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Structural Phylogenetics of DNA Base Excision Repair

  • Chapter
DNA Repair

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 12))

Abstract

Maintaining the chemical and informational integrity of DNA is vital for all cells. DNA both codes for the proteins and RNA essential for cellular metabolism, and provides the blueprints through which these instructions are passed to successive generations. As a hedge against devolution, a means of protecting the essential information inherent in primordial DNA must have arisen very early, and perhaps was mediated by recombination. The repair of DNA damage is fundamental to living organisms and is implicated for reactive oxygen and pathogen defenses, for controlling degenerative diseases and aging (Halliwell and Aruoma 1993), and for the development of sex and meiosis (Bernstein and Bernstein 1991).

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  1. Department of Molecular Biology MB-4, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA

    C. D. Mol, S. S. Parikh, T. P. Lo & J. A. Tainer

  2. the Skaggs Institute for Chemical Biology, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA

    C. D. Mol, S. S. Parikh, T. P. Lo & J. A. Tainer

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  1. C. D. Mol
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  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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Mol, C.D., Parikh, S.S., Lo, T.P., Tainer, J.A. (1998). Structural Phylogenetics of DNA Base Excision Repair. In: Eckstein, F., Lilley, D.M.J. (eds) DNA Repair. Nucleic Acids and Molecular Biology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48770-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-48770-5_2

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