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Diabetologie

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Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 88))

Zusammenfassung

Wir versuchten in vivo, ob Insulin eine negative Rückkopplung auf seine eigene Sekretion ausübt. Zur Klärung der physiologischen Bedeutung eines derartigen Feedbacks wurden gesunde ideal- bis normalgewichtige Freiwillige untersucht. Bei zwei Erkrankungen mit Hyperinsulinismus, der Adipositas und dem Insulinom, stellte sich die Frage, ob ein gestörter Feedback eine pathophysiologische Rolle spielen könnte. Über die Mehrzahl unserer Befunde bei Gesunden und Adipösen berichteten wir bereits ausführlich [3, 4]. Im folgenden werden diese Ergebnisse zusammengefaßt und durch die Befunde bei Insulinomen ergänzt [vgl. 2].

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Literatur

  1. Beischer W, Keller L, Maas M, Schiefer E, Pfeiffer EF (1976) Human C-peptide, part I: radioimmunoassay. Klin Wochenschr 54: 709–715

    PubMed  CAS  Google Scholar 

  2. Beischer W, Riegger R, Kerner W, Schmid M, Pfeiffer EF (1982) Feedback inhibition of insulin in patients with beta-cell adenoma. Horm Metab Res (in press)

    Google Scholar 

  3. Beischer W, Schmid M, Kerner W, Keller L, Pfeiffer EF (1978) Does insulin play a role in the regulation of its own secretion? Horm Metab Res 10: 168–169

    PubMed  CAS  Google Scholar 

  4. Beischer W, Schmid M, Kerner W, Keller L, Pfeiffer EF (1979) Feedback inhibition of insulin in healthy and overweight subjects studied by use of an artificial endocrine pancreas. Horm Metab Res [Suppl] 8: 97–106

    CAS  Google Scholar 

  5. Elahi D, Nagulesparan M, Hershcopf RJ, Muller DC, Tobin JD, Blix PM, Rubenstein AH, Unger RH, Andres R (1982) Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity. N Engl J Med 306: 1196–1202

    PubMed  CAS  Google Scholar 

  6. Verspohl EJ, Ammon HPT (1980) Evidence for the presence of insulin receptors in rat islets of Langerhans. J Clin Invest 65: 1230–1237

    PubMed  CAS  Google Scholar 

  7. Drost H (1978) Untersuchungen zur Glukagonsekretion und deren metabolische Bedeutung bei Erkrankungen des Kohlenhydrat-und Fettstoffwechsels. Habilitationsschrift Düsseldorf

    Google Scholar 

  8. Valverde I, Dobbs R, Unger RH (1975) Heterogeneity of plasma-glucagon immunoreactivity in normal, depancreatized and alloxan diabetic dogs. Metabolism 24: 1021–1028

    PubMed  CAS  Google Scholar 

  9. Recant L, Perrino PV, Bhathena SJ, Danforth DN, Lavine RL (1976) Plasma immunoreactive glucagon fractions in four cases of glucagonoma: increased “large glucagon-immunoreactivity”. Diabetologia 12: 319–326

    PubMed  CAS  Google Scholar 

  10. Miller LL (1973) Technique of isolated liver perfusion In: Bartosek I, Guaitani A, Miller LL (eds) Isolated liver perfusion and its applications. Raven Press, New York, pp 11–52

    Google Scholar 

  11. Schwenen M (1970) Glukoneogenese aus extrahepatischen Substraten: Cortisolwirkungen auf den Stoffwechsel der isoliert perfundierten Rattenleber. Dissertation Düsseldorf

    Google Scholar 

  12. Beck-Nielson H (1978) The pathogenic role of an insulin receptor defect in diabetes mellitus of obese. Diabetes 27: 1175

    Google Scholar 

  13. Berry MD, Friend DS (1969) High-yield preparation of isolated rat liver parenchymal cells. J Cell Biol 43: 506

    PubMed  CAS  Google Scholar 

  14. Blackard WG, Guzelian PS, Small ME (1978) Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer. Endocrinology 103: 548

    PubMed  CAS  Google Scholar 

  15. Davies JPA, Davies DR, Levitzki A, Maxfield FR, Milhaud P, Willingham MC, Pastan IH (1980) Transglutaminase is essential in receptor mediated endocytosis of a2-macroglobulin and polypeptide hormones. Nature 283: 162

    PubMed  CAS  Google Scholar 

  16. De Meyts P, Bianco AR, Roth J (1976) Site-site interactions among insulin receptors. Characterisation of the negative cooperativity. J Biol Chem 251: 1877

    Google Scholar 

  17. Fleig WE, Nöther-Fleig G, Fußgänger R, Ditschuneit H (1982) Insulin binding, internalisation and degradation in cultured hepatocytes. Effects of chloroquine, bacitracin and dansylcadaverine (Eingereicht zur Publikation)

    Google Scholar 

  18. Fußgänger RD, Kahn CR, Roth J, De Meyts P (1976) Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity J Biol Chem 251: 2761 — 8. Olefsky 1M, Reaven GM (1974) Decreased insulin binding to lymphocytes from diabetic patients. J Clin Invest 54: 1323

    Google Scholar 

  19. Olefsky JM, Reaven GM (1976) Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. Am J Med 60: 89

    PubMed  CAS  Google Scholar 

  20. Prince MJ, Olefsky JM (1980) Direct effect of a sulfonylurea to increase human fibroblast insulin receptors. J Clin Invest 66: 603

    Google Scholar 

  21. Reaven GM, Dray J (1967) Effect of chlorpropamide on serum glucose and immunoreactive insulin concentrations in patients with maturity onset diabetes mellitus. Diabetes 16: 487

    PubMed  CAS  Google Scholar 

  22. Scatchard G (1949) The attractions of proteins for small molecules and ions. Ann NY Acad Sci 51: 660

    CAS  Google Scholar 

  23. Schudt Ch (1980) Influence of insulin, glucocorticoids and glucose on glycogen synthase activity in hepatocyte cultures. Biochim Biophys Acta 629: 499

    PubMed  CAS  Google Scholar 

  24. Shen SW, Bressler R (1977) Clinical pharmacology of oral antidiabetic agents. N Engl J Med 296: 493, 787

    PubMed  CAS  Google Scholar 

  25. Stange EF, Fleig WE, Schneider A, Nöther-Fleig G, Alavi M, Preclik G, Ditschuneit H (1982) 3-Hydroxy-3-methylglutaryl coenzyme A reductase in cultured hepatocytes. Regulation by heterologous lipoproteins and hormones. Atherosclerosis 41: 67

    Google Scholar 

  26. Bratusch-Marrain P, Smith D, DeFronzo RA (1982) The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metab (in press)

    Google Scholar 

  27. DeFronzo RA, Beckles AD (1979a) Glucose intolerance following chronic metabolic acidosis in man. Am J Physiol 5: E328 — E334

    Google Scholar 

  28. DeFronzo RA, Tobin J, Andres R (1979b) The glucose clamp technique. A method for the quantification of beta cell sensitivity to glucose and of tissue sensitivity to insulin. Am J Physiol 237: E214 — E223

    PubMed  CAS  Google Scholar 

  29. Waldhäusl W, Kleinberger G, Korn A, Dudczak R, Bratusch-Marrain P, Nowotny P (1979a) Severe hyperglycemia: Effect of rehydration on endocrine derangements and blood glucose concentration. Diabetes 28: 577–584

    Google Scholar 

  30. Waldhäusl WK, Kleinberger G, Kastner G, Komjati M, Korn A, Nowotny P, Bratusch-Marrain P (1979b) Glucose utilization: effects of hyperosmolality and counterregulatory hormones. Studies in vivo and in vitro. Acta Endocrinol (Kbh) [Suppl] 225: 405

    Google Scholar 

  31. DeFronzo RA, Lang R (1980) Hypophosphataemia and glucose intolerance: evidence for tissue insensitivity to insulin. N Engl J Med 303: 1259–1263

    PubMed  CAS  Google Scholar 

  32. Kanter J, Gerson JR, Bessmann AN (1977) 2,3-Diphosphoglycerate, nucleotide phosphate, and organic and inorganic phosphate levels during the early phases of diabetic ketoacidosis. Diabetes 26: 429

    Google Scholar 

  33. Yasuda K, Hurukawa Y, Okuyama M, Kikuchi M, Yoshinaga K (1975) Glucose intolerance and insulin secretion in patients with parathyroid disorders: effect of serum calcium in insulin release. N Engl J Med 292: 501–504

    PubMed  CAS  Google Scholar 

  34. Houssay BA, Biasotti A (1981) Pankreas, Diabetes and Hypophyse beim Hund. Arch Physiol 227: 664

    Google Scholar 

  35. Poulson JE (1953) Recovery from retinopathy in a case of diabetes with Simmonds’ disease. Diabetes 2: 712

    Google Scholar 

  36. Drury MI, O’Loughlin S, Sweeney E (1970) Houssay phenomenon in a diabetic. Br Med J 1: 709

    Google Scholar 

  37. Schalch DS, Burday SZ (1971) Antepartum pituitary insufficiency in diabetes mellitus. Ann Intern Med 74: 357–360

    PubMed  CAS  Google Scholar 

  38. Pi-Sunyer FX, Cushman P Jr (1972) Sheehan’s syndrome and diabetes mellitus: Observations on the Houssay phenomenon in man. Am J Med Sci 264: 143–147

    Google Scholar 

  39. Hedner P (1972) Diabetes mellitus and defective pituitary reserve capacity. Acta Med Scand 191: 87–90

    PubMed  CAS  Google Scholar 

  40. Nikkilä EA, Pelkonen MR, Paskinen MR, Aro A (1974) Insulin deficiency associated with hypoglycemia and good glucose tolerance in hypopituitarism. Acta Med Scand 195: 435–439

    PubMed  Google Scholar 

  41. Greenwood RH, Ireland JT, Jones DH, Mahler RF (1975) Diabetic complications in a patient with coexisting anterior hypopituitarism. Diabetes 24: 1027–1031

    PubMed  CAS  Google Scholar 

  42. Herbai G, Werner I (1976) Sheehan’s syndrome of hypothalamic origin in a woman with juvenile diabetes mellitus. Acta Med Scand 199: 539–541

    PubMed  CAS  Google Scholar 

  43. Olson D, Winternitz WW (1977) Hypopituitarism: A complication of diabetes. South Med J 70: 411–413

    Google Scholar 

  44. Allen RC, Stjernholm RL, Steele RH (1972) Evidence for the generation of an electronic excitation state (s) in human polymorphonuclear leucocytes and its participation in bactericidal activity. Biochem Biophys Res Commun 47: 679–684

    PubMed  CAS  Google Scholar 

  45. Becker HJ, Munder G, Fischer H (1958) Über den Leukocytenstoffwechsel bei der Phagozytose. Hoppe Seylers Z Physiol Chem 313: 266–275

    PubMed  CAS  Google Scholar 

  46. Drachmann K, Koot K, Wood WB (1966) Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defense. I. Demonstration of defects in phagocytosis. J Exp Med 124: 227–230

    Google Scholar 

  47. Fischer H, Kato T, Wokalek H, Ernst M, Eggert H, Rietschel E Th (1981) Measurements of granulocyte and platelet chemiluminscence in small samples of whole blood. In: Deluca MA, McElroy WD (eds) Bioluminescence and chemiluminescence. Academic Press, pp 617–622

    Google Scholar 

  48. Haupt E (1974) Diabetes mellitus und Infektionskrankheiten. In: Mehnert H, Schöffling K (Hrsg) Diabetologie in Klinik und Praxis. Thieme, Stuttgart, S 481–485

    Google Scholar 

  49. Kato T, Wokalek H, Schöpf E, Eggert H, Ernst M, Rietschel ETh, Fischer H (1981) Measurements of chemiluminescence in freshly drawn human blood. Klin Wochenschr 59: 203–211

    PubMed  CAS  Google Scholar 

  50. Nohl H (1981) Physiologische und pathophysiologische Bedeutung von Superoxid-Radikalen und die regulatorische Rolle des Enzyms Superoxiddismutase. Klin Wochenschr 59: 1081–1091

    PubMed  CAS  Google Scholar 

  51. Sbarra AT, Karnovsky ML (1959) The biochemical basis of phagocytosis I. Metabolic change during the ingestion of particels by polymorphonuclear leucocytes. J Biol Chem 234: 1355–1362

    Google Scholar 

  52. Tauber AI (1981) Current views of neutrophil dysfunction. Am J Med 70: 1237–1246

    PubMed  CAS  Google Scholar 

  53. Van Dyke K, Dyke C van, Peden D, Matamoros M (1981) Preliminary events leading to the production of luminol-dependent chemiluminescence by human granulocytes. In: Deluca MA, McElroy WD (eds) Bioluminescence and chemiluminescence. Academic Press, pp 45–53

