Abstract
This report describes preliminary observations of immunological function on 7 patients with bone marrow grafts. Three patients with aplastic anemia were prepared for grafting with cyclophosphamide (CY) and received marrow from HL-A-matched siblings [7, 10]. Four patients with hematological malignancy were prepared for grafting with whole body irradiation; 2 of these patients received marrow from an identical twin [6], and 2 patients received marrow from an HL-A-matched sibling [8, 9]. Table 1 summarizes the clinical and hematological data in these patients. None of these patients had significant graft-versus-host (GVH) disease and none has, as yet, shown recurrence of disease. Thus, immunologic parameters could be studied in the absence of these 2 important variables.
This work was supported by grants CA 10895 and CA 05231 from the National Cancer Institute and by contract PH 43-67-1435 from the National Institutes of Health, U. S. Public Health Service.
Dr. Thomas is supported by Research Career Award 5 K 6 AI 02425 from the National Institute of Allergy and Infectious Diseases.
Dr. Fefer is a scholar of the Leukemia Society of America.
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Thomas, E.D., Fass, L., Ochs, H.D., Mickelson, E.M., Storb, R., Fefer, A. (1974). Immunological Reactivity of Human Recipients of Syngeneic and Allogeneic Marrow Grafts. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_3
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