Skip to main content
SpringerLink
Log in

Hämostasiologie

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 88))

  • 36 Accesses

Zusammenfassung

Die Pathogenese erworbener Thrombozytopathien ist bisher nur unzureichend aufgeklärt. Klinische Erfahrung zeigt, daß bei Patienten mit lokaler oder disseminierter intravasaler Gerinnung, wie sie z. B. im Rahmen einer Sepsis beobachtet wird, eine Störung der primären Blutstillung auftreten kann, die über das Maß der Thrombozytopenie hinausgeht. In den vorliegenden Untersuchungen wurden deswegen Thrombozyten in vitro mit Thrombin behandelt und funktionelle sowie biochemische Eigenschaften derartiger Plättchen bestimmt.

Mit Unterstützung der Deutschen Forschungsgemeinschaft (Re 555/1-1)

und (Scha 358/1-1)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Massini P, Käser-Glanzmann R, Löscher EF (1978) Movement of calcium ions and their role in the activation of platelets. Thromb Haemostas 40: 212

    CAS  Google Scholar 

  2. Mustard JF, Perry DW, Ardlie NG, Packham MA (1972) Preparation of suspensions of washed platelets from humans. Br J Haematol 22: 193

    Article  PubMed  CAS  Google Scholar 

  3. Reimers HJ, Kinlough-Rathbone RL, Cazenave JP, Senyi AF, Hirsh J, Packham MA, Mustard JF (1976) In vitro and in vivo functions of thrombin-treated platelets. Thromb Haemostas 35: 151

    CAS  Google Scholar 

  4. Bunting S, O’Grady J, Fabiani JN, Terrier E, Moncada S, Vane JR, Dubost C (1981) Cardiopulmonary bypass in man: effects of prostacyclin. In: Lewis PJ, O’Grady J (eds) Clinical pharmacology of prostacyclin. Raven Press, New York, p 201

    Google Scholar 

  5. Davies GC, Mowschenson PM, Salzman EW (1978) Thromboxane B2 and fibrinopeptide A levels in platelet consumption and thrombosis. Surg Forum 29: 471–472

    PubMed  CAS  Google Scholar 

  6. Harker LA, Malpass TW, Branson HE, Hessel EA II, Slichter SJ (1980) Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective a-granule release. Blood 56: 824–834 —

    Google Scholar 

  7. Heinrich D, Schleussner E, Walter P, Wagner WL, Seilmann R, Ditter H, Matthias FR, Hehrlein FW (1981) Einfluß von Prostacyclin auf das Hämostasepotential unter den Bedingungen der extrakorporalen Zirkulation bei aortokoronaren Venenbypassoperationen. In: Blümel G, Haas S (Hrsg) Mikrozirkulation and Prostaglandinstoffwechsel. Schattauer, New York Stuttgart, S 241 —

    Google Scholar 

  8. Hennessy VL, Hicks RE, Niewiarowski S, Edmunds LH, Colman RW (1977) Function of human platelets during extracorporeal circulation. Am J Physiol 232: H622 — H628

    PubMed  CAS  Google Scholar 

  9. Longmore DB, Gueirrara D, Bennett G, Smith M, Bunting S, Reed P, Moncada S, Read NN, Vane JR (1979) Prostacyclin: a solution to some problems of extracorporeal circulation (experiments in greyhounds). Lancet 2: 1002–1005

    Article  Google Scholar 

  10. McKenna R, Bachmann F, Whittaker B, Gilson JR, Weinberg M (1975) The hemostatic mechanism after openheart surgery. II Frequency of abnormal platelet functions during and after extracorporeal circulation. J Thorac Cardiovasc Surg 70: 298–308

    Google Scholar 

  11. Moncada S, Gryglewsky R, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663–665 —9. Moncada S, Vane JR (1979) Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacol Rev 30: 293–331

    Google Scholar 

  12. Peskar BA, Anhut H, Kröner EE, Peskar BM (1979) Development, specificity and some applications of radioimmunoassays for prostaglandins and related compounds. In: Tillement JP (ed) Advances in pharmacology and therapeutics, vol 7. Pergamon Press, Oxford New York, p 275

    Google Scholar 

  13. Woods HF, Ash G, Weston MJ, Bunting S, Moncada S, Vane JR (1978) Prostacyclin can replace heparin in hemodialysis in dogs. Lancet 2: 1075–1077

