Abstract
In the past few years, there has been increasing evidence for cell-mediated immunological reactions against antigens associated with human neoplasms. Most studies have been performed with in vitro assays. It has also been possible to measure cellular immunity in vivo by skin testing for delayed hypersensitivity reactions. This in vivo test might be a closer reflection of the state of immunity in tumor patients than an in vitro assay. [9, 12] prepared crude extracts of carcinomas and skin-tested the autologous patients. Positive reactions were seen in about 25% of the patients. The reactivity of the patients did not correlate well with their clinical state. The specificity of the reactions was not well characterized. Some control extracts produced positive skin reactions. In addition, bacterial contamination of some of the reactions could have contributed to the reactions [12].
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References
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© 1974 Springer-Verlag Berlin · Heidelberg
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Herberman, R.B. (1974). Delayed Hypersensitivity Response toward Autochthonous Tumor Extracts. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_20
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DOI: https://doi.org/10.1007/978-3-642-49284-6_20
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