Abstract
During the past several years there has been increasing evidence that tumor-associated antigens are present in a variety of human neoplasms [25]. In studying the immunological response to human leukemia, Yosjid found that the sera of 71% of patients with acute leukemia gave a positive immune adherence reaction with autologous leukemia cells [46]. In contrast, Dore et al. found by similar methods that only 22% of 140 patients with acute leukemia had antibody to autologous leukemia cells [7]. Cell-mediated immunity was studied by Oren and Herberman who reported that the majority patients with acute leukemia had positive delayed hypersensitivity skin tests to membrane preparation of their own leukemia cells [34]. Cellular reactivity to acute leukemia cells in vitro has also been demonstrated by the mixed leukocyte culture technique (MLC) and lymphocyte cytotoxicity [9, 14, 28, 36, 44].
Supported by Grant ACS CI 22 from the American Cancer Society and Grants CA 05831, FR 05511 and CA 11520 from the National Institutes of Health and Department of Health, Education, and Welfare, U.S. Public Health, Bethesda, Maryland.
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Gutterman, J.U. et al. (1974). Cell-Mediated and Humoral Immune Response to Acute Leukemia Cells and Soluble Leukemia Antigen-Relationship to Immunocompetence and Prognosis. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_13
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