Abstract
Analysis of the transmitter depletion model allowed us to obtain data related to mechanisms of the LFD at central synapses. On the other hand, our analysis revealed some imperfections in the depletion model. The depletion model (Sect. 10.8), in contrast to the quantum hypothesis (see Sect. 6.1), is unsuitable for resolving the problem of localization of plasticity mechanisms (presynaptic versus postsynaptic). It was concluded that the depletion model could not give additional methods of determination of the quantal parameters. The hippocampal responses appeared to be inconvenient for the application of the depletion model in view of complicated postactivation changes which include PPF and FF in addition to LFD. Therefore, it seemed reasonable to concentrate our further work on the analysis of plasticity mechanisms using the methods of quantal analysis (Chap. 8). Before starting an analysis of LTP mechanisms, we decided to consider more simple phenomena of PPF and LFD [88, 621, 1018, 1045–1047]. We hoped that this analysis would, firstly, be of interest by itself (Sect. 7.10), and secondly, test the sensitivity of these methods for distinguishing pre- versus postsynaptic localization of plasticity mechanisms.
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© 1993 Springer-Verlag Berlin Heidelberg
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Voronin, L.L. (1993). Quantal Analysis of Short-Term Plasticities at Central Synapses. In: Synaptic Modifications and Memory. Studies of Brain Function, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47615-0_12
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DOI: https://doi.org/10.1007/978-3-642-47615-0_12
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