Science 241: 708–712

    Article  PubMed  CAS  Google Scholar 

  • Raz A, Wyche A, Siegel N, Needleman P (1988) Regulation of fibroblast cyclooxygenase synthesis by interleukin-1. J Biol Chem 263: 3022–3028

    PubMed  CAS  Google Scholar 

  • Rhyne JA, Mizel SB, Taylor RG, Chedid M, McCall CE (1988) Characterization of the human interleukin 1 receptor on human polymorphonuclear leukocytes. Clin Immunol Imunopathol 48: 354–361

    Article  CAS  Google Scholar 

  • Robertson B, Dostal K, Daynes R (1988) Neuropeptide regulation of inflammatory and immunologic responses. The capacity of alpha-melanocyte-stimulating hormone to inhibit tumor necrosis factor and IL-1-inducible biologic responses. J Immunol 140: 4300–4307

    PubMed  CAS  Google Scholar 

  • Rosenstreich DL, Tu JH, Kinkade PR, Maurer-Fogy I, Kahn J, Barton RW, Farina PR (1988) A human urine-derived interleukin 1 inhibitor. Homology with deoxyribonuclease 1. J Exp Med 168: 1767–1779

    Article  PubMed  CAS  Google Scholar 

  • Rosenwasser U, Webb AC, Clark BD, Irie S, Chang L, Dinarello CA, Gehrke L, Wolff SM, Rich A, Auron PE (1986) Expression of biologically active human interleukin 1 subpeptides by transfected simian COS cells. Proc Natl Acad Sci USA 83: 5243–5246

    Article  PubMed  CAS  Google Scholar 

  • Rosoff PM, Savage N, Dinarello CA (1988) Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. Cell 54: 73–81

    Article  PubMed  CAS  Google Scholar 

  • Rothlein R, Czajkowski M, O’Neill MM, Marlin SD, Mainolfi E, Merluzzi VJ (1988) Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies. J Immunol 141: 1665–1669

    Google Scholar 

  • Rubin RM, Rosenbaum JT (1988) A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. Biochem Biophys Res Commun 154: 429–436

    Article  PubMed  CAS  Google Scholar 

  • Rupp EA, Cameron PM, Ranawat CS, Schmidt JA, Bayne EK (1986) Specific bioactivities of monocyte-derived interleukin 1a and interleukin 1ß are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells. J Clin Invest 78: 836–839

    Article  PubMed  CAS  Google Scholar 

  • Sabatini M, Boyce B, Aufdemorte T, Bonewald L, Mundy GR (1988) Infusions of recombinant human interleukins 1a and 1ß cause hypercalcemia in normal mice. Proc Natl Acad Sci USA 85: 5235–5239

    Article  PubMed  CAS  Google Scholar 

  • Saklatvala J, Pilsworth LMC, Sarsfield SJ, Gavrilovic J, Heath JK (1984) Pig catabolin is a form of interleukin 1. Biochem J 224: 461–466

    PubMed  CAS  Google Scholar 

  • Santoli D, Yang YC, Clark SC, Kreider BL, Caracciolo D, Rovera G (1987) Synergistic and antagonistic effects of recombinant human interleukin (IL) 3, IL-1a, granulocyte and macrophage colony-stimulating factors ( G-CSF and M-CSF) on the growth of GM-CSF-dependent leukemic cell lines. J Immunol 139: 3348–3354

    Google Scholar 

  • Sapolsky R, Rivier C, Jamamoto G, Plotsky P, Valew (1987) Interleukin 1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238: 522–524

    CAS  Google Scholar 

  • Sauder DN, Carter CS, Katz SI, Oppenheim J (1982) Epidermal cell production of thymocyte activating factor ( ETAF ). J Invest Dermatol 79: 34–39

    Google Scholar 

  • Sauder DN, Mounessa NL, Katz SI, Dinarello CA, Gallin JI (1984) Chemotactic cytokines: the role of leukocyte pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis. J Immunol 132: 828–832

