Zusammenfassung
Für den Nachweis eines akuten Alkoholmißbrauchs stehen aus labordiagnostischer Sicht mit der Ethanolbestimmung in Serum, Plasma bzw. Vollblut mit enzymatischen Verfahren oder Headspace-Gaschromatographie sowie ergänzenden Begleitstoffanalysen (z. B. Methanol, Aceton, iso-Propanol und Butanol) analytisch und diagnostisch valide Meßgrößen zur Verfügung (19, 21, 28).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Allen JP, Litten RZ, Anton RF, Cross GM (1994) Carbohydrate-deficient transferrin as a measure of immoderate drinking: remaining issues. Alcohol Clin Exp Res 18:799–812
Anton F, Moak DH (1994) Carbohydrate-deficient transferrin and γ-glutamyltransferase as markers of heavy alcohol consumption: gender differences. Alcohol Clin Exp Res 18:747–754
Arndt T, Gressner AM, Kropf J (1994) Labordiagnostik und Kontrolle des Alkoholabusus — ein Plädoyer für Carbohydrate-deficient Transferrin (CDT). Med Welt 45:247–257
Arndt T, Hackler R, Müller T, Kleine TO, Gressner AM (1997) Increased serum concentration of carbohydrate-deficient transferrin in patients with combined pancreas and kidney transplantation. Clin Chem 43:344–351
Arndt T, Czylwik D, Hackler R, Helwig-Rolig A, Gilg T (1998) Carbohydrate-deficient transferrin is not affected by serum separators. Alcohol Alcoholism 33:447–450
Arndt T, Kropf J, Brandt R, Gressner AM, Hackler R, Herold M, van Pelt J, Mårtensson O, Salzmann K, Velmans MH (1998) CDTect-RIA and CDTect-EIA for determination of serum carbohydrate-deficient transferrin compared. Alcohol Alcoholism 33:639–645
Arndt T, Hackler R, Kleine TO, Gressner AM (1998) Validation by isoelectric focusing of the anion-exchange isotransferrin fractionation step involved in determination of carbohydrate-deficient transferrin by the CDTect assay. Clin Chem 44:27–34
Arndt T, Behnken LJ, Martens B, Hackler R (1999) Evaluation of the cut-off for serum carbohydrate-deficient transferrin (CDT) as marker of chronic alcohol abuse determined by the ChronAlco I.D.™-Assay. J Lab Med (im Druck)
Behrens UJ, Worner T, Braly L, Schaffner F, Lieber C (1988) Carbohydrate-deficient transferrin, a marker for chronic alcohol consumption in different ethnic populations. Alcohol Clin Exp Res 12:427–432
Bell H, Tallaksen C, Sjåheim T, Weberg R, Raknerud N, Ørjascæter H, Try K, Haug E (1993) Serum carbohydrate-deficient transferrin as a marker of alcohol consumption in patients with chronic liver diseases. Alcohol Clin Exp Res 17:246–252
Bell H, Tallaksen CCM, Haug E, Try K (1994) A comparison between two commercial methods for determining carbohydrate deficient transferrin (CDT). Scand J Clin Lab Invest 54:453–457
Bell H, Tallaksen CME, Try K, Haug E (1994) Carbohydrate-deficient transferrin and other markers of high alcohol consumption: a study of 502 patients admitted consecutively to a medical department. Alcohol Clin Exp Res 18:1103–1108
Borg S, Helander A, Voltaire Carlsson A, Hogstrom Brandt AM (1995) Detection of relapses in alcohol-dependent patients using carbohydrate-deficient transferrin: improvement with individualized reference levels during long-term monitoring. Alcohol Clin Exp Res 19:961–963
de Feo TM, Duca L, Meloni AR, Colucci P, Cappellini MD, Fargion SR, Fiorelli G (1997) Clinical utility of carbohydrate-deficient transferrin (CDT) in conditions of iron deficiency and iron overload. Alcohol Alcoholism 32:381 (Abstract)
de Jong G, van Dijk JP, van Eijk HG (1990) The biology of transferrin. Clin Chim Acta 190:1–46