    Article  PubMed  CAS  Google Scholar 

  14. Roskamm H (1981) Herzinfarkt im jugendlichen Alter (unter 40 Jahren) Risikofaktoren, Koronarmorphologie, Prognose und Progression der Koronargefäßsklerose. Cardiology 68: 23–30 —

    Google Scholar 

  15. Gohlke H, Stürzenhofecker P, Thilo A, Droste C, Görnandt L, Roskamm H (1981) Coronary angiographic findings and risk factors in postinfarction patients under the age of 40. In: Roskamm H (ed) Myocardial infarction at young age. Springer, Berlin Heidelberg New York, p 61

    Chapter  Google Scholar 

  16. Burkart F (1981) Die koronare Herzkrankheit beim jungen Patienten unter 35 Jahren in der Schweiz. Schweiz Med Wochenschr 110: 1631–1643

    Google Scholar 

  17. Rutsch W, Schmutzler H (1981) Intracoronary fibrinolysis in acute myocardial infarction in young patients. In: Roskamm H (ed) Myocardial infarction at young age. Springer, Berlin Heidelberg New York, p 156

    Chapter  Google Scholar 

  18. Ritter B, Schöll V, Gohlke H, Betz P, Budde U, Behnke B, Roskamm H (1982) Spielt der Plättchenfaktor 4 bei der Pathogenese des Herzinfarktes während körperlicher Belastung eine Rolle? (Abstract) Z Kardiol 48: 218

    Google Scholar 

  19. Pepper DS, Ludlam CA (1977) Beta-Thromboglobulin — A new approach to the diagnosis of thrombosis. In: Mills DCB, Pareti FI (eds) Platelets and thrombosis. Proceedings of the Serono Symposium, vol 10. London New York San Francisco, p 145

    Google Scholar 

  20. Delaye J, Beaune J, Delahaye JP (1981) Myocardial infarction at young age during high physical exercise. In: Roskamm H (ed) Myocardial infarction at young age. Springer, Berlin Heidelberg New York, p 115

    Chapter  Google Scholar 

  21. Pic A, Broustet JP, Saliou B, Gosse P, Guern P (1981) Coexistence of vigorous exercise and heavy smoking on triggering acute myocardial infarction in men under 35 years — Fact or fiction? In: Roskamm H (ed) Myocardial infarction at young age. Springer, Berlin Heidelberg New York, p 108

    Chapter  Google Scholar 

  22. Gohlke H, Gohlke-Bärwolf C, Stürzenhofecker P, Görnandt L, Roskamm H (1981) Der transmurale Herzinfarkt unter 40 Jahren — Korrelation von angiographischen Befunden mit Riskofaktoren und Anamnese bei 619 Patienten (Abstract) Z Kardiol 69: 724

    Google Scholar 

  23. Dawes J, Smith RL, Pepper DS (1978) The release, distribution and clearance of human ß-thromboglobulin and platelet factor 4. Thromb Res 12: 851–861

    Article  PubMed  CAS  Google Scholar 

  24. Schmitz-Huebner U, Balleisen L, Asbeck F, van de Loo J (1981) In vivo studies on the inhibition of coagulation by fractionated heparin and by a heparin analogue. I. Effects of heparin fractions. Thromb Haemostas 46: 612–616

    Google Scholar 

  25. Busch C, Dawes J, Pepper DS, Wasteson A (1980) Binding of platelet factor 4 to cultured human umbilical vein endothelial cells. Thromb Res 19: 129–137

    Article  PubMed  CAS  Google Scholar 

  26. Yin ET, Wessler S, Butler J (1973) Plasma heparin: A unique, practical, submicrogram sensitive assay. J Lab Clin Med 81: 298–310

    Google Scholar 

  27. Pumphrey CW, Pepper DS, Dawes J (1979) Heparin-PF 4 pulsing as a measure of platelet endothelial cell reaction in vivo. Thromb Haemostas 42: 43 (Abstract)

    Google Scholar 

  28. Asbeck F, Meyer-Boernecke D, van de Loo J (1977) Inhibition of fibrinolytic system in Behçet’s disease? Haemostasis 6: 303–309

    PubMed  CAS  Google Scholar 

  29. Brown C, Bradshaw W, Natelson C (1976) Defective platelet function following the administration of penicillin compounds. Blood 47: 949–956

    PubMed  CAS  Google Scholar 

  30. Johnson G, Rao G, White J (1978) Platelet dysfunction induced by parenteral carbenicillin and ticarcillin. Am J Pathol 91: 85–106

    PubMed  CAS  Google Scholar 

  31. Andrassy K, Scher M, Ritz E, Walter E (1976) Penicillin-induced coagulation disorder. Lancet 2: 1039–1041

    Article  PubMed  CAS  Google Scholar 

  32. Andrassy K, Zimmermann R, Höffler D, Ritz E (1977) Plättchenfunktionsstörung — eine Carbenicillin-Nebenwirkung bei normaler Nierenfunktion. Klin Wochenschr 55: 1021–1023

    Article  PubMed  CAS  Google Scholar 

  33. Cazenave J, Guccione M, Packham M, Mustard J (1977) Effects of cephalotin and penicillin G on platelet function in vitro. Br J Haematol 35: 135–152

    Article  CAS  Google Scholar 

  34. Shattil S, Bennett J, Donough M, Turnbull J (1980) Carbenicillin and penicillin G inhibit platelet function in vitro by impairing the interaction of agonists with the platelet surface. J Clin Invest 65: 329–337

    Article  PubMed  CAS  Google Scholar 

  35. Salzman W, Levine L (1971) Cyclic 3’5’-adenosine monophosphate in human platelets. J Clin Invest 50: 131–141

    Article  PubMed  CAS  Google Scholar 

  36. Bruno J, Taylor L, Droller M (1974) Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation. Nature 231: 721–723

    Article  Google Scholar 

  37. Ahn YS, Byrnes JJ, Harrington WJ, Cayer ML, Smith DS, Brunskill DE, Pall LM (1978) The treatment of idiopathic thrombocytopenia with vinblastineloaded platelets. N Engl J Med 298: 1101

    Article  PubMed  CAS  Google Scholar 

  38. Bowring CS, Glass HI, Lewis SM (1976) Rate of clearance by the spleen of heat-damaged erythrocytes. J Clin Pathol 29: 852–854

    Article  PubMed  CAS  Google Scholar 

  39. Finch SC, Castro O, Cooper M, Covey W, Erichson R, McPhedran P (1974) Immunsuppressive therapy of chronic idiopathic thrombocytopenic purpura. Am J Med 56: 4

    Article  PubMed  CAS  Google Scholar 

  40. Fineman SM, Mudawwar FB, Geha RS (1979) Characteristics and mechanisms of action of the concanavalin A-activated suppressor cell in man. Cell Immunol 45: 120–132

    Article  PubMed  CAS  Google Scholar 

  41. Imbach P, Barandun S, d’Apuzzo V, Baumgartner C, Hirt A, Morell A, Rossi E, Schöni M, Vest M, Wagner HP (1981) High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1: 1228–1230

    Article  PubMed  CAS  Google Scholar 

  42. McMillan R (1981) Chronic idiopathic thrombocytopenic purpura. N Engl J Med 304: 1135–1147

    Article  PubMed  CAS  Google Scholar 

  43. Mueller-Eckhardt C, Mahn I, Schulz G, Mueller-Eckhardt G (1978) Detection of platelet autoantibodies by a radioactive anti-immunoglobulin test. Vox Sang 35: 357

    Article  PubMed  CAS  Google Scholar 

  44. Schmidt RE, Mueller-Eckhardt C, Kayser W, Budde U, Schneider M, Stroehmann I (1979) Die Wirkung von Vinblastin-beladenen Thrombozyten im Fall einer idiopathischen thrombozytopenischen Purpura Immun Infekt 7: 129–133

    CAS  Google Scholar 

  45. Schmidt RE, Budde U, Schäfer G, Stroehmann I (1981) High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura. Lancet 2: 475–476

    Article  PubMed  CAS  Google Scholar 

  46. Aberg M, Nilsson IM, Hedner U (1973) Antithrombin III after operation. Lancet 2: 1337 —

    Google Scholar 

  47. Gofferje H, Fekl W (1979) Diagnostik der Mangelernährung. Infusionstherapie 6: 95–99 —

    Google Scholar 

  48. Hedner U, Nilsson IM (1973) Antithrombin III in a clinical material. Thromb Res 3: 631–641 —

    Google Scholar 

  49. Jorgensen KA, Stoffersen E, Sorensen PJ, Ingeberg S, Hüttel M, Ahlbom G (1980) Alteration in plasma antithrombin III following total hip replacement and elective cholecystectomy. Scand J Haematol 24: 101–104

    Article  PubMed  CAS  Google Scholar 

  50. Lechner K, Thaler E, Niessner H, Nowotny Ch, Partsch H (1980) Antithrombin III-Mangel und Thromboseneigung. Wien Klin Wochenschr 89: 215–222

