Abstract
BCG is widely used for vaccination against tuberculosis and this is its primary use. The initial strain of Calmette and Guérin has been maintained in many laboratories for more than 40 years during which time the original BCG strain has undergone some genotypic changes that are noticeable in vitro as well in animal tests and in man [6]. There are now some dozens of BCG daughter strains, differing in particular in the degree of attenuation [5]. It is difficult to compare these daughter strains and to evaluate their immunogenic properties [6].
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Asselineau, J., Portelance, V. (1974). Comparative Study of the Free Lipids of Eight BCG Daughter Strains. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_31
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DOI: https://doi.org/10.1007/978-3-642-49284-6_31
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