    PubMed  CAS  Google Scholar 

  • Saus J, Quinones S, Otani Y, Nagase H, Harris ED, Kurkinen M (1988) The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin. J Biol Chem 263 (14): 6742–6745

    PubMed  CAS  Google Scholar 

  • Sayers TJ, Wiltrout TA, Bull CA, Denn AC III, Pilaro AM, Lokesh B (1988) Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin-and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor. J Immunol 141: 1670–1677

    PubMed  CAS  Google Scholar 

  • Scala G, Morrone G, Tamburrini M, Alfinito F, Pastore CI, D’Alessio G, Venuta S (1987) Autocrine growth function of human interleukin 1 molecules on ROHA-9, an EBV-transformed human B cell line. J Immuno1138: 2527–2534

    Google Scholar 

  • Schar HP, Priestle JP, Grutter MG (1987) Crystallization and preliminary X-ray diffrac- tion studies of recombinant human interleukin-1#. J Biol Chem 262: 13724–13725

    PubMed  CAS  Google Scholar 

  • Schleef RR, Bevilacqua MP, Sawdey M, Gimbrone MA, Loskutoff DJ (1988) Cytokine activation of vascular endothelium. Effects of tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 263: 5797–5803

    PubMed  CAS  Google Scholar 

  • Schmidt JA, Mizel SB, Cohen D, Green I (1982) Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol 128: 2177–2182

    PubMed  CAS  Google Scholar 

  • Schmidt JA, Oliver CN, Lepe-Zuniga JL, Green I, Gery I (1984) Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis. J Clin Invest 73: 1462–1472

    Article  PubMed  CAS  Google Scholar 

  • Schnyder J, Payne T, Dinarello CA (1987) Human monocyte or recombinant interleukin 1’s are specific for the secretion of a metalloproteinase from chondrocytes. J Immunol 138: 496–503

    PubMed  CAS  Google Scholar 

  • Schroder JM, Mrowietz U, Morita E, Christophers E (1987) Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity. J Immunol 139: 3474–3483

    PubMed  CAS  Google Scholar 

  • Seckinger P, Williamson K, Balavoine JF, Mach B, Mazzei G, Shaw A, Dayer JM (1987a) A urine inhibibor of interleukin 1 activity affects both interleukin 1a and 1ß but not tumor necrosis factor a. J Immunol 139: 1541–1545

    PubMed  CAS  Google Scholar 

  • Seckinger P, Lowenthal JW, Williamson K, Dayer JM, MacDonald HR (1987b) A urine inhibitor of interleukin 1 activity that blocks ligand binding. J Immunol 139: 1546–1549

    PubMed  CAS  Google Scholar 

  • Segal GM, McCall E, Stueve T, Bagby GC (1987) Interleukin-1 stimulates endothelial cells to release multilineage human colony stimulating activity. J Immunol 138: 1772–1778

    PubMed  CAS  Google Scholar 

  • Sehgal PB, Walther Z, Tamm I (1987) Rapid enhancement of ß2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Biochemistry 84: 3663–3667

    CAS  Google Scholar 

  • Shirakawa F, Tanaka Y, Ota T, Suzuki H, Eto S, Yamashita U (1987) Expression of interleukin 1 receptors on human peripheral T cells. J Immunol 138: 4243–4248

    PubMed  CAS  Google Scholar 

  • Shirakawa F, Yamashita U, Chedid M, Mizel SB (1988) Cyclic AMP-an intracellular second messenger of interleukin 1 Proc Natl Acad Sci USA 85: 8201–8205

    CAS  Google Scholar 

  • Sideras P, Funa K, Zalcberg-Quintana I, Xanthopoulos KG, Kisielow P, Palacios R (1988) Analysis of in situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and in peripheral lymphocytes from mice. Proc Natl Acad Sci USA 85: 218–221

    Article  PubMed  CAS  Google Scholar 

  • Sieff CA, Tsai S, Faller DV (1987) Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest 79: 48–51

