Zusammenfassung
Seit Sciner Erstanwendung am Menschen hat Clonidin aufgrund Scines spezifischen Wirkungsmechanismus, der Alpha2 -Rezeptorenstimulation, die eine Reduktion neuronaler noradrenerger Aktivität bewirkt, Physiologie und Pathophysiologie um neue Erkenntnisse bereichert. Dies führte auch dazu, daß die Substanz Clonidin, ursprünglich als Antihypertonikum in Anwendung, bei einer Reihe weiterer Erkrankungen genutzt werden kann. Das Spektrum der Erkrankungen, die durch Clonidin günstig zu beeinflussen sind, ist immer noch nicht vollständig bekannt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Aghajanian GK: Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by Clonidine. Nature 276:186–187 (1978).
Ahsanuddin K: Tourette’s Syndrome — Treatment with Clonidine, a Centrally Acting Alpha-Adrenergic Agonist. Drug Intell Clin Pharmacy 14:4, 288–292 (1980).
Barr W: Problems Related to Postmenopausal Women. S A Medical Journal 49:437–439 (1975).
Beckmann H: Biochemische Grundlagen der endogenen Depression. Nervenarzt 49: 557–568 (1978).
Björkvist SE: Clonidine in Alcohol Withdrawal. Acta psychiat scand 52:256–263 (1975).
Bolli P et al: Clondine in Menopausal Flushing: A Double-Blind Trial. N Z Med J 548: 196–197 (1975).
Bottari SP et al: Hormonal Regulation of Adrenergic Receptor Subtypes in Human Myometrium. vortrag gehalten auf dem VIth F.R.E.S.E.R.H. Internat. Symp., Uterine Contractility, Brüssel 22.–24. 9. 1982.
Bravalo EL et al: Clonidine-Suppression Test. A Useful Aid in the Diagnosis of Pheochro-mocytoma. New Engl J Med 305:623–626 (1982).
Briant RH et al: Interaction between Clonidine and Desipramine in Man. Brit Med J 1:522–523(1973).
Casper RF et al: Menopausal Flushes: A Neuroendocrine Link with Pulsatile Luteinizing Hormone Secretion. Science 205:823–825 (1979).
Charney DS et al: Iatrogenic Opiate Addiction: Successful Detoxification with Clonidine. Am J Psychiatry 137:989–990 (1980).
Charney DS et al: The Clinical Use of Clonidine in Abrupt Withdrawal From Methadone. Arch Gen Psychiatry 38:1273–1277 (1981).
Charney DS et al: Adrenergic Receptor Sensitivity in Depression. Arch Gen Psychiatry 39:290–294(1982).
Checkley SA et al: Growth Hormone and other Responses to Clonidine in Patients with Endogenous Depression. Brit J Psychiat 138:51–55 (1981).
Clayden JR: Effect of Clonidine on Menopausal Flushing Lancet 2:1361 (1972).
Clayden JR et al: Menopausal Flushing: Double-Blind Trial of a Non-Hormonal Medication. Brit Med J 1:409–412 (1974).
Clayden JR: A GP’s personal experience of a clinical trial. MIMS Magazine, 33–39, March 1981.
Cohen DJ et al: Clonidine in Tourette’s Syndrome Lancet 2:551–553 (1979).
Cohen DJ et al: Clonidine Ameliorates Gilles de la Tourette Syndrome. Arch Gen Psychiatry 37:1350–1357 (1980).
Cottereau MJ et al: Essai de la Clonidine dans le sevalrage des toxicomanies aux opiacés. La Nouvelle Presse Médicale, Nr. 40, 3267 (1979).
Dorsey R: Clonidine and Gilles de la Tourette Syndrome. Arch Gen Psychiatry 38:1185 (1981).
Edington RF et al: Clonidine (Dixarit) for menopausal flushing. CMA Journal 123:23–26 (1980).
Elliott HL et al: Pharmacodynamic Studies on Mianserin and Its Interaction with Clonidine. Eur J Clin Pharmacol 21:97–102 (1981).