Fagerberg B, Agewall S, Berglund A, Wysocki M, Lundberg PA, Lindstedt G (1994) Is carbohydrate-deficient transferrin in serum useful for detecting excessive alcohol consumption in hypertensive patients? Clin Chem 40:2057–2063
Fagerberg B, Agewall S, Urbanavicius V, Attvall S, Lundberg P-A, Lindstedt G (1994) Carbohydrate-deficient transferrin is associated with insulin sensitivity in hypertensive men. J Clin Endocrinol Metab 79:712–715
Ghosh P, Lakshman MR (1997) Chronic ethanol induced impairment of hepatic glycosylation machinery in rat is independent of dietary carbohydrate. Alcohol Clin Exp Res 21:76–81
Gibitz HJ, Schütz H (Hrsg) (1993) Bestimmung von Ethanol im Serum. Mitteilung XX der Senatskommission für klinisch-toxikologische Analytik. VCH Verlagsgesellschaft mbH, Weinheim
Gilg T (1995) Diagnose von Alkoholmißbrauch und Alkoholismus, biologische und biochemische Alkoholismusmarker bzw.-parameter. In: Soyka M (Hrsg) Die Alkoholkrankheit — Diagnose und Therapie. Chapman and Hall, London Glasgow Weinheim New York Tokyo Melbourne Madras S 79–104
Gilg T, Weidinger S, Josephi E, Tutsch-Bauer E, von Meyer L, Bieger WP (1994) Determination of CDT (Carbohydrate Deficient Transferrin), γ-GT, methanol, isopropanol and ethanol in forensic blood samples for assessment of chronic alcohol abuse. Lab med 18:143–153
Gordon HM, Fyffe JA, Morgan MY (1998) Serial serum carbohydrate-deficient transferrin (CDT) measurements in healthy volunteers and patients with non-alcoholic liver disease. Alcohol Clin Exp Res 22:180 (Abstract)
Hackler R, Arndt T, Kleine TO, Gressner AM (1995) Effect of separation conditions on automated isoelectric focusing of carbohydrate-deficient transferrin and other human isotransferrins using the PhastSystem. Anal Biochem 230:281–289
Helander A (1999) Absolute or relative measurement of carbohydrate-deficient transferrin in serum? Experiences with three immunological assays. Clinical Chemistry 45:131–135
Helander A, Carlsson S (1996) Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy. Alcohol Clin Exp Res 20:1202–1205
Helander A, Borg S, Vabö E, Dahl H (1998) Intra-and interindividual variability of carbohydrate-deficient transferrin, γ-glutamyltransferase and mean corpuscular volume in teetotalers. Alcohol Clin Exp Res 22:180 (Abstract)
Henriksen JH, Grønbæk M, Møller S, Bendtsen F, Becker U (1997) Carbohydrate deficient transferrin (CDT) in alcoholic cirrhosis: a kinetic study. J Hepatol 26:287–292
Iffland R, Balling P, Börsch G, Herold C, Kaschade W, Löffler T, Schmidtmann U, Stettner J (1994) Zur Wertung erhöhter Spiegel von GGT, CDT, Methanol, Aceton und Isopropanol im Blut alkoholauffälliger Kraftfahrer. Alkoholismusindikatoren anstelle medizinisch-psychologischer Untersuchungen? Blutalkohol 31:273–314
Jensen PD, Peterslund NA, Hjelm Poulsen J, Jensen FT, Christensen T, Ellegaard J (1994) The effect of iron overload and iron reductive treatment on the serum concentration of carbohydrate-deficient transferrin. Brit J Haematol 88:56–63
Jeppsson JO, Kristensson H, Fimiani C (1993) Carbohydrate-deficient transferrin quantified by HPLC to determine heavy consumption of alcohol. Clin Chem 39:2115–2120
Kamboh MI, Ferrell RE (1987) Human transferrin polymorphism. Hum Hered 37:65–81
Kwoh-Gain I, Fletcher LM, Price J, Powell LW, Halliday JW (1990) Disialylated transferrin and mitochondrial aspartate aminotransferase compared as laboratory markers of excessive alcohol consumption. Clin Chem 36:841–845
