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Peptide Growth Factors and Their Receptors I pp 577–607Cite as

Interleukin-4

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

Lymphokines produced by activated helper T cells were originally classified based on the target cells on which they act. Interleukin-2 (IL-2) stimulates predominantly the proliferation of cells belonging to the T-cell lineage, while interleukin-3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulate proliferation and differentiation of various hematopoietic progenitor cells. A number of molecules such as interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-6 (IL-6) stimulate proliferation and differentiation of cells of the B-lymphocyte lineage. Since many lymphokines are composed of single polypeptide chains, their coding sequences can be isolated by functional expression in appropriate host cells. Based on this expression cloning protocol, many T-cell lymphokine genes have been isolated and their primary structures determined. These studies have revealed that lymphokines are neither lineage specific nor are they confined to a single functional role. Instead, each lymphokine has multiple effects on its target cell(s). The current model describes a regulatory network between lymphoid and hematopoietic cells where various cells produce and react to multifunctional lymphokines (K. Arai et al. 1986; Miyajima et al. 1988).

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  1. T. Yokota
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  2. N. Arai
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  3. K.-I. Arai
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  4. A. Zlotnik
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  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Yokota, T., Arai, N., Arai, KI., Zlotnik, A. (1990). Interleukin-4. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_12

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