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Acute Catabolic State pp 217–225Cite as

Use of Cyclooxygenase Inhibitors in the Acute Catabolic State

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Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 21))

Abstract

In the early phases of an acute catabolic state, different cascades in the inflammatory process are activated. Among the many important mediators involved in the acute catabolic state are the eicosanoids. These substances are generated from phospholipids in response to a great variety of stimuli. After the discovery of prostaglandin in the 1930s, later work with these substances has elucidated the knowledge of a great diversity of eicosanoids with different properties.

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References

  1. DeWitt DL, Smith WL (1988) Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 85:1412–1416

    Article  PubMed  CAS  Google Scholar 

  2. O’Banion MK, Winn VD, Young DA (1922) cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 89:4888–4892

    Article  Google Scholar 

  3. Lee SH, Soyoola E, Chanmngam P et al. (1992) Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267:25934–25938

    PubMed  CAS  Google Scholar 

  4. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR (1994) Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inductible cyclooxygenase. Proc Natl Acad Sci USA 90:11693–11697

    Article  Google Scholar 

  5. Vane JR (1971) Inhibition of prostataglandins synthesis as a mechanism of action for asperin-like drugs. Nature New Biology 231:232–239

    PubMed  CAS  Google Scholar 

  6. Lands WE (1981) Actions of anti-inflammatory drugs. Trends Pharmacol Sci 2:78–80

    Article  CAS  Google Scholar 

  7. Dinarello CA (1988) Biology of interleukin-I. FASEB J 2:108–115

    PubMed  CAS  Google Scholar 

  8. Rang HP, Dale MM (eds) (1991) Pharmacology, 2nd edn. Churchill Livingstone, London

    Google Scholar 

  9. Butler RR Jr, Wise WC, Haluska PV (1983) Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. J Pharmacol Exp Ther 225:94–101

    PubMed  CAS  Google Scholar 

  10. Jacobs ER, Soulsby ME, Bone RC et al. (1982) Ibuprofen in canine endotoxin shock. J Clin Invest 70:536–541

    Article  PubMed  CAS  Google Scholar 

  11. Fletcher JR, Ramwell PW (1980) Indomethacin treatment following baboon endotoxin shock improves survival. Adv Shock Res 4:103–111

    PubMed  CAS  Google Scholar 

  12. Zanaboni PB, Bradley JD, Baundendistel LJ et al. (1990) Cyclooxygenase inhibition prevents PMA-induced increases in lung vascular permeability. J Appl Physiol 69:1494–1501

    PubMed  CAS  Google Scholar 

  13. Ljungman AG, Grum CM, Deeb GM et al. (1991) Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury. Am Rev Respir Dis 143:610–617

    PubMed  CAS  Google Scholar 

  14. Jacobs ER, Bone RC, Balk RA et al. (1986) Increased survival in bacteremic sheep treated with ibuprofen. J Crit Care 1:142–149

    Article  Google Scholar 

  15. Rome LH, Lands WEM (1975) Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc Natl Acad Sci USA 72:4863–4865

    Article  PubMed  CAS  Google Scholar 

  16. Evans DA, Jacobs DO, Revhaug A, Wilmore DW (1989) The effects of tumor necrosis factor and their selective inhibition by ibuprofen. Ann Surg 209:312–321

    Article  PubMed  CAS  Google Scholar 

  17. Hansbrough J, Peterson V, Zapata-Sirvent RL, Claman HN (1984) Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs. Surgery 95:290

    PubMed  CAS  Google Scholar 

  18. Zapata-Sirvent RL, Hansbrough JF (1985) Postburn immunosuppression in an animal model. III. Maintenance of normal splenic helper and suppressor lymphocyte subpopulations by immunomodulating drugs. Surgery 97:721

    PubMed  CAS  Google Scholar 

  19. Okusawa S, Gelfand JA, Ikejima T et al. (1988) Interleukin 1 induces a shock-like state in rabbits: Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest 81:1162–1172

    Article  PubMed  CAS  Google Scholar 

  20. Fink MP, Rothschild HR, Deniz YF, Wang H, Lee PC, Cohn SM (1989) Systemic and mesenteric O2 metabolism in endotoxic pigs: effect of ibuprofen and meclofenamate. J Appl Physiol 67:1950–1957

    PubMed  CAS  Google Scholar 

  21. Revhaug A, Michie HR, Manson J McK et al. (1988) Inhibition of cyclooxygenase attenuates the metabolic response to endotoxin in humans. Arch Surg 123:162–170

    Article  PubMed  CAS  Google Scholar 

  22. Michie HR, Manogue KR, Spriggs DR et al. (1988) Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318:1481–1486

    Article  PubMed  CAS  Google Scholar 

  23. Ganong WF (1986) Neuroendocrine responses to injury. In: Little R, Faryn K (eds) The scientific basis for the care of the critically ill. Manchester University Press, Manchester, pp 45–60

    Google Scholar 

  24. Bessey P, Waiters J, Aoki T, Wilmore D (1984) Combined hormonal infusion stimulates the metabolic response to injury. Ann Surg 200:264–281

    Article  PubMed  CAS  Google Scholar 

  25. Michie HR, Eberlein TJ, Spriggs DR et al. (1988) Interleukin-2 initiates metabolic responses associated with critical illness in humans. Ann Surg 208:493–503

