Enzymes of Synthesis of Purine and Pyrimidine Nucleotides

Wang, Dalton; Waygood, E. R.

doi:10.1007/978-3-642-48141-3_11

Dalton Wang &
E. R. Waygood

Part of the book series: Modern Methods of Plant Analysis / Moderne Methoden der Pflanzenanalyse ((PFLANZENANAL.,volume 7))

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Abstract

The biosynthetie pathways of the nucleotides of purines and pyrimidmes have been recently elucidated and soundly established. Schemes of the pathways of these groups of compounds are shown in Figs. 1,2. Enzymes that catalyze these chemical reactions have been isolated from animals and microorganisms and some have been purified to a considerable extent. Credit for the elucidation of the enzymatic synthesis of purine nucleotides should be given particularly to Buchanan, Kornberg and Greenberg, and of pyrimidine nucleotides to Reichabd, Cohen, and Lieberman and their colleagues. Despite the advances made in this field in animals and micro-organisms the existence of these enzymes in higher plants has not been demonstrated so far. Undoubtedly, research on plant enzyme systems is urgently needed in this respect.

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Abbreviations

ADP:: adenosine diphosphate
AICAR:: 5-amino-4-imidazole carboxamide ribotide
AICR:: 5-amino-4-imidazolecarboxylic acid ribotide
AIR:: 5-aminoimidazole ribotide
AISCAR:: 5-ammo-4-imidazole-N-succino-carboxamide ribotide
APDPN:: 3-acetyl pyridine analogue of DPN
APDPNH:: reduced form of APDPN
ATP:: adenosine triphosphate
ATPase:: adenosine triphosphate pyro-phosphorylase
CA:: carbamylaspartic acid
CP:: carbamylphosphate
DEA:: diethanolamine-diethanolamine hydrochloride
DPN:: diphosphopyridine nucleotide
DPNH:: reduced form of DPN
FAICAR:: 5-formyl-amino-4-imidazolecarboxamide ribotide
FGAMR:: formylglycin-amidine ribotide
FGAR:: formylglycinamide ribotide
GAR:: glycinamide ribotide
GSH:: glutathione
IMP:: inosinic acid
N⁵,N¹⁰-anhydroformyl-THFA:: N⁵,N¹⁰-anhydroformyl tetra-hydrofohc acid
O-5-P:: orotidine-5-phosphate
Pi:: orthophosphate
PGA:: 3-phosphogly eerie acid
PP:: pyrophosphate
PRA:: 5-phosphoribosylamine
PRPP:: 5-phosphoribosylpyrophos-phate
R-5-P:: ribose-5-phosphate
TCA:: trichloroacetic acid
THFA:: tetrahydrofolic acid
TPN:: triphosphopyridine nucleotide
TPNH:: reduced form of TPN
Tris:: tris (hydroxymethyl) aminomethane
U-5-P:: uridine-5-phosphate; Versene, ethylenediaminetetraacetic acid

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Dalton Wang
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E. R. Waygood
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Editors and Affiliations

Department of Microbiology, University of Manitoba, Winnipeg, Canada
B. D. Sanwal Dr. (Associate Professor) (Associate Professor)

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Wang, D., Waygood, E.R. (1964). Enzymes of Synthesis of Purine and Pyrimidine Nucleotides. In: Linskens, H.F., Sanwal, B.D., Tracey, M.V. (eds) Modern Methods of Plant Analysis / Moderne Methoden der Pflanzenanalyse. Modern Methods of Plant Analysis / Moderne Methoden der Pflanzenanalyse, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48141-3_11

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DOI: https://doi.org/10.1007/978-3-642-48141-3_11
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