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Wirkungsmechanismen klinisch gebräuchlicher Antiepileptika

  • Conference paper
Aktuelle Neuropädiatrie 1986

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Zusammenfassung

Im Zentrum jeder epileptischen Manifestation steht die gestörte Funktion zerebraler Neuronen. Charakteristisch für das „epileptische“ Neuron ist dabei die abnorme Labilität des Membranpotentials mit einer Neigung zu Spontanentladungen. Jedes Neuron kann unter pathophysiologischen Bedingungen epileptisch werden durch

  1. 1.

    Störung spezifischer Membranfunktionen,

  2. 2.

    Störung des extra- und intrazellulären Ionenhaushalts,

  3. 3.

    Depolarisation der Zellmembran als Folge einer gesteigerten Konzentration exzitatorischer oder Mangel an inhibitorischen Transmittersubstanzen oder

  4. 4.

    Fehlen normaler inhibitorischer Einflüsse von seiten besonderer Nervenzellen mit inhibitorischer Funktion.

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Authors
  1. W. Löscher
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Editors and Affiliations

  1. Universitäts-Kinderklinik, Adenauerallee 119, 5300, Bonn 1, Deutschland

    Helmut Fichsel

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Löscher, W. (1987). Wirkungsmechanismen klinisch gebräuchlicher Antiepileptika. In: Fichsel, H. (eds) Aktuelle Neuropädiatrie 1986. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47569-6_21

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  • DOI: https://doi.org/10.1007/978-3-642-47569-6_21

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