    Article  PubMed  CAS  Google Scholar 

  26. Plotsky PM, Cunningham ET, Widmaier EP (1989) Catecholaminergic modulation of corticotropin-releasing factor and adrenocorticotropin secretion. Endocr Rev 10:437–458

    Article  PubMed  CAS  Google Scholar 

  27. Michie HR, Majzoub JA, O’Dwyer ST, Revhaug A, Wilmore DW (1990) Both cyclooxygen-ase-dependent and cyclooxygenase-independent pathways mediate the neuroendocrine response in humans. Surgery 108:254–261

    PubMed  CAS  Google Scholar 

  28. Michie HR, Eberlein TJ, Spriggs DR, Manogue KR, Cerami A, Wilmore DW (1988) Interleukin-2 initiates metabolic responses associated with critical illness in humans. Ann Surg 208:493–503

    Article  PubMed  CAS  Google Scholar 

  29. Asoh T, Shirasaka C, Uchida I et al. (1987) Effects of indomethacin on endocrine responses and nitrogen loss after surgery. Ann Surg 206:770–777

    Article  PubMed  CAS  Google Scholar 

  30. Rodrick ML, Moss NM, Grbic JT et al. (1992) Effects of in vivo endotoxin infusions on in vitro cellular immune responses in humans. J Clin Immunol 12:440–450

    Article  PubMed  CAS  Google Scholar 

  31. Faist E, Ertel W, Cohnert T, Huber P, Iknthorn D, Heberer G (1988) Immune protective effects of cyclo-oxygenase inhibition in patients with major surgical trauma. J Trauma 30:8

    Article  Google Scholar 

  32. Hyers TM, Tricomi SM, Liao J-J (1992) Inhibition of some human neutrophil functions by the cyclooxygenase inhibitor ketorolac tromethamine. J Leukoc Biol 51:490–495

    PubMed  CAS  Google Scholar 

  33. Abrahamson S, Weissmann G (1989) The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum 32:1

    Article  Google Scholar 

  34. Bernard GR, Reines HD, Metz CA et al. (1988) Effects of a short course of ibuprofen in patients with severe sepsis. Am Rev Respir Dis 137(4 Part 2):137 (abstr)

    Google Scholar 

  35. Bernard GR, Reines HD, Halushka PV et al. (1991) Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Am Res Respir Dis 144:1095

    Article  CAS  Google Scholar 

  36. Lanza FL (1989) A review of gastric ulcer and gastroduodenal injury in normal volunteers receiving aspirin and other non-steroidal anti-inflammatory drugs. Scand J Gastroenterol Suppl 163:24–31

    Article  PubMed  CAS  Google Scholar 

  37. Svartholm E, Arvidsson S, Fait K, Haglund U (1989) Influence of prostanoids on gastrointestinal mucosal injury in experimental septic shock. AMPIS 97:61–67

    CAS  Google Scholar 

  38. Ball HA, Parratt JR, Zeitlin IJ (1983) Effect of dazoxiben, a specific inhibitor of thromboxane synthetase, on acute pulmonary responses to E. coli endotoxin in anaesthetized cats. Br J Clin Pharmacol 15:121S-127S

    Google Scholar 

  39. Watkins WD, Hüttemeier PC, Kong D, Peterson MB (1982) Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep; effect of an imidazole derivative. Prostaglandins 23:273–285

    Article  PubMed  CAS  Google Scholar 

  40. Bennett WM, DeBroe ME (1989) Analgesic nephropathy — a preventable renal disease. New Engl J Med 320:1269–1271

    Article  PubMed  CAS  Google Scholar 

  41. Cryer HM, Unger LS, Garrison N, Harris PD (1988) Prostaglandins maintain renal microvascular blood flow during hyperdynamic bacteremia. Circ Shock 26:71

    PubMed  CAS  Google Scholar 

  42. DiBona GF (1986) Prostaglandins and nonsteroidal antiinflammatory drugs: effects on renal hemodynamics. Am J Med 80:12

    Article  PubMed  CAS  Google Scholar 

  43. Carmichael J, Shankel SW (1985) Effects of nonsteroidal antiinflammatory drugs on prostaglandins and renal function. Am J Med 78:992

    Article  PubMed  CAS  Google Scholar 

  44. Hardie EM, Olsen NC (1987) Prostaglandin and thromboxane levels during endotoxin-in-duced respiratory failure in pigs. Prostaglandins Leuko Med 28:255

    Article  CAS  Google Scholar 

  45. Harris RH, Zmudka M, Maddox Y, Ramwell PW, Fletcher JR (1980) Relationships of TXB2 and 6-keto-PGF1αto the hemodynamic changes during baboon endotoxic shock. In: Samuelsson B, Ramwell RW, Paoletti R (eds) Advances prostaglandins thromboxane research, vol 7. Raven, New York, pp 843

    Google Scholar 

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Authors
  1. A. Revhaug
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Editors and Affiliations

  1. School of Medicine Department of Surgery, University of Tromsø, 9038, Tromsø, Norway

    Arthur Revhaug

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© 1996 Springer-Verlag Berlin Heidelberg

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Revhaug, A. (1996). Use of Cyclooxygenase Inhibitors in the Acute Catabolic State. In: Revhaug, A. (eds) Acute Catabolic State. Update in Intensive Care and Emergency Medicine, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48801-6_19

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  • DOI: https://doi.org/10.1007/978-3-642-48801-6_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48803-0

  • Online ISBN: 978-3-642-48801-6

  • eBook Packages: Springer Book Archive

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