Abstract
De Jong in 1950 published a case of juvenile long-term diabetes with severe clinical and histological central nervous system abnormalities and coined the term “diabetic encephalopathy”. Apart from this paper very little has been published on the histology of the brain in diabetes during the last decades, and modern textbooks — with the exception of Henke-Lubarsch’s (Bodechtel and Erbslöh, 1958) — either ignore the brain or state that there are no cerebral abnormalities in diabetes mellitus (Warren and LeCompte, 1952; Joslin, 1959; Williams, 1960). Bodechtel and Erbslöh (1958), discussing cerebral changes in diabetic coma, state that “a specific diabetic encephalopathy does not exist, not even a characteristic histological pattern”. Under the heading “Diabetic Vascular Disease and Softening of the Brain” they mention a special clinical type of juvenile diabetes with multiple cerebral insults, quoting De Jong’s patient (1950) and briefly summarizing some clinical and histological findings in three personally observed cases.
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Literature
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Reske-Nielsen, E., Lundbaek, K. (1971). Diabetic Encephalopathy. In: Pfeiffer, E.F. (eds) Pathophysiologie und Klinik / Pathophysiology and Clinical Considerations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47669-3_28
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DOI: https://doi.org/10.1007/978-3-642-47669-3_28
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