Skip to main content

Zusammenfassung

Der Ausdruck „Hyperlipämie“ wird in der klinischen Terminologie als Sammelbegriff für eine Vermehrung verschiedener Lipide im Nüchternplasma verwen-det. Triglyceride, Cholesterin und Phospholipide werden im Blut in Form von Lipoproteiden transportiert. Hyperlipämien sind demnach eigentlich „Hyperlipo-proteidämien“. Die einzelnen Lipoproteidfraktionen unterscheiden sich neben dem Apoprotein vor allem durch ihren relativen Gehalt an Triglyceriden, Cholesterin und Phospholipiden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abrams, M. E., R. . Jarrett, H. Keen, D. R. Boyns and J. N. Crossley: Oral glucose tolerance and related factors in a normal population sample. II. Interrelationship of glycerides, cholesterol, and other factors with the glucose and insulin response. Brit. med. J. 1, 599 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Adlersberg, D. and L. Eisler: Circulating lipids in diabetes mellitus. J. Amer. med. Ass. 170, 1261 (1959).

    Article  CAS  Google Scholar 

  • Adlersberg, D. and C.-I. Wang: Syndrome of idiopathic hyperlipemia, mild diabetes mellitus, and severe vascular damage. Diabetes 4, 210 (1955).

    PubMed  CAS  Google Scholar 

  • Ahrens, E. H. jr., J. Hirsch, W. Insull jr., T. T. Tsaltas, R. Blomstrand and M. L. Peterson: The influence of dietary fats on serum lipid levels in man. Lancet I, 943 (1957a).

    Article  Google Scholar 

  • Ahrens, E. H. jr., J. Hirsch, W. Insull jr., T. T. Tsaltas, R. Blomstrand and M. L. Peterson: Dietary control of serum lipids in relation to atherosclerosis. J. Amer. med. Ass. 164, 1905 (1957b).

    Article  CAS  Google Scholar 

  • Ahrens, E. H. jr. K. Oette, J. W. Farquhar and Y. Stein: Carbohydrate-induced and fat-induced lipemia. Trans. Ass. Amer. Phycns. 74, 134 (1961).

    CAS  Google Scholar 

  • Albrink, M. J. and P. C. Davidson: Impaired glucose tolerance in patients with hypertri-glyceridemia. J. Lab. clin. Med. 67, 573 (1966).

    CAS  Google Scholar 

  • Albrink, M. J. and E. B. Man: Effect of carbohydrate ingestion on postprandial lipemia. Amer. J. Dig. Dis. 2, 649 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Albrink, M. J. and E. B. Man: Serum triglycerides in health and diabetes. Diabetes 7, 194 (1958).

    PubMed  CAS  Google Scholar 

  • Albrink, M. J. and E. B. Man: Serum triglycerides in coronary artery disease. Arch. Int. Med. 103, 4 (1959).

    Article  CAS  Google Scholar 

  • Albrink, M. J. and J. W. Meigs: Interrelationship between skinfold thickness, serum lipids and blood sugar in normal men. Amer. J. clin. Nutr. 15, 255 (1964).

    PubMed  CAS  Google Scholar 

  • Albrink, M. J. J. R. Fitzgerald and E. B. Man: Reduction of alimentary lipemia by glucose. Metabolism 7, 162 (1958).

    PubMed  CAS  Google Scholar 

  • Albrink, M. J. P. H. Lavietes and E. B. Man: Vascular disease and serum lipids in diabetes mellitus. Observations over thirty years (1931–1961). Ann. Int. Med. 58, 305 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Alterman, S. L. and A. A. Lopez-Gomez: Phenformin effect on body weight, lipids, and glucose regulation. Ann. N.Y. Acad. Sci. 148, 884 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Anderson, J. T., F. Grande, Y. Matsumoto and A. Keys: Glucose, sucrose and lactose in the diet and blood lipids in man. J. Nutrition 79, 349 (1963).

    CAS  Google Scholar 

  • Antar, M. A. and M. A. Ohlson: Effect of simple and complex carbohydrates upon total lipids, nonphospholipids, and different fractions of phospholipids of serum in young men and women. J. Nutrition 85, 329 (1965).

    CAS  Google Scholar 

  • Antonis, A. and I. Bersohn: The influence of diet on serum triglycerides in South African white and Bantu prisoners. Lancet I, 3 (1961).

    Article  Google Scholar 

  • Armstrong, D. T., R. Steele, N. Altszuler, A. Dunn, J. S. Bishop and R. C. de Bodo: Regulation of plasma free fatty acid turnover. Amer. J. Physiol. 201, 9 (1961).

    PubMed  CAS  Google Scholar 

  • Bagdade, J. D., D. Porte jr. and E. L. Bierman: Diabetic lipemia: A form of acquired fat-induced lipemia. New Eng. J. Med. 276, 427 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Bagdade, J. D., D. Porte jr. and E. L. Bierman: Acute insulin withdrawal and the regulation of plasma triglyceride removal in diabetic subjects. Diabetes 17, 127 (1968a).

    PubMed  CAS  Google Scholar 

  • scBagdade, J. D., D. Porte jr. and E. L. Bierman: Hypertriglyceridemia. A metabolic consequence of chronic renal failure. New. Engl. J. Med. 279, 181 (1968b).

    Article  PubMed  CAS  Google Scholar 

  • Bailey, C. C. and O. T. Bailey: The production of diabetes mellitus in rabbits with alloxan. J. Amer. Med. Ass. 122, 1165 (1943).

    Article  CAS  Google Scholar 

  • Beveridge, J. M. R., S. N. Jagannathan and W. F. Connell: The effect of the type and amount of dietary fat on the level of plasma triglycerides in human subjects in the post-absorptive state. Canad. J. Biochem. 42, 999 (1964).

    Article  CAS  Google Scholar 

  • Bezman, A., J. M. Felts and R. J. Havel: Relation between incorporation of triglyceride fatty acids and heparin-released lipoprotein lipase from adipose tissue slices. J. Lipid Res. 3, 427 (1962).

    CAS  Google Scholar 

  • Bierman, E. L. and J. T. Hamlin, III: The hyperlipemic effect of a low-fat, high-carbohydrate diet in diabetic subjects. Diabetes 10, 432 (1961).

    PubMed  CAS  Google Scholar 

  • Bierman, E. L. and J. T. Hamlin, III: The effect of insulin and glucagon on the removal of C-14-labeled particulate triglyceride in man. Metabolism 12, 666 (1963).

    PubMed  CAS  Google Scholar 

  • Bierman, E. L. V. P. Dole and T. N. Roberts: An abnormality of nonesterified fatty acid metabolism in diabetes mellitus. Diabetes 6, 475 (1957a).

    PubMed  CAS  Google Scholar 

  • Bierman, E. L., I. L. Schwarz and V. P. Dole: Action of insulin on release of fatty acids from tissue stores. Amer. J. Physiol. 191, 359 (1957b).

    PubMed  CAS  Google Scholar 

  • Bierman, E. L. J. A. P. Amaral and B. H. Belknap: Hyperlipemia and diabetes mellitus. Diabetes 15, 675 (1966).

    PubMed  CAS  Google Scholar 

  • Blix, G.: Studies on diabetic lipemia. II. General remarks on the diabetics studied. Acta med. Scand. 64, 175 (1926).

    Article  CAS  Google Scholar 

  • Bolinger, R. E., S. R. Shane and C. H. Kirkpatrick: Secondary rise in plasma free fatty acids following glucose load. J. clin. Endocr. 22, 873 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Bolzano, K., S. Sailer, F. Sandhofer und H. Braunsteiner: Über das Verhalten der endogenen Lipoproteidlipase-Aktivität im Plasma während einer intravenösen Fettinfusion bei Normalpersonen und Patienten mit Hypertriglyceridämie. Klin. Wschr. 45,1104 (1967).

