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Pharmakologische Methoden

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Zentralnervensystem

Part of the book series: Handbuch der Experimentellen Pharmakologie ((HEP,volume 16 / 7))

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Zusammenfassung

Die experimentelle Erzeugung von Tremor verfolgt im allgemeinen das Ziel, im Tierversuch ein dem menschlichen Parkinsonismus ähnliches Zustandsbild zu reproduzieren. Im Idealfall sollte ein derartiges Syndrom zur pharmakologischen Auswertung von Parkinsonmitteln und für ähnliche Untersuchungen zu verwenden sein.

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Literatur

  • Abbozzo, G., E. Genazzani et L. Donatelli: L’action du Néoantergan sur les convulsions au Cardiazol et sur la narcose a l’Avertine. Arch. int. Pharmacodyn. 88, 209–222 (1951).

    CAS  Google Scholar 

  • Abood, L. G., E. Kun and E. M. K. Geiling: Phosphorylated intermediates of chronically and acutely morphinized rats. J. Pharmacol. exp. Ther. 98, 373–379 (1950).

    PubMed  CAS  Google Scholar 

  • —, and E. B. Sigg: Correlation between experimental catatonia and inhibition of phosphorylation. Fed. Proc. 14, 1 (1955).

    Google Scholar 

  • Ahmed, A., P. B. Marshall and D. M. Shepherd: Pharmacology of tremor-producing ammo alcohols. J. Pharm. (Lond.) 10, 672–682 (1958).

    CAS  Google Scholar 

  • Albertoni, P.: Untersuchungen über die Wirkung einiger Arzneimittel auf die Erregbarkeit des Großhirns nebst Beiträgen zur Therapie der Epilepsie. Pflügers Arch. ges. Physiol. 15, 248–288 (1882).

    Google Scholar 

  • Albus, G.: Tierexperimentelle Untersuchungen über die Weckwirkung handelsüblicher Analeptica unter besonderer Berücksichtigung von Cardiazol und Coramin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 182, 471–476 (1936).

    CAS  Google Scholar 

  • Alema, G., and C. Sergio: On the influence of some pharmacological substances upon the experimental catatonia produced by bulbocapnine, reserpine and chlorpromazine in rats. In: S. Garattini and V. Ghetti: Psychotropic Drugs, p. 168–170. Elsevier Publishing Company 1957.

    Google Scholar 

  • Amsler, C.: Zur Pathogenese der Gewöhnung an Morphin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 161, 233–246 (1931).

    Google Scholar 

  • Armstrong, M. D., and N. L. Low: Phenylketonuria VIII. Relation between age, serum phenylalanine level, and phenylpyruvic acid excretion. Proc. Soc. exp. Biol. (N. Y.) 94, 142–146 (1957).

    CAS  Google Scholar 

  • Arnold, A., and C. A. Elvehjem: Is running fits a deficiency disease? J. Amer. vet. med. Ass. 95, 303–308 (1939).

    CAS  Google Scholar 

  • Arrigoni-Martelli, E., e M. Kramer: Studio farmacologico di un nuovo derivato feno-tiazinico: la perfenazina. Arch. int. Pharmacoyn. 119, 311–333 (1959).

    CAS  Google Scholar 

  • Auerbach, V. H., and H. A. Waisman: The metabolism of aromatic amino acids in leukemic rats. Cancer Res. 18, 536–542 (1958).

    PubMed  CAS  Google Scholar 

  • — — and L. B. Wyckoff, jr.: Phenylketonuria in the rat associated with decreased temporal discrimination learning. Nature (Lond.) 182, 871–872 (1958).

    Google Scholar 

  • Axmacher, F.: Über erregende und analeptische Eigenschaften des Methylimidazols nebst Vergleich mit der Wirkung von Cardiazol und Coramin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 183, 478–499 (1936).

    CAS  Google Scholar 

  • Azima, H., and B. Grad: Production of a permanent state of excitation in mice and rats with β,β-iminodipropionitrile. Fed. Proc. 15, 6 (1956).

    Google Scholar 

  • Bachem, C.: Das Verhalten des Veronals (Veronalnatriums) im Tierkörper bei einmaliger und bei chronischer Darreichung. Naunyn-Schmiddeberg’s Arch. exp. Path. Pharmak. 63, 228–241 (1910).

    Google Scholar 

  • Bachhuber, T. E., J. J. Lalich, D. M. Angevine, E. D. Schilling and F. M. Strong: Lathyrus factor activity of beta-aminopropionitrile and related compounds. Proc. Soc. exp. Biol. (N. Y.) 89, 294–297 (1955).

    CAS  Google Scholar 

  • Bárány, E.: The influence of the electrode arrangement in the determination of drug action by means of electrical convulsive thresholds. Arch. int. Pharmacodyn. 73, 189–192 (1946).

    PubMed  Google Scholar 

  • —, and E. Stein-Jensen: The mode of action of anticonvulsant drugs on electrically induced convulsions in the rabbit. Arch. int. Pharmacodyn. 73, 1–47 (1946).

    Google Scholar 

  • Barbour, H. G., J. A. Porter and J. M. Seelye: Morphinism as a metabolic stimulant. J. Pharmac. exp. Ther. 65, 332–342 (1939).

    CAS  Google Scholar 

  • Barlow, O. W.: The relative efficiency of a series of analeptics as antidotes to sublethal and lethal dosages of pentobarbital, chloral hydrate, and tribromethanol (“avertin”). J. Pharmacol. exp. Ther. 55, 1–23 (1935).

    CAS  Google Scholar 

  • —, and J. R. Lewis: Toxicology and addiction liability of meperidine (demerol) in experimental animals. J. Pharmacol. exp. Ther. 103, 147–152 (1951).

    Google Scholar 

  • Baruk, H., et H. de Jong: Études sur la catatonie expérimentale. L’épreuve de la bulbo-capnine chez divers animaux avec et sans néopallium. Rev. neurol. 2, 532–541 (1929).

    Google Scholar 

  • Batelli, M. F.: Production de l’accès épileptiforme par les courants électriques industriels. C. R. Soc. Biol. (Paris) 55, 883 (1903).

    Google Scholar 

  • Bauthier, J., et H. Vandersmissen: Antagonisme entre le carbamate de propynyl-cyclo-hexanol et deux stimulants nerveux centreaux. Arch. int. Pharmacodyn. 119, 258–263 (1959).

    PubMed  CAS  Google Scholar 

  • Beer, A. G.: Beiträge zur Pharmakologie des extrapyramidalen Systems. I. Mitteilung: Die Wirkung des Harmins bei Katzen mit intaktem Nervensystem. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 193, 377–392 (1939a).

    CAS  Google Scholar 

  • — Beiträge zur Pharmakologie des extrapyramidalen Systems. IL Mitteilung: Die Wirkung des Harmins bei Katzen ohne Neocortex. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 193, 393–407 (1939b).

    Google Scholar 

  • Bein, H. J., F. Gross, J. Tripod U. R. Meier: Experimentelle Untersuchungen über „Serpa-sil“(Reserpin), ein neues, sehr wirksames Rauwolfiaalkaloid mit neuartiger zentraler Wirkung. Schweiz. med. Wschr. 83, 1007–1012 (1953).

    PubMed  CAS  Google Scholar 

  • Belford, J., and D. C. Bonnycastle: The effects of some anticonvulsant agents upon agene-induced convulsions in dogs. J. Pharmacol. exp. Ther. 99, 325–328 (1950).

    PubMed  CAS  Google Scholar 

  • Bentley, H. R., E. E. Mc Dermott, J. Pace, J. K. Whitehead and T. Moran: Action of nitrogen trichloride on proteins: Progress in the isolation of the toxic factor. Nature (Lond.) 163, 675–676 (1949a).

    CAS  Google Scholar 

  • — — — — — Action of nitrogen trichloride (“agene”) on proteins: Isolation of cristalline toxic factor. Nature (Lond.) 164, 438–439 (1949b).

    Google Scholar 

  • — — — — — Toxic factor from “agenized” proteins: Methionine as the essential reactant. Nature (Lond.) 165, 150–151 (1950a).

    Google Scholar 

  • — — — and J. K. Whitehead: Action of nitrogen trichloride on proteins: A synthesis of the toxic factor from methionine. Nature (Lond.) 165, 735 (1950b).

    Google Scholar 

  • Bertschik, G.: Über Wiederherstellung der infolge von Gewöhnung an Morphin aufgehobenen Cocainanästhesie der Hornhaut bzw. über Aufhebung derselben bei nicht morphingewöhnten Tieren durch Milch. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 177, 56–59 (1935).

    Google Scholar 

  • Bianchi, C: Reserpine and serotonin in experimental convulsions. Nature (Lond.) 179, 202–203 (1957).

    CAS  Google Scholar 

  • —, and J. Franceschini: Experimental observations on Haffner’s method for testing analgesic drugs. Brit. J. Pharmacol. 9, 280–284 (1954).

    Google Scholar 

  • Biberfeld, J.: Zur Kenntnis der Gewöhnung. III. Über experimentelle Gewöhnung an Schlafmittel. Biochem. Z. 92, 198–210 (1918).

    CAS  Google Scholar 

  • Bickis, I. J., J. P. Kennedy and J. H. Quastel Phenylalanine inhibition of tyrosine metabolism in the liver. Nature (Lond.) 179, 1124–1126 (1957).

    CAS  Google Scholar 

  • Biehler, W.: Krampfgrenze und Krampfhemmung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 178, 693–699 (1935).

    CAS  Google Scholar 

  • Bikeles, G., u. L. Zbyszewski: Über Erregbarkeit der Großhirnrinde und Auslösbarkeit von Rindenepilepsie unter Einfluß von Schlafmitteln wie nach Verabreichung größerer Bromgaben. Pflügers Arch. ges. Physiol. 158, 235–251 (1914).

    Google Scholar 

  • Blockus, L. E., and G. M. Everett: Tremor producing drug 1,4 dipyrrolidino-2-butyne (“Tremorme”). Fed. Proc. 16, 283 (1957).

    Google Scholar 

  • Blum, B., and S. Zacks: Analysis of the relationship between drug-induced convulsions and mortality in rats. J. Pharmacol. exp. Ther. 124, 350–356 (1958).

    PubMed  CAS  Google Scholar 

  • Borek, E., A. Brecher, G. A. Jervis and H. Waelsch: Oligophrenia phenylpyruvica. II. Constancy of the metabolic error. Proc. Soc. exp. Biol. (N. Y.) 75, 86–89 (1950).

    CAS  Google Scholar 

  • Bouma, J.: Über Gewöhnungsversuche mit Kodein. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 50, 353–360 (1903).

    Google Scholar 

  • Bovet, D., and V. G. Longo: The action on nicotine-induced tremors of substances effective in parkinsonism. J. Pharmacol. Ther. 102, 22–30 (1951).

    CAS  Google Scholar 

  • Boyd, E. M.: Chlorpromazine tolerance and physical dependence. J. Pharmacol. exp. Ther. 128, 75–78 (1960).

    PubMed  CAS  Google Scholar 

  • Brock, N., D. Lorenz U. H. Veigel: Beitrag zur Wirkung von Antihistamin-Substanzen. II. Zur Pharmakologie des Systral. Arzneimittel-Forsch. 4, 262–268 (1954).

    CAS  Google Scholar 

  • Brodie, B. B., L. C. Mark, P. A. Lief, E. Bernstein and E. M. Papper: Acute tolerance to thiopental. J. Pharmacol. exp. Ther. 102, 215–218 (1951).

    PubMed  CAS  Google Scholar 

  • Broom, W. A., M. R. Gurd and G. L. M. Harmer: Effect of diet on toxicity to rabbits of the toxic factor from “agenized” flour. Nature (Lond.) 167, 772–773 (1951).

    CAS  Google Scholar 

  • van der Brook, M. S., and G. E. Cartland: J. Pharmacol. exp. Ther. 80, 119 (1944); zit. bei Ch. M. Gruber and G. F. Keyser: J. Pharmacol. exp. Ther. 86, 186–196 (1946).

    CAS  Google Scholar 

  • Brown, W. C.: Unveröffenthcht. Zit. bei Swinyard U. Mitarb. (1952).

    Google Scholar 

  • — D. O. Schiffman, E. A. Swinyard and L. s. Goodman: Comparative assay of antiepileptic drugs by “psychomotor” seizure test and minimal electroshock threshold test. J. Pharmacol. exp. Ther. 107, 273–283 (1953).

    Google Scholar 

  • Brücke, F. Th.: Beiträge zur Pharmakologie des Bulbocapnins. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 179, 504–523 (1935).

    Google Scholar 

  • — Das Wesen der Bulbocapninstarre. Naunyna-Schmiedeberg’s Arch. exp. Path. Pharmak. 182, 324–330 (1936).

    Google Scholar 

  • Bruns, F., F. Hahn U. W. Schild: Untersuchungen zur Pharmakologie der Wärmeregulation. I. Mitteilung. Über den Wirkungsmechanismus und die Angriffspunkte der Narkotika, Krampfgifte und Antipyretika. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 209, 104–129 (1950).

    CAS  Google Scholar 

  • Buchman, E. F., and C. P. Richter: Abolition of bulbocapnine catatonia by cocaine. A. M. A. Arch. Neurol. Psychiat. 29, 499–503 (1933).

    Google Scholar 

  • Büch, O.: Zur antikonvulsiven Wirkung des kurzwirkenden Injektionsnarkoticums 2-Methoxy-4-allylphenoxyessigsäure-N,N-diäthylamid (G 29505). Arch. int. Pharmacodyn. 114, 439–445 (1958).

    PubMed  Google Scholar 

  • Burns, R. H., D. A. Mc Carthy, G. A. Deneau and M. H. Seevers: Comparison of dose dependent effects of nalorphine with those of levallorphan in production of graded abstinence in morphine dependent monkeys. Fed. Proc. 17, 355 (1958).

    Google Scholar 

  • Butler, J. A. V., and G. L. Mills: Concentration of the toxic substance from “agenized” flour. Nature (Lond.) 163, 835–836 (1949).

    CAS  Google Scholar 

  • Butler, T. C., C. Mahaffee and W. J. Waddell: Phenobarbital: Studies of elimination, tolerance, and dosage schedules. J. Pharmacol. exp. Ther. 111, 425–435 (1954).

    PubMed  CAS  Google Scholar 

  • Cahen, R.: Hyposensibilité cellulaire acquise vis-a-vis de la morphine. Arch. int. Pharmacodyn. 53, 426–456 (1936).

    CAS  Google Scholar 

  • Cahen, R. L.: Action of nicotinic stimulant agents on rabbit skeletal muscle. I. Nicotine and acetylcholine. Proc. Soc. exp. Biol. (N. Y.) 84, 474–476 (1953).

    CAS  Google Scholar 

  • — E. Groskinsky and P. Parisek: Comparative effect of morphine and morphine derivatives on chemically induced convulsant seizures. J. Pharmacol. exp. Ther. 119, 137 (1957).

    Google Scholar 

  • —, and T. E. Lynes: Nicotinolytic drugs. I. Drugs inhibiting nicotine-induced tremors. J. Pharmacol. exp. Ther. 103, 44–53 (1951).

    Google Scholar 

  • — — Nicotinolytic drugs. II. Action of adrenergic blocking agents on nicotine-induced tremors. J. Pharmacol. exp. Ther. 107, 424–436 (1953).

    Google Scholar 

  • Camp, W. J. R.: The pharmacology of cardiazol. J. Pharmacol. exp. Ther. 33, 81–92 (1928).

    CAS  Google Scholar 

  • Campbell, P. N., T. S. Work and E. Mellanby: Isolation of a crystalline toxic factor from agenized wheat flour. Nature (Lond.) 165, 345–346 (1950).

    CAS  Google Scholar 

  • Carmichael, E. B., and L. C. Posey: Observations on effect of repeated administration of nembutal in guinea pigs. Proc. Soc. exp. Biol. (N. Y.) 30, 1329–1330 (1933).

    Google Scholar 

  • Carter, R. L., and A. Wikler: Use of N-allylnormorphine in early demonstration of physical dependence on potent analgesic in dogs. Fed. Proc. 13, 342 (1954).

    Google Scholar 

  • — — Chronic meperidine intoxication in intact and chronic spinal dogs. Fed. Proc. 14, 325 (1955).

    Google Scholar 

  • Chakravarti, M.: A quantitative comparison of different analeptics. J. Pharmacol. exp. Ther. 67, 153–174 (1939).

    CAS  Google Scholar 

  • Chen, G.: The anti-tremorine effect of some drugs as determined by Haffner’s method of testing analgesia in mice. J. Pharmacol. exp. Ther. 124, 73–76 (1958).

    PubMed  CAS  Google Scholar 

  • —, and B. Bohner: A study of the neuropharmacologic properties of certain convulsants, anticonvulsants and reserpine. J. Pharmacol. exp. Ther. 117, 142–147 (1956).

    Google Scholar 

  • — — A study of central nervous system stimulants. J. Pharmacol. exp. Ther. 123, 212–215 (1958).

    Google Scholar 

  • — — and C. R. Ensor: Evaluation of five methods for testing anticonvulsant activities. Proc. Soc. exp. Biol. (N. Y.) 87, 334–339 (1954b).

    Google Scholar 

  • — C. R. Ensor and B. Bohner: A facilitation action of reserpine on the central nervous system. Proc. Soc. exp. Biol. (N. Y.) 86, 507–510 (1954a).

    Google Scholar 

  • — — — Anticonvulsant effects of certain CNS depressants on convulsions induced by strychnine, metrazol or caffeine. Arch. int. Pharmacodyn. 104, 333–338 (1956).

    Google Scholar 

  • Cheymol, J., et J. Thuillier: Anticonvulsants et crises toxiques chez la souris. Arch. int. Pharmacodyn. 83, 593–601 (1950).

    PubMed  CAS  Google Scholar 

  • Chin, L., and E. A. Swinyard: Tolerance and withdrawal hyperexcitability induced in mice by chronic administration of phenaglycodol. Proc. Soc. exp. Biol. (N. Y.) 97, 251–254 (1958).

    CAS  Google Scholar 

  • Chu, Wei-Chang, and R. L. Driver: Effects of some old and proposed anticonvulsants on the threshold for electrical convulsions. Proc. Soc. exp. Biol. (N. Y.) 64, 245–248 (1947).

    CAS  Google Scholar 

  • Chusid, J. G., L. M. Kopeloff and N. Kopeloff: Reserpine (Serpasil) effects on epileptic monkeys. Proc. Soc. exp. Biol. (N. Y.) 88, 276–277 (1955).

    CAS  Google Scholar 

  • Cochin, J., and J. A. Axelrod: Analgesic response and N-dealkylation of narcotics after short-term administration of morphine, nalorphine and normorphine. Fed. Proc. 17, 359 (1958).

    Google Scholar 

  • — — Biochemical and pharmacological changes in the rat following chronic administration of morphine, nalorphine and normorphine. J. Pharmacol. exp. Ther. 125, 105–110 (1959).

    Google Scholar 

  • — C. C. Gruhzit, L. A. Woods and M. H. Seevers: Further observations on addiction to methadon in the monkey. Proc. Soc. exp. Biol. (N. Y.) 69, 430–431 (1948).

    Google Scholar 

  • — J. Haggart, L. A. Woods and M. H. Seevers: Plasma levels, urinary and fecal excretion of morphine in non-tolerant and tolerant dogs. J. Pharmacol. exp. Ther. 111, 74–83 (1954).

    Google Scholar 

  • —, and C. Kornetsky: A comparison of the effects of chronic morphine administration on analgesic response and swimming time in the rat. J. Pharmacol. exp. Ther. 122, 12A–13A (1958).

    Google Scholar 

  • Cole, J., and P. Glees: Ritalin as an antagonist to reserpine in monkeys. Lancet 270, 338 (1956).

    PubMed  CAS  Google Scholar 

  • Conrad, E. A., G. H. Armstrong and J. M. Little: Factors affecting seizures in mice induced by the oral administration of pentylenetetrazol. J. Pharmacol. exp. Ther. 122, 14 (1958).

    Google Scholar 

  • Courvoisier, S., R. Ducrot, J. Fournel et L. Julou: Propriétés pharmacodynamiques générales de la prochlorpémazine (6. 140 R.P.). C. R. Soc. Biol. (Paris) 151, 1144–1148 (1957b).

    Google Scholar 

  • — — et L. Julou: Nouveaux aspects expérimentaux der l’activité centrale des dérivés de la phénothiazine. In: S. Garattini and V. Ghetti: Psychotropic Drugs. p. 373–391. Elsevier Publishing Company, 1957 (a).

    Google Scholar 

  • Dahlbom, R., T. Edlund, T. Ekstrand and A. Katz: The ability of some phenothiazine derivatives to inhibit nicotine-induced tremors. Arch. int. Pharmacodyn. 90, 241–250 (1952).

    PubMed  CAS  Google Scholar 

  • Dallemagne, M. J.: L’accoutumance expérimentale a l’évipan et au numal. Arch. int. Pharmacodyn. 65, 52–62 (1941).

    CAS  Google Scholar 

  • Dasler, W.: Production by semicarbazide of gross skeletal changes in rats similar to osteola-thyrism. Proc. Soc. exp. Biol. (N. Y.) 97, 112–114 (1958).

    CAS  Google Scholar 

  • Davenport, V. D., and H. W. Davenport: J. Nutr. 36, 139 (1948); zit. bei Woodbury and Davenport (1952).

    PubMed  CAS  Google Scholar 

  • Davis, H., C. H. Hine, M. W. Neal, H. E. Christensen and F. J. Murphy: Some pharmacologic comparisons of l-ethoxy-3-isopropoxy-propane-2-ol and 3-(2′-methylphenoxy)-propane-l,2-diol (Myanesin). Arch. int. Pharmacodyn. 89, 145–159 (1952).

    PubMed  CAS  Google Scholar 

  • Decsi, L., M. Várszegi and J. Méhes: Tolerance to tremorine. J. Pharm. (Lond.) 13, 127 (1961).

    CAS  Google Scholar 

  • de Jong, H.: Über Bulbocapnin-Katalepsie. Klin. Wschr. 1, 684–685 (1922).

    Google Scholar 

  • — Experimental catatonia in a chimpanzee. Proc. Soc. exp. Biol. (N. Y.) 41, 395–396 (1939).

    Google Scholar 

  • —, et H. Baruk: Étude comparative expérimentale et clinique des manifestations du syndrome catatonique. Rev. neurol. 1, 21–34 (1929a).

    Google Scholar 

  • — — Études sur la catatonie expérimentale. L’épreuve de la bulbocapnine chez les singes. Comparaison des stades de l’intoxication bulbocapninique avec les aspects de la Catatonie humaine. Rev. neurol. 2, 541–547 (1929b).

    Google Scholar 

  • — — La Catatonie Expérimentale par la Bulbocapnine. Étude physiologique et clinique. Paris: Masson et Cie. 1930.

    Google Scholar 

  • —, and E. Chase: Emontial expressions of cats in bulbocapnine catatonia. J. nerv. ment. Dis. 98, 478–484 (1934).

    Google Scholar 

  • de Jong, H. H.: Experimental Catatonia. A General Reaction-Form of the Central Nervous System and Its Implications for Human Pathology. Baltimore: Wilhams & Wilkins Company 1945.

    Google Scholar 

  • de Jongh, D. K.: An apparatus for the induction of supramaximal electroshock seizures in groups of ten mice. Acta physiol. pharmacol. neerl. 6, 511–514 (1957).

    Google Scholar 

  • —, and E. G. van Proosdij-Hartzema: Anticonvulsant activity of a series of substituted acetamides and thioacetamides. Acta physiol. pharmacol. neerl. 5, 485–488 (1957).

    Google Scholar 

  • Delay, Denkier, Ropert, Beck, Barande et Eurieult: Presse méd. 67, 123 (1959) ; zit. bei M. W. Parkes: Tranquillizers. In: G. P. Ellis and G. B. West: Progress in medicinal chemistry. Vol. I., p. 72–131. Butterworths 1961.

    PubMed  CAS  Google Scholar 

  • Delay, J., P. Pichot, J. Thuillier et J.-P. Marquiset: Action de I’aminodipropionitrile sur le comportement moteur de la souris blanche. C. R. Soc. Biol. (Paris) 146, 533–534 (1952).

    CAS  Google Scholar 

  • Deneau, G., J. Kissel and M. H. Seevers: Influence of frequency of administration on development of physical dependence to analgesics in monkey. Fed. Proc. 13, 347 (1954).

    Google Scholar 

  • Deneau, G., and M. H. Seevers: Thresholds of electrical excitability and electrograms in monkeys with permanently implanted cortical and subcortical electrodes during a cycle of morphine “addiction”. Fed. Proc. 17, 362 (1958).

    Google Scholar 

  • Detrick, L. E., and C. H. Thienes: Tissue hydration during morphine addiction and withdrawal in rats on low calcium diet and on high calcium diet with parathyroid hormone injection. Arch. int. Pharmacodyn. 66, 130–137 (1941).

    CAS  Google Scholar 

  • Deuel, H. J., W. H. Chambers and A. J. Milhorat: J. biol. Chem. 69, 249 (1926); zit. bei Gruber, Ch. M., and G. F. Keyser: J. Pharmacol. exp. Ther. 86, 186–196 (1946).

