Abstract
It has long been recognized that certain microorganisms or bacterial extracts increase the host’s resistance to a variety of unrelated bacterial or viral infections and also stimulate immunity against tumors [4, 14, 16, 21, 24, 31, 18]. It seems reasonable to assume that evolutionary pressure has preserved feedback mechanisms in the host-parasite relationship, such as stimulation of the host by certain substances of the infective agent, e.g. the lipopolysaccharide of gram-negative bacteria [9]. However, when compared to endotoxins, which also enhance nonspecific immunity very strongly [8, 24] mycobacteria appear to possess 2 major advantages: 1. they can trigger cell-mediated immunity 1, which probably plays the major role in resistance, particularly to tumors; 2. some of the varied biological activities of mycobacteria can be related to different components which can be separated by chemical fractionation.
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Chedid, L., Lamensans, A. (1974). Experimental Screening of Systemic Adjuvants Extracted from Mycobacteria. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_22
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DOI: https://doi.org/10.1007/978-3-642-49284-6_22
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