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Symposium: Substratumsatz menschlicher Gewebe bei normalem und gestörtem Stoffwechsel

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 87))

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Zusammenfassung

Der Substratstoffwechsel von Organen kann grundsätzlich auf zweierlei Weise studiert werden: Einmal mit Hilfe der Kathetertechnik und andererseits mit Hilfe der Isotopentechnik. Bei der Kathetertechnik wird die Konzentration des jeweiligen Substrates vor und hinter dem Organ simultan gemessen. Gleichzeitig wird der Durchfluß des Organs pro Zeiteinheit bestimmt. Werden diese Messungen unter konstanten Bedingungen durchgeführt, kann man nach dem Fickschen Prinzip aus der Konzentrationsdifferenz der Substrate × der Durchblutung die Aufnahme oder Abgabe eines Substrats kalkulieren [1]. Während es nicht schwierig ist, den Substratfluß in ein Organ durch Messung der Konzentration der Substrate in einer zugänglichen Arterie zu bestimmen, wird es schwieriger im lebenden Organismus, das aus inneren Organen austretende Blut zu gewinnen. Dies ist praktisch nur möglich mit Hilfe eines Katheters, der im venösen Gefäßsystem hinter das Organ vorgeschoben wird. Trotzdem fanden bereits am Ende des letzten Jahrhunderts Messungen des Substratumsatzes von Geweben am lebenden Tier statt. Ein gutes Beispiel sind die Studien von Chaveau und Kaufmann aus dem Jahre 1887 [2], die an einem leicht zugänglichen Muskel, dem Lippenmuskel am Pferd, den Einfluß der Muskelaktivität auf den Substratumsatz beobachteten.

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Author information

Authors and Affiliations

  1. III. Med. Klinik, Stoffwechsel und Endokrinologie des Akadem, Lehrkrankenhauses Schwabing der Univ, München, Germany

    G. J. Dietze

  2. Dept. of Medicine and the General Clinical Research Center, Temple University Health Sciences Center, Philadelphia and the Dept. of Biochemistry, Medical School, Case Western Reserve University, Cleveland, USA

    E. Owen, M. S. Patel & G. Boden

  3. Klinik für Herz-und Kreislauferkrankungen, Deutsches Herzzentrum, München, Germany

    W. Rudolph & J. Dirschinger

  4. Diabetes and Lipid Research Laboratory, St. Bartholomew’s Hospital, London, UK

    D. J. Galton, J. Stocks, P. Dodson & G. Holdsworth

  5. Klin.-chem. Inst. und Forschergruppe Diabetes, Städt. Krankenhaus München-Schwabing, Germany

    W. G. Guder

  6. III. Med. Abt., Stoffwechsel und Endokrinologie des Akadem, Lehrkrankenhauses der Univ, München, Germany

    M. Wicklmayr & H. Mehnert

  7. Dept. of Clinical Physiology, Karolinska Institute, Huddinge Hospital, and the Dept. of Clinical Chemistry, Karolinska Hospital, Stockholm, Germany

    J. Wahren & L. Hagenfeldt

  8. Med. Klinik E der Univ, Düsseldorf, Germany

    M. Berger

  9. III. Med. Klinik, Stoffwechsel und Endokrinologie des Akadem, Lehrkrankenhauses Schwabing der Univ, München, Germany

    G. J. Dietze

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  1. G. J. Dietze
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K. Miehlke

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© 1981 Springer-Verlag Berlin Heidelberg

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Dietze, G.J. et al. (1981). Symposium: Substratumsatz menschlicher Gewebe bei normalem und gestörtem Stoffwechsel. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_30

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  • DOI: https://doi.org/10.1007/978-3-642-47092-9_30

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0327-6

  • Online ISBN: 978-3-642-47092-9

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