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Patterns of Cellular Immunity in Malignant Melanoma

  • Conference paper
Investigation and Stimulation of Immunity in Cancer Patients

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 47))

Abstract

Rejection of a growing solid tumor, such as malignant melanoma, appears to depend on an effective cell-mediated immune response. For example, the primary lesions of melanoma often contain areas of flattening and depigmentation overlying sites of dense lymphoid infiltration [26]; metastatic deposits regressing either spontaneously [16] or as a result of immunologic stimulation [45] show features of delayed hypersensitivity [4[. Cellular immunity can also be detected in patients who do not show these phenomena either by a positive delayed hypersensitivity skin test to tumor antigens [4], or by in vitro testing. Data from in vitro tests indicate that cell-mediated immunity is present [18, 21, 31] in cancer patients, even with advanced disease, but is antagonized by serum blocking factors [6, 21, 24] which allow the tumor to grow through the mechanism of immunological enhancement.

Supported by Grants: T-550, American Cancer Society Ca 12924–01, National Cancer Institute DRG-1067, Damon Runyon Memorial Fund.

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Authors and Affiliations

  1. Medical Oncology Service, Department of Medicine, New England Medical Center Hospital and Tufts University School of Medicine, Boston, Mass., USA

    D. A. Clark & L. Nathanson

Authors
  1. D. A. Clark
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  2. L. Nathanson
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Editors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, F-94, Villejuif, France

    Georges Mathé (Professor) (Professor)

  2. Children’s Cancer Research Foundation, 35 Binney Street, 02115, Boston, MA, USA

    Roy Weiner M.D.

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Clark, D.A., Nathanson, L. (1974). Patterns of Cellular Immunity in Malignant Melanoma. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-49284-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49286-0

  • Online ISBN: 978-3-642-49284-6

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