    CAS  Google Scholar 

  • Dietrich, S., u. H. Ebster: Über den Einfluß von Muskelkrämpfen auf die Gase und die Reaktion des Blutes nebst einer Bemerkung über den Mechanismus des Strychnintodes. Arch. exp. Path. Pharmak. 129, 339–353 (1928).

    CAS  Google Scholar 

  • Divry, et Evrard: Reserches sur certaines substances antagonistes de la bulbocapnine. J. belge Neurol. Psychiat. 34, 506–523 (1934).

    Google Scholar 

  • Dongen, K. van: Beiträge zur Frage der Morphingewöhnung. Pflügers Arch. ges. Physiol. 162, 54–66 (1915).

    Google Scholar 

  • Dundee, J. W., H. J. Price and R. D. Dripps: Brit. J. Anaesth. 28, 344 (1956), zit. bei Maynert, E. W. and G. I. Klingman: J. Pharmacol. exp. Ther. 128, 192–200 (1960).

    PubMed  CAS  Google Scholar 

  • Eddy, N. B.: The effect of the repeated administration of diethyl barbituric acid and of cyclohexenyl-ethyl barbituric acid. J. Pharmacol. exp. Ther. 37, 261–271 (1929).

    CAS  Google Scholar 

  • —, and J. G. Reid: Studies of morphine, codeine and their derivatives. VII. Dihydromorphine (paramorphan), dihydromorphinone (dilaudid), and dihydrocodeinone (dicodid). J. Pharmacol. exp. Ther. 52, 468–493 (1934).

    Google Scholar 

  • Egmond, A. A. J. van: Über die Wirkung des Morphins auf das Herz. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 65, 197–213 (1911).

    CAS  Google Scholar 

  • Ehrlich, P.: Chemotherapeutische Trypanosomen-Studien. Berl. klin. Wschr. 44, 280–283 (1907).

    Google Scholar 

  • Eichholtz, F., H. Veigel u. J. Seeman: Der Antagonismus von convulsiven und spasmo-lytischen Substanzen. Naunyn-Schmiedeberg’s Aich. exp. Path. Pharmak. 76, 127–140 (1948).

    Google Scholar 

  • Elithorn, A., D. M. Johnson and M. A. Crosskey: Effects of agenized flour on man. Lancet 1949 I, 143.

    Google Scholar 

  • Essig, C. F., and J. D. Ainslie: Addiction to meprobamate (equanil, miltown). J. Amer. med. Ass. 164, 1382 (1957).

    Google Scholar 

  • —, and A. Wikler: Prevention of barbiturat withdrawal in cats by cerebral electrostimulation. Fed. Proc. 15, 59 (1956).

    Google Scholar 

  • Ettinger, G. H.: The duration of anaesthesia produced in the dog by the repeated administration of dial and nembutal. J. Pharmacol. exp. Ther. 63, 82–87 (1938).

    Google Scholar 

  • Everett, G. M.: Tremor produced by drugs. Nature (Lond.) 177, 1238 (1956a).

    CAS  Google Scholar 

  • — A study of tremor and the Parkinson-like syndrome produced by 1,4-dipyrrolidino-2-butyne, “Tremorine”. XXth International Physiological Congress, Brussels, 1956, Abstracts of Communications, p. 281–282 (b).

    Google Scholar 

  • — L. E. Blockus and I. M. Shepperd: Tremor induced by tremorine and its antagonism by anti-parkinson drugs. Science 124, 79 (1956a).

    Google Scholar 

  • — — — and J. E. Toman: Production of tremor and a Parkinson-like syndrome by 1–4 dipyrrolidino-2-butyne, “Tremorine.” Fed. Proc. 15, 420–421 (1956b).

    Google Scholar 

  • —, and R. K. Richards: Pharmacological studies of phenacetylurea (phenurone), an anticonvulsant drug. J. Pharmacol. exp. Ther. 106, 303–313 (1952).

    Google Scholar 

  • Evrard, E., U. E. A. Spiegel: Durchbrechung der Bulbocapnin-Katalepsie durch Cocain. Z. ges. Neurol. Psychiat. 138, 197–202 (1932).

    Google Scholar 

  • Faust, E. S.: Über die Ursachen der Gewöhnung an Morphin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 44, 217–238 (1900).

    Google Scholar 

  • Fazio, C., and U. Sacchi: Experimental catalepsy produced by substances introduced into subarachnoid spaces and ventricles. In: S. Garattini and V. Ghetti: Psychotropic Drugs. Elsevier Publishing Company, 1957, p. 104–109.

    Google Scholar 

  • Feer, H., U. P. G. Waser: Beziehungen zwischen der chemischen Struktur und der antikonvulsiven Wirksamkeit einiger bromierter Hydantoine. Helv. physiol. pharmacol. Acta 14, 29–36 (1956).

    PubMed  CAS  Google Scholar 

  • Feldberg, W., and S. L. Sherwood: Behaviour of cats after intraventricular injections of eserine and DEP. J. Physiol. (Lond.) 125, 488–500 (1954).

    CAS  Google Scholar 

  • — — — Injections of bulbocapnine into the cerebral ventricles of cats. Brit. J. Pharmacol. 10, 371–374 (1955).

    Google Scholar 

  • Ferraro, A., and E. Barrera: Experimental Catalepsy. Utica, N. Y.: New York States Hospitals Press. 1932.

    Google Scholar 

  • Finnegan, J. K., H. B. Haag, P. S. Larson and M. L. Dreyfuss: Observations on the comparative actions of 6-dimethylamino-4,4-diphenyl-3-heptanone (amidone) and mor-phine. J. Pharmacol. exp. Ther. 92, 269–276 (1948).

    PubMed  CAS  Google Scholar 

  • Fischer, J., Z. Lodin and J. Koloušek: A contribution to the histopathology of experimental seizures evoked by methionine sulfoximine (MSI). Proc. First Internat. Congr. of Neurol. Sci., Brusseles, Vol. III, p. 610–612 (1957).

    Google Scholar 

  • Fitch, R. H.: An experimental study of tolerance to barbiturates. J. Pharmacol. exp. Ther. 39, 266–267 (1930).

    Google Scholar 

  • Flury, F.: Beiträge zur Pharmakologie der Steppenraute (Peganum Harmala). Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 64, 105–125 (1911).

    CAS  Google Scholar 

  • Formanek, K., u. A. Lindner: Einfluß der Außentemperatur auf die Wirkung von Krampfgiften. Wien. med. Wschr. 110, 461–463 (1960).

    PubMed  CAS  Google Scholar 

  • Fränkel, S.: Chemie und Pharmakologie des Haschisch. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 49, 266–284 (1903).

    Google Scholar 

  • Fraser, H. F., and H. Isbell: Chronic intoxication of dogs with sodium barbital. Fed. Proc. 13, 355 (1954a).

    Google Scholar 

  • — — Abstinence syndrome in dogs after chronic barbiturate medication. J. Pharmacol. exp. Ther. 112, 261–267 (1954b).

    Google Scholar 

  • Fritsch, G., U. E. Hitzig: Über die elektrische Erregbarkeit des Großhirns. Virchows Arch. path. Anat. 1870, p. 300; zit. bei Schilf.

    Google Scholar 

  • Fröhlich, A., U. H. H. Meyer: Über die Dauerverkürzung der gestreiften Warmblütermuskeln. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 87, 173–188 (1920).

    Google Scholar 

  • Frommel, Ed., et I.T. Beck: Étude comparative de la marge thérapeutique entre les doses convulsivantes et mortelles de la coramine, du cyclitron, du cardiazol, de la strychnine, de la Picrotoxine et de la caféine. Schweiz. med. Wschr. 78, 1176–1178 (1948).

    PubMed  CAS  Google Scholar 

  • — C. Radouco, Ph. Gold, G. Greder, D. Melkonian, L. Strassberger, F. Vallette et M. Ducommun: Étallonnage de la toxicité et de la puissance de diverses substances anti-convulsivantes sur l’animal soumis au choc chimique. Arch. int. Pharmacodyn. 92, 44–70 (1952).

    Google Scholar 

  • Gardner, A. F.: Experimental lathyrism. Review of the literature. Amer. J. clin. Nutr. 7, 312–323 (1959).

    Google Scholar 

  • Garello, L., e G. Dolce: Boll. Soc. ital. biol. sper., Sezione di Genova, 1956; zit. bei C. Fazio and U. Sacchi (1957).

    Google Scholar 

  • Gerlich, N.: Experimentelle Studien über die Beziehungen zwischen Schilddrüse und Krampfbereitschaft. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 207, 159–172 (1949).

    Google Scholar 

  • Gessner, O.: Vergleichend-pharmakologische Untersuchungen über die analeptische Wirkung von Salamandrin, Pikrotoxin und Cardiazol. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 205, 1–20 (1948).

    CAS  Google Scholar 

  • Ginzel, K. H.: Vergleichende Untersuchung einiger antikonvulsiv wirksamer Glyzerinäther. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 212, 331–338 (1951).

    CAS  Google Scholar 

  • Girndt, O., u. G. Schaltenbrand: Beiträge zur Pharmakologie der Körperstellung und der Labyrinthreflexe. XVI. Mitteilung. Die Wirkung des Bulbocapnins auf Thalamuskatzen. Pflügers Arch. ges. Physiol. 209, 653–663 (1925).

    CAS  Google Scholar 

  • Gold, H.: On morphine habituation: Tolerance to the stimulant action of morphine. J. Pharmacol. exp. Ther. 35, 355–362 (1929).

    CAS  Google Scholar 

  • Goldin, A., H. A. Noe, B. H. Landing, D. M. Shapiro and B. Goldberg (with the technical assistance of R. A. Fugmann, M. A. Miller and A. J. Fisk): A neurological syndrome induced by administration of some chlorinated tertiary amines. J. Pharmacol. exp. Ther. 94, 249–261 (1948).

    PubMed  CAS  Google Scholar 

  • Goodman, L. S., M. S. Grewal, W. C. Brown and E. A. Swinyard: Comparison of maximal seizures evoked by pentylene-tetrazol (Metrazol) and electroshock in mice, and their modification by anticonvulsants. J. Pharmacol. exp. Ther. 108, 168–176 (1953a).

    CAS  Google Scholar 

  • — E. A. Swinyard and J. E. Toman: Effects of 1(+) glutamic acid and other agents on experimental seizures. A. M. A. Arch. Neurol. Psychiat. 56, 20–29 (1946).

    Google Scholar 

  • — — W. C. Brown, D. O. Schiffman, M. S. Grewal and E. L. Bless: Anticonvulsant properties of 5-phenyl-5-ethyl-hexahydropyrimidine-4,6-dione (mysoline), a new anti-epileptic. J. Pharmacol. exp. Ther. 108, 428–436 (1953b).

    Google Scholar 

  • — — — — Anticonvulsant properties of 5,5-diphenyl-tetrahydro-glyoxaline-4-one (SKP No. 2599). J. Pharmacol. exp. Ther. 109, 403–410 (1953c).

    Google Scholar 

  • — J. E. P. Toman and E. A. Swinyard: Anticonvulsant drugs: Mechanisms of action and methods of assay. Arch. int. Pharmacodyn. 78, 144–162 (1949).

    Google Scholar 

  • Gottlieb, R.: Vergleichende Messungen über die Gewöhnung des Atemzentrums an Morphin, Dicodid und Dilaudid. Münch. med. Wschr. 73, 595 (1926).

    Google Scholar 

  • Greig, M. E., R. A. Walk and A. J. Gibbons: Bulbocapnine catatonia in mice. Fed. Proc. 17, 373 (1958).

    Google Scholar 

  • Gros, O., u. H. T. A. Haas: Der Antagonismus der Narkotica gegen Cardiazol. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 182, 348–362 (1936).

    CAS  Google Scholar 

  • Gross, E. G., and R. M. Featherstone: Studies with tetrazole derivatives. I. Some pharmacologic properties of aliphatic substituted pentamethylene tetrazole derivatives. J. Pharmacol. exp. Ther. 87, 291–298 (1946).

    PubMed  CAS  Google Scholar 

  • —, and I. H. Pierce: Effect of morphine on the oxygen consumption of brain tissue in the rat. J. Pharmacol. exp. Ther. 53, 156–168 (1935).

    Google Scholar 

  • Gruber, Ch. M., and G. F. Keyser: A study on the development of tolerance and cross tolerance to barbiturates in experimental animals. J. Pharmacol. exp. Ther. 86, 186–196 (1946).

    PubMed  CAS  Google Scholar 

  • Grüneberg, H.: The Genetics of the Mouse. Cambridge Univerity Press, 1943.

    Google Scholar 

  • Grüninger, U.: Die Wirkung einmaliger und verteilter Morphingaben auf die Atmung des Kaninchens. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 126, 77–86 (1927).

    Google Scholar 

  • Gutierrez-Noriega, Rotondo y Alarco: An. Fac. Med. (Lima) 21, 263 (1939); zit. in „Cardiazol“, Knoll A.-G. Chemische Fabriken, Ludwigshafen am Rhein, 1951.

    Google Scholar 

  • Haas, H., U. W. Klavehn: Über 3-Piperidino-l-phenyl-l-bicycloheptenyl-propanol-(l) (Akineton). Naunyn-Schmiedeberg’s Arch. exp. Pharmak. 226, 18–35 (1955).

    CAS  Google Scholar 

  • Haeffer, F., U. F. Wind: Über Gewöhnung an Narkotika. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 116, 125–134 (1926).

    Google Scholar 

  • Hahn, F.: Vergleichende Untersuchungen über die Krampf- und Blutdruckwirkung einiger Analeptica an dekapitierten Katzen. Naunyn-Schmiedeberg–s Arch. exp. Path. Pharmak. 198, 509–527 (1941).

    CAS  Google Scholar 

  • — Untersuchungen über die Angriffspunkte von Cardiazol und Coramin. I. Über die Krampfund Weckwirkung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 205, 552–562 (1948).

    Google Scholar 

  • — Untersuchungen über die Angriffspunkte von Cardiazol und Coramin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 208, 29–31 (1949).

    Google Scholar 

  • — Analeptics. Pharmacol. Rev. 12, 447–530 (1960).

    Google Scholar 

  • Hanna, C.: A demonstration of morphine tolerance and physical dependence in the rat. Arch. int. Pharmacodyn. 124, 326–329 (1960).

    PubMed  CAS  Google Scholar 

  • Hara, S.: Pharmacological studies in the functions of the extrapyramidal system. Report No. 1. Jap. J. Pharmacol. 2, 127–138 (1953).

    PubMed  CAS  Google Scholar 

  • —, and K. Kawamori: Pharmacological studies on the function of the extrapyramidal system. Report No. 2. Mechanism of the appearance of tremor due to extrapyramidal poisons. Jap. J. Pharmacol. 3, 149–156 (1954).

    Google Scholar 

  • —, and Mori: Jap. J. med. Sci. Pharmacol. 7, 78–79 (1933); zit. bei A. G. Beer (1939a).

    Google Scholar 

  • Harned, B. K., R. W. Cunningham, M. C. Clark, C. H. Hine, M. M. Kane, F. H. Smith jr., R. E. Vessey, N. N. Yuda and F. W. Zabransky: The pharmacology of N-benzyl-beta-chloropropionamide (hibicon), a new anticonvulsant. J. Pharmacol. exp. Ther. 107, 403 bis 423 (1953).

    PubMed  CAS  Google Scholar 

  • Harris, H.: Human Biochemical Genetics. Cambridge University Press, 1959.

    Google Scholar 

  • Hartmann, H. A., and H. F. Stich: Psychopathologic symptoms induced by bis-beta-amino-propionitrile. Science 125, 445 (1957).

    PubMed  CAS  Google Scholar 

  • Hatcher, R. A., and H. Gold: The mechanism of morphine habituation. J. Pharmacol. exp. Ther. 35, 257–279 (1929).

    CAS  Google Scholar 

  • Hausmann, W.: Zur Kenntnis der chronischen Morphinvergiftung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 52, 315–325 (1905).

    Google Scholar 

  • Henry, G. W.: Experimental catatonia in birds. Psychiat. Quart. 5, 68–81 (1931).

    Google Scholar 

  • —, and H. de Jong: A comparative study of the action of bulbocapnine and some other drugs in producing catatonic states. Acta psychiat. (Kbh.) 5, 463–471 (1930).

    Google Scholar 

  • Helaers, E.: Contribution a l’étude de divers analeptiques respiratoires chez le lapin normal ou intoxiqué par la morphine ou le somnifène. Arch. int. Pharmacodyn. 35, 221–265 (1929).

    Google Scholar 

  • Herken, H.: Änderungen von Zellfunktionen im Nervensystem durch Hexachlorcyclohexan. (Untersuchungen am Warmblütler.) Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 211, 143–152 (1950).

    CAS  Google Scholar 

  • — Eingriffe am Nervensystem mit Hexachlorcyclohexan. Arzneimittel-Forsch. 1, 356–359 (1951).

    Google Scholar 

  • Herrmann, O.: Eine biologische Nachweismethode des Morphins. Biochem. Z. 39, 216–231 (1912).

    Google Scholar 

  • Hewetson, H. R.: Vet. Rec. 48, 1202 (1936); zit. bei Newell U. Mitarb. (1948).

    Google Scholar 

  • Heymans, C., and J. J. Estable: On new nicotinolytic compounds. Science 109, 122 (1949).

    PubMed  CAS  Google Scholar 

  • — — et S. Castillo de Bonneveaux: Sur la pharmacologie de la phénothiazinyl-éthyl-diéthylamine (2987 R.P.). Arch. int. Pharmacodyn. 79, 123–138 (1949a).

    Google Scholar 

  • — — — Nicotinolytic action of diethylaminoethylphenothiazine (2987 R.P. or Diparcol). Arch. int. Pharmacodyn. 79, 185–188 (1949b).

    Google Scholar 

  • Heymans, C., et G. R. de Vleeschhouwer: Actions pharmacologiques de l’ester diéthyl-aminoéthylique de l’acide phényl-cyclopentane-carboxylique (Parpanit). Arch. int. Pharmacodyn. 75, 307 bis 324 (1948).

    PubMed  CAS  Google Scholar 

  • Hildebrandt, F.: Über Veränderungen des Stoffwechsel nach chronischer Morphinzufuhr. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 92, 68–96 (1922).

    CAS  Google Scholar 

  • — Pentamethylentetrazol (Cardiazol). I. Mitteilung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 116, 100–109 (1926).

    Google Scholar 

  • Himmelsbach, C. K., G. H. Gerlich and E. J. Stanton: A method for testing addiction, tolerance and abstinence in the rat. Results of its application to several morphine alkaloids. J. Pharmacol. exp. Ther. 53, 179–188 (1935).

    Google Scholar 

  • —, and L. F. Small: Clinical studies of drug addiction. II. “Rossium” treatment of drug addiction. Publ. Hlth Rep. Suppl. No. 125 (1937).

    Google Scholar 

  • Hoff, H., U. O. Kauders: Über chronische experimentelle Medinalintoxikation. Z. ges. Neurol. Psychiat. 103, 176–184 (1926).

    Google Scholar 

  • Hofmann, A.: Inaug. Diss. Gießen 1906.

    Google Scholar 

  • Hotovy, R.: Zur Pharmakologie des Belladonnins. Arzneimittel-Forsch. 4, 287–292 (1954).

    CAS  Google Scholar 

  • Hubbard, T. F., and L. R. Goldbaum: The mechanism of tolerance to thiopental in mice. J. Pharmacol. exp. Ther. 97, 488–491 (1949).

    PubMed  CAS  Google Scholar 

  • Ingram, W. R., and S. W. Ranson: Bulbocapnine. Effect of animals with lesions of the central nervous system. A. M. A. Arch. Neurol. Psychiat. 31, 987–1006 (1934).

    Google Scholar 

  • Irwin, S., and M. H. Seevers: Comparative study of regular and N-allylnormorphine induced withdrawal in monkeys addicted to morphine, 6-methyldihydromorphine, Dromoran, methadone and ketobemidone. J. Pharmacol. exp. Ther. 106, 397 (1952).

    Google Scholar 

  • — M. Slabok, P. L. Debiase and W. M. Govier: Perphenazine (Trilafon), a new potent tranquilizer and antiemetic: I. Behavior profile, acute toxicity and behavioral mode of action. Arch. int. Pharmacodyn. 118, 358–374 (1959).

    Google Scholar 

  • Isbell, H., and H. F. Fraser: Addiction to analgesics and barbiturates. Pharmacol. Rev. 2, 355–397 (1950).

    Google Scholar 

  • — A. Wikler, N. B. Eddy, J. L. Wilson and C. F. Moran: Tolerance and addiction liability of 6-dimethylamino-4,4-diphenyl-heptanone-3 (methadon). J. Amer. med. Ass. 135, 888 bis 894 (1947).

    Google Scholar 

  • Jellinek, ST.: Elektropathologische Versuche mit Gleichstrom. Med. Klin. 1920, Nr. 44, S. 1128; zit. bei Schilf.

    Google Scholar 

  • Jenney, E. H., and C. C. Pfeiffer: Ann. N. Y. Acad. Sci. 64, 679 (1956); zit. bei Mitchell and Keasling.

    PubMed  CAS  Google Scholar 

  • Jervis, G. A.: Studies on phenylpyruvic oligophrenia. The position of the metabolic error. J. biol. Chem. 169, 651–656 (1947).

    PubMed  CAS  Google Scholar 

  • — Excretion of phenylalanine and derivatives in phenylpyruvic oligophrenia. Proc. Soc. exp. Biol. (N. Y.) 75, 83–86 (1950).

    Google Scholar 

  • — Phenylpyruvic oligophrenia deficiency of phenylalanine-oxidizing system. Proc. Soc. exp. Biol. (N. Y.) 82, 514–515 (1953).

    Google Scholar 

  • — R. J. Block, D. Bolling and E. Kanze: Chemical and metabolic studies on phenylalanine. II. The phenylalanine content of the blood and spinal fluid in phenylpyruvic oligophrenia. J. biol. Chem. 134, 105–113 (1940).

    Google Scholar 

  • Joël, E.: Beiträge zur Pharmakologie der Körperstellung und der Labyrinthreflexe. XIII. Mitteilung. Haschisch. Pflügers Arch. ges. Physiol. 209, 526–536 (1925).

    Google Scholar 

  • —, u. A. Ettinger: Zur Pathologie der Gewöhnung. III. Mitteilung: Experimentelle Studien über Morphingewöhnung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmakol. 115, 334 bis 350 (1926).

    Google Scholar 

  • Kadoyama, Ch.: Wirkung des Harmans auf das Zentralnervensystem. Tôkohu J. exp. Med. 17, 1–9 (1931); ref. Ber. ges. Physiol. 61, 818; zit. bei A. G. Beer (1939a).

    CAS  Google Scholar 

  • Kaelber, W. W., and R. J. Joynt: Tremor production in cats given chlorpromazine. Proc. Soc. exp. Biol. (N. Y.) 92, 399–402 (1956).

    CAS  Google Scholar 

  • Kaufman, M. R., u. E. A. Spiegel: Experimentelle Analyse der Beeinflussung katatoner Zustände durch Einatmen von Kohlensäure-Sauerstoffmischungen. Z. ges. Neurol. Psychiat. 127, 312–320 (1930).

    Google Scholar 

  • Kaymakcalan, S., and L. A. Woods: Response of morphine-tolerant dogs and rats to methimazole and/or nalorphine. Fed. Proc. 13, 373 (1954).

    Google Scholar 

  • — — Nalorphine-induced “abstinence syndrome” in morphine-tolerant albino rats. J. Pharmacol. exp. Ther. 117, 112–116 (1956).

    Google Scholar 

  • Keasling, H. H., E. G. Gross, F. A. D. Alexander, C. Hirschler and L. Marshall: The effect of chronic morphine administration on tooth pulp thresholds in dogs. J. Pharmacol. exp. Ther. 126, 345–348 (1959).

    PubMed  CAS  Google Scholar 

  • Keeser, E., H. A. Oelkers U. W. Raetz: Über das Schicksal des Morphins im Tierkörper. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 173, 622–632 (1933).

    CAS  Google Scholar 

  • Kennedy, A.: The effect of cardiazol convulsions on the so-called“Bulbocapnine-Catatonia” in the monkey. J. Neurol. Psychiat. 2, 115–124 (1939).

    CAS  Google Scholar 

  • Kennedy, W. P.: Sodium salt of C-C-cyclohexenylmethyl-N-methyl barbituric acid (evipan) anaesthesia in laboratory animals. J. Pharmacol. exp. Ther. 50, 347–353 (1934).

    CAS  Google Scholar 

  • Kewitz, H., U. H. Reinert (unter Mitarbeit von G. Schaeffer U. F. Massberg): Zum Nachweis von Funktionsänderungen im Zentralnervensystem durch elektrisch und chemisch induzierte Krämpfe. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 215, 93–99 (1952).

    CAS  Google Scholar 

  • Kobayashi, A.: Über die Morphingewöhnung und die dabei beobachtete erregende Wirkung des Morphins. Jap. J. med. Sci., Trans IV., Pharmacol. 4, 189 (1930); ref. Ber. Physiol. 57, 505.

