Abstract
It is generally agreed that a stimulated and active immune system is operative in the suppression of neoplastic cells. BCG is one of the most active stimulators of the immune system, as indicated by its effects on the lymphoreticuloendothelial system (RES) [4, 8]. Its activity, both specific [7] and nonspecific [4], depends on the physiological state of the organism, the route of administration, the species of animal and the dose. In some species of animals (mouse, monkey) the dermal route of administration of BCG is relatively ineffective, but the intravenous or aerosol routes are highly effective [1]. In the guinea pig and in man the dermal route is effective but to a lesser degree than the intravenous or aerosol routes [2, 10].
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© 1974 Springer-Verlag Berlin · Heidelberg
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Rosenthal, S.R. (1974). BCG and the Lympho-Reticuloendothelial System. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_34
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DOI: https://doi.org/10.1007/978-3-642-49284-6_34
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