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The Lungs and the Catabolic State

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Acute Catabolic State

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 21))

Abstract

Infection, trauma, and surgery induce a catabolic state characterized by hypermetabolism. This catabolic state usually resolves spontaneously after minor insults to the organism such as elective surgery. However, in sepsis, multiple trauma, and major surgery hypermetabolism may persist and organ failure develop. The sequential failure of lungs, liver, and kidneys has been recognized for many years as a potential sequela of ruptured aneurysm, acute pancreatitis, septic shock, and surgical complications, as well as burns and other trauma. Acute lung injury is the earliest and most frequent organ complication in prolonged catabolic states. Injurious agents such as endotoxin and fibrin split products have been suggested as mediators of acute lung injury. In experimental studies it has been found that a large number of agents may cause lung injury. The bulk of these studies have focused on damage to the pulmonary vascular endothelium. Less attention has been paid to the metabolic function of the lungs with respect to energy utilization as well as specific metabolic functions. This review is concerned with: (1) metabolic changes in the lungs with respect to injurious agents released in sepsis, and following multiple trauma and major surgery; (2) interorgan metabolism in catabolic states with respect to the lungs.

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Authors
  1. J. Kjæve
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Editors and Affiliations

  1. School of Medicine Department of Surgery, University of Tromsø, 9038, Tromsø, Norway

    Arthur Revhaug

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© 1996 Springer-Verlag Berlin Heidelberg

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Kjæve, J. (1996). The Lungs and the Catabolic State. In: Revhaug, A. (eds) Acute Catabolic State. Update in Intensive Care and Emergency Medicine, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48801-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-48801-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48803-0

  • Online ISBN: 978-3-642-48801-6

  • eBook Packages: Springer Book Archive

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