    Google Scholar 

  • Kobinger, W.: Förderung von Streckkrämpfen und experimentelle Katatonie. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 236, 123–124 (1959).

    CAS  Google Scholar 

  • Koch, R.: Audiogene sowie durch Pentamethylentetrazol und Strychnin hervorgerufene Krämpfe bei adrenalektomierten Ratten. Arzneimittel-Forsch. 8, 90–92 (1958).

    CAS  Google Scholar 

  • —, u. U. Hagen: Vergleichende toxikologische Untersuchungen an Cysteaminderivaten und entsprechenden Aminoalkoholen. Arch. int. Pharmacodyn. 109, 108–120 (1957).

    Google Scholar 

  • Kohn, R., u. M. Jacobi: Untersuchungen über qualitative und quantitative Beziehungen zwischen Schlafmitteln und Analepticis. Arch. Naunyn-Schmiedeberg’s exp. Path. Pharmak. 179, 448–458 (1935).

    CAS  Google Scholar 

  • Kok, D. J.: L’intoxication aigue par la bulbocapnine chez le chien. Proc. roy. Acad. Sci. Amst. 37, 357–361 (1934).

    Google Scholar 

  • Komlos, E., u. I. Földes: Ausbildung bedingter Reflexe während Morphingewöhnung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 229, 463–468 (1956).

    Google Scholar 

  • Koopman, J.: Studies on morphinism. Arch. int. Pharmacodyn 29, 19–30 (1924).

    Google Scholar 

  • Kornetsky, C., J. Cochin and E. Kammen: Protracted tolerance to morphine in the rat. Fed. Proc. 18, 411 (1958).

    Google Scholar 

  • Kouzmanoff, S. P., and R. Tislow: Experimental states of catatonia elicited by bulbocapnine and some phenothiazine compounds. Fed. Proc. 17, 385 (1958).

    Google Scholar 

  • Krause, F., U. H. de Jong: Über die Lokalisation einiger motorischer Erscheinungen bei der Bulbocapnin-Katatonie. Z. ges. Neurol. Psychiat. 133, 754–761 (1931).

    Google Scholar 

  • Krisch, H., U. E. A. Spiegel: Sichtbarmachung latenter, experimentell hervorgerufener Tonusstörungen mit Bulbocapnin. Z. ges. Neurol. Psychiat. 122, 535–544 (1929).

    Google Scholar 

  • Krueger, H., N. B. Eddy and M. Sumwalt: The pharmacology of the opium alkaloids. Publ. Hlth. Rep. Suppl. No 165, 1941.

    Google Scholar 

  • Kun, E., and L. G. Abood: “In vivo” action of morphine, urethane and phenobarbital on the glycogen synthesis from glucose in the rat liver. Arch. int. Pharmacodyn. 80, 51–61 (1949).

    PubMed  CAS  Google Scholar 

  • Laffan, R. J., E. A. Swinyard and L. S. Goodman: Stimulus intensity, maximal electro-shock seizures, and potency of anticonvulsants in rats. Arch. int. Pharmacodyn. 111, 60–69 (1957).

    PubMed  CAS  Google Scholar 

  • Lambert, P.-A., S. Courvoisier et L. Julou: Notes sur l’activité neuroleptique d’un dérivé phénothiazine à propriété pure. Étude pharmacodynamique et clinique de la diméthyl-sulfamido-3[(Méthylsulfonyl-4″-Piperazino)3′Tropyl]-10 Phé;nothiazine (9.260 R. P.). Psychopharmacologia 2, 209–213 (1961).

    PubMed  CAS  Google Scholar 

  • Langer, H.: Über Heroinausscheidung und -gewöhnung. Biochem. Z. 45, 221–238 (1912).

    Google Scholar 

  • Langley, J. N.: On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J. Physiol. (Lond.) 33, 374–413 (1905).

    Google Scholar 

  • —, and W. L. Dickinson: Pituri and nicotin. J. Physiol. (Lond.) 11, 265–306 (1890).

    Google Scholar 

  • Laurence, D. R., and R. S. Stagey: The effect of methonium compounds on nicotine convulsions. Brit. J, Pharmacol. 7, 80–84 (1952).

    CAS  Google Scholar 

  • Lending, M., L. B. Slobody and J. Mestern: Effect of prolonged convulsions on the blood-cerebrospinal fluid barrier. Amer. J. Physiol. 197, 465–468 (1959).

    PubMed  CAS  Google Scholar 

  • Lenke, D.: Narkosepotenzierende und analgetische Wirkung von l,4-Dipyrrolidino-2-butin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 234, 35–45 (1958).

    CAS  Google Scholar 

  • Lessin, A. W., and M. W. Parkes: The effects of reserpine and other agents upon leptazol convulsions in mice. Brit. J. Pharmacol. 14, 108–111 (1959).

    PubMed  CAS  Google Scholar 

  • Levy, B. M.: New method for rapid determination of lathyrogenic agents. Science 129, 720 (1959).

    PubMed  CAS  Google Scholar 

  • Lewin, L.: Untersuchungen über Banisteria Caapi Spr. (Ein südamerikanisches Rauschmittel). Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 129, 133–149 (1928).

    CAS  Google Scholar 

  • Lewis, J. R.: The development of tolerance in rats to some new synthetic analgesics. J. Pharmacol. exp. Ther. 96, 31–37 (1949).

    PubMed  CAS  Google Scholar 

  • Liberson: Yale J. Biol. Chem. 17, 572 (1945); zit. bei Woodbury U. Swinyard (1947).

    Google Scholar 

  • Lodin, Z., and K. Koloušek: The metabolism of methionine and methionine sulfoximine function of the central nervous system. XXth Internat. Physiol. Congr., Bruxelles, Abstr. of Comm. 583–584 (1956).

    Google Scholar 

  • Loewe, S.: Studies on the pharmacology and acute toxicity of compounds with marihuana activity. J. Pharmacol. exp. Ther. 88, 154–161 (1946).

    PubMed  CAS  Google Scholar 

  • — Cannabiswirkstoffe und Pharmakologie der Cannabinole. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 211, 175–193 (1950).

    Google Scholar 

  • Mac Kay, E. M.: The relation of acquired morphine tolerance to the adrenal cortex. J. Pharmacol. exp. Ther. 43, 51–60 (1931).

    CAS  Google Scholar 

  • Maloney, A. H.: An analysis of the stimulant-depressant action of caffeine, coramine and metrazol (cardiazol) based on experimental data. Arch. int. Pharmacodyn. 52, 373–380 (1935).

    Google Scholar 

  • Marshall, P. G., and D. K. Vallance: Anticonvulsant activity. Derivatives of succinimide, glutarimide, thiazolidinedione and methanol, and some miscellaneous compounds. J. Pharm. (Lond.) 6, 740–746 (1954).

    CAS  Google Scholar 

  • Masuda, M., R. N. Budde and J. M. Dille: J. Amer. pharm. Ass. 27, 830 (1938); zit. bei Ch. M. Gruber and G. F. Keyser: J. Pharmacol. exp. Ther. 86, 186–196 (1946).

    CAS  Google Scholar 

  • Matschulan, G.: Jahresrhythmen in Entwicklung und Verlauf der Morphingewöhnung und Entwölnung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 186, 113–117 (1937a).

    Google Scholar 

  • — Abhängigkeit der Morphingewöhnung und -entwöhnung von der Ernährimg. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 187, 230–233 (1937b).

    Google Scholar 

  • Maynert, E. W., and G. I. Klingman: Acute tolerance to intravenous anesthetics in dogs. J. Pharmacol. exp. Ther. 128, 192–200 (1960).

    Google Scholar 

  • —, and L. Losin: The metabolism of butabarbital (butisol) in the dog. J. Pharmacol. exp. Ther. 115, 275–282 (1955).

    Google Scholar 

  • Mcquarrie, D. G., and E. Fingl: Hyperexcitability in mice following cessation of chronic administration of ethanol. Fed. Proc. 14, 369 (1955).

    Google Scholar 

  • Mehl, W.: Addition der Wirkung von einigen Analepticis zu Medinal. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 151, 41–48 (1930).

    CAS  Google Scholar 

  • Mellanby, E.: Diet and canine hysteria: Experimental production by treated flour. Brit. med. J. 2, 885–887 (1946).

    PubMed  CAS  Google Scholar 

  • — Further observations on the production of canine hysteria by flour treated with nitrogen trichloride (Agene process). Brit. med. J. 1947 II, 288/289.

    Google Scholar 

  • Mellett, L. B., and L. A. Woods: The distribution and fate of morphine in the non-tolerant and tolerant monkey. J. Pharmacol. exp. Ther. 116, 77–83 (1956).

    PubMed  CAS  Google Scholar 

  • Melnick, D., and G. R. Cowgill: The toxicity of high-gliadin diets: Studies on the dog and on the rat. J. Nutr. 14, 401–418 (1937).

    CAS  Google Scholar 

  • Merrit, H. H., and T. J. Putnam: A new series of anticonvulsant drugs testes by experiments on animals. A. M. A. Arch. Neurol. Psychiat. 39, 1003–1015 (1938).

    Google Scholar 

  • Miller, G. H., and O. H. Plant: Effect of morphine and some other opium alkaloids on the muscular activity of the alimentary canal. II. Influence of continued administration of morphine and of withdrawal on the contractions of small intestines of dogs. J. Pharmacol. exp. Ther. 28, 241–249 (1926).

    CAS  Google Scholar 

  • Mirsky, J. H., H. D. White and T. B. O’Dell: Central nervous system depressant effects of some indolylethylpyridines. J. Pharmacol. exp. Ther. 125, 122–127 (1959).

    PubMed  CAS  Google Scholar 

  • Mitchell, C. L., and H. H. Keasling: A comparison of three anticonvulsant testing methods. J. Pharmacol. exp. Ther. 128, 79–84 (1960).

    PubMed  CAS  Google Scholar 

  • Mode, A.: Über die physiologischen Eigenschaften des Bulbocapninum hydrochloricum. Diss. Berlin, 1892.

    Google Scholar 

  • Moir, W. M.: The influence of age and sex on the repeated administration of sodium pentobarbital to albino rats. J. Pharmacol. exp. Ther. 59, 68–85 (1937).

    Google Scholar 

  • M⊘ller-Nielsen, I., and K. Neuhold: The comparative pharmacology and toxicology of the trans-isomer of 2-chloro-9-(3′-dimethylaminopropylidene)-thiaxanthene, HCl (Chlorpro-thixene) = N714 trans and chlorpromazine. Acta pharmacol. (Kbh.) 15, 335–355 (1959).

    Google Scholar 

  • Moran, T.: Lancet 1947II, 289, zit. bei Newell U. Mitarb. (1948).

    Google Scholar 

  • Morgan, T. H.: Ann. N. Y. Acad. Sci. 21, 87 (1911); zit. bei Goldin U. Mitarb.

    Google Scholar 

  • Mott, F. W., D. L. Woodhouse and F. A. Pickworth: Brit. J. Exper. Path. 7, 325 (1926); zit. bei E. J. Stanton: J. Pharmacol. exp. Ther. 57, 245–252 (1936).

    CAS  Google Scholar 

  • Myers, H. B.: The effect of chronic morphine poisoning upon growth, the oestrus cycle and fertility of the white rat. J. Pharmacol. exp. Ther. 41, 317–323 (1931).

    CAS  Google Scholar 

  • —, and J. B. Flynn: Effect of morphine in moderate doses upon growth of the white rat. Proc. Soc. exp. Biol. (N. Y.) 25, 786–787 (1928).

    Google Scholar 

  • Neuner, A., u. H. Tappeiner: Über die Wirkung der Alkaloide von Peganum Harmala, insbesondere des Harmalins. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 35, 69–76 (1894).

    Google Scholar 

  • Newell, G. W., T. C. Erickson, W. E. Gilson and C. A. Elvehjem: Effect of wheat gluten diet on the electroencephalograms of dogs. Proc. Soc. exp. Biol. (N. Y.) 65, 115–116 (1947a).

    CAS  Google Scholar 

  • — — —S. N. Gershoff and C. A. Elvehjem: Role of “agenized” flour in the production of running fits. J. Amer. med. Ass. 135, 760–763 (1947b).

    Google Scholar 

  • — S. N. Gershoff, F. H. Fung and C. A. Elvehjem: Effect of adiminstering agenized amino acids and wheat gluten to dogs. Amer. J. Physiol. 152, 637–644 (1948).

    Google Scholar 

  • Nicholas, J. S., and D. H. Barron: The use of sodium amytal in the production of anesthesia in the rat. J. Pharmacol. exp. Ther. 46, 125–129 (1932).

