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Liver Regeneration

  • Chapter
Tumors of the Liver

Abstract

Most of the studies relative to regeneration of the liver after hepatic resections have been performed in rats. The rat liver is composed of relatively separated lobes (Fig. 1) which are, on the whole, easy to resect. The different lobes constitute a surprisingly constant proportion of the liver weight: the two caudate lobes, 9%, the right anterior and posterior lobes, 23%, the left lateral lobe, 34% and the median lobe, 34%. Most studies are performed after resection of the left lateral and median lobes according to a method originally introduced by Higgins and Andersson (1931). This resection means a reduction of the liver mass by rather constantly 68% (Slonaker rats: 68.4%, Brues, Drury and Brues, 1936; Wistar rats: 68.3%, Bucher and Glinos, 1950; Sprague-Dawley rats: 68.3%, Bucher and Swaffield, 1964). This procedure is generally referred to as partial hepatectomy.

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References

  • Abercrombie, M., Harkness, R. D.: The growth of cell populations and the properties in tissue culture of regenerating liver of the rat. Proc. roy. Soc. B 138, 544 (1951).

    CAS  Google Scholar 

  • Adibi, S., Paschkis, K. E., Cantarow, A.: Stimulation of liver mitosis by blood serum from hepatectomized rats. Exp. Cell Res. 18, 396 (1959).

    Article  Google Scholar 

  • Alston, W. C., Thomson, R. Y.: Humoral and local factors in liver regeneration. Cancer Res. 23, 901 (1963).

    PubMed  CAS  Google Scholar 

  • Andersson, E. P., Aqvist, S.: Further studies on the turnover of polynucleotides in regenerating rat liver. Acta Chem. Scand. 10, 1576 (1956).

    Article  Google Scholar 

  • Aqvist, S., Andersson, E. P.: The synthesis of polynucleotides and protein in regenerating rat liver. Acta chem. scand. 10, 1583 (1956).

    Article  CAS  Google Scholar 

  • Aronsen, K. F., Bengmark, S., Dahlgren, S., Engevik, L., Ericsson, B., Thorén, L.: Liver resection in the treatment of blunt injuries to the liver. Surgery 63, 236 (1968).

    Google Scholar 

  • Aterman, K.: Some local factors in the restoration of the rat’s liver after partial hepatectomy. Arch. Path. 53, 197 (1952).

    CAS  Google Scholar 

  • Balasubrahmanyan, M.: The ground substance of the fibrous tissue in experimental liver cirrhosis. J. Path. Bact. 65, 123 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Bartok, J., Horvath, E., Domjan, G., Korpassy, B.: Histochemical studies of regenerating rat liver in experimental cirrhosis after partial hepatectomy. Path. Microbiol. (Basel) 25, 809 (1962).

    CAS  Google Scholar 

  • Bengmark, S.: Liver surgery. Prog. Surg. 6, 1–59 (1968).

    Google Scholar 

  • Bengmark, S., Ekdahl, P. H., Olsson, R.: Changes in the conjugation of bile acids in the rat liver after partial hepatectomy. Gastroenterologia (Basel) 99, 327 (1963).

    CAS  Google Scholar 

  • Bengmark, S., Ekdahl, P. H., Olsson, R.: Effect of taurine and glycine treatment on the conjugation of bile acids in partially hepatectomized rats. Acta chir. scand. 128, 180 (1964).

    PubMed  CAS  Google Scholar 

  • Bengmark, S., Ekholm, R, Olsson, R.: Transaminase activity in subcellular fractions of the normal and regenerating rat liver. Acta hepato-splenol. (Stuttg.) 14, 80 (1967).

    CAS  Google Scholar 

  • Bengmark, S., Engevik, L., Olsson, R.: Changes in ornithine carbamoyl transferase activity in serum and liver after partial hepatectomy in rats. Scand. J. Gastroent. 3, 264 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Bengmark, S., Hafström, L.: The natural history of primary and secondary tumors of the liver. Cancer 23, 198 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Bengmark, S., Olsson, R.: Experimental study of liver healing after partial hepatectomy. With special regard to the changes in the content of liver glutamic pyruvic transaminase. Acta hepatosplenol. (Stuttg.) 10, 282 (1962).

    Google Scholar 

  • Bengmark, S., Olsson, R.: The effect of vitamin Bi, on liver regeneration after partial hepatectomy. Gastroenterologia (Basel) 100, 75 (1963).

    CAS  Google Scholar 

  • Bengmark, S., Olsson, R.: The effect of testosterone on liver healing after partial hepatectomy. Acta chir. scand. 127, 93 (1964).