    Article  PubMed  CAS  Google Scholar 

  • Sims JE, March CJ, Cosman D, Widmer MB, MacDonald HR, McMahan CJ, Grubin CE, Wignall JM, Jackson JL, Call SM, Friend D, Alpert AR, Gillis S, Urdal DL, Dower SK (1988) cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241: 585–589

    Google Scholar 

  • Singer II, Scott S, Hall GL, Limjuco G, Chin J, Schmidt J (1988) Interleukin lß is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human rhonocytes. J Exp Med 167: 389–407

    Article  PubMed  CAS  Google Scholar 

  • Stanton TH, Maynard M, Bomsztky K (1986) Effect of interleukin-1 on intracellular concentration of sodium, calcium, and potassium in 70Z/3 cells. J Biol Chem 261: 5699–5701

    PubMed  CAS  Google Scholar 

  • Staruch MJ, Wood DD (1985) Reduction of serum interleukin-1-like activity after treatment with dexamethasone. J Leukocyte Biol 37: 193–207

    PubMed  CAS  Google Scholar 

  • Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Ago JM (1987) Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J Immunol 138: 1464–1468

    PubMed  CAS  Google Scholar 

  • Stya M, Dower SK, Prickett KS, Gillis S, Conlon PJ (1988) Development and characterization of two neutralizing monoclonal antibodies to human interleukin-1a. J Biol Response Mod 7: 162–172

    PubMed  CAS  Google Scholar 

  • Symons JA, Wood NC, Di Giovine FS, Duff GW (1988) Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 activity. J Immunol 141: 2612–2618

    PubMed  CAS  Google Scholar 

  • Takacs L, Kovacs EJ, Smith MR, Young HA, Durum SK (1988) Detection of IL-1a and IL-1ß gene expression by in situ hybridization. Tissue localization of IL-1 mRNA in the normal C57BL/6 mouse. J Immunol 141: 3081–3095

    PubMed  CAS  Google Scholar 

  • Tanaka K, Ishikawa E, Ohmoto Y, Hirai Y (1987) In vitro production of human interleukin 1a and interleukin 1 ß by peripheral blood mononuclear cells examined by sensitive sandwich enzyme immunoassay. Eur J Immunol 17: 1527–1530

    Article  PubMed  CAS  Google Scholar 

  • Tartakovsky B, Finnegan A, Muegge K, Brody DT, Kovacs EJ, Smith MR, Berzofsky JA, Young HA, Durum SK (1988) IL-1 is an autocrine growth factor in T cell clones. J Immunol 141: 3863–3867

    PubMed  CAS  Google Scholar 

  • Telford JL, Macchia G, Massone A, Carinci V, Palla E, Melli M (1986) Murine interleukin 1,6 gene: structure and evolution. Nucleic Acids Res 14: 9955–9963

    Article  PubMed  CAS  Google Scholar 

  • Thieme TR, Hefeneider SH, Wagner CR, Burger DR (1987) Recombinant murine and human IL la bind to human endothelial cells with an equal affinity, but have an unequal ability to induce endothelial cell adherence of lymphocytes. J Immunol 139: 1173–1178

    PubMed  CAS  Google Scholar 

  • Tocci MJ, Hutchinson NI, Cameron PM, Kirk KE, Norman DJ, Chin J, Rupp EA, Limjuco GA, Bonilla-Argudo VM, Schmidt JA (1987) Expression in Escherichia coli of fully active recombinant human IL 1/3: comparison with native human IL 1ß. J Immunol 8: 1109–1114

    Google Scholar 

  • Tovey MG, Content J, Gresser I, Gugenheim J, Blanchard B, Guymarho J, Poupart P, Gigou M, Shaw A, Fiers W (1988) Genes for IFN-ß-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals. J Immunol 141: 3106–3110

    PubMed  CAS  Google Scholar 

  • Urdal DL, Call SM, Jackson JL, Dower SK (1988) Affinity purification and chemical analysis of the interleukin-1 receptor. J Biol Chem 263: 2870–2877

    PubMed  CAS  Google Scholar 

  • Valone FH, Epstein LB (1988) Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1ß, tumor necrosis factor, or IFN-y. J Immunol 141: 3945–3950

    PubMed  CAS  Google Scholar 

  • Van Damme JM, DeLey M, Opdenakker G, Billiau A, DeSomer P, Van Beeumen J (1985) Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature 314: 266–268

    Article  PubMed  Google Scholar 

  • Van Damme J, Opdenakker G, Simpson RJ, Rubira MR, Cayphas S, Vink A, Billiau A, Van Snick J (1987) Identification of the human 26-kD protein, interferon /32 (IFN-ß2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 165: 914–919

    Article  PubMed  Google Scholar 

  • Van der Meer JWM, Barza M, Wolff SM, Dinarello CA (1988) A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection. Immunology 85: 1620–1623

    Google Scholar 

  • Vermeulen MW, David JR, Remold HG (1987) Differential mRNA responses in human macrophages activated by interfereon-y and muramyl dipeptide. J Immunol 139: 7–9

    PubMed  CAS  Google Scholar 

  • Verner K, Schatz G (1988) Protein translocation across membranes. Science 241: 1307–1313

    Article  PubMed  CAS  Google Scholar 

  • Wallach D, Holtmann H, Engelmann H, Nophar Y (1988) Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1. J Immunol 140: 2994–2999

    PubMed  CAS  Google Scholar 

  • Walther Z, May LT, Sehgal PB (1988) Transcriptional regulation of the interferon-ß2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J Immunol 140: 974–977

    PubMed  CAS  Google Scholar 

  • Warner SJC, Auger KR, Libby P (1987a) Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells. J Exp Med 165: 1316–1331

    Article  PubMed  CAS  Google Scholar 

  • Warner SJC, Auger KR, Libby P (1987b) Interleukin 1 induces interleukin 1 II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells. J Immunol 139: 1911–1917

    PubMed  CAS  Google Scholar 

  • Warren DJ, Moore AS (1988) Synergism among interleukin 1, interleukin 3, and interleukin 5 in the production of eosinophils from primitive hemopoietic stem cells. J Immunol 140: 94–99

    PubMed  CAS  Google Scholar 

  • Weaver CT, Unanue ER (1986) T cell induction of membrane IL 1 on macrophages. J Immunol 137: 3868–3873

    PubMed  CAS  Google Scholar 

  • Weaver CT, Hawrylowicz CM, Unanue ER (1988) T helper cell subsets require the expression of distinct costimulatory signals by antigen presenting cells. Proc Natl Acad Sci USA 85: 8181–8185

    Article  PubMed  CAS  Google Scholar 

  • Webb AC, Collins KL, Auron PE, Eddy RL, Nakai H, Byers MG, Haley LL, Henry MW, Shows TB (1986) Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2. Lymphokine Res 5: 77–85

    PubMed  CAS  Google Scholar 

  • Werber HI, Emancipator SN, Tykocinski ML, Sedor JR (1987) The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis. J Immunol 138: 3207–3212

    PubMed  CAS  Google Scholar 

  • Wewers MD, Rennard SI, Hance AJ, Bitterman PB, Crystal RG (1984) Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin 1. J Clin Invest 74: 2208–2218

    Article  PubMed  CAS  Google Scholar 

  • Wewers MD, Saltini C, Sellers S, Tocci MJ, Bayne EK, Schmidt JA, Crystal RG (1987) Evaluation of alveolar macrophages in normals and individuals with active pulmonary sarcoidosis for the spontaneous expression of the interleukin-1ß gene. Cell Immunol 107: 479–488

    Article  PubMed  CAS  Google Scholar 

  • Wijelath ES, Kardasz AM, Drummond R, Watson J (1988) Interleukin-1 induced inositol phospholipid breakdown in murine macrophages: possible mechanism of receptor activation. Biochem Biophys Res Commun 152: 392–397