    CAS  Google Scholar 

  • Nieschulz, O., I. Hoffmann U. K. Popendiker: Pharmakolohische Untersuchungen über N-Methyl-piperazinyl-N′-propyl-phenothiazin. Arzneimittel-Forsch. 8, 199–210 (1958).

    CAS  Google Scholar 

  • Nyáry, A. V.: Die krampfhemmende Wirkung der Hypnotica. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 165, 504–515 (1932).

    Google Scholar 

  • Oettel, H., U. A. Krautwald: Über chronische Schlafmittelvergiftung. Klin. Wschr. 16, 299–300 (1937).

    CAS  Google Scholar 

  • Ohkawa, J.: Einige Versuche über den Kohlehydratstoffwechsel beim morphingewohnten Kaninchen. Mitt. med. Akad. Kioto 28, 895 (1940); ref. Ber. Physiol. 121, 429.

    Google Scholar 

  • Orahovats, P. D., C. A. Winter and E. G. Lehman: The effect of N-allylnormorphine upon the development of tolerance to morphine in the albino rat. J. Pharmacol. exp. Ther. 109, 413–416 (1953).

    PubMed  CAS  Google Scholar 

  • — — — and L. Flataker: Comparative studies of 6-substituted delta6-desoxymorphines and morphine with special reference to 6-methyl-delta6-desoxymorphine. J. Pharmacol. exp. Ther. 114, 100–109 (1955).

    Google Scholar 

  • Orloff, M. J., H. L. Williams and C. C. Pfeiffer: Timed intravenous infusion of metrazol and strychnine for testing anticonvulsant durgs. Proc. Soc. exp. Biol. (N. Y.) 70, 254–257 (1949).

    CAS  Google Scholar 

  • Pace, J., and E. E. Mc Dermott: Methionine sulfoximine and some enzyme systems involving glutamine. Nature (Lond.) 169, 415–416 (1952).

    CAS  Google Scholar 

  • P’an, S. Y., R. Carioto, E. Timmens and J. F. Gardocki: Tremorine antagonism studies with a new anticholinergic agent, oxyphencyclimine. Arch. int. Pharmacodyn. 120, 222–228 (1959).

    PubMed  Google Scholar 

  • Paterson, A. S., and C. P. Richter: Action of scopolamine and carbon dioxide on catalepsy produced by bulbocapnine. A. M. A. Arch. Neurol. Psychiat. 29, 231–240 (1933).

    Google Scholar 

  • Peters, F.: Pharmakologische Untersuchungen über Corydalisalkaloide. Naunyn-Schmiede-berg’s Arch. exp. Path. Pharmak. 51, 130–174 (1904).

    Google Scholar 

  • Peters, J. J., A. R. Vonderahe and P. A. Palmisano: The influence of pentylenetetrazol, strychnine and curare on the electrical activity of the brain and cord of the salamander. J. Pharmacol. exp. Ther. 114, 225–230 (1955).

    PubMed  CAS  Google Scholar 

  • — — and T. H. Powers: Comparative effects of some convulsant drugs on the behavior and electrical activity of the nervous and muscular system of the salamander. J. Pharmacol. exp. Ther. 123, 28–34 (1958).

    Google Scholar 

  • Phatak, N. M., and N. A. David: Effects of hydergine (CCK/179) on the modification of tolerance to morphine and 1-isomethadone hyperglycemia in rabbits. J. Pharmacol. exp. Ther. 109, 139–147 (1953).

    PubMed  CAS  Google Scholar 

  • — J. Maloney and N. David: Use of hyperglycemic response for estimating addiction poten-tialities of analgesic compounds. Fed. Proc. 7, 249 (1948).

    Google Scholar 

  • Pierce, I. H., and O. H. Plant: Excretion of morphine in dogs made tolerant by long continued administration of moderate doses. J. Pharmacol. exp. Ther. 39, 265–266 (1930).

    Google Scholar 

  • — — Studies of chronic morphine poisoning in dogs. IV. Excretion of morphine in tolerant and non-tolerant animals. J. Pharmacol. exp. Ther. 46, 201–228 (1932).

    Google Scholar 

  • Plant, O. H., and I. H. Pierce: General symptoms and behavior of dogs during morphine tolerance and withdrawal. J. Pharmacol. exp. Ther. 31, 210–211 (1927).

    CAS  Google Scholar 

  • — — — Studies of chronic morphine poisoning in dogs. I. General symptoms and behavior during addiction and withdrawal. J. Pharmacol. exp. Ther. 33, 329–357 (1928).

    Google Scholar 

  • — — Studies of chronic morphine poisoning in dogs. V. Recovery of morphine from tissues of tolerant and non-tolerant animals. J. Pharmacol. exp. Ther. 49, 432–449 (1933).

    Google Scholar 

  • —, and D. Slaughter: Effects of dinitrophenol on the excretion of morphine in tolerant and non-tolerant dogs (Preliminary report). J. Pharmacol. exp. Ther. 54, 157–158 (1935).

    Google Scholar 

  • — — Studies of chronic morphine poisoning in dogs. VI. Effect of increasing tissue oxidations by dinitrophenol on the excretion of morphine in tolerant and non-tolerant dogs. J. Pharmacol. exp. Ther. 58, 417–427 (1936).

    Google Scholar 

  • — — Studies of chronic morphine poisoning in dogs. VII. Effect of thyroid feeding on the excretion of morphine in tolerant and non-tolerant dogs. J. Pharmacol. exp. Ther. 62, 106–110 (1938).

    Google Scholar 

  • Preziosi, P., and G. R. de Vleeschhouwer: Anti-“Tremorine” effects of the diethylamino-ethylester of monoethylphenylethylmalonate. Arch. int. Pharmacodyn. 120, 108–113 (1959).

    PubMed  CAS  Google Scholar 

  • Pulewka, P.: Über die relative Wirksamkeit türkischer Hanfpflanzen. Naunyn-Schmiedeberg–s Arch. exp. Path. Pharmak. 211, 278–286 (1950).

    CAS  Google Scholar 

  • Radomski, J. L., and G. Woodard: Pharmacological studies on the causative agent of canine hysteria. J. Pharmacol. exp. Ther. 95, 429–437 (1949).

    PubMed  CAS  Google Scholar 

  • — — and A. J. Lehman: J. Nutr. 36, 15 (1948); zit. bei Bentley U. Mitarb. (1949a).

    Google Scholar 

  • Radouco, C., Ed. Frommel, Ph. Gold, G. Greder, D. Melkonian, S. Radouco, L. Strass-berger, F. Vallette et M. Ducommun: Étude physio-pathologique de l’action du pentaméthylènetétrazol (cardiazol). Deuxiéme mémoire. Arch. int. Pharmacodyn. 92, 13–38 (1952a).

    CAS  Google Scholar 

  • — — — G. Greder, D. Melkonian, S. Radouco, L. Strassberger, F. Vallette et M. Ducommun: La physiologie de l’épilepsie électrique expérimentale. Arch. int. Pharmacodyn. 92, 129–162 (1952b).

    Google Scholar 

  • Ravdin, I. S., D. L. Drabkin and A. E. Bothe: J. Lab. clin. Med. 16, 561 (1930) ; zit. bei Ch. M. Gruber and G. F. Keyser: J. Pharmacol. exp. Ther. 86, 186–196 (1946).

    Google Scholar 

  • Reinhard, J. F., O. J. Plekss and J. V. Scudi: Some pharmacological actions of amphenidone, a new psychotherapeutic drug. Proc. Soc. exp. Biol. (N. Y.) 104, 480–482 (1960).

    CAS  Google Scholar 

  • Rentz, E., U. D. N. Kesarbani: Gewöhnung des Meerschweinchendarms an Morphin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 198, 107–113 (1941).

    CAS  Google Scholar 

  • Reuse, J. J.: A propos des propriétés antinicotiniques des certains dérivés de la thiodiphényl-amme. Arch. int. Pharmacodyn. 89, 117–121 (1952).

    PubMed  CAS  Google Scholar 

  • — Effects de la réserpine sur les réponses circulatoires et respiratoires de doses convulsivantes de pentétrazol et de bémégride chez le Lapin. Modifications par l’atropine et la respiration artificielle. C. R. Soc. Biol. (Paris) 153, 1479–1482 (1959).

    Google Scholar 

  • Richter, C. P., and A. S. Paterson: Bulbocapnine catalepsy and the grasp reflex. J. Pharmacol. exp. Ther. 43, 677–691 (1931).

    CAS  Google Scholar 

  • Rickards, J. C., G. E. Boxer and C. C. Smith: Studies on the distribution and metabolism of methadone in normal and tolerant rats by a new colorimetric method. J. Pharmacol. exp. Ther. 98, 380–391 (1950).

    PubMed  CAS  Google Scholar 

  • Ridder, C: Pentamethylentetrazol (Cardiazol). IV. Mitteilung: Wird Cardiazol in der Leber entgiftet? Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 120, 126–128 (1927).

    Google Scholar 

  • Ro: Jap. J. med. Sci., IV. Pharmacology 9, 59 (1935); zit. bei N. M. Phatak, J. Maloney and N. David: Fed. Proc. 7, 249 (1948).

    CAS  Google Scholar 

  • Rothlin, E., u. A. Cerletti: Über einige pharmakologische Untersuchungen an Mäusen mit congenitaler Drehsucht. Helv. physiol. pharmacol. Acta 10, 319–327 (1952).

    PubMed  CAS  Google Scholar 

  • Rudberg, T.: Occurrence of the “Waltzing syndrome” in mice after administration of amino-dipropionitrile. Acta pharmacol. (Kbh.) 13, 233–239 (1957).

    CAS  Google Scholar 

  • — Effects of atropine on “Waltzing syndrome” in mice after iminodipropionitrile. Acta physiol. scand. 42, 199–203 (1958).

    Google Scholar 

  • Rübsamen, W.: Experimentelle Untersuchungen über die Gewöhnung an Morphin. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 59, 227–244 (1908).

    Google Scholar 

  • Sacchi, U., A. Brusa e G. Gianniotti: Boll. Soc. ital. Biol. sper. 32, 438 (1956); zit. bei C. Fazio and U. Sacchi (1957).

    PubMed  Google Scholar 

  • Sacchi, U., e G. Gianniotti: Boll. Soc. ital. Biol. sper. 32, 175 und 177 (1956); zit. bei C. Fazio and U. Sacchi (1957).

    PubMed  CAS  Google Scholar 

  • Sasaki, T., u. I. Otsuka: Beiträge zur Kenntnis der chemischen Konstitution und der biologischen Wirkung. Über amyostatische Gifte. I. Mitt. J. Biochem. (Tokyo) 12, 429–458 (1930); ref. Berg. ges. Physiol. 60, 506.

    CAS  Google Scholar 

  • —, u. H. Ueda: Beiträge zur Kenntnis des Zusammenhanges zwischen chemischer Konstitution und biologischer Wirkung. II. Biochem. Z. 232, 260–268 (1931); ref. Ber. ges. Physiol. 62, 215.

    Google Scholar 

  • Sato, M.: Über die Entstehung der Schwimm- und Laufbewegungen durch das Harman und seine Drivate. Tôhoku J. exp. Med. 26, 161–163 (1935); ref. Ber. ges. Physiol. 89, 201; zit. bei A. G. Beer (1939a).

    CAS  Google Scholar 

  • Scarborough, E. M.: The influence of thyroid feeding on chronic morphine poisoning. J. Pharmacol. exp. Ther. 27, 421–429 (1926).

    CAS  Google Scholar 

  • Scott, C. C., and K. K. Chen: The action of l,l-diphenyl-l-(dimethylaminoisopropyl)-butanone-2, a potent analgesic agent. J. Pharmacol. exp. Ther. 87, 63–71 (1946).

    PubMed  CAS  Google Scholar 

  • — — — K. G. Kohlstaedt, E. B. Robbins and F. W. Isbell: Further observations on the pharmacology of “dolophine” (methadon, Lilly). J. Pharmacol. exp. Ther. 91, 147–156 (1947b).

    Google Scholar 

  • Scott, C. C., K. G. Kohlstaedt, E. B. Robbins and F. W. Isbell: Further observations on the pharmacology of dolophine. Fed. Proc. 6, 370 (1947a).

    CAS  Google Scholar 

  • Schaltenbrand, G.: Über die Bewegungsstörungen bei akuter Bulbocapninvergiftung. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 103, 1–16 (1924).

    CAS  Google Scholar 

  • — Beiträge zur Pharmakologie der Körperstellung und der Labyrinthreflexe. XIV. Mitteilung. Die Wirkung des Bulbocapnins auf unverletzte Katzen. Pflügers Arch. ges. Physiol. 209, 623–642 (1925a).

    Google Scholar 

  • — Beiträge zur Pharmakologie der Körperstellung und der Labyrinthreflexe. XV. Mitteilung. Wirkung des Bulbocapnins auf Rückenmarks- und decerebrierte Katzen. Pflügers Arch. ges. Physiol. 209, 643–652 (1925b).

    Google Scholar 

  • — Beiträge zur Pharmakologie der Körperstellung und der Labyrinthreflexe. XVII. Mitteilung. Die Wirkimg der Bulbocapnins auf Katzen mit Cortexverletzungen. Versuch einer Lokalisation der Symptome, die bei Bulbocapninvergiftung unverletzter Tiere entstehen. Pflügers Arch. ges. Physiol. 209, 664–674 (1925c).

    Google Scholar 

  • — Die Beziehungen der extrapyramidalen Symptomenkomplexe zu den Lage- und Bewegungsreaktionen, zum motorischen Haushalt und zu den Stammganglien. Dtsch. Z. Nervenheilk. 108, 209–245 (1929).

    Google Scholar 

  • — Buchbesprechung zu: H. de Jong et H. Baruk: La Catatonie Expérimentale par la Bulbo-capnine. Paris: Masson et Cie. 1931. — Dtsch. Z. Nervenheilk. 124, 307–311 (1932).

    Google Scholar 

  • —, and S. Cobb: Brain 53, 449 (1931); zit. bei J. N. Voss (1940).

    Google Scholar 

  • Schaumann, O.: Morphin und morphinähnlich wirkende Verbindungen. Handb. d. exper. Pharmakol., Ergänzungswerk, 12. Band, 1957.

    Google Scholar 

  • Schilf, E.: Über experimentelle Erzeugung epileptischer Anfälle durch dosierte Starkstromenergie. Einfluß von Maßnahmen pharmakologischer, chirurgischer und serologischer Art auf die künstlich erzeugte Epilepsie. Z. ges. exp. Med. 28, 127–143 (1922).

    Google Scholar 

  • Schlichtegroll, A. von: Zentrale und periphere Dämpfungswirkungen in der Reihe der Thiophenylpyridylamin-Derivate. Arzneimittel-Forsch. 8, 489–503 (1958).

    Google Scholar 

  • Schmidt, C. F., and A. E. Livingston: The action of morphine on the mammalian circulation. J. Pharmacol. exp. Ther. 47, 411–441 (1933a).

    CAS  Google Scholar 

  • — — The relation of dosage to the development of tolerance to morphine in dogs. J. Pharmacol. exp. Ther. 47, 443–471 (1933b).

    Google Scholar 

  • Schoen, R.: Beiträge zur Pharmakologie der Körperstellung und der Labyrinthreflexe. XXII. Mitteilung: Hexeton und Cardiazol. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 113, 257–274 (1926).

    CAS  Google Scholar 

  • Schuebel, K., u. W. Gehlen: Vergleichende Untersuchungen über atmungserregende Pharmaka am morphinvergifteten Kaninchen. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 133, 295–316 (1928).

    Google Scholar 

  • Seevers, M. H.: Addiction potentialities of morphine, codeine, heroine and dilaudid in the monkey. J. Pharmacol. exp. Ther. 51, 141–142 (1934).

    Google Scholar 

  • — Opiate addiction in the monkey. L Method of study. J. Pharmacol. exp. Ther. 56, 147–156 (1936a).

    Google Scholar 

  • — Opiate addiction in the monkey. II. Dilaudid in comparison with morphine, heroine and codaine. J. Pharmacol. exp. Ther. 56, 157–165 (1936b).

    Google Scholar 

  • — Animal experimentation in studying addiction to the new synthetics. Ann. N. Y. Acad. Sci. 51, 98–108 (1948).

    Google Scholar 

  • — Adaptation to narcotics. Fed. Proc. 13, 672–684 (1954).

    Google Scholar 

  • —, and A. L. Tatum: Chronic experimental barbital poisoning. J. Pharmacol. exp. Ther. 42, 217–231 (1931).

    Google Scholar 

  • —, and L. A. Woods: The phenomena of tolerance. Amer. J. Med. 14, 546–557 (1953).

    Google Scholar 

  • Shideman, F. E.: Effects of morphine and its derivatives on intermediary metabolism. IV. The influence of chronic morphine and heroin poisoning on the oxygen consumption of dog, rat and mouse skeletal muscle. J. Pharmacol. exp. Ther. 86, 242–247 (1946).

    PubMed  CAS  Google Scholar 

  • —, and H. T. Johnson: Acute vascular tolerance to morphine, demerol. and 1,1-diphenyl-l-(dimethylamino-isopropyl)butanone-2 (amidone) in the dog. Fed. Proc. 6, 371–372 (1947).

    Google Scholar 

  • — — Acute vascular tolerance to morphine, isonipecaine (demerol), and methadon (amidone) in the dog. J. Pharmacol. exp. Ther. 92, 414–420 (1948).

    Google Scholar 

  • — A. R. KELLY and B. J. Adams: Blood levels of thiopental (Pentothal) following repeated intravenous administration to the dog. Fed. Proc. 7, 255 (1948).

    Google Scholar 

  • Silver, M. L.: Anat. Rec. 100, 78 (1948); zit. bei Silver U. Pollock.

    Google Scholar 

  • — R. E. Johnson, R. M. Kark, J. R. Klein, E. P. Monahan and S. S. Zevin: White bread and epilepsy in animals. J. Amer. med. Ass. 135, 757–760 (1947c).

    Google Scholar 

  • — E. P. Monahan and J. R. Klein: Canine epilepsy caused by flour bleached with nitrogen trichloride (agene). II. Role of amino acids. Proc. Soc. exp. Biol. (N. Y.) 66, 410–412 (1947b).

    Google Scholar 

  • Silver, M. L., and G. H. Pollock:: Pôle of carbon dioxide and of the hindbrain in agene-induced canine epilepsy. Amer. J. Physiol. 154, 439–442 (1948).

    PubMed  CAS  Google Scholar 

  • — S. S. Zevin, R. M. Karrk and R. E. Johnson: Canine epilepsy caused by flour bleached with nitrogen trichloride (agene). I. Experimental method. Proc. Soc. exp. Biol. (N. Y.) 66, 408–409 (1947a).

    Google Scholar 

  • Smith, R. G.: The sequence of events in the excitation of the respiratory center by caffeine and some other convulsants. J. Pharmacol. exp. Ther. 33, 147–165 (1928).

    CAS  Google Scholar 

  • Spiegel, E.: Bulbocapnine-benzedrine antagonism. J. Pharmacol. exp. Ther. 63, 438–442 (1938).

    CAS  Google Scholar 

  • Spiegel, E. A.: Quantitative determination of the convulsive reactivity by electric stimulation of the brain with the skull intact. J. Lab. clin. Med. 22, 1274–1276 (1937).

    Google Scholar 

  • — Zur Pharmakologie der zentralen Tonusinnervation. Dtsch. Z. Nervenheilk. 124, 104–116 (1932).

    Google Scholar 

  • —, and E. G. Szekely: Prolonged stimulation of the head of the caudate nucleus. A. M. A. Arch. Neurol. 4, 67–77 (1961).

    Google Scholar 

  • Stanton, E. J.: Dihydromorphinone hydrochloride (dilaudid): its tranquilizing potency, respiratory depressant effects and addiction liability, as tested on the rat. J. Pharmacol. exp. Ther. 56, 252–263 (1935).

    Google Scholar 

  • — Addiction and tolerance to barbiturates? The effect of daily administration and abrupt withdrawal of phenobarbital-sodium and pentobarbital-sodium in the albino rat. J. Pharmacol. exp. Ther. 57, 245–252 (1936).

    Google Scholar 

  • — Insulin treatment of morphine abstinence symptoms. J. Pharmacol. exp. Ther. 60, 387 to 395 (1937).

    Google Scholar 

  • Stein, W. H., and S. Moore: The free amino acids of human blood plasma. J. biol. Chem. 211, 915–926 (1954).

    PubMed  CAS  Google Scholar 

  • Stender, O., U. C. Amsler: Beiträge zur Kenntnis der Morphingewöhnung. Arch. exp. Path. Pharmakol. 160, 195–204 (1931).

    CAS  Google Scholar 

  • Stern, P., u. D. Mitrović-Kocić: Pharmakologische Analyse der Bulbocapnin-Katalepsie an der Maus. Arch. int. Pharmacodyn. 116, 489–498 (1958).

    PubMed  CAS  Google Scholar 

  • — D. Ratković and Ž. Fuks: Pharmacological influences on intentional tremor. Arch. int. Pharmacodyn. 130, 1–8 (1961).

    Google Scholar 

  • Stille, G., u. I. Brunckow: Die ganglioplegische Wirkung von 3-Alkylaminoalkyl-Hydantoine Arzneimittel-Forsch. 4, 723–725 (1954).

    CAS  Google Scholar 

  • Stone, C. A., K. L. Meckelnburg and M. L. Torchiana: Antagonism of nicotine-induced convulsions by ganglionic blocking agents. Arch. int. Pharmacodyn. 117, 419–434 (1958).

    PubMed  CAS  Google Scholar 

  • Stumpf, CH.: Die Wirkung des Nicotin auf die Hippocampustätigkeit des Kaninchens. Naunyn-Schmiedeberg—s Arch. exp. Path. Pharmak. 235, 421–436 (1959).

    CAS  Google Scholar 

  • Sung, Chen-Yu, and E. L. Way: Studies on the fate of d,l-methadone in rats made tolerant to the compound. J. Pharmacol. exp. Ther. 101, 34 (1951).

    Google Scholar 

  • — — and K. G. Scott: Studies on the relationship of metabolic fate and hormonal effects of D,L-methadone to the development of drug tolerance. J. Pharmacol. exp. Ther. 107, 12–23 (1953).

    Google Scholar 

  • Swanson, E. E., M. M. Weaver and K. K. Chen: Amer. J. Med. Sci. 193, 246 (1937); zit. bei Ch. M. Gruber and G. F. Keyser: J. Pharmacol. exp. Ther. 86, 186–196 (1946).

    Google Scholar 

  • Swinyard, E. A.: Validity of laboratory anticonvulsant tests for predicting antiepileptic potency and specifity. Fed. Proc. 6, 376 (1947).

    PubMed  CAS  Google Scholar 

  • — Laboratory assays of clinically effective antiepileptic drugs. J. Amer. pharm. Ass. 38, 201–204 (1949a).

    Google Scholar 

  • — Effect of extracellular electrolyte depletion on brain electrolyte pattern and electroshock seizure threshold. Amer. J. Physiol. 156, 163–169 (1949b).

    Google Scholar 

  • — W. C. Brown and L. S. Goodman: Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol. exp. Ther. 106, 319–330 (1952).

    Google Scholar 

  • — L. Chin and E. Fingl: Withdrawal hyperexcitability following chronic administration of meprobamate to mice. Science 125, 739–741 (1957).

    Google Scholar 

  • —, and L. S. Goodman: Laboratory assay of anticonvulsant potency of some hydantoinates. Fed. Proc. 5, 205–206 (1946).

    Google Scholar 

  • Szerb, J. C., and D. H. Mc Curdy: Concentration of morphine in blood and brain after intravenous injection of morphine in non-tolerant. tolerant and neostigmine-treated rats. J. Pharmacol. exp. Ther. 118, 446–450 (1956).

    PubMed  CAS  Google Scholar 

  • Tanabe, T., and E. J. Cafruny: Adrenal hypertrophy in rats treated chronically with morphine. J. Pharmacol. exp. Ther. 122, 148–153 (1958).

    PubMed  CAS  Google Scholar 

  • Tartler, O. P.: Über den Antagonismus und Synergismus zwischen einigen Analepticis und Medinal. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmakol. 143, 65–78 (1929).

    CAS  Google Scholar 

  • Tatum, A. L., K. H. Collins and M. H. Seevers: Further observations in experimental chronic morphinism. J. Pharmacol. exp. Ther. 31, 213–214 (1927).

    CAS  Google Scholar 

  • — M. H. Seevers and K. H. Collins: Morphine addiction and its physiological interpretation on experimental evidence. J. Pharmacol. exp. Ther. 36, 447–475 (1929).

    Google Scholar 

  • Tedeschi, D. H., E. A. Swinyard and L. S. Goodman: Effects of variations in stimulus intensity on maximal electroshock seizure pattern, recovery time, and anticonvulsant potency of phenobarbital in mice. J. Pharmacol. exp. Ther. 116, 107–113 (1956).

    PubMed  CAS  Google Scholar 

  • — R. E. Tedeschi, L. Cook, P. A. Mattis and E. J. Fellows: The neuropharmacology of trifluoperazine: a potent psychotherapeutic agent. Arch. int. Pharmacodyn. 122, 129–143 (1959).

    Google Scholar 

  • Ten Cate, J., et D. W. Swijgman: Localisation de l’origine des convulsions produites par le cardiazol et la coramine. Arch. int. Pharmacodyn. 70, 293–306 (1945).

    Google Scholar 

  • Thienes, C. H., and L. E. Detrick: Morphine addiction and withdrawal: Effect of calcium therapy and tissue hydration. J. Pharmacol. exp. Ther. 66, 36 (1939).

    Google Scholar 

  • Thuillier, J., A. Burger et P. Mouille: Contribution à l’étude du syndrome motéur pro-vorqué chez la souris par l’amino-dipropionitrile (souris tournantes). C. R. Soc. Biol. (Paris) 147, 1052–1055 (1953).

    CAS  Google Scholar 

  • — — Contributation à l’étude du syndrome moteur provoqué chez la couris par l’amino-dipropionitrile (souris tournantes). Experientia (Basel) 10, 223–224 (1954).

    Google Scholar 

  • —, et H. Nakajima: Action comparée des drogues psychotropes sur les «souris tournantes» provoquées par l’imino-β,β′-dipropionitrile. In: Psychotropic Drugs. p. 136–158. Elsevier Publishing Company 1957.

    Google Scholar 

  • Toman, J. E. P.: Neuropharmacologic considerations in psychic seizures. Neurology 1, 444–460 (1951).

    PubMed  CAS  Google Scholar 

  • —, and L. S. Goodman: Anticonvulsants. Physiol. Rev. 28, 409–432 (1948).

    Google Scholar 

  • Torda, C.: Ammonium ion content and electrical activity of the brain during preconvulsive and convulsive phases induced by various convulsants. J. Pharmacol. exp. Ther. 107, 197–203 (1953).

    PubMed  CAS  Google Scholar 

  • Tripod, J., H. J. Bein and R. Meier: Characterization of central effects of serpasil (reserpin, a new alkaloid of rauwolfia serpentina B.) and of their antagonistic reactions. Arch. int. Pharmacodyn. 96, 406–423 (1953).

    Google Scholar 

  • Udenfriend, S., and S. P. Bessman: The hydroxylation of phenylalanine and antipyrine in phenylpyrurc oligophrenia. J. biol. Chem. 203, 961–966 (1953).

    PubMed  CAS  Google Scholar 

  • —, and J. R. Cooper: The enzymatic conversion of phenylalanine to tyrosine. J. biol. Chem. 194, 503–511 (1952).

    Google Scholar 

  • Voss, J.: Pentamethylentetrazol (Cardiazol). III. Mitteilung: Über die Wirkung von Cardiazol bei peroraler Applikation. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 118, 259–266 (1926).

    CAS  Google Scholar 

  • Voss, J. N.: Über das Verhalten halbseitig großhirnloser Tiere und Bulbocapnin in mittleren Gaben. Pflügers Arch. ges. Physiol. 243, 496–504 (1940).

    Google Scholar 

  • Wachtel, C.: Nachweis und Bestimmung des Morphins und anderer Alkaloide in tierischen Ausscheidungen und Organen. Biochem. Z. 120, 265–283 (1921).

    CAS  Google Scholar 

  • Wagner, J. R., and C. A. Elvehjem: J. Nutr. 28, 431 (1944); zit. bei Newell U. Mitarb. (1948).

    CAS  Google Scholar 

  • Waisman, H. A., H. L. Wang, H. Herlow and R. R. Sponholz: Experimental phenylketonuria in the monkey. Proc. Soc. exp. Biol. (N. Y.) 101, 864–865 (1959).

    CAS  Google Scholar 

  • — —G. Palmer and H. F. Harlow: Phenylketonuria in infant monkeys. Nature (Lond.) 188, 1124–1125 (1960).

    Google Scholar 

  • Wastl, H.: Influence of various salts on metrazol reactions. Arch. int. Pharmacodyn. 66, 397–408 (1941).

    CAS  Google Scholar 

  • Watt, J. M.: The influence of cardiazol on the cardio-vascular system and its utility in cases of circulatory failure. Arch. int. Pharmacodyn. 36, 225–232 (1936).

    Google Scholar 

  • Wawzonek, S., I. V. Poseti, R. S. Shepard and L. G. Wiedenmann: Epiphysal plate lesions, degenerative arthritis, and dissecting aneurysm of the aorta produced by aminonitriles. Science 121, 63–65 (1955).

    PubMed  CAS  Google Scholar 

  • Way, E. L., Chen-Yu Sung and J. M. Fujimoto: The effect of adrenalectomy on the development of tolerance to morphine and methadone. J. Pharmacol. exp. Ther. 110, 51–52 (1954).

    Google Scholar 

  • Weger, P., U. C. Amsler: Beschleunigung der Gewöhnung an Morphin bzw. Verzögerung der Entwöhnung davon durch Vitamin D-Mangel. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 183, 9–12 (1936a).

    CAS  Google Scholar 

  • — — Weiteres zum Problem der Gewöhnung am Morphin. Naunyn-Schmideberg’s Arch. exp. Path. Pharmak. 181, 489–493 (1936b).

    Google Scholar 

  • Werner, H. W., and A. L. Tatum: A comparative study of the stimulant analeptics Picrotoxin, metratzol and coramine. J. Pharmacol. exp. Ther. 66, 260–278 (1939).

    CAS  Google Scholar 

  • Widlocher, D., H. Nakajima et J. Thuillier: Action des monoéthylamide (LAE) et diéthylamide (LSD) de l’acide lysergique sur le comportement de la Souris tournante provoquée par l’imino-β,β′-dipropionitrile. C. R. Soc. Biol. (Paris) 151, 668–670 (1957).

    CAS  Google Scholar 

  • Wienke, H.: Zur Frage der Beeinflussung der Elektro- und Cardiazolkrampfschwellen durch vegetative Nervengifte. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 217, 312 (1953).

    CAS  Google Scholar 

  • Wikler, A.: Hindlimb reflexes in chronic spinal dogs during a cycle of morphine addiction. Fed. Proc. 4, 141 (1945).

    Google Scholar 

  • — Reactions of chronic totally decorticated dogs during a cycle of morphine addiction. Fed. Proc. 5, 212–213 (1946).

    Google Scholar 

  • —, and K. Frank: Tolerance and physical dependence in intact and chronic spinal dogs during addiction to 10820 (4,4-diphenyl-6-dimethylamino-heptanone-3). Fed. Proc. 6, 384 (1947).

    Google Scholar 

  • — — Hindlimb reflexes of chronic spinal dogs during cycles of addiction to morphine and methadon. J. Pharmacol. exp. Ther. 94, 382–400 (1948).

    Google Scholar 

  • Windle, W. F., J. Cammermeyer, E. R. Feringa, J. Joralemon, J. O. Smart and M. P. Mc Quillen: Tremor in African green monkeys. Fed. Proc. 15, 202 (1956).

    Google Scholar 

  • Winiwarter, F.: Über die Wirkung von Schlafmitteln, Antipyreticis und Analepticis auf normale und großhirnlose Tauben. Arch. exp. Path. Pharmak. 185, 95–101 (1937).

    CAS  Google Scholar 

  • Winter, C. A., and L. Flataker: Studies on heptazone (6-morpholino-4,4-diphenyl-3-heptanone hydrochloride) in comparison with other analgesic drugs. J. Pharmacol. exp. Ther. 98, 305–317 (1950).

    PubMed  CAS  Google Scholar 

  • Wirth, W.: Zur pharmakologischen Wirkung von Promazin. Arzneimittel-Forsch. 8, 507–511 (1958).

    CAS  Google Scholar 

  • — R. Gösswald, U. Hörlein, K.-H. Risse U. H. Kreiskott: Zur Pharmakologie acylierter Phenothiazin-Derivate. Arch. int. Pharmacodyn. 115, 1–31 (1958).

    Google Scholar 

  • — — u. W. Vater: Zur Pharmakolgie acylierter Phenothiazin-Derivate. Arch. int. Pharmacodyn. 123, 78–114 (1959).

    Google Scholar 

  • Wolf, J.: Versuche zum Nachweis exzitierender Wirkungen narkotischer Stoffe und Rauschgifte mit Hilfe des Elektroschockverfahrens. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 214, 14–28 (1951).

    CAS  Google Scholar 

  • Wolf-Heidegger, G., F. Schürmann U. J. Meier: Erbliche Drehbewegungen bei Mäusen. Verh. Schweiz. Naturforsch. Ges. 1941, 205.

    Google Scholar 

  • Woodbury, D. M., R. E. Hurley, N. G. Lewis, M. W. Mc Arthur, W. W. Copeland, J. F. Kirschvink and L. S. Goodman: Effect of thyroxine, thyroidectomy and 6-n-propyl-2-thiouracil on brain function. J. Pharmacol. exp. Ther. 106, 331–340 (1952).

    PubMed  CAS  Google Scholar 

  • Woodbury, J. W., J. Simons, R. Evans, T. Y. Burton and J. E. P. Toman: Effect of di-phenylhydantoin on recovery of various central nervous functions following maximal electroshock seizures in cats. Amer. J. Physiol. 155, 479–480 (1948).

    Google Scholar 

  • Woodbury, L. A., and V. D. Davenport: Design and use of a new electroshock apparatus, and analysis of factors altering seizure threshold and pattern. Arch. int. Pharmacodyn. 92, 97–107 (1952).

    PubMed  CAS  Google Scholar 

  • —, and E. A. Swinyard: Energy requirements for the electrical production of seizures. Fed. Proc. 6, 230 (1947).

    Google Scholar 

  • Woods, L. A., J. B. Wyngaarden and M. H. Seevers: The addiction potentialities of l,l-diphenyl-l-(dimethylaminopropyl)-butanone-2 (amidone) in the monkey. Fed. Proc. 6, 387 (1947a).

    Google Scholar 

  • — — — Addiction potentialities of l,l-diphenyl-l-(beta-dimethylaminopropyl)-butanone-2-hydrochloride (amidone) in the monkey. Proc. Soc. exp. Biol. (N. Y.) 65, 113–114 (1947b).

    Google Scholar 

  • Woolfe, G., and A. D. Mc Donald: Evaluation of the analgesic action of pethidine hydrochloride (demerol). J. Pharmacol. exp. Ther. 80, 300 (1944) ; zit. bei H. Isbell, A. Wikler, N. B. Eddy, J. L. Wilson and C. F. Moran: J. Amer. med. Ass. 135, 888–894 (1947).

    CAS  Google Scholar 

  • Woolley, D. E., P. S. Timiras, M. R. Rosenzweig, D. Krech and E. L. Bennett: Sex and strain differences in electroshock convulsions of the rat. Nature (Lond.) 190, 515–516 (1961).

    CAS  Google Scholar 

  • Zauder, H. L.: The effect of certain analgesic drugs and adrenal cortical hormones on the brain of normal and hypophysectomized rats as measured by the thiobarbituric acid reagent. J. Pharmacol. exp. Ther. 101, 40–46 (1951).

    PubMed  CAS  Google Scholar 

  • — The effect of prolonged morphine administration on the in vivo and in vitro conjugation of morphine in rats. J. Pharmacol. exp. Ther. 104, 11–19 (1952).

    Google Scholar 

  • Zetler, G.: Substanz P, ein Polypeptid aus dem Darm und Gehirn mit depressiven, hyper-algetischen und Morphin-antagonistischen Wirkungen auf das Zentralnervensystem. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 228, 513–538 (1956).

    CAS  Google Scholar 

  • — Der Harmin-Tremor und seine Antagonisten. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 231, 34–54 (1957).

    Google Scholar 

  • — Versuche zur antikonvulsiven Wirksamkeit des Polypeptids SubstanzP. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 237, 11–16 (1959).

    Google Scholar 

  • — K. Mahler U. F. Daniel: Versuche zu einer pharmakologischen Differenzierung katalep-tischer Wirkungen. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 238, 486–501 (1960).

    Google Scholar 

  • —, u. E. Moog: Die Bulbocapnin-Katatonie, ihre Synergisten und Antagonisten. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 232, 442–458 (1958).

    Google Scholar 

  • — W. Müller u. I. Warm: Jactatio capitis, eine pharmakologisch ausgelöste Stereotypie der Maus. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 237, 247–263 (1959).

    Google Scholar 

  • Zipf, K., W. A. Windschus U. F. Kokoschka: Zur Wirkung von Cardiazol, Coramin, Hexeton, Strychnin und Ikoral gegenüber Narkotica. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 185, 113–124 (1937).

    Google Scholar 

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Stumpf, C. (1962). Pharmakologische Methoden. In: Stumpf, C., Petsche, H., Eichler, O. (eds) Zentralnervensystem. Handbuch der Experimentellen Pharmakologie, vol 16 / 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48100-0_1

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