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Immunostimulating Activity of Whole Cells, Cell-Walls and Fractions of Anaerobic Corynebacteria

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Investigation and Stimulation of Immunity in Cancer Patients

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 47))

Abstract

Heat-killed whole cells of Mycobacterium (Myc. butyricum and Myc. tuberculosis H 37 Ra) have been used as immunostimulants for many years. The studies of [11, 23] have shown that anaerobic corynebacteria display imrnunostimulant activity similar to or even stronger than that of mycobacteria. Most adult humans exhibit a delayed-hypersensitivity reaction towards mycobacteria, so that repeated injections may be hazardous. However, repeated inoculations by scarification of living BCG cells of appropriate strains have been employed by [18] in leukemic patients. Although a positive cutaneous reaction to anaerobic corynebacteria is present in most adults [30], the delayed-hypersensitivity directed to the latter does not elicit the same general effects as tuberculin hypersensitivity. Large-scale testing has demonstrated that heat-killed cells of anaerobic corynebacteria can be repeatedly injected into humans without serious harm.

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Authors and Affiliations

  1. Service Immunochimie, Institut Pasteur, Garches, France

    B. Kouznetzova, B. Bizzini, J.-C. Chermann, F. Degrand, A.-R. Prevot & M. Raynaud

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  1. B. Kouznetzova
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  2. B. Bizzini
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  3. J.-C. Chermann
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  4. F. Degrand
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  5. A.-R. Prevot
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  6. M. Raynaud
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Editors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, F-94, Villejuif, France

    Georges Mathé (Professor) (Professor)

  2. Children’s Cancer Research Foundation, 35 Binney Street, 02115, Boston, MA, USA

    Roy Weiner M.D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Kouznetzova, B., Bizzini, B., Chermann, JC., Degrand, F., Prevot, AR., Raynaud, M. (1974). Immunostimulating Activity of Whole Cells, Cell-Walls and Fractions of Anaerobic Corynebacteria. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_41

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  • DOI: https://doi.org/10.1007/978-3-642-49284-6_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49286-0

  • Online ISBN: 978-3-642-49284-6

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