    Google Scholar 

  54. Beutler E (1975) Red cell metabolism. A manual of biochemical methods, 2nd edn. Grune & Stratton, New York

    Google Scholar 

  55. Gachon AM, Ghaddab M, Kitzis A, Wajcman H, Dastugue B (1982) Fast fluctuations of glycosylated hemoglobins. Clin Chim Acta 121: 125–131

    PubMed  CAS  Google Scholar 

  56. Goebel KM, Goebel FD, Schubotz R, Schneider J (1979) Hemolytic implications of alcoholism in liver disease. J Lab Clin Med 94: 123–132

    PubMed  CAS  Google Scholar 

  57. Goebel KM, Goebel FD, Neitzert A, Hausmann L, Schneider J (1975) Adaptation of red cell enzymes and intermediates in metabolic disorders. Enzyme 19: 201–211

    PubMed  CAS  Google Scholar 

  58. Lowe GDO, Barbenel JC, Sorbes CD (1981) Clinical aspects of blood viscosity and cell deformibility. Springer, Berlin Heidelberg. New York

    Google Scholar 

  59. Stäubli M, Straub PW (1979) Red cell filtration by paper filters. Blut 39: 333–344

    PubMed  Google Scholar 

  60. Bretzel RG, Breidenbach Ch, Hofmann I, Federlin K (1979) Islet transplantation in experimental diabetes of the rat. VI. Rate of regression in diabetic kidney lesions after isogeneic islet transplantation: quantitative measurements. Horm Metab Res 11: 200–207

    PubMed  CAS  Google Scholar 

  61. Bretzel RG, Menden A, Richardt M, Brocks DG, Draeger KE, Federlin K (1981) Renal collagen glucosyltransferase activity following islet transplantation in streptozotocin-diabetic rats. Diabetologia 21: 428–429

    PubMed  CAS  Google Scholar 

  62. Bretzel RG, Menden A, Richardt M, Gensicke J, Timpl R, Federlin K (1981) Basalmembranfragmente im Serum diabetischer und inseltransplantierter Ratten. Mögliche Marker einer diabetischen Mikroangiopathie. Aktuel Endokrinol 2: 84–85

    Google Scholar 

  63. Bretzel RG, Schneider J, Zimmermann I, Köppers B, Weise M, Federlin K (1981) Urinary excretion of alanine aminopeptidase and total proteinuria in experimental diabetes mellitus before and after islet transplantation. In: Weise M (ed) Experimental and clinical aspects of proteinuria. Karger, Basel München Paris London New York Sydney, p 153

    Google Scholar 

  64. Eyre DR (1980) Collagen: Molecular diversity in the body’s protein scaffold. Science 207: 1315–1322

    PubMed  CAS  Google Scholar 

  65. Kefalides NA (1978) Biology and chemistry of basement membranes. Academic Press, New York

    Google Scholar 

  66. Madri JA, Roll FJ, Furthmayr H, Foidart J-M (1980) Ultrastructural localization of fibronectin and laminin in the basement membranes of the murine kidney. J Cell Biol 86: 682–687

    PubMed  CAS  Google Scholar 

  67. Risteli J, Rohde H, Timpl R (1981) Sensitive radioimmunoassays for 7-s collagen and laminin. Application to serum and tissue studies of basement membranes. Anal Biochem (in press)

    Google Scholar 

  68. Timpl R, Wick G, Gay S (1977) Antibodies to distinct types of collagens and procollagens and their application in immunohistology. J Immunol Methods 18: 165–182

    PubMed  CAS  Google Scholar 

  69. Tunbridge WMG (1981) Factors contributing to deaths of diabetics under fifty years of age. Lancet 2: 569–572

    PubMed  CAS  Google Scholar 

  70. Fölsch UR (1982): Therapeutic potential of a-glucosidase-inhibitors. Hepato-Gastroenterol 29: 47–48

    Google Scholar 

  71. Caspary WF (1978): Sucrose malabsorption in man after ingestion of a-glucoside-hydrolase inhibitor. Lancet 1: 1231–1232

    PubMed  CAS  Google Scholar 

  72. Fölsch UR, Ebert R, Creutzfeldt W (1981) Response of insulin, GIP and glucose to sucrose during long-term application of acarbose. Scand J Gastroenterol 16: 629–632

    Google Scholar 

  73. Lembcke B, Hönig M, Caspary WF (1980): Different actions of neomycin and metronidazole on breath hydrogen (H2) exhalation. Z Gastroenterol 3: 155–160

    Google Scholar 

  74. Lembcke B, Fölsch UR, Caspary WF, Creutzfeldt W (1982): Influence of metronidazole on intestinal side effects of acarbose. Excerpta Medica (in press)

