Zusammenfassung
Wir versuchten in vivo, ob Insulin eine negative Rückkopplung auf seine eigene Sekretion ausübt. Zur Klärung der physiologischen Bedeutung eines derartigen Feedbacks wurden gesunde ideal- bis normalgewichtige Freiwillige untersucht. Bei zwei Erkrankungen mit Hyperinsulinismus, der Adipositas und dem Insulinom, stellte sich die Frage, ob ein gestörter Feedback eine pathophysiologische Rolle spielen könnte. Über die Mehrzahl unserer Befunde bei Gesunden und Adipösen berichteten wir bereits ausführlich [3, 4]. Im folgenden werden diese Ergebnisse zusammengefaßt und durch die Befunde bei Insulinomen ergänzt [vgl. 2].
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Beischer, W. et al. (1982). Diabetologie. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 88. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47093-6_18
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