    Article  PubMed  CAS  Google Scholar 

  • — Über das Verhalten der endogenen und Post-Heparin-Lipoproteidlipase-Aktivität im Plasma nach intravenöser Glucosebelastung bei Normalpersonen und Patienten mit „primärer kohlenhydratinduzierter Hypertriglyceridämie“. In Vorbereitung.

    Google Scholar 

  • Borgström, B. and T. Olivecrona: The metabolism of palmitic acid-1-C14 in functionally hepatectomized rats. J. Lipid Res. 2, 263 (1961).

    Google Scholar 

  • Bowman, R. H.: The effect of long-chain fatty acids on glucose utilization in the isolated perfused rat heart. Biochem. J. 84, 14 P (1962).

    Google Scholar 

  • Bradley, R. F., R. Eccles and A. E. Freelender: Hyperlipemia as an early manifestation of diabetes mellitus (abstract). Program for the 21st Annual Meeting of the American Diabetes Ass., June 25, 1961.

    Google Scholar 

  • Brady, R. O. and S. Gurin: Biosynthesis of labeled fatty acids and cholesterol in experimental diabetes. J. biol. Chem. 187, 589 (1950).

    PubMed  CAS  Google Scholar 

  • Bragdon, J. H. and R. S. Gordon jr.: Tissue distribution of C-14 after the intravenous injection of labeled chylomicrons and unesterified fatty acids in the rat. J. clin. Invest. 37, 574 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Bragdon, J. H., R. J. Havel and R. S. Gordon jr.: Effects of carbohydrate feeding on serum lipids and lipoproteins in the rat. Amer. J. Physiol. 189, 63 (1957).

    PubMed  CAS  Google Scholar 

  • Braunsteiner, H., R. di Pauli, S. Sailer und F. Sandhofer: Hyperlipämie und latenter Diabetes mellitus. Klin. Wschr. 43, 715 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Braunsteiner, H., S. Sailer und F. Sandhofer: Plasmalipide bei Patienten mit Diabetes mellitus. Klin. Wschr. 44, 116 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Braunsteiner, H., M. Herbst, S. Sailer und F. Sandhofer: Familienuntersuchungen bei essentieller „kohlen-hydratinduzierter“ Hyperlipämie. Dtsch. med. Wschr. 92, 646 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Braunsteiner, H., H. Berger, S. Sailer und F. Sandhofer: Untersuchungen bei einem Fall von fettinduzierter (exogener) Hypertriglyceridämie. Schweiz. med. Wschr. 98, 458 (1968a).

    PubMed  CAS  Google Scholar 

  • Braunsteiner, H., P. v. Dittrich, S. Sailer und F. Sandhofer: Nicht veröffentlicht (1968b).

    Google Scholar 

  • Braunsteiner, H., M. Herbst, S. Sailer und F. Sandhofer: Diabetes mellitus bei primärer Hypertriglyceridämie mit Kontraindikation zur Insulinbehandlung. Wien. klin. Wschr. 80, 415 (1968c).

    PubMed  CAS  Google Scholar 

  • — S. Sailer und F. Sandhofer: Besonderheiten des Diabetes mellitus bei primärer Hypertriglyceridämie. 3. Symposium über „Klinische Ernährungslehre“, München, 19. April (1968d).

    Google Scholar 

  • Brown, D.F.: Triglyceride metabolism in the alloxan-diabetic rat. Diabetes 16, 90 (1967).

    PubMed  CAS  Google Scholar 

  • Brown, D.F. and T. Olivecrona: The effect of glucose availability and utilization on chylomicron metabolism in the rat. Acta physiol. Scand. 66, 9 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Brunner, W.: Beitrag zur pankreatogenen Lipämie. Klin. Wschr. 14, 1853 (1935).

    Article  CAS  Google Scholar 

  • Buckle, R. M.: Mobilization of free fatty acids from adipose tissue from normal and diabetic subjects. Diabetes 12, 133 (1963).

    PubMed  CAS  Google Scholar 

  • Butturini, U., A. Gnudi, C. Coscelli, G. Valenti and V. Palmari: Glucose tolerance test in normal and obese subjects with low plasma free fatty acid levels experimentally induced by nicotinic acid. Diabetologia 2, 143 (1966).

    Google Scholar 

  • Cagan, R. N., A. E. Sobel, R. A. Nichols and L. Loewe: Serum lipids in normal and alloxan diabetic rats. Metabolism 3, 168 (1954).

    PubMed  CAS  Google Scholar 

  • Cagan, R. N., R. Nichols and L. Loewe: Serum lipids in diabetic and nondiabetic rats. Effect of varying lipid diets. Diabetes 5, 112 (1956).

    PubMed  CAS  Google Scholar 

  • Carlson, L. A.: Studies on the incorporation of injected palmitic acid-1-C14 into liver and plasma lipids in man. Acta Soc. Med. Upsala 65, 85 (1960).

    CAS  Google Scholar 

  • Carlson, L. A. and L.-G. Ekelund: Splanchnic production and uptake of endogenous triglycerides in the fasting state in men. J. clin. Invest. 42, 714 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Carlson, L. A. S.-O. Liljedahl and C. Wirsén: Blood and tissue changes in the dog during and after excessive free fatty acid mobilization. Acta med. Scand. 178, 81 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Cherkes, A. and R. S. Gordon jr.: The liberation of lipoprotein lipase by heparin from adipose tissue incubated in vitro. J. Lipid Res. 1, 97 (1959).

    CAS  Google Scholar 

  • Chernick, S. S. and R. O. Scow: Early effects of “total” pancreatectomy on fat metabolism in the rat. Amer. J. Physiol. 196, 125 (1959).

    PubMed  CAS  Google Scholar 

  • Chernick, S. S. and R. O. Scow: Synthesis in vitro of glyceride-glycerol by the liver of normal and pancreatectomized rats. J. biol. Chem. 239, 2416 (1964).

    PubMed  CAS  Google Scholar 

  • Christensen, S., E. Dollerup and S. E. Jensen: Idiopathic hyperlipaemia, latent diabetes mellitus, and severe neuropathy. Acta med. Scand. 161, 57 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Christophe, J. and J. Mayer: Influence of diet on utilization of glucose and incorporation of acetate-1-C14 into liver fatty acids and cholesterol in rats. Amer. J. Physiol. 197, 55 (1959).

    PubMed  CAS  Google Scholar 

  • Creutzfeldt, W., A. Appels, R. Katterman, H. Frerichs, H. Proschek, K. Hubrich und H.-D. Söling: Zur Wirkung von Buformin mit und ohne Kombination von Sulfonylharn-stoffen auf Gewicht und verschiedene Stoffwechselgrößen bei Diabetikern. 2. Int. Biguanid-Symposium, 5./6. Mai 1967, Düsseldorf.

    Google Scholar 

  • Csorba, T. R., I. Matsuda and N. Kalant: Effects of insulin and diabetes on flux rates of plasma glucose and free fatty acids. Metabolism 15, 262 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Davidson, M. H. and R. Kaye: A study of blood glucose and ketone bodies and plasma FFA, cholesterol, phospholipids and total lipids in juvenile diabetes. J. Pediat. 66, 313 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Davidson, P. C. and M. J. Albrink: Insulin resistance in hyperglyceridemia. Metabolism 14, 1059 (1965a).

    Article  PubMed  CAS  Google Scholar 

  • Davidson, P. C. and M. J. Albrink: The relation of insulin responsiveness to plasma triglyceride levels. Clin. Res. 13, 71 (1965b).

    Google Scholar 

  • Denborough, M. A. and B. Paterson: Clearing factor, fibrinolysis and blood lipids in diabetes mellitus. Clin. Sci. 23, 485 (1962).

    PubMed  CAS  Google Scholar 

  • Dine, M. S., R. L. Jackson and B. J. Bornong: Serum cholesterol in juvenile diabetes. Serial determinations in cases of recent onset. Diabetes 2, 206 (1953).

    CAS  Google Scholar 

  • Dole, V. P.: A relation between non-esterifled fatty acids in plasma and the metabolism of glucose. J. clin. Invest. 35, 150 (1956).

    Article  PubMed  CAS  Google Scholar 

  • — Diabetes. p. 158. P. B. Hoeber, Inc., New York, 1960.

    Google Scholar 

  • Eagle, G. R. and D. S. Robinson: The ability of actinomycin D to increase clearing-factor lipase activity of rat adipose tissue. Biochem. J. 93, 10 C (1964).

    CAS  Google Scholar 

  • Elwood, J. C. and J. T. van Bruggen: Lipid metabolism in the diabetic rat. III. Acetate metabolism and acetoacetate synthesis in vitro. J. biol. Chem. 235, 568 (1960).

    PubMed  CAS  Google Scholar 

  • Farquhar, J. W., G. M. Reaven, R. C. Gross and R. Wagner: Rate of plasma triglyceride synthesis in carbohydrate-induced lipemia (abstract). J. clin. Invest. 42, 930 (1963).

    Article  Google Scholar 

  • Farquhar, J. W., R. C. Gross, R. W. Wagner and G. M. Reaven: Validation of an incompletely coupled two-compartment nonrecycling catenary model for turnover of liver and plasma triglyceride in man. J. Lipid Res. 6, 119 (1965).

    PubMed  CAS  Google Scholar 

  • Farquhar, J. W., A. Frank, R. C. Gross and G. M. Reaven: Glucose, insulin, and triglyceride responses to high and low carbohydrate diets in man. J. clin. Invest. 45, 1648 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Fasoli, A., E. B. Magid, M. D. Glassman and P. P. Foà: Serum lipoproteins in experimental diabetes. I. Serum lipoprotein pattern of normal and depancreatized dogs. Proc. Soc. exp. Biol. Med. 85, 609 (1954).

    PubMed  CAS  Google Scholar 

  • Felber, J.-P. and A. Vannotti: Effects of fat infusion on glucose tolerance and insulin plasma levels. Med. Exp. 10, 153 (1964).

    PubMed  CAS  Google Scholar 

  • Felber, J.-P. A. J. Moody et A. Vannotti: Acides gras et diabète. Helv. Med. Acta 32, 323 (1965).

    Google Scholar 

  • Fillios, L. C., C. Naito, S. B. Andrus, O. W. Portman and R. S. Martin: Variations in cardiovascular sudanophilia with changes in the dietary level of protein. Amer. J. Physiol. 194, 275 (1958).

    PubMed  CAS  Google Scholar 

  • Fine, M. B. and R. H. Williams: Effect of fasting, epinephrine and glucose and insulin on uptake of nonesterified fatty acids. Amer. J. Physiol. 199, 403 (1960).

    PubMed  CAS  Google Scholar 

  • Fischer, B.: Über Lipämie und Cholesterämie, sowie über Veränderungen des Pancreas und der Leber bei Diabetes mellitus. Virchow’s Arch. 172, 30, 218 (1903).

    Article  Google Scholar 

  • Fredrickson, D. S. and R. S. Lees: Familial hyperlipoproteinemia. In: The Metabolic Basis of Inherited Disease. Second edition. J. B. Stanbury, J. B. Wyngaarden and D. S. Fredrickson, Hrsg., Mc-Graw-Hill, New York 1966.

    Google Scholar 

  • Fredrickson, D. S., D. L. McCollester and K. Ovo: The role of unesterified fatty acid transport in chylomi-cron metabolism. J. clin. Invest. 37, 1333 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Fredrickson, D. S., K. Ovo and L. L. Davis: Lipolytic activity of post-heparin plasma in hyperglyceridemia. J. Lipid Res. 4, 24 (1963).

    PubMed  CAS  Google Scholar 

  • Fredrickson, D. S., R. I. Levy and R. S. Lees: Fat transport in lipoproteins — an integrated approach to mechanisms and disorders. New Engl. J. Med. 276, 32, 94, 148, 215, 273 (1967).

    Google Scholar 

  • Friedberg, S. J., R. F. Klein, D. L. Trout, M. D. Bogdonoff and E. H. Estes, jr.: The incorporation of plasma free fatty acids into plasma triglycerides in man. J. clin. Invest. 40, 1846 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Garland, P. B., E. A. Newsholme and P. J. Randle: Effect of fatty acids, ketone bodies, diabetes and starvation on pyruvate metabolism in rat heart and diaphragm muscle. Nature 195, 381 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Gershberg, H., M. Hulse, Z. C. Javier, A. Hecht and S. Mari: Blood lipids of maturity-onset diabetes treated with phenformin and tolbutamide. Diabetes 14, 456 (1965).

    Google Scholar 

  • Gershberg, H., Z. Javier, M. Hulse and A. Hecht: Influence of hypoglycemic agents on blood lipids and body weight in ketoacidosis-resistent diabetics. Ann. N.Y. Acad. Sci. 148, 914 (1967).

    Article  Google Scholar 

  • Gibbs, G. E. and I. L. Chaikoff: Lipid metabolism in experimental pancreatic diabetes. I. Blood and liver lipids of dogs fasted during total insulin deprivation. Endocrinology 29, 877 (1941a).

    Article  CAS  Google Scholar 

  • Gibbs, G. E. and I. L. Chaikoff: Lipid metabolism in experimental pancreatic diabetes. II. Blood and liver lipids of dogs fed during total insulin deprivation. Endocrinology 29, 885 (1941b).

    Article  CAS  Google Scholar 

  • Gidez, L. I., P. S. Roheim and H. A. Eder: Effect of plasma free fatty acid concentrations on triglyceride synthesis by the perfused liver. Fed. Proc. 21, 289 (1962).

    Google Scholar 

  • Gillman, J., C. Gilbert and J. C. Allan: The relationship of hyperglycaemia to hyperlipaemia and ketonaemia in depancreatized baboons (Papio ursinus). J. Endocrinol. 17, 349 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Goetz, F. C., J. W. Maney and B. Z. Greenberg: The regulation of insulin secretion: Effects of the infusion of glucose, ribose, and other sugars into the portal veins of dog. J. Lab. clin. Med. 69, 537 (1967).

    PubMed  CAS  Google Scholar 

  • Goldner, M. G. and G. Gomori: Alloxan diabetes in dog. Endocrinology 33, 297 (1943).

    Article  CAS  Google Scholar 

  • Gordon, R. S., jr. and A. Cherkes: Unesterified fatty acid in human plasma. J. clin. Invest. 35, 206 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Goto, Y., Y. Maruhama, J. Kikuchi, K. Fukuda, I. Takaku and T. Katuse: Control of diabetes and serum lipids with special reference to development of diabetic retinopathy. J. Jap. Diabet. Soc. 10, 80 (1967).

    Google Scholar 

  • Grant, W. C. and M. J. Fahrenbach: Effect of dietary sucrose and glucose on plasma cholesterol in chicks and rabbits. Proc. Soc. exp. Biol. Med. 100, 250 (1959).

    PubMed  CAS  Google Scholar 

  • Gries, F. A., S. Potthoff and K. Jahnke: Effects of insulin on the metabolism of triglycerides. Fifth Congr. Intern. Diab. Fed., Toronto, 1964. Exc. med. 74, 12 (1964).

