Abstract
There have been many reports that monoamines influence transmission in the spinal cord. Systemic administration of adrenaline (A) and noradrenaline (NA) may give both facilitatory and inhibitory effects on spinal reflexes (for references see McLennan 1963, p. 84) but since these catecholamines in all likelihood do not penetrate the blood brain barrier it is possible that the effects are secondary to circulatory changes. The same indirect action probably also applies to experiments with systemic injection of 5-hydroxytryptamine (5-HT). Some effects have been found with topical application of monoamines on the spinal cord (cf. McLennan 1963), but Curtis, Phillis and Watkins (1961) found no effect of electrophoretically administered NA and 5-HT on single cells in this tissue.
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Lundberg, A. (1965). Monoamines and Spinal Reflexes. In: Curtis, D.R., McIntyre, A.K. (eds) Studies in Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48612-8_30
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DOI: https://doi.org/10.1007/978-3-642-48612-8_30
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