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Klinische Immunologie

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 87))

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Zusammenfassung

Die spontane oder natürliche zelluläre Zytotoxizität vermittelt durch natürliche Killer (NK)-Zellen wurde in den letzten Jahren zunehmend als eigenständige zytotoxe Reaktionsform erkannt. Sie läßt sich nach Art der Effektorzellen und des Effektormechanismus von der spezifischen zytotoxen T-Zellreaktion (CTC) und der antikörperabhängigen zellvermittelten Zytotoxizität (ADCC) abgrenzen [1]. NK-Zellen lysieren in vitro spontan Tumorzellen, virusinfizierte Zellen sowie auch Subpopulationen von normalen Thymus- und Knochenmarkszellen. Vor allem Ergebnisse aus dem Maussystem deuten darüber hinaus darauf hin, daß der durch NK-Zellen vermittelten Zytotoxizität auch in vivo eine wesentliche Bedeutung bei der Eliminierung maligner und virusinfizierter Zellen zukommt [2].

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Authors and Affiliations

  1. 1 Inst. für Immunologie, München, Deutschland

    J. Lohmeyer, E. P. Rieber, H. Feucht & M. Hadam

  2. 2 Med. Klinik II, München-Großhadern, Deutschland

    G. Pape

  3. 3 Med. Klinik, Augsburg, Deutschland

    G. Schlimok

  4. 4 Inst. für Immunologie, München, Deutschland

    G. Riethmüller

  5. Abt. I und Abt. II, Med, Klinik der Univ, Tübingen, Deutschland

    K. H. Wiedmann, A. Melms & P. A. Berg

  6. I. Univ.-Klinik für Gastroenterologie und Hepatologie, Deutschland

    B. Dragosics

  7. Univ.-Klinik für Chemotherapie, Deutschland

    W. Graninger

  8. Inst. für Klin. Chemie und Laboratoriumsdiagnostik, Deutschland

    K. Bauer & K. Czerwenka-Howorka

  9. I. Med. Univ.-Klinik, Deutschland

    E. Thaler

  10. Inst. für Patholog, Anatomie der Univ, Wien, Austria

    G. Syre

  11. Inst. für Immunologie und Serologie, Heidelberg, Deutschland

    U. Huschka, A. Pfarr, P. Kohl & E. W. Rauterberg

  12. III. Med. Klinik und Poliklinik der Univ, Gießen, Deutschland

    T. Boeder & K. Helmke

  13. Inst. für physikalische Biochemie der Univ, München, Deutschland

    H. P. Schultheiß, M. Klingenberg & H. W. Intorp

  14. Innere Abt. des St. Josefs-Hospitals Krefeld-Uerdingen, Deutschland

    F. Moshake

  15. Med. Univ.-Poliklinik Münster, Deutschland

    H. Losse

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  1. J. Lohmeyer
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K. Miehlke

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Lohmeyer, J. et al. (1981). Klinische Immunologie. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_21

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