    Google Scholar 

  • Grodsky, G. M., A. A. Batts, L.L. Bennet, C. Ucella, N. B. McWilliams and D. F. Smith: Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Amer. J. Physiol. 205, 638 (1963).

    PubMed  CAS  Google Scholar 

  • Guggenheim, K., J. Ilan and E. Peretz: Effect of dietary carbohydrates and aureomycin on serum and liver cholesterol in rats. J. Nutrition 72, 93 (1960).

    CAS  Google Scholar 

  • Haft, D. E. and L. L. Miller: Alloxan diabetes and demonstrated direct action of insulin on metabolism of isolated perfused rat liver. Amer. J. Physiol. 192, 33 (1958).

    PubMed  CAS  Google Scholar 

  • Hamwi, G. J., O. Garcia, F. A. Kruger, G. Gwinup and D. G. Cornwell: Hyperlipidemia in uncontrolled diabetes. Metabolism 11, 850 (1962).

    PubMed  CAS  Google Scholar 

  • Harlan, W. R. jr., P. S. Winesett and A. J. Wasserman: Tissue lipoprotein lipase in normal individuals and in individuals with exogenous hypertriglyceridemia and the relationship of this enzyme to assimilation of fat. J. clin. Invest. 46, 239 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Harris, L. V. D., M. J. Albrink, W. F. van Eck, E. B. Man and J. P. Peters: Serum lipids in diabetic acidosis. Metabolism 2, 120 (1952).

    Google Scholar 

  • Harris-Jones, J. N. and D. J. Ward: Hypercholesterolaemia and diabetes mellitus. J. clin. Pathol. 14, 279 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Hatch, F. T., L. L. Abell and F. E. Kendall: Effects of restriction of dietary fat and cholesterol upon serum lipids and lipoproteins in patients with hypertension. Amer. J. Med. 19, 48 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Havel, R. J.: Early effects of fasting and of carbohydrate ingestion on lipids and lipoproteins of serum in man. J. clin. Invest. 36, 855 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Havel, R. J.: Conversion of plasma free fatty acids into triglycerides of plasma lipoprotein fractions in man. Metabolism 10, 1031 (1961).

    PubMed  CAS  Google Scholar 

  • Havel, R. J. and A. Goldfien: The role of the liver and extrahepatic tissues in the transport and metabolism of fatty acids and triglycerides in the dog. J. Lipid. Res. 2, 389 (1961).

    CAS  Google Scholar 

  • Havel, R. J. and R. S. Gordon jr.: Idiopathic hyperlipemia: Metabolic studies in an affected family. J. clin. Invest. 39, 1777 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Havel, R. J., J. M. Felts and C. M. van Duyne: Formation and fate of endogenous triglyceride in blood plasma of rabbits. J. Lipid Res. 3, 297 (1962).

    CAS  Google Scholar 

  • Haymond, T. A. and K. Berry, jr.: Persistent hyperlipemia and hepatosplenomegaly in a patient with controlled diabetes mellitus. Ann. Int. Med. 41, 609 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Heimberg, M., D. R. van Harken and T. O. Brown: Hepatic lipid metabolism in experimental diabetes. II. Incorporation of (I-14C) palmitate into lipids of the liver and of the d <1.020 perfusate lipoproteins. Biochim. biophys. Acta 137, 435 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Hennes, A. R., M. Z. Moore and Y. F. Masters: Studies of cholesterol metabolism with C14-acetate in diabetic patients and in patients with hypercholesterolemia. Metabolism 11, 925 (1962).

    PubMed  CAS  Google Scholar 

  • Hirsch, E. F., B. P. Phibbs and L. Carbonaro: Parallel relation of hyperglycemia and hyperlipemia (esterified fatty acids) in diabetes. Arch. Int. Med. 91, 106 (1953).

    Article  CAS  Google Scholar 

  • Hodges, R. E. and W. A. Krehl: The role of carbohydrates in lipid metabolism. Amer. J. clin. Nutr. 17, 334(1965).

    PubMed  CAS  Google Scholar 

  • Hollenberg, C. H.: Effect of nutrition on activity and release of lipase from rat adipose tissue. Amer. J. Physiol. 197, 667 (1959).

    PubMed  CAS  Google Scholar 

  • Hotta, S. and I. L. Chaikoff: Cholesterol synthesis from acetate in the diabetic liver. J. biol. Chem. 198, 895 (1952).

    PubMed  CAS  Google Scholar 

  • Houssay, B. A., C. T. Rietti, E. Ashkar, E. J. del Castillo, M. E. Galli, A. Roldán and E. J. Urgoiti: Fatty metabolism and ketogenesis after liver denervation or bilateral thoracolumbar sympathectomy in pancreatectomized dogs. Diabetes 16, 259 (1967).

    PubMed  CAS  Google Scholar 

  • Hug, G. and W. K. Schubert: Serum insulin in type I glycogenosis. Effect of galactose or fructose administration. Diabetes 16, 791 (1967).

    PubMed  CAS  Google Scholar 

  • Hunt, H.: In: E. P. Joslin, H. F. Root, P. White, A. Marble and C. C. Bailey: The treatment of diabetes mellitus. Lea and Febiger, Philadelphia 1948.

    Google Scholar 

  • Jahnke, K.: Pathophysiologische und klinische Aspekte des Fettstoffwechseis. Symposium 25. April–5. Mai 1965. G. Schettler und R. Sanwald (Hrsg.) Georg Thieme Verlag, Stuttgart 1966.

    Google Scholar 

  • Jones, D. P. and R. A. Arky: Effects of insulin on triglyceride and free fatty acid metabolism in man. Metabolism 14, 1287 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Jones, D. P., G. R. Plotkin and R. A. Arky: Lipoprotein lipase activity in patients with diabetes mellitus, with and without hyperlipemia. Diabetes 15, 565 (1966).

    PubMed  CAS  Google Scholar 

  • Kahan, M., I. Hirshleifer and E. E. Mandel: Serum lipids in diabetes mellitus: A comparison of the effects of tolbutamide, phenformin hydrochloride and NPH insulin. Diabetes 15, 536 (1966).

    Google Scholar 

  • Kalant, N., J. I. Teitelbaum, A. A. Cooperberg and W. A. Harland: Dietary athero-genesis in alloxan diabetes. J. Lab. clin. Med. 63,147 (1964).

    PubMed  CAS  Google Scholar 

  • Kalkhoff, R. K., K. R. Hornbrook, H. B. Burch and D. M. Kipnis: Studies of the metabolic effects of acute insulin deficiency. II. Changes in hepatic glycolytic and Krebs-cycle intermediates and pyridine nucleotides. Diabetes 15, 451 (1966).

    PubMed  CAS  Google Scholar 

  • Kallio, I. V. I. and H. A. Saarimaa: Changes in blood lipids, postprandial lipemia and intravenous tolbutamide test response after insulin shock treatment. Amer. J. Med. Sci. 254, 619 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Kane, J. P., C. Longcope, F. C. Pavlatos and G. M. Grodsky: Studies of carbohydrate metabolism in idiopathic hypertriglyceridemia. Metabolism 14, 471 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Kaufmann, N. A., R. Poznanski, S. H. Blondheim and Y. Stein: Changes in serum lipid levels of hyperlipemic patients following the feeding of starch, sucrose and glucose. Amer. J. clin. Nutr. 18, 261 (1966).

    PubMed  CAS  Google Scholar 

  • Keiding, N. R., G. V. Mann, H. F. Root, E. Y. Lawry and A. Marble: Serum lipoproteins and cholesterol levels in normal subjects and in young patients with diabetes in relation to vascular complications. Diabetes 1, 434 (1952).

    PubMed  CAS  Google Scholar 

  • Kendall, F. E., W Meyer, L. Lewis and J. Victor: Alloxan diabetes in rabbits. Production of hypercholesterolemia, hyperlipemia and adrenal cortical lesions. Proc. Soc. exp. Biol. Med. 60, 190 (1945).

    PubMed  CAS  Google Scholar 

  • Kessler, J. I.: Effect of insulin on release of plasma lipolytic activity and clearing of emulsified fat intravenously administered to pancreatectomized and alloxanized dogs. J. Lab. clin. Med. 60, 747 (1962).

    PubMed  CAS  Google Scholar 

  • Kessler, J. I.: Effect of diabetes and insulin on the activity of myocardial and adipose tissue lipoprotein lipase of rats. J. clin. Invest. 42, 362 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Keys, A., J. T. Anderson and F. Grande: Diet-type (fats constant) and blood lipids in man. J. Nutrition 70, 257 (1960).

    CAS  Google Scholar 

  • Klemperer: Über diabetische Lipämie. Dtsch. med. Wschr. 36, 2373 (1910).

    Article  Google Scholar 

  • Knittle, J. L. and E. H. Ahrens jr.: Carbohydrate metabolism in two forms of hypergly-ceridemia. J. clin. Invest. 43, 485 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Kolb, F. O., O. F. de Lalla and J. W. Gofman: The hyperlipemias in disorders of carbohydrate metabolism: Serial lipoprotein studies in diabetic acidosis with xanthomatosis and in glycogen storage disease. Metabolism 4, 310 (1955).

    PubMed  CAS  Google Scholar 

  • Kornberg, A. and W. E. Pricer: Enzymatic esterification of α-glycerophosphate by long chain fatty acids. J. biol. Chem. 204, 345 (1953).

    PubMed  CAS  Google Scholar 

  • Kritchevsky, D., R. R. Kolman, R. M. Guttmacher and M Forbes: Influence of dietary carbohydrate and protein on serum and liver cholesterol in germ-free chickens. Arch. Biochem. 85, 444 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Kritchevsky, D., P. Sallata and S. A. Tepper: Experimental atherosclerosis in rabbits fed cholesterol-free diets. Part 2. Influence of various carbohydrates. J. Atheroscler. Res. 8, 697 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Krut, L. H. and R. F. Barsky: Effect of enhanced glucose utilization on postprandial lipaemia in ischaemic heart-disease. Lancet II, 1136 (1964).

    Article  Google Scholar 

  • Kuo, P. T.: Dietary sugar in the production of hyperglyceridemia in patients with hyperlipemia and atherosclerosis. Trans. Ass. Amer. Phycns. 78, 97 (1965).

    CAS  Google Scholar 

  • Kuo, P. T. and D. R. Bassett: Dietary sugar in the production of hyperglyceridemia. Ann. int. Med. 62, 1199 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Kuo, P. T. and J. C. Carson: Dietary fats and the diurnal serum triglyceride levels in man. J. clin. Invest. 38, 1384 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Kuo, P. T., D. R. Bassett, A. M. Digeorge and G. G. Carpenter: Lipolytic activity of post-heparin plasma in hyperlipemia and hypolipemia. Circulation Res. 16, 221 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Laurell, S.: Plasma free fatty acids in diabetic acidosis and starvation. Scand. J. clin. Lab. Invest. 8, 81 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Laurell, S.: Recycling of intravenously injected palmitic acid-1-C14 as esterified fatty acid in the plasma of rats and turnover rate of plasma triglycerides. Acta physiol. Scand. 47, 218 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, R. D.: Lipodystrophy and hepatomegaly with diabetes, lipaemia, and other metabolic disturbances: A case throwing new light on action of insulin. Lancet I, 724, 773 (1946).

    Article  Google Scholar 

  • Lees, R. S.: The plasma lipid response to two types of dietary carbohydrate. Clin. Res. 13, 549 (1965).

    Google Scholar 

  • Lees, R. S. and D. S. Fredrickson: Carbohydrate induction of hyperlipemia in normal man. Clin. Res. 13, 327 (1965).

    Google Scholar 

  • Lever, W. F., P. A. J. Smith and N. A. Hurley: Idiopathic hyperlipemic and primary hypercholesteremic xanthomatosis. I. Clinical data and analysis of the plasma lipids. J. Invest. Dermat. 22, 33 (1954).

    Article  CAS  Google Scholar 

  • Lewin, A. I.: Zur Kenntnis des Fettlipoidstoffwechsels bei depankreatisierten Hunden. Z. ges. exp. Med. 96, 548 (1935).

    Article  CAS  Google Scholar 

  • Lloyd, A. V.: Ph. D. Thesis, University of Edinburgh (1963). Zit. nach: Pantelakis, S. N., A. H. Cameron, S. Davidson, P. M. Dunn, A. S. Fosbrooke, J. K. Lloyd, J. M. Malins a. O. H. Wolff: The diabetic pregnancy. A study of serum lipids in maternal and umbilical cord blood and of the uterine and placental vasculature. Arch. Dis. Childh. 39, 334 (1964).

    CAS  Google Scholar 

  • Lowy, A. D. jr., J. H. Barach and Z. Hrubec: A study of serum lipoprotein and cholesterol determinations in 901 diabetics. Diabetes 6, 342 (1957).

    PubMed  Google Scholar 

  • Lynch, H. T., A. R. Kaplan, M. J. Henn and A. J. Krush: Familial coexistence of diabetes mellitus, hyperlipemia, short stature, and hypogonadism. Amer. J. med. Sci. 252, 323 (1966).

    Article  PubMed  CAS  Google Scholar 

  • MacDonald, I.: The lipid response of young women to dietary carbohydrates. Amer. J. clin. Nutr. 16, 458 (1965a).

    PubMed  CAS  Google Scholar 

  • MacDonald, I.: The effects of various dietary carbohydrates on the serum lipids during a five-day regimen. Clin. Sci. 29, 193 (1965b).

    PubMed  CAS  Google Scholar 

  • MacDonald, I.: Dietary fructose and serum lipid levels in man. Proc. Nutr. Soc. 25, ii (1966a).

    Google Scholar 

  • MacDonald, I.: Influence of fructose and glucose on serum lipid levels in men and pre-and postmeno-pausal women. Amer. J. clin. Nutr. 18, 369 (1966b).

    PubMed  CAS  Google Scholar 

  • MacDonald, I.: The lipid response of postmenopausal women to dietary carbohydrates. Amer. J. clin. Nutr. 18, 86 (1966c).

    PubMed  CAS  Google Scholar 

  • MacDonald, I.: Ingested glucose and fructose in serum lipids in healthy men and after myocardial infarction. Amer. J. clin. Nutr. 21, 1366 (1968).

    PubMed  CAS  Google Scholar 

  • MacDonald, I. and D. M. Braithwaite: The influence of dietary carbohydrates on the lipid patterns in serum and in adipose tissue. Clin. Sci. 27, 23 (1964).

    PubMed  CAS  Google Scholar 

  • MacDonald, I. and J. B. Roberts: The incorporation of various C14 dietary carbohydrates into serum and liver lipids. Metabolism 14, 991 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Major, R. H.: The treatment of diabetes mellitus with insulin. J. Amer. Med. Ass. 80, 1597 (1923).

    Article  Google Scholar 

  • Man, E. B. and J. P. Peters: Lipoids of serum in diabetic acidosis. J. clin. Invest. 13, 237 (1934).

    Article  PubMed  CAS  Google Scholar 

  • Marchand: Über einen Fall von Lipämie bei Coma diabeticum. Münch. med. Wschr. 62, 19 (1915).

    Google Scholar 

  • Maruhama, Y.: Diet and blood lipids in normal and diabetic rats. Metabolism 14, 78 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Maruhama, Y., Y. Goto and S. Yamagata: Diabetic treatment and the diurnal plasma triglyceride. Metabolism 16, 985 (1967).

    Article  PubMed  CAS  Google Scholar 

  • McElroy, W. T. jr., W. L. Siefert and J. J. Spitzer: Relationship of hepatic uptake of free fatty acids to plasma concentration. Proc. Soc. exp. Biol. Med. 104, 20 (1960).

    CAS  Google Scholar 

  • Meng, H. C. and J. L. Goldfarb: Heparin-induced lipemia clearing factor in rats. Role of the pancreas in its production. Diabetes 8, 211 (1959).

    CAS  Google Scholar 

  • Miettinen, T. A., R. Pelkonen, M.-R. Vesenne and E. A. Nikkilä: Effects of plasma triglyceride, FFA, and glycerol levels on plasma insulin and its response to glucose. Diabetologia 2, 232 (1966).

    Google Scholar 

  • Mirsky, S.: Influence of hypoglycemie therapy on blood lipids and body weight in diabetes mellitus. Ann. N. Y. Acad. Sci. 148, 937 (1967).

    Article  Google Scholar 

  • Morris, J. H., D. A. West and R. E. Bolinger: Effect of oral sulonylurea on plasma triglycerides in diabetics. Diabetes 13, 87 (1964).

    PubMed  CAS  Google Scholar 

  • Mortimer, J. G.: Cord blood lipids of normal infants and infants of diabetic mothers. Arch. Dis. Childh. 39, 342 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Munkner, C.: Some metabolic aspects of free fatty acids in diabetes. Diabetologia 2, 230 (1966a).

    Google Scholar 

  • Munkner, C.: Some investigations of the endogenous lipoprotein lipase activity in diabetics and non-diabetics. Diabetologia 2, 231 (1966b).

    Google Scholar 

  • Muntz, J. A. and M. Vanko: The metabolism of intraportally injected fructose in rat liver in vivo. J. biol. Chem. 237, 3582 (1962).

    PubMed  CAS  Google Scholar 

  • Nestel, P. J.: Relationship between plasma triglycerides and removal of chylomicrons. J. clin. Invest. 43, 943 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Nestel, P. J.: Triglyceride turnover in coronary heart disease and the effect of dietary carbohydrate. Clin. Sci. 31, 31 (1966).

    PubMed  CAS  Google Scholar 

  • Nestel, P. J.: Relationship between FFA flux and TGFA influx in plasma before and during the infusion of insulin. Metabolism 16, 1123 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Nestel, P. J. and D. Steinberg: Fate of palmitate and linoleate perfused through the isolated rat liver at high concentration. J. Lipid Res. 4, 461 (1963).

    PubMed  CAS  Google Scholar 

  • Nestel, P. J., K. F. Carroll and M. S. Silverstein: Influence of free-fatty-acid metabolism on glucose tolerance. Lancet 2, 115 (1964).

    Article  PubMed  CAS  Google Scholar 

  • New, M. I., T. N. Roberts, E. L. Bierman and G. G. Reader: The significance of blood lipid alterations in diabetes mellitus. Diabetes 12, 208 (1963).

    PubMed  CAS  Google Scholar 

  • Nikkilä, E. A. and K. Ojala: Induction of hyperglyceridemia by fructose in the rat. Life Sci. 4, 937 (1965).

    Article  PubMed  Google Scholar 

  • Nikkilä, E. A. and K. Ojala: Acute effects of fructose and glucose on the concentration and removal rate of plasma triglyceride. Life Sci. 5, 89 (1966).

    Article  PubMed  Google Scholar 

  • Nikkilä, E. A. R. Pelkonen and A. Miettinen: Relationship between glucose metabolism and serum triglyceride and cholesterol levels. Diabetologia 2, 232 (1966).

    Google Scholar 

  • O’Connor, T. P. and J. D. Schnatz: Lipoprotein lipase activity and hypertriglyceridemia in alloxan diabetic rabbits. Metabolism 17, 838 (1968).

    Article  PubMed  Google Scholar 

  • Pantelakis, S. N., A. H. Cameron, S. Davidson, P. M. Dunn, A. S. Fosbrooke, J. K. Lloyd, J. M. Malins and O. H. Wolff: The diabetic pregnancy. A study of serum lipids in maternal and umbilical cord blood and of the uterine and placental vasculature. Arch. Dis. Childh. 39, 334 (1964).

    CAS  Google Scholar 

  • Pav, J. and J. Wenkeova: Significance of adipose tissue lipoprotein lipase. Nature 185, 926 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Pelkonen, R., T. A. Miettinen, M.-R. Taskinen and E. A. Nikkilä: Effect of acute elevation of plasma glycerol, triglyceride and FFA levels on glucose utilization and plasma insulin. Diabetes 17, 76 (1968).

    PubMed  CAS  Google Scholar 

  • Petren, K., G. Blix, M. Odin und E. Persson: Weitere Beobachtungen über Diabetes gravis und dessen Behandlung. Wien. med. Wschr. 43, 1901, 2000.

    Google Scholar 

  • Portman, O. W., E. Y. Lawry and D. Bruno: Effect of dietary carbohydrate on experimentally induced hypercholesteremia and hyperbetalipoproteinemia in rats. Proc. Soc. exp. Biol. Med. 91, 321 (1956).

    PubMed  CAS  Google Scholar 

  • Randle, P. J., P. B. Garland, C. N. Hales and E. A. Newsholme: The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet I, 785 (1963).

    Article  Google Scholar 

  • Randle, P. J., R. M. Denton and P. J. England: Enzyme mechanisms controlling substrate supply in cardiac muscle. Proc. 6th Congress of the Internat. Diabetes Federation, Stockholm 1967.

    Google Scholar 

  • Reaven, G., A. Calciano, R. Cody, C. Lucas and R. Miller: Carbohydrate intolerance and hyperlipemia in patients with myocardial infarction without known diabetes mellitus. J. clin. Invest. 23, 1013 (1963).

    CAS  Google Scholar 

  • Reaven, G., J. W. Farquhar, L. B. Salans, R. C. Gross and R. M. Wagner: Carbohydrate-induced lipemia. Clin. Res. 12, 277 (1964).

    Google Scholar 

  • Reaven, G., A. Frank, R. Gross, L. Salans and J. Farquhar: Glucose and insulin metabolism in carbohydrate-induced lipemia. Clin. Res. 13, 332 (1965).

    Google Scholar 

  • Reaven, G., R. L. Lerner, M. P. Stern, J. W. Farquhar and R. Nakanishi: Role of insulin in endogenous hypertriglyceridemia. J. clin. Invest. 46, 1756 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Robinson, D. S. and J. E. French: Heparin, the clearing factor lipase, and fat transport. Pharmacol. Rev. 12, 241 (1960).

    PubMed  CAS  Google Scholar 

  • Rose, H., M. Vaughan and D. Steinberg: Utilization of fatty acids by rat liver slices as a function of medium concentration. Amer. J. Physiol. 206, 345 (1964).

    PubMed  CAS  Google Scholar 

  • Rudas, B.: Das Verhalten der Serumlipide in verschiedenen Diabetesstadien der Ratte. Wien. klin. Wschr. 79, 377 (1967).

    PubMed  CAS  Google Scholar 

  • Sailer, S., F. Sandhofer und H. Braunsteiner: Steuerung der endogenen Lipoproteid-Lipase-Aktivität im Plasma bei Normalpersonen und Patienten mit essentieller Hyperlipämie. Dtsch. med. Wschr. 90, 865 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Sailer, S., F. Sandhofer und H. Braunsteiner: Overweight and triglyceride level in normal persons and patients with diabetes mellitus. Metabolism 15, 135 (1966a).

    Article  PubMed  CAS  Google Scholar 

  • Sailer, S., F. Sandhofer und H. Braunsteiner: Umsatzraten für freie Fettsäuren und Triglyceride im Plasma bei essentieller Hyperlipämie. Klin. Wschr. 44,1032 (1966b).

    Article  PubMed  CAS  Google Scholar 

  • Sailer, S., K. Bolzano und H. Braunsteiner: Über den Einfluß der Glucose auf den Umsatz der freien Fettsäuren des Plasmas, die Einbaurate der freien Fettsäuren in Plasmatriglyceride und die Wirkung von Noradrenalin auf diese Stoffwechselgrößen beim Menschen. Klin. Wschr. 45, 918 (1967a).

    Article  PubMed  CAS  Google Scholar 

  • Sailer, S., und H. Braunsteiner: Beziehungen zwischen Blutzuckerspiegel, Umsatzrate der freien Fettsäuren und Fettsäureeinbau in Plasmatriglyceride bei Diabetikern. Klin. Wschr. 45, 86 (1967b).

    Article  PubMed  CAS  Google Scholar 

  • Sailer, S., K. Bolzano, F. Sandhofer, P. Spath und H. Braunsteiner: Triglyceridspiegel und Insulinkonzentration im Plasma nach oraler Glukosegabe bei Patienten mit primärer koh-lenhydratinduzierter Hypertriglyceridämie. Schweiz. med. Wschr. 98, 1512 (1968a).

    PubMed  CAS  Google Scholar 

  • — F. Sandhofer, K. Bolzano and H. Braunsteiner: Action of norepinephrine and pro-pranolol on the turnover of free fatty acids and the esterification rate of free fatty acids to plasma triglycerides in man. Third International Symposium on Drugs Affecting Lipid Metabolism, Milan (1968b).

    Google Scholar 

  • Salaman, M. R.: Zit. nach: Robinson, D. S.: Clearing Factor Lipase and Fat Transport, in: Advances in Lipid Research, 1, 145, Paoletti, R. and D. Kritchevsky (Hrsg.), Academic Press, New York 1963.

    Google Scholar 

  • Salans, L. B. and G. M. Reaven: Effect of insulin pretreatment on glucose and lipid metabolism of liver slices from normal rats. Proc. Soc. exp. Biol. Med. 122, 1208 (1966).

    PubMed  CAS  Google Scholar 

  • Salt, H. B., O. H. Wolff, A. Nestadt and J. K. Lloyd: Control of lipaemia in children with diabetes mellitus. The role of insulin and the effects of a diet rich in unsaturated fatty acids. Lancet I, 71 (1960).

    Article  Google Scholar 

  • Sanbar, S. S., A. J. Zweifler and F. J. Conway: Carbohydrate metabolism in essential hyperlipidemia. Circulation 30, suppl. III, 27 (1964).

    Google Scholar 

  • Sandhofer, F., S. Sailer und H. Braunsteiner: Untersuchungen über die Lipoproteinlipase. III. Mitteilung. Die Post-Heparin-Lipoproteidlipase beim Menschen unter normalen und pathologischen Bedingungen. Klin. Wschr. 39, 968 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Sandhofer, F., S. Sailer und H. Braunsteiner: Untersuchungen über endogene Lipoproteidlipaseaktivität. Klin. Wschr. 40, 855 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Sandhofer, F., M. Herbst und H. Braunsteiner: Untersuchungen über die Post-Heparin-Lipoproteidlipase-Aktivität bei sechs Fällen von essentieller Hyperlipämie. Dtsch. med. Wschr. 90, 755 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Sandhofer, F., K. Bolzano, S. Sailer und H. Braunsteiner: Die Verwendung von Plasmaglucose-Koh-lenstoff zur Bildung von Plasmatriglycerid-Glycerol bei Patienten mit primärer „kohlen-hydratinduzierter“ Hypertriglyceridämie. Klin. Wschr. 46, 1034 (1968).

    Article  PubMed  CAS  Google Scholar 

  • — S. Sailer, K. Bolzano and H. Braunsteiner: Incorporation of plasma glucose carbon into plasma triglycerides in normal subjects and in patients with “carbohydrate-induced hypertriglyceridaemia”. Third Annual Meeting of the European Society for Clinical Investigation, Scheveningen, 1969a.

    Google Scholar 

  • Sandhofer, F., K. Bolzano, S. Sailer und H. Braunsteiner: Quantitative Untersuchungen über den Einbau von Plasmaglucose-Kohlenstoff in Plasmatriglyceride und die Veresterungsrate von freien Fettsäuren des Plasmas zu Plasmatriglyceriden während oraler Zufuhr von Glucose bei primärer kohlenhydratinduzierter Hypertriglyceridämie. Klin. Wschr. 47, 1086 (1969b).

    Article  PubMed  CAS  Google Scholar 

  • Sanwald, R. und P. Wahl: Über das Verhalten der Lipoproteide bei Diabetikern unter der Behandlung mit Biguaniden. Schweiz. med. Wschr. 94, 1459 (1964).

    PubMed  CAS  Google Scholar 

  • Schaefer, L. E.: Hyperlipidemia. Ann. N. Y. Acad. Sci. 148, 925 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Schalch, D. S. and D. M. Kipnis: Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids. J. clin. Invest. 44, 2010 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Schlierf, G. and L. W. Kinsell: Effect of insulin in hypertriglyceridemia. Proc. Soc. exp. Biol. Med. 120, 272 (1965).

    PubMed  CAS  Google Scholar 

  • Schnatz, J. D. and T. P. O’Connor: Studies on lipemia of diabetic acidosis. Diabetes 16, 534 (1967).

    Google Scholar 

  • Schnatz, J. D. and R.H. Williams: Adipose tissue lipolytic activity during insulin lack. Clin. Res. 10, 118 (1962).

    Google Scholar 

  • Schnatz, J. D. and R.H. Williams: The effect of acute insulin deficiency in the rat on adipose tissue lipolytic activity and plasma lipids. Diabetes 12, 174 (1963).

    PubMed  CAS  Google Scholar 

  • Schwartz, M. J., S. Mirsky and L. E. Schaefer: Phenformin, serum lipids, and diabetes mellitus. Lancet I, 959 (1965).

    Article  Google Scholar 

  • Schwartz, M. J. The effect of phenformin hydrochloride on serum cholesterol and triglyceride levels of the stable adult diabetic. Metabolism 15, 808 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Shah, S., V. Pomeroy, G. Michaels, M. Coelho and L. W. Kinsell: Glyceride and fatty acid response to fat loading in normal and abnormal subjects. Metabolism 12, 887 (1963).

    PubMed  CAS  Google Scholar 

  • Shipp, J. C.: Interrelation between carbohydrate and fatty acid metabolism of isolated perfused rat heart. Metabolism 13, 852 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Shipp, J. C. and J. F. Munroe: Effects of sulfonylurea compounds on hyperlipemia and hyperchole-steremia in patients with minimal impairment of glucose tolerance. Diabetes (suppl.) 11, 69 (1962).

    Google Scholar 

  • Shipp, J. C., L. H. Opie and D. Challoner: Fatty acid and glucose metabolism in the perfused heart. Nature 189, 1018 (1961).

    Article  CAS  Google Scholar 

  • Shipp, J. C., F. C. Wood jr. and A. Marble: Hyperlipemia following sulfonylurea therapy in young diabetics. J. Amer. Med. Ass. 188, 468 (1964).

    Article  CAS  Google Scholar 

  • Shoemaker, W. C., P. J. Carruthers, D. H. Elwyn and J. Ashmore: Effect of insulin on fatty acid transport and regional metabolism. Amer. J. Physiol. 203, 919 (1962).

    PubMed  CAS  Google Scholar 

  • Sigstad, H.: A family with mild diabetes mellitus, hyperlipemia and atherosclerosis. Acta med. Scand. 177, 465 (1965).

    PubMed  CAS  Google Scholar 

  • Smith, L. H. jr., R. H. Ettinger and D. Seligson: A comparison of the metabolism of fructose and glucose in hepatic disease and diabetes mellitus. J. clin. Invest. 32, 273 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Soling, H. D., R. Koschel, W. Drägert, P. Kneer und W. Creutzfeldt: Die Wirkung von Insulin auf den Stoffwechsel der isolierten perfundierten Leber normaler und alloxan-diabetischer Ratten. I. Der Stoffwechsel isolierter perfundierter Lebern von normalen und alloxandiabetischen Ratten unter verschiedenen experimentellen Bedingungen. Diabeto-logia 2, 20 (1966a).

    Article  CAS  Google Scholar 

  • Soling, H. D., P. Kneer, W. Drägert und W. Creutzfeldt: Die Wirkung von Insulin auf den Stoffwechsel der isolierten perfundierten Leber normaler und alloxandiabetischer Ratten. II. Stoffwechselveränderungen unter dem Einfluß intraportaler Insulininfusionen. Diabeto-logia 2, 32 (1966b).

    Article  CAS  Google Scholar 

  • Spitzer, J. J. and W. T. McElroy jr.: Some hormonal effects on uptake of free fatty acids by the liver. Amer. J. Physiol. 199, 876 (1960).

    CAS  Google Scholar 

  • Spitzer, J. J. and W. T. McElroy jr.: Some hormonal influences on the hepatic uptake of free fatty acids in diabetic dogs. Diabetes 11, 222 (1962).

    PubMed  CAS  Google Scholar 

  • Stein, Y. and B. Shapiro: The synthesis of neutral glycerides by fractions of rat liver homo-genates. Biochim. biophys. Acta 24, 197 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Stein, Y. and B. Shapiro: Assimilation and dissimilation of fatty acids by the rat liver. Amer. J. Physiol. 196, 1238 (1959).

    PubMed  CAS  Google Scholar 

  • Sterky, G., Y. Larsson and B. Persson: Blood lipids in diabetic and non-diabetic schoolchildren. Acta Paediat. (Stockholm) 52, 11 (1963).

    Article  CAS  Google Scholar 

  • Sterky, G., B. E. H. Persson and Y. A. A. Larsson: Dietary fats, the diurnal blood lipids and ketones in juvenile diabetes. Diabetologia 2, 14 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Swan, D. C., P. Davidson and M. J. Albrink: Effect of simple and complex carbohydrates on plasma non-esterified fatty acids, plasma-sugar and plasma-insulin during oral carbohydrate tolerance tests. Lancet I, 60 (1966).

    Article  Google Scholar 

  • Thannhauser, S. J.: Serum lipids and their value in diagnosis. New Engl. J. Med. 237, 515, 546 (1947).

    Article  PubMed  CAS  Google Scholar 

  • — Lipidoses, diaseases of the intracellular metabolism. Oxford Medical Publications, 2nd ed., Oxford 1950.

    Google Scholar 

  • Thorell, J., B. Persson and G. Sterky: Effect of fat infusion on plasma glucose, FFA, glycerol and insulin levels during intravenous and oral glucose tolerance tests. Diabetologia 2, 232 (1966).

    Google Scholar 

  • Tuller, E. F., G. V. Mann, F. Schertenleib, C. B. Roehrig and H. F. Root: Effects of diabetic acidosis and coma upon the serum lipoproteins and cholesterol. Diabetes 3, 279 (1954).

    PubMed  CAS  Google Scholar 

  • Tzur, R., E. Tal and B. Shapiro: α-Glycerophosphate as regulatory factor in fatty acid esteri-fication. Biochim. biophys. Acta 84, 18 (1964).

    PubMed  CAS  Google Scholar 

  • Waddell, W. R. and R. P. Geyer: Effect of insulin on clearance of emulsified fat from the blood in depancreatized dogs. Proc. Soc. exp. Biol. Med. 96, 251 (1957).

    PubMed  CAS  Google Scholar 

  • Waddell, W. R. N. Hurley and F. J. Stare: Abnormal carbohydrate metabolism in patients with hyper-cholesterolemia and hyperlipemia. Metabolism 7, 707 (1958).

    PubMed  CAS  Google Scholar 

  • Wahl, P.: Veränderungen der Konzentration von Glucose, freien Fettsäuren und Triglyceriden nach intravenöser Injektion von Buformin bei Diabetikern. 2. Int. Biguanid Symposium, Düsseldorf 1967.

    Google Scholar 

  • Weiss, S. B., E. P. Kennedy and J. Y. Kiyasu: The enzymatic synthesis of triglycerides. J. biol. Chem. 235, 40 (1960).

    PubMed  CAS  Google Scholar 

  • Wieland, O. und I. Neufeld: Zur Cholesterin-und Fettsäuresynthese in der diabetischen Rattenleber. Hoppe-Seyler’s Z. Physiol. Chem. 324, 101 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Wijnhausen, O. J.: Über Xanthomatose in einem Falle von recidivierender Pankreatitis. Berl. klin. Wschr. 58, 1268 (1921).

    Google Scholar 

  • Wilkinson, C. F. jr., E. A. Hand and M. T. Fliegelman: Essential familial hypercholestero-lemia. Ann. Int. Med. 29, 671 (1948).

    Article  PubMed  CAS  Google Scholar 

  • Wise, F. and J. Garb: Xanthoma diabeticorum with unusual form of eruption. Arch. Dermat. Syph. 45, 723 (1942).

    Article  Google Scholar 

  • Wolff, O. H. and H. B. Salt: Serum-lipids and blood-sugar levels in childhood diabetes. Lancet I, 707 (1958).

    Article  Google Scholar 

  • Wong, R. K. L. and J. T. van Bruggen: Lipid metabolism in the diabetic rat. I. Acetate metabolism and lipid synthesis in vivo. J. biol. Chem. 235, 26 (1960a).

    PubMed  CAS  Google Scholar 

  • Wong, R. K. L. and J. T. van Bruggen: Lipid metabolism in the diabetic rat. II. Cholesterol turnover studies. J. biol. Chem. 235, 30 (1960b).

    PubMed  CAS  Google Scholar 

  • Zakim, D., R. S. Pardini, R. H. Herman and H. E. Sauberlich: Mechanism for the differential effects of high carbohydrate diets on lipogenesis in rat liver. Biochim. biophys. Acta 144, 242 (1967a).

    Article  PubMed  CAS  Google Scholar 

  • Zakim, D., R. S. Pardini, R. H. Herman and H. E. Sauberlich: The relation of hepatic α-glycerophosphate concentration to lipogenesis in rat liver. Biochim. biophys. Acta 137, 179 (1967b).

    Article  PubMed  CAS  Google Scholar 

  • Zemplényi, T. e D. Grafnetter: Vliv hladovení a heparinu na lipolytickou aktivitù tkaní. Čas. Lék. čes. 98, 97 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sailer, S., Sandhofer, F., Braunsteiner, H. (1971). Diabetes mellitus und Hyperlipämie. In: Pfeiffer, E.F. (eds) Pathophysiologie und Klinik / Pathophysiology and Clinical Considerations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47669-3_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47669-3_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-47671-6

  • Online ISBN: 978-3-642-47669-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics