Skip to main content
SpringerLink
Log in

Adjuvante Strahlentherapie beim Rektumkarzinom

Adjuvant Radiotherapy for Rectal Carcinoma

  • Conference paper
Deutsche Gesellschaft für Chirurgie

  • 4 Accesses

Summary

Evaluation and refinement of surgical techniques in rectal carcinoma have reduced the rate of local recurrences. Nevertheless recurrence it remains high at more than 20% in patients with extensive infiltration of perirectal tissues and cures are an exception. Overview of many years of experience with adjuvant radiotherapy shows that local recurrence rate can be reduced and survival the rate improved.

Zusammenfassung

Die Verfeinerung der Operationstechniken hat in den letzten Jahren zu einer Senkung der Häufigkeit von Lokalrezidiven geführt, dennoch ist bei Patienten mit ausgedehnter Infiltration des perirektalen Gewebes das Risiko mit über 20% immer noch hoch. Nur noch ausnahmsweise kann das Lokalrezidiv geheilt werden. Dieser Überblick über eine lange Erfahrung mit der adjuvanten Strahlenbehandlung zeigt, daß eine Reduzierung der Lokalrezidivrate und eine Verbesserung des Überlebens möglich sind.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aldermann SJ, Aprile IJ, Butler JJ et al. (1981) The value of postoperative irradiation in the treatment of adenocarcinoma of the rectum and rectosigmoid colon. Int J Radiat Oncol Biol Phys 7 (Suppl) 1:71

    Article  Google Scholar 

  2. Allee PE, Gunderson LL, Munzenrider JE (1981) Postoperative radiation therapy for residual colorectal carcinoma. ASTR Proceedings. Int J Radiat Oncol 7:1208

    Article  Google Scholar 

  3. Allen CV, Fletcher WS (1972) A pilot study on preoperative irradiation of rectosigmoid carcinoma. Am J Roentgenol 114:504–508

    Article  CAS  Google Scholar 

  4. Balslev IB, Pedersen M, Teglbjverg PS, Handberg-Sorensen F, Bone J, Jacobson NO, Overgaard J, Sell A, Bertelsen K, Hage E, Hansen L, Kronborg O, Hostrup H, Norgaard-Pedresen B (1986) Postoperative radiotherapy in carcinoma of the rectum and rectosigmoid Dukes’ B and C. A randomized multicentre study. Cancer 58:22–28

    Article  PubMed  CAS  Google Scholar 

  5. Boulis-Wassif S, Gerard A, Loygue J, Camelot D, Buyse M, Duez N (1984) Final results of a randomized trial on the treatment of cancer with preoperation radiotherapy of rectal cancer with pre- operation alone or incombination with 5-fluorouracil, followed by radical surgery. Cancer 53:1811–1818

    Article  PubMed  CAS  Google Scholar 

  6. Combes PF, Gary-Bobo J, Naja A, Nguyen-Saumon M, Bugat R, Mathieu A, el Safidi M (1983) Cancers du rectum: radiotherapie pre-operatoire (344 cas). Bull Cancer (Paris) 70:317–322

    CAS  Google Scholar 

  7. Dosoretz DE; Gunderson LL, Hoskins B, Hedberg SE, Rodbey G, Shipley WV, Blitzer PH, Chen AC (1983) Preoperative irradiation for localized carcinoma of the rectum and rectosigmoid: Patterns of failure, survival and future treatment strategies. Cancer 52:814–818

    Article  PubMed  CAS  Google Scholar 

  8. Emami B, Pilepich M, Willett C, Munzenrider JE, Miller HH (1982) Management of unresectable colorectal carcinoma (preoperative radiotherapy and surgery). Int J Radiat Oncol Biol Phys 8:1295–1299

    Article  PubMed  CAS  Google Scholar 

  9. Friedman P, Pack WC, Afonya II et al. (1978) Adjuvant radiation therapy on colorectal carcinoma. Am J Surg 135:512–518

    Article  Google Scholar 

  10. Gastrointestinal Tumor Study Group (1986) Survival after postoperative combination treatment of rectal cancer. N Engl J Med 315:1294–1295

    Article  Google Scholar 

  11. Gerard A, Berrod JL, Pene F, Loygue J, Laugier A, Bruckner R, Camelot G, Arnand JP, Metzger V, Buyse M, Dalesio O, Duez N (1985) Interim analysis of a phase III study on preoperative radiation therapy in resectable rectal carcinoma. Trial of the Gastrointestinal Tract Cancer Cooperative Group of the European Organization for Research on Treatment of Cancer (EORTC). Cancer 55:2373–2379

    Article  PubMed  CAS  Google Scholar 

  12. Ghossein NA, Samala EC, Alpert S (1981) Elective postoperative radiotherapy after incomplete resection of colorectal cancer. Dis Colon Rectum 24:252–256

    Article  PubMed  CAS  Google Scholar 

  13. Glimelius B, Graffman S, Pahlman L, Rimsten A, Wilander E (1982) Preoperative irradiation with high-dose fractionation in adenocarcinoma of the rectum and rectosigmoid. Acta Radiol (Oncol) 21:373–379

    Article  CAS  Google Scholar 

  14. Gunderson LL, Cohen AM, Welch CE (1980) Residual inoperable or recurrent colorectal cancer. Interaction of surgery and radiotherapy. Am J Surg 139:518–525

    Article  PubMed  CAS  Google Scholar 

  15. Gunderson LL, Dosoretz DE, Heidberg SE et al. (1983) Low-dose preoperative irradiation, surgery and elective postoperative radiation therapy for resectable rectum and rectosigmoid carcinoma. Cancer 52:446–451

    Article  PubMed  CAS  Google Scholar 

  16. Higgins jr GA, Conn JH, Jordan JH et al. (1975) Preoperative radiotherapy for colorectal cancer. Ann Surg 191:624–631

    Article  Google Scholar 

  17. Hoskins B, Gunderson LL, Dosoretz D, Galdabini J (1980) Adjuvant postoperative radiotherapy in carcinoma of the rectum and rectosigmoid. Int J Radiat Oncol Biol Phys 6:1380 (abstr)

    Article  Google Scholar 

  18. Hoskins B, Gunderson LL, Dosoretz D et al. (1985) Adjuvant postoperative radiotherapy in carcinoma of the rectum and rectosigmoid. Cancer 55:61–71

    Article  PubMed  CAS  Google Scholar 

  19. Houge RC, Smith RR (1961) The effectiveness of small amounts of preoperative irradiation in preventing the growth of tumor cells disseminated at surgery: an experimental study. Cancer 14:284–295

    Article  Google Scholar 

  20. Kligermann MM, Urdaneta N, Knowlton A et al. (1972) Preoperative irradiation of rectosigmoid carcinoma including its regional lymph nodes. Am J Roentgenol Rad Ther Nucl Med 114:498–503

    Article  Google Scholar 

  21. Mendenhall WM, Million RR, Pfaff WW (1985) Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: implications in treatment planning with adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 9:977–985

    Article  Google Scholar 

  22. Mendenhall WM, Million RR, Bland KI, Pfaff WW, Copeland EM (1987) Initially unresectable rectal andenocarcinoma treated with preoperative irradiation and surgery. Ann Surg 205:41–44

    Article  PubMed  CAS  Google Scholar 

  23. Mohiuddin M, Marks G, Kramer S, Pajak T (1984) Adjuvant radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys 10:977–980

    Article  PubMed  CAS  Google Scholar 

  24. MRC Working Party (1984) The evaluation of low-dose preoperative x-ray therapy in the management of operable rectal cancer: Results of a randomly controlled trial. Br J Surg 71:21–25

    Article  Google Scholar 

  25. Nias AHW (1967) Radiobiological aspects of preoperative irradiation. Br J Rad 40:166

    Article  CAS  Google Scholar 

  26. Powers WE, Tolmach LJ (1964) Preoperative radiation therapy: Biological basis and experimental investigation. Nature 201:172–204

    Article  Google Scholar 

  27. Rider WD, Palmer JA, Mahoney LJ et al. (1977) Preoperative irradiation in operable cancer of the rectum: Report of the Toronto trial. Can J Surg 20:335–338

    PubMed  CAS  Google Scholar 

  28. Rominger CJ, Gelber R, Gunderson LL (1985) (for Radiation Therapy Oncology Group): Radiation therapy alone or in combination with chemotherapy in the treatment of residual or inoperable carcinoma of the rectum and rectosigmoid or pelvic recurrence following colorectal surgery. Am J Clin Oncol 8:118–127

    Article  PubMed  CAS  Google Scholar 

  29. Romsdal M, Withers HP (1978) Radiotherapy combined with curative surgery. Arch Surg 113:446–453

    Article  Google Scholar 

  30. Roswit B, Higgins GA, Keehn RJ (1975) Preoperative irradiation for carcinoma of the rectum and rectosigmoid colon: Report of a National Veterans Admistration randomized study. Cancer 35:1597–1602

    Article  PubMed  CAS  Google Scholar 

  31. Ruff CC, Dockerty MB, Frickle RE (1961) Preoperative radiation therapy for adenocarcinoma of the rectum and rectosigmoid. Surg Gynecol Obstet 112:715–723

    PubMed  CAS  Google Scholar 

  32. Salmon RJ, Guilett JL, Bige P, Durand JC, Fenton J, Mathieu G, Rousseau J, Pilleron JP (1983) Cancers operables du rectum: radiotherapie preoperatoire. Etude retrospective de 192 cas traites a l’Institut Curie. Bull Cancer (Paris) 70:429–433

    CAS  Google Scholar 

  33. Shank B, Enker W, Santana J et al. (1987) Local control with preoperative radiotherapy alone versus “Sandwich” radiotherapy for rectal carcinoma. Int J Radiat Oncol Biol Phys 13:111–115

    Article  PubMed  CAS  Google Scholar 

  34. Stearns jr MR, Deddish MR, Quan SHQ (1959) Preoperative roentgen therapy for cancer of the rectum. Surg Gynecol Obstet 109:225

    PubMed  Google Scholar 

  35. Stevens KR, Allen CV, Fletcher WS (1976) Preoperative radiotherapy for adenocarcinoma of the rectosigmoid. Cancer 37:2866–2874

    Article  PubMed  Google Scholar 

  36. Tepper JE, Cohen AM, Wood WC, Orlow EL, Hedberg SE (1987) Postoperative radiation therapy of rectal cancer. Int J Radiat Oncol Biol Phys 13:5–15

    Article  PubMed  CAS  Google Scholar 

  37. Zucali R, Gardani G, Volterrani F (1980) Adjuvant postoperative radiotherapy in locally advanced rectal and rectosigmoid cancer. Tumori 86:595–600

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Strahlenklinik Universitätsklinikum Essen, Hufelandstraße 55, D-4300, Essen, Deutschland

    H. Sack, M. Bamberg & V. Budach

Authors
  1. H. Sack
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Bamberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Budach
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Generalsekretär d. Deutschen Gesellschaft f. Chirurgie, Steinbacher Hohl 28, D-6000, Frankfurt a.M. 90, Deutschland

    E. Ungeheuer

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sack, H., Bamberg, M., Budach, V. (1990). Adjuvante Strahlentherapie beim Rektumkarzinom. In: Ungeheuer, E. (eds) Deutsche Gesellschaft für Chirurgie. Langenbecks Archiv für Chirurgie Gegründet 1860 Kongreßorgan der Deutschen Gesellschaft für Chirurgie, vol 1990. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48163-5_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-48163-5_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52926-2

  • Online ISBN: 978-3-642-48163-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation