Zusammenfassung
Vitamin A-Säure und chemisch analoge Retinoide haben im Tierexperiment zwei onkologisch relevante Wirkungen: Sie reduzieren die Tumorinzidenz bei Tieren, die mit chemischen Karzinogenen behandelt werden [5, 15, 16] und führen bei einigen bereits etablierten Tumoren außerdem zur Regression [2, 3, 7, 17].
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Literature
Bashor MM, Toft DO, Chytil F (1973) In vitro binding of Retinol to rat-tissue components. Proc Natl Acad Sci USA 70: 3483–3487
Bollag W (1971) Therapy of chemically induced skin tumors of mice with vitamin A palmitate and vitamin A acid. Experientia 27: 90–92
Bollag W (1974) Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer 10: 731–737
Brookes P (1966) Quantitative aspects of the reaction of some carcinogens with nucleic acids and the possible significance of such reactions in the process of carcinogenesis. Cancer Res 26: 1994–2003
Chu EW, Malmgren RA (1965) An inhibitory effect of vitamin A on the induction of tumors of the forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons. Cancer Res 25: 884–895
Chytil F, Ong DE (1976) Mediation of retinoic acid-induced growth and antitumour activity. Nature 260: 49–51
Felix EL, Loyd B, Cohen MH (1975) Inhibition of the growth and development of a transplantable murine melanoma by vitamin A. Science 181: 886–888
Jetten AM, Jetten MER (1979) Possible role of retinoic acid binding protein in retinoid stimulation of embryonal carcinoma cell differentiation. Nature 278: 180–182
Miller JA (1970) Carcinogenesis by chemicals: An overview G.H.A. Clowes memorial lecture. Cancer Res 30: 559–576
Nebert DW, Gelboin HV (1968) Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J Biol Chem 243: 6242–6249
Nebert DW, Gelboin HV (1968) Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction. J Biol Chem 243: 6250–6261
Ong DE, Chytil F (1975) Specificity of cellular retinol-binding protein for compounds with vitamin A activity. Nature 255: 74–75
Ong DE, Page DL, Chytil F (1975) Retinoic acid-binding protein: Occurance in human tumors. Science 190: 60–61
Rüdiger HW, Marxen J, Kohl F-V, Melderis H, Wiehert P v (1979) Metabolism and formation of DNA adducts of benzo(a)pyrene in human diploid fibroblasts. Cancer Res 39: 1083–1088
Saffiotti U, Montesano R, Sellakumar AR, Borg SA (1967) Experimental cancer of the lung. Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors. Cancer 20: 857–864
Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35: 1332–1338
Trown PW, Buck MJ, Hansen R (1976) Inhibition of growth and regression of a transplantable rat chondrosarcoma by three retinoids. Cancer Treat Rep 60: 1647–1653
Trown PW, Palleroni AV, Bohoslawec O, Richelo BN, Halpern JM, Gizzi N, Geiger R, Lewinski C, Machlin LJ, Jetten A, Jetten MER (1980) Relationship between binding affinities to cellular retinoic acid-binding protein and in vivo and in vitro properties for 18 retinoids. Cancer Res 40: 212–220
Wiggert B, Russell R, Lewis M, Chader G (1977) Differential binding to soluble nuclear receptors and effects on cell viability of retinol and retinoic acid in cultured retinoblastoma cells. Biochem Biophys Res Commun 79: 218–225
Greco FA, Richardson RL, Snell JD, Stroup SL, Oldham RK (1979) Small cell lung cancer. Complete remission and improved survival. Am J Med 66: 625–630
Hansen M, Hansen HH, Dombernowsky P (1980) Long-term survival in small cell carcinoma of the lung. JAMA 244: 247–250
Ihde DC, Cohen MH, Bernath AM, Matthews MJ, Bunn PA, Minna JD (1978) Serial fiberoptic bronchoscopy during chemotherapy for small cell carcinoma of the lung: Early detection of patients at high risk of relaps. Chest 74: 531–536
Ihde DC, Cohen MH, Simms EB, Matthews MJ, Bunn PA, Minna JD (1980) Evaluation of response to chemotherapy with fiberoptic bronchoscopy in non-small cell lung cancer. Cancer 45: 1693–1696
Niederle N, Schmidt CG, Seeber S (1980) Nichtoperative Therapie des Bronchialkarzinoms. Internist Welt 10: 359–368
Niederle N, Nakhosteen JA, Maassen W, Seeber S (1981) Advanced bronchogenic carcinoma Control of therapy by bronchoscopy. In: Nakhosteen JA, Maassen W (eds) Bronchology: research, diagnostik, and therapeutic aspects. Martinus Nijhoff Publ., The Hague Boston London, pp 367–370
Schmidt N, Schmidt-Hermes HJ, Sommer F (1974) Zur Bedeutung der Bronchoskopie bei der Therapiekontrolle und der Verlaufsbeobachtung des hochvoltbestrahlten Bronchialkarzinoms. Strahlentherapie 148: 549–555
Seeber S, Niederle N, Schilcher RB, Schmidt CG (1980) Adriamycin, Cyclophosphamid und Vincristin („ACO“) beim kleinzelligen Bronchialkarzinom. Verlaufsanalyse und Langzeitergebnisse. Onkologie 3: 5–11
Cox JD, Byhardt R, Komaki R, Wilson JF, Libnoch JA, Hansen R (1979) Interaction of thoracic irradiation and chemotherapy on local control and survival in small cell carcinoma of the lung. Cancer Treat Rep 63: 1251–1255
Cohen MH, Ihde DC, Bunn PA, Fossieck BE, Matthews MJ, Shackney SE, Johnston-Early A, Makuch R, Minna JD (1979) Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma. Cancer Treat Rep 63: 163–170
Cohen MH, Ihde DC, Fossieck BE, Bunn PA, Matthews MJ, Shackney SE, Johnston AV, Minna JD (1978) ASCO Abstr No. C-209 —4. Cohen MH, Ihde DC, Fossieck BE, Bunn PA, Matthews MJ, Johnston AV, Minna JD (1977) Proc Am Assoc Cancer Res 18: 286
Ayvazian LF, Schneider B, Gewirtz G, Yalow RS (1975) Ectopic production of big ACTH in carcinoma of the lung. Am Rev Respir Dis 111: 279–287
Silva OL, Becker KL, Primack A (1974) Ectopic secretion of calcitonin big oat-cell carcinoma. N Engl J Med 290: 1122–1124
Roberts JL, Herbert E (1977) Characterisation of a common precursor to corticotropin and -lipotropin. Proc Natl Acad Sci USA 74: 5300–5304
Mains RE, Eipper BA, Ling N (1974) Common precursor to corticotropin and endorphins. Proc Natl Acad Sci USA 74: 3014–3018
Gropp C, Havemann K, Pflüger KH (1980) Calcitonin als Tumormarker beim Bronchialkarzinom. Dtsch Med Wochenschr 105: 1175–1178
Goldstein G, Slyzys IS, Chase MW (1961) Studies on fluorescincouples sheep anti-rabbit globuline. J Exp Med 114: 89–94
Weber K, Osborn M (1969) The reliability of molecular weight determinations be dodecylt sulfate-polyacryl-amide gel electrophoresis. J Biol Chem 244: 4406–4412
Goltsman D, Tischler AS (1978) Characterization of calcitonin released by medullary thyroid carcinoma in tissue culture. J Clin Invest 61: 449–458
Schwarz N et al. (1976) Wien Klin Wochenschr 13: 423
Ambrus JL et al. (1975) J Med 6: 61
Fisher MM et al. (1951) JAMA 147: 1213
McKay DG et al. (1953) Cancer 6: 862
Storer Jet al. (1953) Surgery 33: 683
Sun NCJ (1974) Mayo Clin Proc 49: 636
Caprini JA (1976) Thromb Res 9: 167
Harker LA et al. (1972) N Engl J Med 287: 999
Lyman GH et al (1978) Cancer 41: 1113
Losito R et al. (1976) Am J Clin Pathol 68: 258
Brugarolas A et al. (1973) Surg Gynecol Obstet 136: 75
Cooper EH et al. (1978) Biomedicine 29: 154
Child JA et al (1978) Lancet 1: 897
Späti B et al. (1980) Acta Haematol (Basel) 64: 79
Child JA (1980) Cancer 45: 318
Ostendorf P et al. (1978) Therapiewoche 28: 2353
Amlot PL et al. (1973) Exp J Cancer 15: 791
Baldwin RW, Price MR, Robins RA (1972) Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumor-specific antigen-antibody complexes. Nature [New Biol] 238: 185–187
Collip PJ (1972) Hypoglycemia and leukemia. Pediatrics 49: 788–789
Gropp C, Havemann K, Scheuer A, Gerdes H (1979) Ektopische Hormonproduktion bei Patienten mit Bronchialkarzinom. Verh Dtsch Ges Inn Med 85: 1067
Gropp C, Havemann K, Pflüger K-H (1980) Calcitonin als Tumormarker beim Bronchialkarzinom. Dtsch Med Wochenschr 34: 1175
Havemann K, Gropp C, Schärfe T, Gramse M (1979) ACTH like activity in immune complexes of patients with oat cell carcinoma of the lung. Br J Cancer 39: 43
Heath H, Sizemore GW (1979) Immunochemical heterogeneity of calcitonin in tumor, tumor venous effluent, and peripheral blood of patients with medullary thyroid carcinoma. J Lab Clin Med 93: 390–401
Jullienne A, Segond N, Calmettes C, Moukhtar MS, Milhaud G (1980) Biosynthesis of human calcitonin: evidence for a prohormone. Biochem Biophys Res Commun 95: 932–937
Lumsden J, Ham J, Ellison ML (1980) Purification and partial characterization of high-molecular-weight forms of ectopic calcitonin for a human bronchial cell line. Biochem J 191: 239–246
MacMillan P, Mundy G (1980) Hypercalcemia and osteolytic bone lesions in chronic lymphocytic leukemia. Br Med J 281: 1107
Pflüger K-H, Gropp C, Gramse M, Scheuer A, Havemann K (1980) The incidence of paraneoplastic hormone production and autoantibody formation against proteohormones in solid tumors and leukemias. 15. Dtsch Krebskongr, Dtsch Krebsges eV München 11–15 März, 1980
Odell WD, Wolfsen SS (1978) Humoral syndromes associated with cancer. Annu Rev Med 29: 379–406
Resch R, Haas H, Berger H (1980) Hypercalcämie als Erstmanifestation einer akuten lymphatischen Leukämie. Dtsch Med Wochenschr 105: 123–127
Tanaka K, Nicholson WE, Orth DN (1978) The nature of the immunoreactive lipotropins in human plasma and tissue extracts. J Clin Invest 62: 94–104
Baxter JD, Harris AW, Tomkins GM, Cohn M (1971) Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Science 171: 189–191
Bloomfield CD, Smith KA, Peterson BA, Hildebrandt L, Zaleskas J, Gajl-Peczalska KJ, Frizzera G, Munck A (1980) In vitro glucocorticoid studies for predicting response for glucocorticoid therapy in adults with malignant lymphoma. Lancet 1: 952–955
Higgins ST, Gehring U (1978) Molecular mechanism of steriod hormon action. Cancer 28: 319–397
Ho AD, Hunstein W, Schmid W (1980) Determination of
glucocorticoid receptors in human leukemias. KIM Wochenschr 58: 43–45
Lippman ME, Yarbro GK, Leventhal BG (1978) Clinical implication of glucocorticoid receptors in human leukemia. Cancer 38: 4251–4256
Mastrangelo R, Malandrino R, Riccardi R, Longo P, Ranelletti FO, Iacobelli S (1980) Clinical implications of glucocorticoid receptor studies in childhood acute lymphoblastic leukaemia. Blood 56: 1036–1040
Rosenau W, Baxter JD, Rousseau GG, Tomkins GM (1972) Mechanism of resistance to steroids: Glucocorticoid receptor defect in lymphoma cells. Nature [New Biol] 237: 20–24
Meinshausen J, Choritz H, Georgii A (1980) Frequency of skeletal metastases as revealed by routinely taken bone marrow biopsies. Virchows Arch [Pathol Anat] 389: 409–417
Hashimoto M (1962) Pathology of bone marrow. Acta Haematol Jpn 27: 193–216
Ito Y, Okuyama S, Suzuki M, Sakurai M, Sato T, Takagi H (1973) Bone marrow scintigraphy in the early diagnosis of experimental metastatic bone carcinoma. Cancer 31: 1222–1230
Munz D, Hör G (1981) Phagocytic and proteolytic activity of liver, splenic, and bone marrow macrophages: valuable parameters of the immune status in tumor patients(in preparation)
Munz D, Standke R, Hör G (1980) 99mTc-labeled human serum albumin millimicrospheres a promising radiopharmaceutical for bone marrow studies. 18th Int Ann Meeting Soc Nucl Med, Nürnberg, proceedings (in press)
Munz D, Standke R, Hör G (1981) Measurement of phagocytic and proteolytic function of macrophages in liver, spleen, and bone marrow. In: Cox PH (ed) Progress in radiopharmacology, vol II. Elsevier/North Holland, Amsterdam, p 261
Nagel G (1980) Diagnostische Maßnahmen bei Skelettmetastasen. Dtsch Med Wochenschr 105: 710–711
Reske SN, Vyska K, Feinendegen LE (1979) The determination of an impaired phagocytosis and catabolic function of liver macrophages in normals and tumor patients by means of 99mTc-microparticles. 17th Int Ann Meeting Soc Nucl Med, Innsbruck, proceedings (in press)
Reske SN, Vyska K, Höck A, Welsh R, Feinendegen LE (1978) Untersuchung zur nuklearmedizinischen Funktionsprüfung des RES und der unspezifischen Immunabwehr. Nuklearmediziner (Gräfelfing) 2: 144–150
Bosl GJ, Cirrincione C, Geller N, Vugrin D, Whitmore, Golbey R (1981) Complete remission in patients with metastatic nonseminomatous germ cell tumors of the testis: Multivariate analysis of prognostic variables. Proc ASCO 22: 393
Carter SK, Torti FM (1980) Combination chemotherapy of nonseminomatous testicular cancer. Cancer Chemother Pharmacol 4: 71–77
Collins DH, Pugh RCB (1964) The pathology of testicular tumours. Livingstone Ltd., Edinburgh London
DeWolf WC, Lange TH, Einarson ME, Yunis EJ (1979) HLA and testicular cancer. Nature 277: 216–217
Germa-Lluch JR, Begent RHJ, Bagshawe KD (1980) Tumour-marker levels and prognosis in malignant teratoma of the testis. Br J Cancer 42: 850–855
Lapes M, Iozzi L, Ziegenfus W, Antoniades K, Vivagua R (1977) Familial testicular cancer in a father and son. Cancer 39: 2317–2320
Samuels ML (1975) Continous intravenous bleomycin therapy with vinblastine in testicular and extragonadal germinal tumors. Proc AACR 16: 112
Scheulen ME, Schilcher RB, Higi M, Mouratidou D, Seeber S, Schmidt CG (1980) Sequentiell alternierende Chemotherapie nichtseminomatöser Hodentumoren mit Velbe/Bleomycin und Adriamycin/cis-Platinum. Ergebnisse einer prospektiven Studie bei 211 Patienten. Verh Dtsch Ges Inn Med 86: 450–454
Seeber S, Gallmeier WM, Höffken K, Osieka R, Bruntsch U, Schmidt CG (1975) Neue Chemotherapie metastasierender maligner Hodenteratome. Dtsch Med Wochenschr 100: 1319–1324
Seeber S, Scheulen ME, Osieka R, Höffken K, Schmidt CG (1978) Development of chemotherapy programs containing vinblastine, bleomycin, adriamycin and cis-dichlorosiammine-platinum (II). In: Carter SK, Crooke ST, Umezawa H (eds) The bleomycins-current status and new developments. Academic Press, New York, pp 215–226
Alexanian R, Haut A, Khan AV et al. (1969) Treatment for multiple myeloma; combination chemotherapy with different melphalan dose regimes. JAMA 208: 1680–1685
Hoogstraaten B, Sheehe PR, Cuttner J et al. (1967) Melphalan and multiple myeloma. Blood 30: 74–83
McAthur JR, Athens JW, Wintrobe MM et al. (1970) Melphalan and myeloma; experience with a low-dose continous regime. Ann Intern Med 72: 655–670
Korst DR, Clifford GO, Fewler WM et al. (1964) Multiple myeloma; analysis of cyclophosphamide therapy in 165 patients. JAMA 189: 758–765 —
Bergsagel DE, Cowan DH, Hasselback R (1972) Plasma cell myeloma: Response of melphalan-resistant patients to high dose intermittent cyclophosphamide. Can Med Assoc J 107:851–855 —
Alberts DS, Chang SY, Chen HSG, Evans TL, Moou TE (1979) Oral melphalan kinetics. Clin Pharmacol Ther 26: 737–745
Durie BGM, Salmon SE (1975) A clinical staging system for multiple myeloma. Cancer 36: 842