    Google Scholar 

  51. Reinicke R, Matthias FR, Lasch HG (1977) Content of soluble fibrin in plasma of patients after myocardial infarction, with carcinomas and consumption coagulopathy. Thromb Res 11: 365–375

    Article  PubMed  CAS  Google Scholar 

  52. Samama H (1980) Low-dose heparin in gynecological surgery: Effect on blood coagulation tests. Scand J Haematol [Supp1 36] 25: 101–106

    Google Scholar 

  53. Schöndorf TH, Lasch HG (1980) Antithrombin III and factor Xa determination in patients with lowdose heparin and hip surgery. In: Lijnen HR, Collen D, Verstraete M (eds) Synthetic substrates in clinical blood coagulation assays. Dev Haematol 1: 51–57

    Google Scholar 

  54. Schöndorf TH (1981) Wertigkeit und Grenzen der Low-dose-Heparinprophylaxe zur Verhütung postoperativer thromboembolischer Komplikationen. Hämostaseologie 1: 143–153

    Google Scholar 

  55. Fritsche HM, Stemberger A, v Sommoggy S, Fischer M, Blümel G (1981) Zur Pathogenese des Gerinnungsdefektes im akuten Leberversagen. Med Welt 32: 389–392

    Google Scholar 

  56. Heene DL (1979) Hämostasestörungen bei Lebererkrankungen. In: Kühn HA, Wernze H (Hrsg) Klinische Hepatologie. Thieme, Stuttgart, S 3105–3119

    Google Scholar 

  57. Greenlee HB, Malcolm MS, Reinhardt GF (1981) Intractable ascites treated with peritoneovenous shunts. Arch Surg 116: 518–524

    Article  PubMed  CAS  Google Scholar 

  58. Stein SF, Fulenwider JT, Ansley JD, Evatt BL (1981) Accelerated fibrinogen and platelet destruction after peritoneovenous shunting. Arch Intern Med 141: 1149–1151

    Article  PubMed  CAS  Google Scholar 

  59. Tawes RL, Sydorak GR, Kennedy PA, Brown WH, Scribner RG, Beare JP, Harris EJ (1981) Am J Surg 142: 52–55

    Article  Google Scholar 

  60. Liehr H (1982) Endotoxins and the pathogenesis of hepatic and gastrointestinal diseases. Ergeb Inn Med Kinderheilkd 48: 117–193

    PubMed  CAS  Google Scholar 

  61. Schölmerich J, Diener W, Maier KP, Eckart F, Gerok W (1981) Short term reinfusion a successfull treatment of refractory ascites. Crit Care Med 9: 278

    Article  Google Scholar 

  62. Gordon S, Unkeless J, Cohn ZA (1974) Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis. J Exp Med 140: 995

    Article  PubMed  CAS  Google Scholar 

  63. Fletcher AP, Biederman O, Moore D, Alkajaersig N, Sherry S (1964) Abnormal plasminogen-plasmin system activity in patients with hepatic cirrhosis: Its cause and consequences. J Clin Invest 43: 681–695

    Google Scholar 

  64. Maier RV, Ulevitch RJ (1981) The induction of a unique procoagulant activity in rabbit hepatic macrophages by bacterial lipopolysaccharides. J Immunol 127: 1596–1800

    PubMed  CAS  Google Scholar 

  65. Vassalli JD, Hammilton J, Reich E (1976) Macrophage plasminogen activator: Modulation of enzyme production by antiinflammatory steroids. Cell 8: 271–281

    Google Scholar 

  66. Hamilton JA (1981) Regulation of prostaglandin and plasminogen activator production by mouse peritoneal macrophages. J Reticuloendothel Soc 30: 115–128

    PubMed  CAS  Google Scholar 

  67. Bernsmeier R, Bruhn HD, Pohl J (1981) Gerinnungsfaktoren (Thrombin, Faktor XIII, Kallikrein und Fibronectin) als Regulatoren der Proliferation von Fibroblasten, glatten Muskelzellen und Endothelzellen. Verh Dtsch Ges Inn Med 87: 782–785

    Google Scholar 

  68. Bruhn HD, Christophers E, Pohl J (1980) Gerinnungsfaktoren ( Thrombin, Faktor XIII) als Wachstumsfaktoren der Fibroblasten. Verh Dtsch Ges Inn Med 86: 1120–1123