Evans J et al: Low-Dosage Clonidine (Dixarit) in Menopausal Flushing. Med J Aust 2:45–46(1979).
Fielding S et al: Antinociceptive Actions of Clonidine. In: Psychopharmacology of Clonidine. Ed Lal H Fielding S; Alan R Liss Inc, New York, 1981.
Forssberg H et al: The locomotion of the acute spinal cat injected with Clonidine i.val. Brain Research 50:184–186 (1973).
Franz DN et al: Spinal Sympathetic Neurons: Possible Sites of Opiate-Withdrawal Suppression by Clonidine. Science 215:1643–1645 (1982).
Freedman R et al: Clonidine Therapy for Coexisting Psychosis and Tardive Dyskinesia. Am J Psychiatry 137:629–630 (1980).
Freedman R et al: Clonidine treatment of schizophrenia: Double-Blind Comparison to Placebo and Neuroleptic Drugs. Acta psychiat scand 65:35–45 (1982).
Fozard JR: Comparative Effects of Four Migraine Prophylactic Drugs on an Isolated Extracranial Artery. Eur J Pharmacol 36:127–139 (1976).
Gáspár L et al: Clonidine Suppression Test in Pheochromocytoma. New Engl J Med 307:189–190 (1982).
Garcia-Sevilla JA et al: Platelet Alpha2-Adrenergic Receptors in Major Depressive Disorder. Arch Gen Psychiatry 38:1327–1333 (1981).
Gil-Ad I et al: Oral Clonidine as a Growth Hormone Stimulation Test. Lancet 2:278–282 (1979).
Gold MS et al: Clonidine in Opiate Withdrawal. Lancet 1:929–930 (1978/1).
Gold MS et al: Clonidine Blocks Acute Opiate-Withdrawal Symptoms. Lancet 2:599–602 (1978/11).
Gold MS et al: Clonidine Decreases Opiate Withdrawal-Related Anxiety: Possible Opiate Noradrenergic Interaction in Anxiety and Panic. Substance and Alcohol Actions/MISUSE 1:239–246(1980/I).
Gold MS et al: Opiate Withdrawal Using Clonidine: A Safe, Effective, and Rapid Nonopiate Treatment. JAMA 243:343–346 (1980/II).
Gold MS et al: Efficacy of Clonidine in Opiate Withdrawal: A Study of Thirty Patients. Drug and Alcohol Dependence 6:201–208 (1980/III).
Gold MS et al: Clinical Utility of Clonidine in Opiate Withdrawal: A Study of 100 Patients. In: Psychopharmacology of Clonidine, Ed: Lal H, Fielding S; Alan R Liss Inc, New York, 1981.
Haggerty JJ et al: Clonidine Therapy and Meperidine Withdrawal Am J Psychiatry 138:698(1981).
Hakkarainen H et al: The Role of Clonidine in the Treatment of Migraine: A Review of the Literature and Personal Experience. Upsala, J Med Sci 31:16–19 (1980).
Halter JB et al: Clonidine-Suppression Test for Diagnosis of Pheochromozytoma. New Engl J Med 1:49–50(1982).
Hamburg M et al: Chronic morphine administration increases the apparent number of Alpha2-adrenergic receptors in rat brain. Nature 291:493–495 (1981).
Herrmann P et al: Erfahrungen beim Opiatentzug mit Clonidin. Mitteilungen der Österr. Sanitätsverwaltung II, 189–192, 1982.
Hoder EL et al: Clonidine in Neonatal Narcotic-Abstinence Syndrome. New Engl J Med 305:1284(1981).
Hoehn-Saric R et al: Effects of Clonidine on Anxiety Disorders. Arch Gen Psychiatry 38:1278–1282(1981).
Hornykiewicz O: Brain catecholamines in schizophrenia — a good case for noradrenaline. Nature 299:484–486 (1982).
Hunt GE et al: The Tetracyclic Antidepressant Mianserin: Evaluation of its Blockade of Presynaptic Alpha-Adrenoceptors in a Self-Stimulation Model Using Clonidine. Eur J Pharmacol 70:59–63 (1981).
Jimerson DC et al: Preliminary Trial of the Noradrenergic Agonist Clonidine in Psychiatric Patients. Biol Psychiatry 15:45–57 (1980).
Jouvent R et al: Antimanic Effect of Clonidine. Am J Psychiatry 137:1275–1276 (1980).
Kass B et al: Propranolol (Inderal) and Clonidine (Catapressan) in the prophylactic treatment of migraine. Acta neurol scandinaval 61:351–356 (1980).
Keup W: Clonidin im Opiat-Entzug: Grundlagen der Anwendung. Münch med Wschr 124:148–152 (1982).
Knesevich JW: Successful Treatment of Obsessive-Compulsive Disorder with Clonidine Hydrochloride. Am J Psychiatry 139:364–365 (1982).
Kobinger W: Clonidine, a drug with many faces? Trends Pharmacol Sci 2:194–196 (1981).
Krulich L et al: Differential Effects of Pharmacological Manipulations of Central Alpha1- and Alpha2-Adrenergic Receptors on the Secretion of Thyrotropin (TSH) and Growth Hormone (GH) in Male Rats. Departments of Physiology and Pharmacology, Univ. of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235, zur Publ. eingereicht.
Lal S et al: Effect of Clonidine on Growth Hormone, Protaction, Luteining Hormone, Follicle Stimulating Hormone and Tyroid Stimulating Hormone in the Serum of Normal Man. J Clin Endocrinol Metab 41:827–832 (1975).
Lauritzen C: Behandlung klimakterischer Beschwerden mit niedrig dosiertem Clonidin. Dtsch med Wschr 197:335–338 (1982).
Lechin F et al: Physiological, Clinical and Therapeutical Basis of a New Hypothesis of Headache. Headache 20:77–89 (1980).
Lechin F et al: On the Use of Clonidine and Thioproperazine in a Woman with Gilles de la Tourette’s Disease. Biological Psychiatry 17:1, 103–108 (1982).
Levens LK: Clonidine in Treatment of Dysmenorrhoea. Brit Med J 1:577 (1974).
Liebowitz MR et al: Clonidine Treatment of Panic Disorder was evaluated. Psychopharmacol Bull 17:3, 122–123(1981).
Lindsay R et al: Failure of response of menopausal vasomotor symptoms to Clonidine. Maturitas 1:21–25 (1978).
Matussek N: Effect of Amphetamine and Clonidine on Human Growth Hormone Release in Psychiatric Patients and Controls. Symposium Rome, May 9–11, 1977 publ. in: Symposia Medica Hoechst 13:431–446 (1978) Stuttgart, New York: Schattauer, 1978.
Matussek N et al: Effect of Clonidine on Growth Hormone Release in Psychiatric Patients and Controls. Psychiatry Research 2:25–36 (1980).
McEntee WJ et al: Memory Impairment in Korsakoff’s Psychosis: A Correlation with Brain Noradrenergic Activity. Science 202:905–907 (1978).
McEntee WJ et al: Memory Enhancement in Korsakoff s Psychosis by Clonidine: Further Evidence for a Noradrenergic Deficit. Ann Neurol 7:446–470 (1980).
McEntee WJ et al: Clonidine in Korsakoff Disease: Pathophysiology and Therapeutic Implications. In: Psychopharmacology of Clonidine, Ed: Lal H; Fielding S; Alan R Liss Inc, New York, 1981.
Metz G: (Publikation in vorbereitung).
Metz SA et al: Autonomic epilepsy: Clonidine blockade of paroxysmal catecholamine release and flushing. Ann intern Med 88:189–193 (1978).
Naftchi NE: Functional Restoration of the Traumatically Injured Spinal Cord in Cats by Clonidine. Science 217:1042–1044 (1982).
Nardoni A et al: Clonidine in the Treatment of the Alcoholic Abstinence Syndrome (Preliminary Report) (unveröffentlichter Bericht).