Guidelines for Protocol Studies (1968) II. Plasma cell myeloma. Chronic Leukaemia-Myeloma Task Force of the National Cancer Institute. Cancer Chemother Rep 1: 17–39
Millington PF, Finean JB, Forbes OC, Frazer AC (1962) Studies of effects of aminopterin on the small intestine of the rat. I. The morphological changes following a single dose of aminopterin. Exp Cell Res 28: 162–178
Robinson JWL, Antonioli JA, Vannotti A (1970) Effect of oral methotrexate on the rat intestine. Biochem Pharmacol 15: 1479–1489
Roche AC, Bognel JC, Bernier JJ (1970) Correlation between the histological changes and glucose intestinal absorption following a single dose of 5-fluorouracil. Digestion 3: 195–212
Altmann GG (1974) Changes in the mucosa of the small intestine following methotrexate administration or abdominal X-irradiation. Am J Anat 140: 263–280
Wurth MA, Musacchia XJ (1973) Mechloretamine effects on intestinal absorption in vitro and on cell proliferation. Am J Physiol 225: 73–80
Fleischer K, Fiedler R (1973) Effects of cyclophosphamide on the excretory function of the rat pancreas. Arch Pharmacol 277: R17
Fromm H, Rodgers IB (1971) Effect of aminopterin on lipid absorption. Depression of lipid reesterifying enzymes. Am J Physiol 221: 998–1003
Kaufmann JH, Spiro HM, Floch MH (1967) Intestinal epithelial enzyme abnormalities induced by 5-fluoro-uracil translocation of Na DPH2-dehydrogenase. Am J Dig Dis 12: 598–606
Vitale JJ, Zamchek N, Di Giorgia J, Hegsted DM (1954) Effects of aminopterin administration on the respiration and morphology of the gastrointestinal mucosa of the rat. J Lab Clin Med 43: 583–594
Rommel K, Dietrich M, Böhmer R, Binder R (1973) Difference in absorption of actively absorbed sugar in “gnotobiotic patients”. In: Henegjyn JB (ed) Germfree research. Academic Press, New York, pp 83–85
Creaven PJ, Cohen MH, Allen LM (1976) Methotrexate plasma kinetics: possible alterations in patients undergoing gut sterilization. Br J Cancer 34: 571–575
Zaharako DS, Bruckner H, Oliveria VT (1969) Antibiotics alter methotrexate metabolism and excretion. Science 166: 887–888
McIntyre OR, Leone L, Pajak TF (1978) The use of intravenous melphalan ( L-PAM) in the treatment of multiple myeloma. Blood [Suppl] 52: 274
Kaduk B, Seiler G (1977) Sekundäre kongestive Kardiomyopathie nach Adriamycin. Dtsch Med Wochenschr 102: 1813–1817
Markiewicz W, Robinson E, Peled B, Kaufmann S, Carter A (1980) Early detection of doxorubicin cardiotoxicity by M-mode echocardiography. Cancer Chemother Pharmacol 5: 119–125
Praga C et al. (1980) Kardiotoxizität von Doxorubicin (Adriamycin): Retrospektive Studie über 1273 Patienten. In: Fetzer J, Füllenbach D, Musil J (Hrsg) Adriamycin, Bd. 3. Kehrer-Verlag, Freiburg, S. 145–159
Modolell M, Andreesen R, Pahlke W, Brugger U, Munder PG (1979) Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by ALP. Cancer Res 39: 4681–4686
Andreesen R, Modolell M, Weltzien HU, Eibl H, Common HH, Löhr GW, Munder PG (1978) Selective destruction of human leukemic cells by ALP. Cancer Res 38: 3894–3899
Andreesen R, Modolell M, Munder PG (1979a) Selective sensitivity of CML cell population to ALP. Blood 54: 519–523
Munder PG, Modolell M, Bausert W, Oettgen HF, Westphal O (1981) Alkyllysophospholipids in cancer therapy. In: Hersh EM et al. (eds) Augmenting agents in cancer therapy. Raven Press, New York, pp 441–458
Andreesen R, Modolell M, Speth V, Munder PG (1979b) Human macrophage activation by ALP. Immunobiology 156: 255
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Kohl, F.V. et al. (1981). Onkologie. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_20
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