    Google Scholar 

  69. Bruhn HD, Bernsmeier R, Broers H, Pohl J (1981) Regulation der Fibroblasten-und Endothelzellenproliferation durch Thrombin, Faktor XIII und Fibronectin. In: Blümel G, Haas S (Hrsg) Mikrozirkulation und Prostaglandinstoffwechsel. Schattauer, Stuttgart New York, S 257–265

    Google Scholar 

  70. Cunningham DD (1981) Proteases as growth factors. In: Baserga R (ed) Tissue growth factors. Springer, Berlin Heidelberg New York, pp 228–248

    Google Scholar 

  71. Laki K (1976) Faktor XIII und Metastasierung. In: Gastpar H (Hrsg) Onkohämostaseologie. Schattauer, Stuttgart New York, S 61–71

    Google Scholar 

  72. Maxfield FR, Davies PJA, Klempner L, Willingham MC, Pastan I (1979) Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proc Natl Acad Sci USA 76: 5731–5735

    Article  PubMed  CAS  Google Scholar 

  73. Pohl J, Bruhn HD, Christophers E (1979) Thrombin and fibrin-induced growth of fibroblasts: role in wound repair and thrombus organization. Klin Wochenschr 57: 273–277

    Article  PubMed  CAS  Google Scholar 

  74. Rouslahti E, Vaheri A (1974) Novel human serumprotein from fibroblast plasma membrane. Nature 248: 789–791

    Article  Google Scholar 

  75. Yamada K, Yamada S, Pastan I (1976) Cell surface protein partially restores morphology, adhesiveness and contact inhibition of movement to transformed fibroblasts. Proc Natl Acad Sci USA 73: 1217–1221

    Article  PubMed  CAS  Google Scholar 

  76. Kirchhof BRJ, Vermeer C, Hemker HC (1978) The determination of prothrombin using synthetic chromogenic substrates; choice of a suitable activator. Thromb Res 13: 219

    Article  PubMed  CAS  Google Scholar 

  77. Avvisati G, TenCate JW, van Wijk EM, Kahlé LH, Marian G (1980) Evaluation of a new chromogenic assay for factor VII and its application in patients on oral anticoagulant therapy. Br J Haematol 45: 343

    Article  PubMed  CAS  Google Scholar 

  78. Bertina RM, van der Marel-van Nieuwkoop W, Loeliger EA (1979) Spectrophotometric assay of prothrombin in plasma of patients using oral anticoagulants. Thromb Haemostas 42: 1296

    CAS  Google Scholar 

  79. Kirchhof BRJ, Muller AD, Vermeer C, Hemker HC (1979) Control of anticoagulant therapy with a chromogenic substrate. Haemostasis 8: 1

    PubMed  CAS  Google Scholar 

  80. Lämmle B, Eichlisberger R, Hänni L, Bounameaux H, Marberg GA, Duckert F (1979) Kontrolle der Antikoagulation: Vergleich zwischen Quick-und kolorimetrischer Faktor-X-Bestimmung bei 107 Patienten. Schweiz Med Wochenschr 109: 1115

    PubMed  Google Scholar 

  81. Erskine JG, Walker ID, Davidson JF (1980) Maintenance control of oral anticoagulant therapy by a chromogenic substrate assay for factor X. J Clin Pathol 33: 445

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Med. Klinik A, Univ. Düsseldorf, Deutschland

