Abstract
Acquired growth hormone (GH) resistance is found in patients who have malnutrition and protein catabolism in common, such as post-surgical and critically ill patients and patients with organ failure [1]. GH resistance is the finding of high GH levels with low levels of the somatomedin insulin-like growth factor I (IGF I), which mediates the anabolic actions of GH. This may be primary, as in patients with Laron syndrome or acquired GH resistance [2]. There is now a body of evidence to suggest that the changes in the GH/IGF I axis are permissive to protein catabolism and that treatment with either GH and/or IGF I may improve the nutritional state of some patient groups [3].
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Ross, R.J.M., Cotterill, A.M. (1996). The Growth Hormone/Insulin-Like Growth Factor I Axis During Surgical Stress and Critical Illness. In: Revhaug, A. (eds) Acute Catabolic State. Update in Intensive Care and Emergency Medicine, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48801-6_25
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DOI: https://doi.org/10.1007/978-3-642-48801-6_25
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