    Google Scholar 

  75. Lembcke B, Caspary WF, Fölsch UR, Creutzfeldt W (1981): Influence of neomycin on postprandial metabolic changes and side-effects due to a-glucosidehydrolase inhibition with acarbose. I. Effects on intestinal hydrogen gas production and side-effects. In: Regulators of intestinal absorption in obesity, diabetes and nutrition, vol 2. Societa Editrice Universo, Roma, pp 236–247

    Google Scholar 

  76. Fölsch UR, Lembcke B, Caspary WF, Ebert R, Creutzfeldt W (1981): Influence of neomycin on postprandial metabolic changes of a glycoside-hydrolase-inhibitor (Acarbose). II. Effect on sucrose tolerance, serum levels of IRI and GIP. In: Regulators of intestinal absorption in obesity, diabetes and nutrition, vol 2. Societa Editrice Universo, Roma, pp 250–258

    Google Scholar 

  77. Melani F, Ditschuneit H, Bartelt KM, Friedrich H, Pfeiffer EF (1965) Über die radioimmunologische Bestimmung von Insulin im Blut. Klin Wochenschr 43: 1000–1007

    PubMed  CAS  Google Scholar 

  78. Kuzio M, Dryburgh JR, Mallory KM, Brown JC (1974): Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology 66: 357–364

    PubMed  CAS  Google Scholar 

  79. Creutzfeldt W, Ebert R, Arnold R, Frerichs H, Brown JC (1976): Gastric inhibitory polypeptide ( GIP), gastrin and insulin response to test meal in coeliac disease and after duodenopancreatectomy. Diabetologia 12: 279–286

    Google Scholar 

  80. Paes IC, Searl P, Rubert MW, Faloon WW (1967): Intestinal lactase deficiency and saccharide malabsorption during oral neomycin administration. Gastroenterology 53: 49–58

    PubMed  CAS  Google Scholar 

  81. Dobbins WO, Herrero BA, Mansbach CM (1968): Morphologic alterations associated with neomycin induced malabsorption. Am J Med Sci 63: 63–77

    Google Scholar 

  82. Sachse G, Willms B (1979) Effect of the a-glucosidase inhibitor Bay g 5421 on blood glucose control of sulphonylurea-treated diabetics and insulin-treated diabetics. Diabetologia 17: 287–290

    PubMed  CAS  Google Scholar 

  83. Clarke BF et al. (1979) Diabetic autonomic neuropathy. Diabetologia 17: 195–212

    PubMed  CAS  Google Scholar 

  84. Deckert T et al. (1967) Prognosis of proliferative retinopathy in juvenile diabetics. Diabetes 16: 728–733

    PubMed  CAS  Google Scholar 

  85. Ewing DJ et al. (1976) Mortality in diabetic autonomic neuropathy. Lancet 1: 601–603

    PubMed  CAS  Google Scholar 

  86. Ewing DJ et al. (1978) Immediate heart rate response to standing: a simple test for autonomic neuropathy in diabetes. Br Med J 1: 145–147

    PubMed  CAS  Google Scholar 

  87. Ewing DJ et al. (1980a) The natural history of diabetic autonomic neuropathy. Q J Med 193: 95–108

    Google Scholar 

  88. Ewing (1980b) Autonomic mechanisms in the initial heart rate response to standing. Am Phys Soc 809–814

    Google Scholar 

  89. Ewing DJ et al. (1981a) Cardiac autonomic neuropathy in diabetes: Comparison of measures of R-R interval variation. Diabetologia 21: 18–24

    PubMed  CAS  Google Scholar 

  90. Ewing DJ et al. (1981b) Heart rate changes in diabetes mellitus. Lancet 1: 183–185

    PubMed  CAS  Google Scholar 

  91. Hoffmann (1981) A skin test for autonomic neuropathy. Eur Neurol 756 (in press)

    Google Scholar 

  92. Lloyd-Mostyn RH, Watkins PJ (1975) Defective innervation of heart in diabetic autonomic neuropathy. Br Med J 3: 15–17

    PubMed  CAS  Google Scholar 

  93. Page MMcB, Watkins PJ (1978) Cardiorespiratory arrest and diabetic autonomic neuropathy. Lancet 1: 14–16

    PubMed  CAS  Google Scholar 

  94. Smith SE. et al. (1981) Cardiac autonomic dysfunction in patients with diabetic retinopathy. Diabetologia 21: 525–528