La Grange L, Anton FA, Garcia S, Herrbold C (1995) Carbohydrate-deficient transferrin in a female population. Alcohol Clin Exp Res 19:100–103
Mårtensson O, Härlin A, Brandt R, Seppä K, Sillanaukee P (1997) Transferrin isoform distribution: gender and alcohol consumption. Alcohol Clin Exp Res 21:1710–1715
Mårtensson O, Schink, E, Brandt, R (1998) Diurnal variability and in vitro stability of carbohydrate-deficient transferrin. Clinical Chemistry 44:2226–2227
Potter BJ, Chapman RWG, Nunes RM, Sorrentino D, Sherlock S (1985) Transferrin metabolism in alcoholic liver disease. Hepatology 5:714–721
Renner F, Kanitz RD (1997) Quantification of carbohydrate-deficient transferrin by ion-exchange chromatography with an enzymatically prepared calibrator. Clin Chem 43:485–490
Renner F, Stratmann K, Kanitz RD, Wetterling T (1997) Determination of carbohydrate-deficient transferrin and total transferrin by HPLC: Diagnostic evaluation. Clin Lab 43:955–964
Schellenberg F, Bénard JY, Le Goff AM, Bourdin C, Weill J (1989) Evaluation of carbohydrate-deficient transferrin compared with Tf index and other markers of alcohol abuse. Alcohol Clin Exp Res 13:605–610
Schmitt UM, Stieber P, Jüngst D, Bilzer M, Wächtler M, Heberger S, Seidel D (1998) Chronischer Alkoholabusus — diagnostischer Wert von kohlenhydratdefizientem Transferrin. Der Bayerische Internist 18:13–22
Stauber RE, Jauk B, Fickert P, Häusler M (1996) Increased carbohydrate-deficient transferrin during pregnancy: relation to sex hormones. Alcohol Alcoholism 31:389–392
Stauber RE, Vollman H, Pesserl L, Jauk B, Lipp R, Halwachs G, Wilders-Trusching M (1996) Carbohydrate-deficient transferrin in healthy women: relation to estrogens and iron status. Alcohol Clin Exp Res 20:1114–1117
Stibler H (1991) Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clin Chem 37:2029–2037
Stibler H, Borg S (1991) Glycoprotein glycosyltransferase activities in serum in alcohol-abusing patients and healthy controls. Scand J Clin Lab Invest 51:43–51
Stibler H, Borg S, Allgulander C (1979) Clinical significance of abnormal heterogeneity of transferrin in relation to alcohol consumption. Acta Med Scand 206:275–281
Stibler H, Borg S, Joustra M (1986) Micro anion exchange chromatography of „carbohydrate-deficient transferrin“ (CDT) in serum in relation to alcohol consumption (Swedish patent 8400587-5). Alcohol Clin Exp Res 10:535–544
Storey EL, Mack U, Powell LW, Halliday JW (1985) Use of chromatofocusing to detect a transferrin variant in serum of alcoholic subjects. Clin Chem 31:1543–1545
van Noort WL, de Jong G, van Eijk HG (1994) Purification of isotransferrins by Concanavalin A sepharose chromatography and preparative isoelectric focusing. Eur J Clin Chem Clin Biochem 32:885–892
Xin Y, Lasker JM, Liebers CS (1995) Serum carbohydrate-deficient transferrin: mechanism of increase after chronic alcohol intake. Hepatology 22:1462–1468
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Steinkopff Verlag, Darmstadt
About this chapter
Cite this chapter
Arndt, T., Hackler, R. (1999). Kohlenhydrat-defizientes Transferrin (CDT) — eine spezifische Kenngröße chronischen Alkoholmißbrauchs. In: Soyka, M. (eds) Klinische Alkoholismusdiagnostik. Steinkopff. https://doi.org/10.1007/978-3-642-47709-6_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-47709-6_8
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-1193-4
Online ISBN: 978-3-642-47709-6
eBook Packages: Springer Book Archive