Nishikawa T et al: Tardive Dyskinesia Treated with Clonidine. Kurume Med J 27:209–210 (1980).
Nutt JG et al: Effects of Baclofen, GABA Mimetics and Adrenergic Agents on the Flexor Reflex of the Chronic Spinal Rat. NIH Guide for Grants and Contracts, App. 1, 7:17 (1978).
Papanicolaou J et al: Anticonvalulsant Effects of Clonidine Mediated Through Central Alpha2-Adrenoceptors. Eur J Pharmacol 77:163–166 (1982).
Plant TM et al: The Sites of Action of Estradiol and Phentolamine in the Inhibition of the Pulsatile, Circhoral Discharges of LH the Rhesus Monkey (Macaca mulatta). Endocrinology 102:1015–1018(1978).
Putkonen PTS et al: Clonidine alleviates cataplectic symptoms in narcolepsy. Depts. of Neurology and Physiology, Univ. of Helsinki (unveröffentlichter Bericht).
Rao MS et al: Use of Clonidine in the Management of Patients with Neurogenic Bladder Dysfunction. Eur Urol 6:261–264 (1980).
Redmond DE et al: II. New Evidence for a Locus Coeruleus-Norepinephrine Connection with Anxiety. Life Sciences 25:2149–2162 (1979).
Reichl R et al: Inhibition of Neurosympathetic Cerebroarterial Constriction by Clonidine in Cats. Eur J Pharmacol 68:349–357 (1980).
Roth RH et al: Clonidine Suppression of Noradrenergic Hyperactivity During Morphine Withdrawal By Clonidine: Biochemical Studies in Rodents and Primates. J Clin Psychiatry 43:42–46(1982).
Rudolph CD et al: Sites at which Clonidine Acts to Affect Blood Pressure and the Secretion of Renin, Growth Hormone and ACTH. Neuroendocrinology 31:121–128 (1980).
Salmi T et al: Clonidine in the treatment of menopausal symptoms. Int J Gynaecol Obstet 16:422–426(1979).
Salti R et al: Oral Clonidine: an effective provalocative test of growth hormone release. Helval paediat Acta 36:527–531 (1981).
Sar M et al: Central noradrenergic neurones concentrate 3H-oestradiol. Nature 289:500–502 (1981).
Schindler AE et al: Studies with Clonidine (Dixarit) in Menopausal Women. Arch Gynecol 227:341–347(1979).
Shapiro AK et al: Clonidine and Haloperidol in Gilles de la Tourette Syndrome. Arch Gen Psychiatry 38:1183–1184 (1981).
Siever LJ et al: Growth Hormone Response to Clonidine as a Probe of Noradrenergic Receptor Responsiveness in Affective Disorder Patients and Controls. Psychiatry Res 6:171–183(1982).
Simpson GM et al: A Preliminary Evaluation of the Sedative Effects of Catapres, a New Antihypertensive Agent, in Chronic Schizophrenic Patients. J Clin Pharmacol 7:221–225 (1967).
Sjöberg N-O: Dysmenorrhea and Uterine Neurotransmitters. Acta Obstet Gynecol Scand 87:57–59(1979).
Smith CB et al: Platelet Alpha2-Adrenoreceptors in Melancholia. J Pharmacol Exp Ther 215:413(1980).
Sonnendecker EWW et al: A comparison of Oestrogen-Progestogen with Clonidine in the Climacteric Syndrome. S Afr Med J 58:753–756 (1980).
Sternberg DE et al: Impaired Presynaptic Regulation of Norepinephrine in Schizophrenia: Effects of Clonidine in Schizophrenic Patients and Normal Controls. Arch Gen Psychiatry 39:285–289(1982).
Sugerman AA: A Pilot Study of ST-155 (Catapres) in Chronic Schizophrenics. J clin pharmac 7:226–228 (1967).
Svensson T et al: Anxiolytic Action of Clonidine. Nordisk Psykiatrisk Tidskrift 32:439–441 (1978).
Sweeney DR et al: Plasma Free and Conjugated MHPG in Psychiatric Patients: A Pilot Study. Arch Gen Psychiatry 37:1100–1103 (1980).
The Health Services Human Growth Hormone Committee Comparison of the Intravenous Insulin and Oral Clonidine Tolerance Tests for Growth Hormone Secretion. Arch Dis Childhood 56:852–854 (1981).
Tseng L-F et al: Effects of Clonidine on Morphine Withdrawal Signs in the Rat. Eur J Pharmacol 30:93–99 (1975).
Tuckman J et al: Clinical Trial of an Alpha-Adrenergic Receptor Stimulating Drug (Clonidine) For Treatment of Spasticity in Spinal Cord Injured Patients. Lab. of Biochem. Pharmacol., Inst. of Rehabil. Med., New York, Univ. Medical Center, 400 East 34 Street, New York, NY 10016 (unveröffentlichter Bericht).
Uhde TW et al: Clonidine and Psychophysical Pain. Lancet 2:1375 (1980).
vetulani J et al: Depression by Clonidine of shaking behaviour elicited by nalorphine in morphine-dependent rats. J Pharm Pharmac 29:567–569 (1977).
Walinder J et al: Clonidine Suppression of the Alcohol Withdrawal Syndrome. Drug and Alcohol Dependence 8:345–348 (1981).
Walland A: Inhibition of sudomotor transmission in the cat’s stellate ganglion by activation of somadendritic Alpha2-adrenoceptors (zur Publ. eingereicht).
Washton AM et al: Clonidine Hydrochloride: A Non-Opiate Treatment for Opiate Withdrawal. Psychopharmac Bull 16:50–52 (1980).
Washton AM et al: Clonidine in Opiate Withdrawal: Review and Appraisal of Clinical Findings. Pharmacotherapy 1:140–146 (1981).
Weick RF: Acute Effects of Adrenergic Receptor Blocking Drugs and Neuroleptic Agents on Pulsatile Discharges of Luteinizing Hormone in the Ovariectomized Rat. Neuroendocrinology 26:108–117 (1978).
Wilkinson M: Clonidine for Migraine. Lancet 2:43 (1969).
Yaksh TL: Activation of Modulatory Receptor Systems in Primate Spinal Cord: The Analgesic Effects of Intrathecal Opiates, Alpha-Adrenergic Agonists and Baclofen in the Monkey. Dept. of Neurol. Surgery and Pharmacology, Mayo Foundation, Rochester, Minnesota 55901, USA (Abstract).
Ylikorkala O: Clonidine in the treatment of menopausal symptoms. Ann Chir Gynaec Fenn 64:242–245(1975).
Young S et al: Noradrenergic Alpha1- and Alpha2-Receptors: Light Microscopic Autoradiographic Localization. Proc Natl Acad Sci USA 77:1696–1700 (1980).
Young WS III et al: Anatomical Mapping of Clonidine (Alpha2-Noradrenergic) Receptors in Rat Brain: Relationship to Function. In: Psychopharmacology of Clonidine, Ed: Lal H, Fielding S; Alan R Liss Inc, New York, 1981.
Zaimis E et al: A Possible Pharmacological Approach to Migraine. Lancet 2:298–300 (1969).
Zaimis E: Hypotensive Drugs: Peripheral versus Central Effects. J Med Sci Scand 31:52–54 (1980).
Zelnik TC et al: Clinical Response to Clonidine and Imipramine, and Platelet Alpha2-Adrenoreceptors in a Case of Agoraphobia with Panic Attacks. Biological Psychiatry 17:761–766(1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt
About this chapter
Cite this chapter
Görlich, H.D. (1983). Sonstige Indikationen von Clonidin. Clonidin: Forschungsinstrument und Therapeutikum. In: Hayduk, K., Bock, K.D. (eds) Zentrale Blutdruckregulation durch α 2-Rezeptorenstimulation. Steinkopff. https://doi.org/10.1007/978-3-642-48440-7_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-48440-7_21
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-0624-4
Online ISBN: 978-3-642-48440-7
eBook Packages: Springer Book Archive