    Article  PubMed  CAS  Google Scholar 

  • Williams JM, Deloria D, Hansen JA, Dinarello CA, Loertscher R, Shapiro HM, Strom TB (1985) The events of primary T cell activation can be staged by use of sepharosebound anti-T3 (64.1) monoclonal antibody and purified interleukin 1 J Immunol 135: 2249–2255

    CAS  Google Scholar 

  • Wingfield P, Payton M, Tavernier J, Barnes M, Shaw A, Rose K, Simona MG, Demczuk S, Williamson K, Dayer JM (1986) Purification and characterization of human interleukin-1ß expressed in recombinant Escherichia coli. Eur J Biochem 160: 491–497

    Article  PubMed  CAS  Google Scholar 

  • Wingfield P, Graber P, Movva NR, Gronenborn AM, MacDonald HR (1987 a) Nterminal-methionylated interleukin-1ß has reduced receptor-binding affinity. FEBS Lett 215: 160–164

    Google Scholar 

  • Wingfield P, Payton M, Graber P, Rose K, Dayer JM, Shaw AR, Schmiessner U (1987 b) Purification and characterization of human interleukin-1a produced in Escherichia coli. Eur J Biochem 165: 537–541

    Google Scholar 

  • Woloski BMRNJ, Smith EM, Meyer WJ III, Fuller GM, Blalock JE (1985) Corticotropin-releasing activity of monokines. Science 230: 1035–1037

    Article  PubMed  CAS  Google Scholar 

  • Wong GHW, Goeddel DV (1988) Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science 242: 941–944

    Article  PubMed  CAS  Google Scholar 

  • Wood DD, Bayne EK, Goldring MB, Gowen M, Hamerman, Humes JL, Ihrie EJ, Lipsky PE, Staruch MJ (1985) The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities. J Immunol 134: 895–903

    PubMed  CAS  Google Scholar 

  • Yamasaki K, Taga T, Hirta Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T (1988) Cloning and expression of the human interleukin-6 (BSF21 FNß 2) receptor. Science 241: 825–828

    Article  PubMed  CAS  Google Scholar 

  • Yem AW, Richard KA, Staite ND, Deibel MR (1988) Resolution and biological properties of three N-terminal analogues of recombinant human interleukin-1ß. Lymholine Res 7: 85–92

    CAS  Google Scholar 

  • Young PR, Hazuda DJ, Simon PL (1988) Human interleukin 1ß is not secreted from hamster fibroblasts when expressed constitutively from a transfected cDNA. J Cell Biol 107: 447–456

    Article  PubMed  CAS  Google Scholar 

  • Zhang YH, Lin JX, Yip YK, Vilcek J (1988a) Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Proc Natl Acad Sci USA 85: 6802–6805

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, Lin JX, Vilcek J (1988b) Synthesis of interleukin 6 (interferon-ß2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. J Biol Chem 263: 6177–6182

    PubMed  CAS  Google Scholar 

  • Zsebo KM, Yuschenkoff VN, Schiffer S, Chang D, McCall E, Dinarello CA, Brown MA, Altrock B, Bagby GC (1988) Vascular endothelial cells and granulopoiesis. Interleukin-1 stimulates release of G-CSF and GM-CSF. Blood 71: 99–103

    PubMed  CAS  Google Scholar 

  • Zucali JR, Dinarello CA, Oblon DJ, Gross MA, Anderson L, Weiner RS (1986) Interleukin-1 stimulates fibroblasts to produce granulocyte macrophage colony-stimulating activity and prostaglandin E2. J Clin Invest 77: 1857–1863

    Article  PubMed  CAS  Google Scholar 

  • Zurawski SM, Pope K, Cherwinski H, Zurawski G (1986) Expression in Escherichia coli of synthetic human interleukin-la genes encoding the processed active protein, mutant proteins, and ß-galactosidase fusion proteins. Gene 49: 61–68

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. J. A. Schmidt
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  2. M. J. Tocci
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Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Schmidt, J.A., Tocci, M.J. (1990). Interleukin-1. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-49295-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49297-6

  • Online ISBN: 978-3-642-49295-2

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