    PubMed  CAS  Google Scholar 

  • Bengmark, S., Olsson, R.: Biochemical studies on carbon tetrachloride-induced liver fibrosis after partial hepatectomy. Acta chir. scand. Suppl. 366, 44 (1966).

    CAS  Google Scholar 

  • Bengmark, S., Olsson, R., Rehnström, B.: The influence of partial hepatectomy in experimental nutritional cirrhosis in the rat. Acta chir. scand. 132, 112 (1966 a).

    Google Scholar 

  • Bengmark, S., Olsson, R., Rehnström, B.: Further studies on the effect of testosterone on liver healing after partial hepatectomy in male rats. Scand. J. Gastroent. 1, 106 (1966 b).

    Google Scholar 

  • Bengmark, S., Olsson, R., Svanborg, A.: Fat infiltration after partial hepatectomy. Changes in glycerides, cholesterol and phospholipids in the residual liver of the rat. Acta hepato-splenol. (Stuttg.) 11, 276 (1964).

    CAS  Google Scholar 

  • Bengmark, S., Olsson, R., Svanborg, A.: The influence of glucose supply on liver steatosis and regeneration rate after partial hepatectomy. Acta chir. scand. 130, 216 (1965).

    Google Scholar 

  • Bernhard, W.: Ultrastructural aspects of nucleocytoplasmic relationship. Exp. Cell Res. Suppl. 6, 17 (1958).

    Google Scholar 

  • Bernhard, W., Rouiller, C.: Close topographical relationship between mitochondria and ergastoplasm of liver cells in a definite phase of cellular activity. J. biophys. biochem. Cytol. 2, 73 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Bogetti, H., Mazzocco, P.: Contenido en grasa, nitrógeno yagua en el higado y en el mlisculo después de la hepatectomia partial, en la rata bianca. Rev. Soc. argent. Biol. 15, 285 (1939).

    CAS  Google Scholar 

  • Bollum, F. J., Potter, V. R.: Nucleic acid metabolism in regenerating rat liver. VI. Soluble enzymes which convert thymidine to thymidine phosphates and DNA. Cancer Res. 19, 561 (1959).

    PubMed  CAS  Google Scholar 

  • Brody, S., Balis, M. E.: Mechanism of growth. I. Interrelation between deoxyribonuclease and deoxyribonucleic acid synthesis in nonmalignant growth. Cancer Res. 19, 538 (1959).

    PubMed  CAS  Google Scholar 

  • Brody, T. M., Calvert, D. N., Schneider, A. F.: Alteration of carbon tetrachloride-induced pathologic changes in the rat by spinal transection, adrenalectomy and andrenergic blocking agents. J. Pharmacol. exp. Ther. 131, 341 (1961).

    Google Scholar 

  • Brues, A. M., Drury, D. R., Brues, M. C.: A quantitative study of cell growth in regenerating liver. Arch. Path. 22, 658 (1936).

    CAS  Google Scholar 

  • Bucher B., Nancy L. R., Ditroia, J. F., Swaffield, Miriam N.: DNA synthesis during hepatic regeneration in rats of various ages. Fed. Proc. 20 (1), 286 (1961).

    Google Scholar 

  • Bucher B., Glinos, A. D.: The effect of age on regeneration of rat liver. Cancer Res. 10, 324 (1950).

    PubMed  CAS  Google Scholar 

  • Bucher B., Scott, J. F., Aus, J. C.: Regeneration of the liver in parabiotic rats. Cancer Res. 11, 457 (1951).

    PubMed  CAS  Google Scholar 

  • Swaffield C., Miriam N.: The rate of incorporation of labeled thymidine into the deoxyribonucleic acid of regenerating rat liver in relation to the amount of liver excised. Cancer Res. 24, 1611 (1964).

    PubMed  Google Scholar 

  • Swaffield C., Miriam N., Ditroia, J. F.: The influence of age upon the incorporation of thymidine-2-C14 into the DNA of regenerating rat liver. Cancer Res. 24, 509 (1964).

    PubMed  Google Scholar 

  • Bullough, W. S., Laurence, Edna B.: Mitotic control by internal secretion: the role of the chalone-adrenalin complex. Exp. Cell Res. 33, 176 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Bullough, W. S., Rytömaa, T.: Mitotic homeostasis. Nature (London) 205, 573 (1965).

    Article  Google Scholar 

  • Cameron, G. R.: Healing in organs. In: General Pathology, 3d ed. Ed.: Sir H. Florey. London 1962, pp. 495–513.

    Google Scholar 

  • Cameron, G. R., Karunaratne, W. A. E.: Carbon tetrachloride cirrhosis in relation to liver regeneration. J. Path. Bact. 42, 1 (1936).

    Article  CAS  Google Scholar 

  • Campbell, P. N.: Protein synthesis with special reference to growth processes both normal and abnormal. Advanc. Cancer Res. 5, 97 (1958).