    H.-J. Reimers, E. Freiberger, R. E. Scharf, M. Planker & W. Schneider

  2. Lukaskrankenhaus, Kinderklinik, Neuß, Deutschland

    G. Braumann

  3. Med. Biologie, Univ. des Saarlandes, Homburg, Deutschland

    E. Morgenstern

  4. Zentrum für Chirurgie, Deutschland

    P. Walter

  5. Zentrum für Innere Medizin, Deutschland

    H. Ditter, F. R. Matthias & D. Heinrich

  6. Zentrum für Innere Medizin, Klinikums der Univ. Gießen, Deutschland

    R. Voss

  7. Rehabilitationszentrum für Herz- und Kreislaufkranke, Bad Krozingen, Deutschland

    B. Ritter, V. Schöll, H. Gohlke, P. Betz & H. Roskamm

  8. Med. Univ.-Klinik, Deutschland

    U. Schmitz-Huebner

  9. Inst. für Arterioskleroseforschung, Deutschland

    H. Beek

  10. Med. Univ.-Klinik Münster, Deutschland

    U. Delvos

  11. Med. Univ.-Klinik Heidelberg, Deutschland

    K. Andrassy, B. Kern, J. Koderisch, W. Kreusser, A. Wietasch & E. Ritz

  12. Med. Univ.-Klinik, Deutschland

    R. E. Schmidt

  13. Inst. für experimentelle Hämatologie und Bluttransfusion, Univ. Bonn, Deutschland

    U. Budde

  14. Inst. für experimentelle Hämatologie und Bluttransfusion, Bonn, Deutschland

    U. Budde

  15. Inst. für Klin. Immunologie und Tranfusionsmedizin Gießen, Deutschland

    C. Mueller-Eckhardt

  16. Zentrum für Innere Medizin Gießen, Deutschland

    T. H. Schöndorf & A. Trüschler

  17. Dept. für Gastroenterologie und Hepatologie, Med. Klinik, Med. Hochschule Hannover, Deutschland

    H. Lösgen, G. Brunner & F. W. Schmidt

  18. Med. Univ.-Klinik Freiburg, Deutschland

    E. Köttgen, J. Schölmerich, D. Böttcher, W. Diener & W. Gerok

  19. Abt. für Nephrologie, Med. Univ.-Klinik Göttingen, Deutschland

    J. Schrader, H. Köstering, B. Freudenberg, H. J. Gröne, E. J. Kirchertz & F. Scheler

  20. I. Med. Univ.-Klinik Kiel, Deutschland

    R. Bernsmeier, P. Lück & H. D. Bruhn

  21. Zentrum für Medizin, Deutschland

    G. Oehler & E. Kunz

  22. Inst. für Klin. Chemie, Gießen, Deutschland

    M. Stibora & L. Ròka

Authors
  1. H.-J. Reimers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Braumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Freiberger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Morgenstern
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. E. Scharf
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Planker
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P. Walter
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. H. Ditter
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. F. R. Matthias
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. D. Heinrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. R. Voss
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. B. Ritter
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. V. Schöll
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. H. Gohlke
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. P. Betz
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. H. Roskamm
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. U. Schmitz-Huebner
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. H. Beek
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. U. Delvos
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. K. Andrassy
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. B. Kern
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. J. Koderisch
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. W. Kreusser
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. A. Wietasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. E. Ritz
    View author publications

    You can also search for this author in PubMed Google Scholar

  27. R. E. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  28. U. Budde
    View author publications

    You can also search for this author in PubMed Google Scholar

  29. C. Mueller-Eckhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  30. T. H. Schöndorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  31. A. Trüschler
    View author publications

    You can also search for this author in PubMed Google Scholar

  32. H. Lösgen
    View author publications

    You can also search for this author in PubMed Google Scholar

  33. G. Brunner
    View author publications

    You can also search for this author in PubMed Google Scholar

  34. F. W. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  35. E. Köttgen
    View author publications

    You can also search for this author in PubMed Google Scholar

  36. J. Schölmerich
    View author publications

    You can also search for this author in PubMed Google Scholar

  37. D. Böttcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  38. W. Diener
    View author publications

    You can also search for this author in PubMed Google Scholar

  39. W. Gerok
    View author publications

    You can also search for this author in PubMed Google Scholar

  40. J. Schrader
    View author publications

    You can also search for this author in PubMed Google Scholar

  41. H. Köstering
    View author publications

    You can also search for this author in PubMed Google Scholar

  42. B. Freudenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  43. H. J. Gröne
    View author publications

    You can also search for this author in PubMed Google Scholar

  44. E. J. Kirchertz
    View author publications

    You can also search for this author in PubMed Google Scholar

  45. F. Scheler
    View author publications

    You can also search for this author in PubMed Google Scholar

  46. R. Bernsmeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  47. P. Lück
    View author publications

    You can also search for this author in PubMed Google Scholar

  48. H. D. Bruhn
    View author publications

    You can also search for this author in PubMed Google Scholar

  49. G. Oehler
    View author publications

    You can also search for this author in PubMed Google Scholar

  50. E. Kunz
    View author publications

    You can also search for this author in PubMed Google Scholar

  51. M. Stibora
    View author publications

    You can also search for this author in PubMed Google Scholar

  52. L. Ròka
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kliniken der Landeshauptstadt Wiesbaden, D-6200, Wiesbaden, Deutschland

    Bernhard Schlegel

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Reimers, HJ. et al. (1982). Hämostasiologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 88. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47093-6_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47093-6_25

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0332-0

  • Online ISBN: 978-3-642-47093-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation