Abstract
The metabolic response to injury is related to the extent of the trauma; the greater the trauma, the greater the response, which generally increases until it plateaus at a maximum level [1]. The signals that stimulate the response are mixed. Nervous afferent signals play a significant role in the early phase after injury, and circulating and local humoral factors act as major mediators for homeostatic adjustments. Pyrogens may serve as circulating afferent signals to the brain to stimulate the output of an integrated hormonal response.
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Reikeraas, O. (1996). Aspects of Bone Tissue in Relation to Catabolic States. In: Revhaug, A. (eds) Acute Catabolic State. Update in Intensive Care and Emergency Medicine, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48801-6_16
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DOI: https://doi.org/10.1007/978-3-642-48801-6_16
Publisher Name: Springer, Berlin, Heidelberg
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