    PubMed  CAS  Google Scholar 

  95. The criteria committee of the New York Heart Association (1981): Nomenclature and criteria for diagnosis of disease of the heart and great vessels, 8th edn. New York

    Google Scholar 

  96. Watkins P et al. (1972) The natural history of diabetic renal disease. Q J Med 41: 437–454

    PubMed  CAS  Google Scholar 

  97. Weissler AM, Warren JV (1978) Syncope. In: Hurst JW (ed) The heart. McGraw-Hill, New York, p 708

    Google Scholar 

  98. Hosking DJ, Bennett T, Hampton JR (1978) Diabetes 27

    Google Scholar 

  99. Clarke BF, Ewing DJ, Campbell IW (1979) Diabetologia 17: 195–212

    PubMed  CAS  Google Scholar 

  100. Mencer M (1953) Lancet 560–565

    Google Scholar 

  101. Bennet T, Farquhar I, Hosking D, Hampton J (1978) Diabetes 27: 1165

    Google Scholar 

  102. Fraser DM, Campbell IW, Ewing DJ, Murray A, Neilson JMM, Clarke BF (1977) Diabetes 26

    Google Scholar 

  103. Campbell IW (1976) Lancet 167

    Google Scholar 

  104. Hreidarsson AB (1981) Diabetologia 20: 475–481

    PubMed  CAS  Google Scholar 

  105. Scott J, Lloyd-Mostyn RH (1976) Lancet 590

    Google Scholar 

  106. Sundkvist GG, Almer L-O, Liljy B (1979) Med J 7: 924–925

    Google Scholar 

  107. Ewing DJ, Campbell IW, Clarke BF (1976) Lancet 601–603

    Google Scholar 

  108. Page M, Watkins PJ (1978) Lancet 14–16

    Google Scholar 

  109. Bank HL, Davis RF, Emerson D (1979) Cryogenic preservation of isolated rat islets of Langerhans: Effect of cooling and warming rates. Diabetologia 16: 195–199

    Google Scholar 

  110. Bretzel RG, Beule B, Schäfer S, Schneider J, Pfeiffer EF, Federlin K (1979) Cryopreservation and tissue culture of pancreatic islets for transplantation in experimental diabetes mellitus. Diabetes 28: 377

    Google Scholar 

  111. Bretzel RG, Schaefer S, Schneider J, Dobroschke J, Federlin K (1979) Cryopreservation of pancreatic islets for transplantation in diabetes mellitus. Exc Med Int Congr Series 481: 32

    Google Scholar 

  112. Bretzel RG, Schneider J, Dobroschke J, Schwemmle K, Federlin K (1980) Gefrierkonservierung (-196° C) tierischer und menschlicher Pankreasinseln zur Transplantation bei Diabetes mellitus. Verh Dtsch Ges Inn Med 86: 1003–1007

    CAS  Google Scholar 

  113. Bretzel RG, Schneider J, Dobroschke J, Schwemmle K, Pfeiffer EF, Federlin K (1980) Islet transplantation in experimental diabetes of the rat. VII. Cryopreservation of rat and human islets. Preliminary results. Horm Metab Res 12: 274–275

    Google Scholar 

  114. Bretzel RG, Schneider J, Zekorn T, Federlin K (1981) Cryopreservation of rat, porcine and human pancreatic islets for transplantation. In: Federlin K, Bretzel RG (eds) Islet isolation, culture and cryopreservation, Thieme, Stuttgart New York, p 152

    Google Scholar 

  115. Ferguson J, Allsopp RH, Taylor RMR, Johnston IDA (1976) Isolation and long term preservation of pancreatic islets from mouse, rat and guinea-pig. Diabetologia 12: 115–121

    PubMed  CAS  Google Scholar 

  116. Knight, MJ, Scharp DW, Kemp CB, Ballinger WF, Lacy PE (1973) Effects of cold storage on the function of isolated pancreatic islets. Cryobiology 10: 89–90

    PubMed  CAS  Google Scholar 

  117. Rajotte RV, Scharp DW, Downing R, Preston R, Molnar GD, Ballinger WF, Greider MH (1981) Pancreatic islet banking: The transplantation of frozen-thawed rat islets transported between centers. Cryobiology 18: 357–369

    Google Scholar 

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Beischer, W. et al. (1982). Diabetologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 88. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47093-6_18

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