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History of Cancer Genetics in Man

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Hereditary Factors in Carcinoma

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Abstract

An Intensely controversial area in medicine as well as in genetics has been the question of a hereditary etiology for malignancies in man. Much of this controversy has stemmed from the myriad problems posed in gathering accurate data on such a complex problem as cancer and particularly in such a poor research subject as man himself. The obvious inability to control matings in man, long generation interval, small number of offspring, difficulty in collecting valid data through more than two generations, problems in population mobility, outright refusal to give authorization to obtain data and/or refusal to submit to physical examination in many cases, and finally, repression and suppression of vital information by some individuals because of fear and anxiety about one of mankind’s most dreaded diseases, have only compounded an already difficult problem.

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Lynch, H.T. (1967). History of Cancer Genetics in Man. In: Hereditary Factors in Carcinoma. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48252-6_1

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