    Article  CAS  Google Scholar 

  • Campbell, P. N., Greengard, Olga, Jones, H. E. H.: The intracellular distribution of amino acid incorporation by slices of liver and liver tumours and by ascites cells. Exp. Cell Res. 12, 689 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Cater, D. B., Homes, Barbara, Mee, L. K.: Cell division and nucleic acid synthesis in the regenerating liver of the rat. Acta Radiol. (Stockh.) 46, 655 (1956).

    Article  CAS  Google Scholar 

  • Child, C. G., Barr, D., Holswade, G. R., Harrison, C. S.: Liver regeneration following portacaval transposition in dogs. Ann. Surg. 138, 600 (1953).

    Article  PubMed  Google Scholar 

  • Christensen, B. G., Jacobsen, E.: Studies on liver regeneration. Acta med. stand. Suppl. 234, 103 (1949).

    Google Scholar 

  • Christensen, H. N., Rothwell, J. T., Sears, R. A., Streicher, J. A.: Association between rapid growth and elevated cell concentrations of amino acids in regenerating liver after partial hepatectomy in rat. J. biol. Chem. 175, 101 (1948).

    PubMed  CAS  Google Scholar 

  • Costa, A., Smorlesi, L.: Réversione rapida della cirrosi dopo asportazione di parte del fegato cirrotico; influsso della dieta epatica; leggi della rigenerazione del fegato. Arch. De Vecchi Anat. Pat. 17, 471 (1951 a).

    Google Scholar 

  • Costa, A., Smorlesi, L.: Il ripristino del fegato e la réversione rapida della cirrosi da CC14 dopo asportazione di larga parte del fegato cirrotico. Arch. De Vecchi Anat. Pat. 16, 49 (1951 b).

    Google Scholar 

  • Dagradi, A., de Candia, G.: Istochimica dell’ attivitâ fosfatasica alcalina nell fegato normale e rigencrante. Fegato 3, 310 (1957).

    CAS  Google Scholar 

  • Daoust, R., le Blond, C. P., Nadler, N. J., Enesco, M.: Rates of deoxyribonucleic acid formation and cell production in regenerating rat liver. J. biol. Chem. 221, 727 (1956).

    PubMed  CAS  Google Scholar 

  • de Lamirande, G., Allard, C., Cantero, A.: Intracellular ribonucleic acid composition in regenerating liver cells. Biochim. biophys. Acta (Amst.) 27, 395 (1958).

    Article  Google Scholar 

  • Dessi, P., Gianni, A. M.: Rigenerazione epatica e processi di transaminazione. Sperimentale 107, 104 (1957).

    PubMed  CAS  Google Scholar 

  • Dole, V. P.: A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. clin. Invest. 35, 150 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Drabkin, D. L.: Liver regeneration and cytochrome c metabolism; influence of amount of tissue excised and of diet, with note on accompanying changes in liver nucleic acids. J. biol. Chem. 171, 395 (1947).

    CAS  Google Scholar 

  • Drabkin, D. L.: Cytochrome c metabolism and liver regeneration; influence of adrenalectomy. J. biol. Chem. 182, 351 (1950).

    CAS  Google Scholar 

  • Edwards, J. L., Koch, A.: Parenchymal and littoral cell proliferation during liver regeneration. Lab. Invest. 13, 32 (1964).

    PubMed  CAS  Google Scholar 

  • Ferrari, V., Harkness, R. D.: Free amino acids in liver and blood after partial hepatectomy in normal and adrenalectomized rats. J. Physiol. (Lund.) 124, 443 (1954).

    CAS  Google Scholar 

  • Fisher, B., Fisher, E. R., Saffer, Elizabeth: Investigations concerning the role of a humoral factor in liver regeneration. Cancer Res. 23, 914 (1963).

    PubMed  CAS  Google Scholar 

  • Friedrich-Freksa, H., Zari, F. G.: Spezifische Mitose-Auslösung in normaler Rattenleber durch Serum von partiell hepatektomierten Ratten. Z. Naturforsch. 9, 394 (1954).

    Google Scholar 

  • Fujioka, M., Koga, M., Lieberman, I.: Metabolism of ribonucleic acid after partial hepatectomy. J. Biol. Chem. 238, 3401 (1963).

    PubMed  CAS  Google Scholar 

  • Glinos, A. D.: The mechanism of liver growth and regeneration. In: Symposium on the Chemical Basis of Development. Eds.: W. D. Mcelroy and B. Glass. Baltimore: Johns Hopkins Press 1958, pp. 813–842.

    Google Scholar 

  • Gordon, R. S., Cherkes, A.: Unesterified fatty acid in human blood plasma. J. clin. Invest. 35, 206 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Greenbaum, A. L., Greenwood, F. C., Harkness, R. D.: Glutamic dehydrogenase and glutamic-aspartic transaminase in regenerating liver of rat. J. Physiol. (Loud.) 125, 251 (1954).

    CAS  Google Scholar 

  • Greenstein, J. P., Edwards, J. E., Andervont, H. B., White, J.: Comparative enzymatic activity of transplanted hepatomas and of normal, regenerating and fetal liver. J. nat. Cancer Inst. 3, 7 (1942).

    CAS  Google Scholar 

  • Greenstein, J. P., Thompson, J. W.: Enzymatic activity of normal adult, regenerating, fetal and neoplastic hepatic tissues of the rat. J. nat. Cancer Inst. 4, 271 (1943).

    Google Scholar 

  • Grindlay, J. H., Bollman, J. L.: Regeneration of the liver in the dog after partial hepatectomy. Surg. Gynec. Obstet. 94, 491 (1952).

    PubMed  CAS  Google Scholar 

  • Grisham, J. W.: A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver: autoradiography with thymidine-H3. Cancer Res. 22, 842 (1962).

    PubMed  CAS  Google Scholar 

  • Grisham, J. W., Leong, G. F., Hole, B. V.: Heterotopic partial autotransplantation of rat liver: Technic and demonstration of structure and function of the graft. Cancer Res. 24, 1474 (1964).

    PubMed  CAS  Google Scholar 

  • Harkness, Margaret L. R., Harkness, R. D.: Further observations on collagen in regenerating liver of the rat. J. Physiol. (London) 123, 482 (1954).

    CAS  Google Scholar 

  • Harkness, R. D.: Regeneration of the liver. Brit. med. Bull. 13, 87 (1957).

    CAS  Google Scholar 

  • Hawkins, J., Walker, J. M.: The effect of colchicine on the enzyme content of regenerating rat liver and on the pressor amine content of the adrenal. Brit. J. Pharmacol. 7, 152 (1952).

    PubMed  CAS  Google Scholar 

  • Hecht, Liselotte I., Potter, V. R.: Nucleic acid metabolism in regenerating rat liver. I. The rate of deoxyribonucleic acid synthesis in vivo. Cancer Res. 16, 988 (1956 a).

    Google Scholar 

  • Hecht, Liselotte I., Potter, V. R.: Nucleic acid metabolism in regenerating rat liver. III. Intermediates in the synthesis of DNA pyrimidine nucleotides. Cancer Res. 16, 999 (1956 b).

    Google Scholar 

  • Hecht, Liselotte I., Potter, V. R.: Nucleic acid metabolism in regenerating rat liver. V. Comparison of results in vivo and in tissue slices. Cancer Res. 18, 186 (1958).

    PubMed  CAS  Google Scholar 

  • Higgins, G. M., Andersson, R. M.: Experimental pathology of the liver. Arch. Path. 12, 186 (1931).

    Google Scholar 

  • Higgins, G. M., Mann, F. C., Priestley, J. T.: Experimental pathology of the liver. Arch. Path. 14, 491 (1932).

    Google Scholar 

  • Holbrook, D. J., JR., Evans, J. H., Irvin, J. L.: Incorporation of labelled precursors into proteins and nucleic acids of nuclei of regenerating liver. Exp. Cell Res. 28, 120 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Holmes, Barbara E.: Influence of radiation on metabolism of regenerating rat liver. In: Ciba Foundation: Symposium on Ionizing Radiations and Cell Metabolism. Eds.: G. E. W. Wolstenholme and Cecelia M. O’connor. London: Churchill 1956, pp. 225–238.

    Google Scholar 

  • Hughes, P. E.: Humoral factors in liver regeneration. Aust. Ann. Med. 9, 41 (1960).

    PubMed  CAS  Google Scholar 

  • Hultin, T., Decken, Alexandra Von der: The incorporation in vitro of labelled amino acids into the proteins of regenerating rat liver. Exp. Cell Res. 13, 83 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Hultin, T., Decken, Alexandra von der: The activity of soluble cytoplasmic constituents from regenerating rat liver in amino acid incorporating systems. Exp. Cell Res. 15, 581 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Islam, A. H., Pack, G. T., Hubbard, J. C.: Regenerative hyperplasia of the cirrhotic liver following hepatectomy. Cancer 11, 663 (1958).

    Article  Google Scholar 

  • Islam, A. H., Pack, G. T., Hubbard, J. C.: The humoral factor in regeneration of the liver in parabiotic rats. Surg. Gynec. Obstet. 108, 549 (1959).

    Google Scholar 

  • Jordan, S. W.: Electron microscopy of hepatic regeneration. Exp. molec. Path. 3, 183 (1964).

    Article  Google Scholar 

  • Kaufmann, G.: Tetrachlorkohlenstoff — Zirrhose and Restauration der Leber. Beitr. path. Anat. 113, 253 (1953).

    Google Scholar 

  • Kerr, J. F. R.: A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes. J. Path. Bact. 90, 419 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Lagerstedt, S.: Hepatic histochemistry. In: Liver Injury. Ed.: F. W. Hoffbauer. New York: Josiah Macy, Jr. Foundation 1953, pp. 216–265.

    Google Scholar 

  • Leong, G. F., Grisham, J. W., Hole, B. V., Albright, M. L.: Effect of partial hepatectomy on DNA synthesis and mitosis in heterotopic partial autografts of rat liver. Cancer Res. 24, 1496 (1964).

    PubMed  CAS  Google Scholar 

  • Leong, G. F., Pessotti, R. L., Bauer, R. W.: Liver function in regeneration rat liver. CrPO4 colloid uptake and bile flow. Amer. J. Physiol. 197, 880 (1959).

    CAS  Google Scholar 

  • Leslie, I.: Content of tissues and cells. In: The Nucleic Acids, Vol. II. Eds.: E. Chargaff and J. K. Davidson. New York: The Academic Press 1955, pp. 1–50.

    Google Scholar 

  • Levenson, S. M., Crowley, L. V., Oates, J. F., Glinos, A. D.: Effect of severe burn on liver regeneration. Surg. Forum 9, 493 (1958).

    PubMed  CAS  Google Scholar 

  • Lieberman, I., Kane, Patricia: Synthesis of ribosomes in the liver after partial hepatectomy. J. biol. Chem. 240, 1737 (1965).

    PubMed  CAS  Google Scholar 

  • Lin, T.-Y., Chen, C.-C.: Metabolic function and regeneration of cirrhotic and non-cirrhotic livers after hepatic lobectomy in man. Ann. Surg. 162, 959 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Llanos, J. M. Echave, Bordin, Celia: The growth effect of a regenerating liver homogenate as a function of the responsiveness of the receptor. Naturwissenschaften 50, 501 (1963).

    Article  Google Scholar 

  • Looney, W. B.: A cytochemical and autoradiographic study of deoxyribonucleic acid synthesis in individual nuclei and the effects of irradiation on synthesis. In: The Cell Nucleus. Ed.: J. S. Mitchell. New York: Academic Press 1960, pp. 98–125.

    Google Scholar 

  • Ludewig, S., Minor, G. R., Hortensteine, J. C.: Lipid distribution in rat liver after partial hepatectomy. Proc. Soc. exp. Biol. (N. Y.) 42, 158 (1939).

    CAS  Google Scholar 

  • Macdonald, R. A.: “Lifespan” of liver cells. A.ch. intern. Med. 107, 335 (1961).

    Article  CAS  Google Scholar 

  • Macdonald, R. A., Rogers, Adrianne E.: Control of regeneration of the liver. Gastroenterology 41, 33 (1961).

    PubMed  CAS  Google Scholar 

  • Macdonald, R. A., Pechet, Giselle S.: Regeneration of the liver. Lab. Invest. 11, 544 (1962).

    CAS  Google Scholar 

  • Macdonald, R. A., Pechet, Giselle S.: Growth and regeneration of the liver. Ann. N. Y. Acad. Sci. 111, 70 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Mackay, E. U., Carne, H. O.: Influence of adrenalectomy and choline on the fat content of regenerating liver during fasting. Proc. Soc. exp. Biol. (N. Y.) 38, 131 (1938).

    CAS  Google Scholar 

  • Mann, F. C.: The portal circulation and restoration of the liver after partial removal. Surgery 8, 225 (1940).

    Google Scholar 

  • Mann, F. C.: Restoration of pathologic reactions of the liver. J. Mt. Sinai Hosp. 11, 65 (1944).

    Google Scholar 

  • Mann, F. C., Fishback, F. C., Gay, J. G., Green, G. F.: The effect of diverting the portal blood on the restoration of the liver after partial removal. Arch. Path. 12, 787 (1931).

    Google Scholar 

  • Marshak, A., Byron, R. L., Jr.: The use of regenerating liver as a method of assay. Proc. Soc. exp. Biol. (N. Y.) 59, 200 (1945).

    CAS  Google Scholar 

  • Mastinska, Maria: Effect of selected surgical interventions on the course of liver injuries produced with carbon tetrachloride in the rabbit. Pozn. Towarzy. Przyjac. Nauk, Wydz. lek. 21, (4), 1–46 (1961).

    Google Scholar 

  • Mcdermott, W. V., JR., Greenberger, N. J., Isselbacher, K. J., Weber, A. L.: Major hepatic resection: Diagnostic techniques and metabolic problems. Surgery 54, 56 (1963).

    Google Scholar 

  • Mcmenamy, R. H., Vang, J., Drapanas, T.: Amino acid and d-keto acid concentrations in plasma and blood of the liverless dog. Amer. J. Physiol. 209, 1046 (1965).

    PubMed  CAS  Google Scholar 

  • Miller, L. L.: The role of the liver and the nonhepatic tissue in the regulation of free amino acid levels in the blood. In: Amino Acid Pools. Ed.: J. T. Holden. Amsterdam: Elsevier 1962, pp. 708–721.

    Google Scholar 

  • Monaco, A. P., Hallgrimsson, J., Mcdermott, W. V., Jr.: Multiple adenoma (hamartoma) of the liver treated by subtotal (90°/e) resection: Morphological and functional studies of regeneration. Ann. Surg. 159, 513 (1964).

    PubMed  CAS  Google Scholar 

  • Morrione, T. G.: Quantitative study of collagen content in experimentel cirrhosis. J. exper. Med. 85, 217 (1947).

    Article  CAS  Google Scholar 

  • Morrione, T. G.: Factors influencing collagen content in experimental cirrhosis. Amer. J. Path. 25, 273 (1949).

    PubMed  CAS  Google Scholar 

  • Norberg, B.: On proteins in regenerating liver; phosphomonoesterases. Acta physiol. scand. 19, 246 (1949).

    Article  Google Scholar 

  • Novikoff, A. B., Essner, E.: The liver cell. Amer. J. Med. 29, 102 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Novikoff, A. B., Essner, E.: Pathological changes in cytoplasmic organelles. Fed. Prog. 21 (2), 1130 (1962).

    CAS  Google Scholar 

  • Novikoff, A. B., Essner, E., Potter, V. R.: Biochemical studies on regenerating liver. J. biol. Chem. 173, 223 (1948).

    PubMed  CAS  Google Scholar 

  • Nygaard, O., Rusch, H. P.: Incorporation of radioactive phosphate into nucleic acids of regenerating rat liver. Cancer Res. 15, 240 (1955).

    PubMed  CAS  Google Scholar 

  • Orita, Y., Zaki, F. G., Hoffbauer, F. W.: Fatty cirrhosis in the rat. V. Regression upon return to normal diet. Amer. J. Path. 42, 729 (1963).

    Google Scholar 

  • Olsson, R.: Partial hepatectomy in experimental carbon tetrachloride-induced liver fibrosis. Acta chir. scand. Suppl. 366, 1–85 (1966).

    Google Scholar 

  • Oppenheimer, M. J., Flock, E. V.: Alkaline phosphatase levels in plasma and liver following partial hepatectomy. Amer. J. Physiol. 149, 418 (1947).

    PubMed  CAS  Google Scholar 

  • Pack, G. T., Islami, A. H., Hubbard, J. C., Brasfield, R. D.: Regeneration of human liver after major hepatectomy. Surgery 52, 617 (1962).

    PubMed  CAS  Google Scholar 

  • Pack, G. T., Molander, D. W.: Hepatic lobectomy for recurrent echinococcus cyst of the liver. Amer. J. Gastroent. 33, 43 (1960).

    PubMed  CAS  Google Scholar 

  • Pechft, Giselle, Macdonald, R. A.: Repair of nutritional cirrhosis. Autoradiographic and histological study after partial hepatectomy. Cancer 14, 963 (1961).

    Article  Google Scholar 

  • Pettinari, V., Dagradi, A.: Le resezioni epatiche. Edizioni Mediche E Scientifiche. Roma 1962, pp. 380–393.

    Google Scholar 

  • Post, J., Klein, Alice, Hoffman, J.: Responses of the liver to injury. Arch. Path. 70, 314 (1960).

    PubMed  CAS  Google Scholar 

  • Price, J. M., Laird, A.K.: Comparison of intracellular composition of regenerating liver and induced liver tumors. Cancer Res. 10, 650 (1950).

    CAS  Google Scholar 

  • Rabinovici, N., Wiener, E.: Liver regeneration after partial hepatectomy in carbon tetrachloride-induced cirrhosis in the rat. Gastroenterology 40, 416 (1961).

    PubMed  CAS  Google Scholar 

  • Rabinovici, N., Wiener, E.: Hemodynamic changes in the hepatectomized liver of the rat and their relationship to regeneration. J. Burg. Res. 3, 3 (1963).

    Article  CAS  Google Scholar 

  • Reifferscheid, M., Schreiber, H. W., Klingelhofer, K. H.: Lebercirrhose; Resektion and Regeneration. Langenbecks Arch. klin. Chir. 290, 315 (1958).

    Google Scholar 

  • Rind, G., Allegri, A., Rizzolini, G. F.: Il comportamento dell’ attivita transaminasica nel fegato rigenerante dopo parziale epatectomia. Arch. Fisiol. 55, 152 (1955).

    Google Scholar 

  • Rogers, Adrianne E., Shaka, J. A., Pechet, Giselle S., Macdonald, R. A.: Regeneration of the liver. Absence of a “humoral factor” affecting hepatic regeneration in parabiotic rats. Amer. J. Path. 39, 561 (1961).

    PubMed  CAS  Google Scholar 

  • Rosenthal, O., Rogers, C. S., Vars, H. M., Ferguson, C. C.: Arginase, adenosinepyrophosphatase and rhodanase in regeneration of rat liver. J. biol. Chem. 189, 831 (1951).

    PubMed  CAS  Google Scholar 

  • Saetren, H.: A principle of autoregulation of growth. Exp. Cell Res. 11, 229 (1956).

    Article  PubMed  CAS  Google Scholar 

  • S. Nchez, Q. Estela, Soberón, G., Palacios, Olivia, Lee, Evangelina, Kuri, Magdalena: Changes in effective enzyme concentration in the growing rat liver. II. Liver regeneration after partial hepatectomy. J. biol. Chem. 236, 1607 (1961).

    Google Scholar 

  • Schalm, L.: Heterotopic auxiliary liver transplantation. I. A physiological concept of functional Competition. Arch. Chir. Neerl. 18, 283 (1966).

    CAS  Google Scholar 

  • Sigel, B., Acevedo, F. J., Dunn, M. R.: The effect of partial hepatectomy on autotransplanted liver tissue. Surg. Gynec. Obstet. 117, 29 (1963).

    PubMed  CAS  Google Scholar 

  • Simpson, G. E. C., Finckh, E. S.: The pattern of regeneration of rat liver after repeated partial hepatectomies. J. Path. Bact. 86, 361 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Solopaev, B. P., Butnev, I P., Kuznetsova, G. G.: On the reparative regeneration of the liver with experimentally induced cirrhosis. Biull. Eksp. Biol. Med. 26, 74 (1961).

    Google Scholar 

  • Spitzer, J. J., Mcelroy, W. T., Jr.: Some hormonal effects on uptake of free fatty acids by the liver. Amer. J. Physiol. 199, 876 (1960).

    CAS  Google Scholar 

  • Stitch, H., Florian, M. L.: The inhibition of liver mitoses by serum and tissue homogenates. Proc. Amer. Ass. Cancer Res. 2, 349 (1958).

    Google Scholar 

  • Straube, R. L., Patt, H. M.: Regeneration following partial hepatectomy as a function of age in the mouse. Fed. Proc. 20 (1), 286 (1961).

    Google Scholar 

  • Takagi, Y., Hecht, Liselotte I., Potter, V. R.: Nucleic acid metabolism in regenerating rat liver. I.. Studies on growing rats. Cancer Res. 16, 994 (1956).

    CAS  Google Scholar 

  • Thomson, R. Y., Clarke, A. M.: Role of portal blood supply in liver regeneration. Nature (London) 208, 392 (1965).

    Article  CAS  Google Scholar 

  • Tiszai, A., Tényi, N.: Serum and liver glutamate oxalacetate transaminase in hepatectomized rats. Experientia 16, 116 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Tsuboi, K. K., Yokoyama, H. O., Stowell, R. E., Wilson, M. E.: The chemical composition of regenerating mouse liver. Arch. Biochem. 48, 275 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Tsukada, K., Lieberman, I.: Metabolism of nuclear ribonucleic acid after partial hepatectomy. J. biol. Chem. 239, 1564 (1964).

    PubMed  CAS  Google Scholar 

  • Tsukada, K., Lieberman, I.: Liver nuclear ribonucleic acid polymerase formed after partial hepatectomy. J. biol. Chem. 240, 1731 (1965).

    PubMed  CAS  Google Scholar 

  • Valdoni, P., Messini, M., Ricci, G., Mancuso, M.: La resezione epatica quale impulso rigenerativo nella terapia della cirrosi. Epatologia 3, 1 (1957).

    Google Scholar 

  • van der Heyde, M. N., Vink, M., Stol, H., Dicke, H. W., Schalm, S. W.: Heterotopic auxiliary liver transplantation. III. Functional competition — cause of atrophy of the auxiliary liver transplant. Arch. Chir. Neerl. 18, 293 (1966).

    PubMed  Google Scholar 

  • van Lancker, J. L., Sempoux, D. O.: Regeneration of various cellular components in rat livers after subtotal hepatectomy. Arch. Biochem. 77, 129 (1958).

    Article  Google Scholar 

  • Virolainen, M.: Humoral control mechanism in liver regeneration. Thesis, Helsinki, 1967.

    Google Scholar 

  • von der Decken, Alexandra, Hultin, T.: The activity of microsomes from regenerating rat liver in amino acid incorporating systems. Exp. Cell Res. 14, 88 (1958).

    Article  Google Scholar 

  • Wachstein, M., Meisel, Elizabeth, Falcon, C.: Enzymatic histochemistry in the experimentally damaged liver. Amer. J. Path. 40, 219 (1962).

    PubMed  CAS  Google Scholar 

  • Wahi, P. N., Tandon, H. D., Bhaptadwaj, T. P.: Adrenal cortex and hepatic cirrhosis. 1. Role of adrenal cortex in evolution of carbon tetrachloride-induced cirrhosis. Arch. Path. 62, 200 (1956).

    CAS  Google Scholar 

  • Weber, G., Cantero, A.: Glucose-6-phosphatase activity in regenerating, embryonic and newborn rat liver. Cancer Res. 15, 679 (1955).

    PubMed  CAS  Google Scholar 

  • Weinbren, K.: The portal blood supply and regeneration of the rat liver. Brit. J. exp. Path. 36, 583 (1955).

    PubMed  CAS  Google Scholar 

  • Weinbren, K., Billing, B. H.: Hepatic clearness of bilirubin as an index of cellular function in the regenerating liver. Brit. J. exp. Path. 37, 199 (1956).

    PubMed  CAS  Google Scholar 

  • Weinbren, K., Taghizadeh: The mitotic response after subtotal hepatectomy in the rat. Brit. J. exp. Path. 46, 413 (1965).

    PubMed  Google Scholar 

  • Weinbren, K., Tarsh, Evelyn: The mitotic response in the liver after different regenerative stimuli. Brit. J. exp. Path. 45, 475 (1964).

    PubMed  CAS  Google Scholar 

  • Weinbren, K., Woodward, ELSA: Delayed incorporation of 32 p from orthophosphate into deoxyribonucleic acid of rat liver after subtotal hepatectomy. Brit. J. exp. Path. 45, 442 (1964).

    PubMed  CAS  Google Scholar 

  • Weiss, P.: Self-regulation of organ growth by its own products. Science 115, 487 (1952).

    Article  Google Scholar 

  • Wenneker, A. S., Sussman, N.: Regeneration of liver tissue following partial hepatectomy in parabiotic rats. Proc. Soc. exp. Biol. (N. Y.) 76, 683 (1951).

    CAS  Google Scholar 

  • Wertheimer, E., Shapiro, B.: Physiology of adipose tissue. Physiol. Rev. 28, 451 (1948).

    PubMed  CAS  Google Scholar 

  • Zimmerman, M., Cellozzi, Evemarie: Stimulation by heparin of parenchymal liver cell proliferation in normal adult rats. Nature (London) 191, 1014 (1961).

    Article  CAS  Google Scholar 

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  1. Department of Surgery II, University of Göteborg, Sweden

    Stig Bengmark M.D.

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  1. Memorial Hospital for Cancer and Allied Diseases, New York, New York, USA

    George T. Pack M.D., F.A.C.S. (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director) (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director)

  2. New York Medical College, New York, New York, USA

    George T. Pack M.D., F.A.C.S. (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director) (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director)

  3. Pack Medical Group, New York, New York, USA

    George T. Pack M.D., F.A.C.S. (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director) (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director)

  4. Pack Medical Foundation, New York, New York, USA

    George T. Pack M.D., F.A.C.S. (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director) (Late Attending Surgeon, Emeritus, Clinical Professor of Surgery, Surgeon, Director)

  5. St. Barnabas Medical Center, Livingston, New Jersey, USA

    Abdol H. Islami Ph.D., M.D., F.A.C.S. (Attending Surgeon and Director of Department of Medical Education, Assistant Clinical Professor of Surgery) (Attending Surgeon and Director of Department of Medical Education, Assistant Clinical Professor of Surgery)

  6. New Jersey College of Medicine and Dentistry, Jersey City, New Jersey, USA

    Abdol H. Islami Ph.D., M.D., F.A.C.S. (Attending Surgeon and Director of Department of Medical Education, Assistant Clinical Professor of Surgery) (Attending Surgeon and Director of Department of Medical Education, Assistant Clinical Professor of Surgery)

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Bengmark, S. (1970). Liver Regeneration. In: Pack, G.T., Islami, A.H. (eds) Tumors of the Liver. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48730-9_13

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